Page last updated: 2024-12-10

ubiquinone q2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Ubiquinone Q2: interacts with iron atom to form acceptor quinone complex; RN given refers to cpd with unspecified isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5280346
CHEMBL ID1236595
CHEBI ID46372
SCHEMBL ID623496
SCHEMBL ID1506676
MeSH IDM0084299

Synonyms (38)

Synonym
CHEMBL1236595
ubiquinone-2 ,
C00399
coenzyme q2, >=90%
(e)-2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
606-06-4
2-[(2e)-3,7-dimethylocta-2,6-dien-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone
CHEBI:46372 ,
2-[(2e)-3,7-dimethylocta-2,6-dien-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
coenzyme q2
ubiquinone q2
2,5-cyclohexadiene-1,4-dione, 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-
DB08690
2-[(2e)-3,7-dimethylocta-2,6-dienyl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
7704-04-3
unii-i7t5v2w47r
p-benzoquinone, 2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-, (e)-
i7t5v2w47r ,
2,5-cyclohexadiene-1,4-dione, 2-((2e)-3,7-dimethyl-2,6-octadien-1-yl)-5,6-dimethoxy-3-methyl-
2,3-dimethoxy-5-geranyl-6-methyl-1,4-benzoquinone
p-benzoquinone, 2-geranyl-5,6-dimethoxy-3-methyl-
ubiquinone 2
q 2
coq2
SCHEMBL623496
dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
SCHEMBL1506676
SQQWBSBBCSFQGC-JLHYYAGUSA-N
2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone
2-[(2e)-3,7-dimethyl-2,6-octadienyl]-5,6-dimethoxy-3-methyl- p-benzoquinone
2-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl- p-benzoquinone
coq8, coenzyme q8 (e. coli), powder
Q27097878
DTXSID001019698
AKOS040755055
HY-118075
CS-0065140

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Bioavailability in normal rats was additionally assessed in various tissues and subcellular fractions after short-term and long-term coenzyme Q10 supplementation."( An Improvement of Oxidative Stress in Diabetic Rats by Ubiquinone-10 and Ubiquinol-10 and Bioavailability after Short- and Long-Term Coenzyme Q10 Supplementation.
Kettawan, A; Okamoto, T; Okuno, M; Posuwan, J; Prangthip, P, 2016
)
0.43

Dosage Studied

ExcerptRelevanceReference
" Because rotenone, a complex I inhibitor, increases H(2)O(2) production in heart but not in liver mitochondria we investigated the CoQ(2) effect in a dose-response assay of complex I inhibition by rotenone in both mitochondria."( Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: role of complex I.
Angoulvant, D; Augeul, L; Couture-Lepetit, E; De Paulis, D; Gharib, A; Gomez, L; Li, B; Ovize, M, 2012
)
0.38
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
ubiquinonesAny benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (9)

PathwayProteinsCompounds
TCA cycle (ubiquinol-2)1824
Succinic acid + Ubiquinone = Fumaric acid + Ubiquinol ( Tyrosine metabolism )24
Citrate cycle ( Citrate cycle )2129
TCA Cycle (Ubiquinol-2)424
superpathway of central carbon metabolism346
superpathway of glycolysis, pyruvate dehydrogenase and TCA cycle134
glycerol metabolism011
superpathway of glyoxylate cycle024
aerobic respiration -- electron donor II09
pyruvate oxidation pathway06

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1659336Induction of neuronal differentiation of neuronal progenitor cells isolated from embryonic mouse cerebrum at 1 uM treated every second day for 4 days and measured after 48 hrs by DAPI/MAP2 fluorescent immunostaining based assay2020Bioorganic & medicinal chemistry letters, 04-15, Volume: 30, Issue:8
Study on structure-activity relationship of vitamin K derivatives: Conversion of the naphthoquinone part into another aromatic ring and evaluation of their neuronal differentiation-inducing activity.
AID1091094Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 21 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID1091096Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 3 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID1091095Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 11 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID1091127Antifeedant activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as filter paper consumption measured 21 days post compound exposure (Rvb = 85 +/- 15.1 mg)2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (594)

TimeframeStudies, This Drug (%)All Drugs %
pre-199055 (9.26)18.7374
1990's64 (10.77)18.2507
2000's45 (7.58)29.6817
2010's419 (70.54)24.3611
2020's11 (1.85)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 9.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index9.15 (24.57)
Research Supply Index6.41 (2.92)
Research Growth Index5.56 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (9.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials9 (1.50%)5.53%
Reviews6 (1.00%)6.00%
Case Studies4 (0.67%)4.05%
Observational0 (0.00%)0.25%
Other581 (96.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]