An agonist that selectively binds to and activates androstane receptors.
ChEBI ID: 77326
| Member | Definition | Class |
|---|---|---|
| diethylhexyl phthalate | A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid. | bis(2-ethylhexyl) phthalate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 496 (15.16) | 18.7374 |
| 1990's | 294 (8.99) | 18.2507 |
| 2000's | 606 (18.52) | 29.6817 |
| 2010's | 1,100 (33.62) | 24.3611 |
| 2020's | 776 (23.72) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 28 (0.81%) | 5.53% |
| Reviews | 172 (5.01%) | 6.00% |
| Case Studies | 7 (0.20%) | 4.05% |
| Observational | 1 (0.03%) | 0.25% |
| Other | 3,228 (93.95%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 29.5193 | 6 | 7 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 13.6854 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 17.8293 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 6.3261 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 31.4821 | 3 | 3 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 27.3060 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.6876 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 15.5939 | 2 | 2 |
| G | Vesicular stomatitis virus | Potency | 17.8293 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 54.4827 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 6.1645 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 17.8293 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 17.8293 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 17.8293 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 7.9433 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 68.5896 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 3.8900 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 14.7318 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 34.6654 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 54.9410 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.4922 | 2 | 2 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 60.1179 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.8635 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 7.6959 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.7536 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 21.8751 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 21.8751 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.3365 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 3.8571 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.7633 | 3 | 3 |