ascorbic-acid and acetylsalicylic-acid-lysinate

ascorbic-acid has been researched along with acetylsalicylic-acid-lysinate* in 2 studies

Other Studies

2 other study(ies) available for ascorbic-acid and acetylsalicylic-acid-lysinate

Article	Year
Liberation of prostaglandin-like substances from the isolated coronary artery in presence of angiotensin and of 4-methylesculetin. Acta vitaminologica et enzymologica, 1985, Volume: 7, Issue:3-4 The aim of this work is to study the mechanism by which 4-Methylesculetin (4-ME) causes the relaxation or inhibits the Angiotensin II (ATN 2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with Ascorbic Acid, on basal tone and ATN 2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in presence of Lysine Acetylsalicylate (LAS) and Indomethacin (IN), known inhibitors of prostaglandin-synthetase. Both LAS and IN decrease but not abolish, the 4-ME induced relaxation and suppressed the depressive effect of 4-ME on the ATN 2 dependent contraction. From R.I.A. tests results that 6-Keto PGF1 alpha (prostacyclines stable metabolite) concentration increased with the addition of 4-ME to the bath. 6-Keto PGF1 alpha concentration was drastically reduced after IN and LAS use. Therefore, it seems reasonable to conclude that 4-ME influence could be mediated by prostacyclines release in the smooth muscle. Topics: Angiotensin II; Animals; Ascorbic Acid; Aspirin; Cattle; Coronary Vessels; Drug Interactions; In Vitro Techniques; Indomethacin; Lysine; Muscle, Smooth, Vascular; Prostaglandins; Scopoletin; Umbelliferones	1985
[Effect of prostaglandin-synthetase inhibitors on responses of segments of coronary arteries to 4-methylesculetol and/or to angiotensin II]. Acta vitaminologica et enzymologica, 1981, Volume: 3, Issue:4 The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) causes the relaxation or inhibits the angiotensin-2 (ATN2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and ATN2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN decreased, but did not abolish, the 4-Me induced relaxation and suppressed the depressive effect of 4-Me on the ATN2 dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle. Topics: Angiotensin II; Animals; Ascorbic Acid; Aspirin; Cattle; Coronary Vessels; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Lysine; Muscle, Smooth, Vascular; Scopoletin; Umbelliferones	1981

Article

Year

Liberation of prostaglandin-like substances from the isolated coronary artery in presence of angiotensin and of 4-methylesculetin.

Acta vitaminologica et enzymologica, 1985, Volume: 7, Issue:3-4

The aim of this work is to study the mechanism by which 4-Methylesculetin (4-ME) causes the relaxation or inhibits the Angiotensin II (ATN 2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with Ascorbic Acid, on basal tone and ATN 2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in presence of Lysine Acetylsalicylate (LAS) and Indomethacin (IN), known inhibitors of prostaglandin-synthetase. Both LAS and IN decrease but not abolish, the 4-ME induced relaxation and suppressed the depressive effect of 4-ME on the ATN 2 dependent contraction. From R.I.A. tests results that 6-Keto PGF1 alpha (prostacyclines stable metabolite) concentration increased with the addition of 4-ME to the bath. 6-Keto PGF1 alpha concentration was drastically reduced after IN and LAS use. Therefore, it seems reasonable to conclude that 4-ME influence could be mediated by prostacyclines release in the smooth muscle.

Topics: Angiotensin II; Animals; Ascorbic Acid; Aspirin; Cattle; Coronary Vessels; Drug Interactions; In Vitro Techniques; Indomethacin; Lysine; Muscle, Smooth, Vascular; Prostaglandins; Scopoletin; Umbelliferones

1985

[Effect of prostaglandin-synthetase inhibitors on responses of segments of coronary arteries to 4-methylesculetol and/or to angiotensin II].

Acta vitaminologica et enzymologica, 1981, Volume: 3, Issue:4

The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) causes the relaxation or inhibits the angiotensin-2 (ATN2) induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and ATN2 induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN decreased, but did not abolish, the 4-Me induced relaxation and suppressed the depressive effect of 4-Me on the ATN2 dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.

Topics: Angiotensin II; Animals; Ascorbic Acid; Aspirin; Cattle; Coronary Vessels; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Lysine; Muscle, Smooth, Vascular; Scopoletin; Umbelliferones

1981