An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA.
| Member | Definition | Class |
|---|
| 1'-acetoxychavicol acetate | An acetate ester that is chavicol acetate substituted by an acetoxy group at position 1'. | 1'-acetoxychavicol acetate |
| bay 11-7085 | A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB. | BAY11-7085 |
| brazilin | A organic heterotetracyclic compound that is a red pigment obtained from the wood of Caesalpinia echinata (Brazil-wood) or Caesalpinia sappan (sappan-wood). | brazilin |
| cblc137 | A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers. | CBL0137 |
| disulfiram | An organic disulfide that results from the formal oxidative dimerisation of N,N-diethyldithiocarbamic acid. A multi-enzyme inhibitor that is used in alcohol aversion therapy and also exhibits anticancer properties. | disulfiram |
| ergolide | A sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetyloxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis. | ergolide |
| eupomatenoid 6 | A member of the class of benzofurans that is 1-benzofuran substituted by a 4-hydroxyphenyl group at position 2, a methyl group at position 3 and a prop-1-en-1-yl group at position 5. It is a lignan derivative isolated from the roots of Krameria lappacea. | rataniaphenol II |
| fr 148083 | A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB. | 5Z-7-oxozeaenol |
| glaucine | An aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. | (S)-glaucine |
| jsh 23 | A diamine that is 1,2-phenylenediamine carrying a methyl substituent at position 4 and a 3-phenylpropyl substituent at position N1. | JSH-23 |
| kojic acid | A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae. | kojic acid |
| oleuropein | A secoiridoid glycoside that is the methyl ester of 3,4-dihydro-2H-pyran-5-carboxylic acid which is substituted at positions 2, 3, and 4 by hydroxy, ethylidene, and carboxymethyl groups, respectively and in which the anomeric hydroxy group at position 2 has been converted into its beta-D-glucoside and the carboxylic acid moiety of the carboxymethyl substituent has been converted to the corresponding 3,4-dihydroxyphenethyl ester (the 2S,3E,4S stereoisomer). The most important phenolic compound present in olive cultivars. | oleuropein |
| piperine | A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum. | piperine |
| pyrrolidine dithiocarbamate | A member of the class of dithiocarbamic acids that is the N-dithiocarboxy derivative of pyrrolidine. | pyrrolidine dithiocarbamate |
| rubimaillin | A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. | rubimaillin |
| tocotrienol, delta | A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2. | delta-tocotrienol |
| tubocapsanolide a | A withanolide that is 5beta,6beta:16alpha,17alpha-diepoxywitha-2,24-dienolide substituted by a hydroxy group at position 4 and an oxo group at position 1. Isolated from Tubocapsicum anomalum, it exhibits cytotoxic activity. | tubocapsanolide A |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 9.1385 | 1 | 8 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.3208 | 1 | 3 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 61.4534 | 4 | 6 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.6270 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 9.5316 | 1 | 8 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.5339 | 1 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 3.1658 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 5.9676 | 10 | 34 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 21.7443 | 3 | 8 |
| arylsulfatase A | Homo sapiens (human) | Potency | 7.5686 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.7372 | 4 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.0343 | 2 | 7 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 20.8472 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.1651 | 2 | 9 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 7.1944 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 6.2870 | 1 | 2 |
| beta-2 adrenergic receptor | Homo sapiens (human) | Potency | 0.6513 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0056 | 2 | 2 |
| BRCA1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 11.4264 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 10.5590 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 11.4264 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 10.5590 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.8502 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 22.5358 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 28.3085 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 58.7637 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 11.6698 | 2 | 7 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 30.3001 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 19.3739 | 2 | 5 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 18.8231 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 19.3739 | 2 | 5 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 30.2117 | 2 | 3 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 0.5380 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 2.9031 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 1.4550 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 7.8647 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 27.0942 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 11.2488 | 2 | 9 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 18.1380 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.5952 | 1 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.6706 | 2 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 89.1251 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 9.8894 | 9 | 35 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 10.3678 | 2 | 6 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 6.5044 | 10 | 40 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 1.5173 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0389 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 14.3111 | 3 | 7 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 3 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 22.6860 | 1 | 5 |
| G | Vesicular stomatitis virus | Potency | 7.8647 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 11.3828 | 1 | 5 |
| geminin | Homo sapiens (human) | Potency | 10.9172 | 4 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.1666 | 3 | 12 |
| GLS protein | Homo sapiens (human) | Potency | 18.2944 | 2 | 5 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 35.7921 | 3 | 3 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.6744 | 1 | 5 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 2.9309 | 2 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 0.1814 | 2 | 6 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 5.7014 | 2 | 14 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.3860 | 1 | 3 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 9.7332 | 2 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 26.2146 | 2 | 8 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 7.8647 | 1 | 3 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 9.6527 | 2 | 5 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.4062 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 0.0130 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 7.8647 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 8.0263 | 2 | 9 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 2.9413 | 2 | 6 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 3.9811 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 8.9834 | 3 | 9 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 14.9763 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 10.0495 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 19.8396 | 1 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 7.0795 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.3905 | 1 | 3 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 37.7950 | 1 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 11.5821 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.6978 | 3 | 10 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.4729 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 2.6451 | 2 | 13 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 2.8554 | 3 | 15 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 15.2615 | 2 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 10.2438 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 26.2818 | 5 | 11 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 1.4170 | 2 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 3.1305 | 1 | 4 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 11.2947 | 1 | 2 |
| polyprotein | Zika virus | Potency | 22.6860 | 1 | 5 |
| polypyrimidine tract-binding protein 1 isoform a | Homo sapiens (human) | Potency | 14.5500 | 2 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 2.9019 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 8.8861 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 19.1498 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 8.1071 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 22.1063 | 2 | 7 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 20.4255 | 2 | 6 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.8489 | 2 | 2 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 2.1064 | 2 | 12 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 39.5359 | 1 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.5907 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 1.3921 | 3 | 15 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 23.1885 | 4 | 11 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 0.5380 | 2 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 0.7360 | 3 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 0.8437 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 7.9744 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.7943 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 28.3627 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.3046 | 2 | 14 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 10.1429 | 2 | 6 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 26.3015 | 3 | 11 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 45.3385 | 4 | 10 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 23.5267 | 2 | 3 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 2.4424 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 11.2947 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 11.2947 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 29.3492 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 2.2065 | 2 | 6 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 18.6434 | 5 | 10 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 5.3926 | 1 | 5 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.6744 | 1 | 5 |
| Vpr | Human immunodeficiency virus 1 | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 4.2905 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.1710 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.9660 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 34.5470 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 11.0515 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.3280 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 16.0010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 7.4290 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.3560 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.2010 | 1 | 1 |
| Aldehyde dehydrogenase, mitochondrial | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 70.3700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 69.8120 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.1780 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 8.3300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 1.1780 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.2010 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 4.9040 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.8390 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 3.2180 | 1 | 1 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 1.4690 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 36.3570 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Mus musculus (house mouse) | Ki | 19.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 0.7665 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Mus musculus (house mouse) | Ki | 3.1900 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| apelin receptor | Homo sapiens (human) | IC50 | 2.6300 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 44.8000 | 2 | 2 |
| bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase | Mycobacterium tuberculosis H37Rv | IC50 | 85.0300 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 71.5000 | 2 | 2 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 3.3225 | 1 | 2 |
| C-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 1.2840 | 1 | 2 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | IC50 | 8.3950 | 1 | 1 |
| C-C chemokine receptor type 4 | Homo sapiens (human) | Ki | 4.3970 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 23.6610 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | Ki | 18.2840 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | IC50 | 6.0130 | 1 | 1 |
| C-X-C chemokine receptor type 2 | Homo sapiens (human) | Ki | 4.2090 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carbamate kinase | Giardia intestinalis | IC50 | 0.6000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 31,000.0000 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 31,000.0000 | 1 | 2 |
| Caspase-1 | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 12.4446 | 1 | 2 |
| D | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 2.0000 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 3.2850 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 1.6425 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 23.0180 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 7.6730 | 1 | 1 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 2.8000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 2.2720 | 1 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.7715 | 1 | 2 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 3.1500 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 1.1050 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 0.8800 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| DNA (cytosine-5)-methyltransferase 3A | Mus musculus (house mouse) | IC50 | 7.0000 | 2 | 2 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 | 0.0296 | 3 | 3 |
| Dual specificity mitogen-activated protein kinase kinase 4 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 7 | Homo sapiens (human) | IC50 | 0.8000 | 2 | 2 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 363.0780 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 101.2380 | 10 | 10 |
| Gasdermin-D | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Gasdermin-D | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 56.7000 | 3 | 3 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 6.1030 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 2.4410 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 10.7300 | 1 | 1 |
| Lysine-specific demethylase 5A | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Lysyl oxidase homolog 2 | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| Lysyl oxidase homolog 3 | Homo sapiens (human) | IC50 | 0.0930 | 1 | 1 |
| Lysyl oxidase homolog 4 | Homo sapiens (human) | IC50 | 0.0590 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 2.5393 | 3 | 3 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 1.5100 | 1 | 1 |
| Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (human) | IC50 | 0.0170 | 8 | 8 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 0.8095 | 2 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 3.5110 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 1.4250 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Mus musculus (house mouse) | IC50 | 3.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 35.8500 | 2 | 2 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 35.8500 | 2 | 2 |
| Nuclear receptor subfamily 2 group C member 2 | Homo sapiens (human) | IC50 | 0.0090 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 6.9590 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 1.6220 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 12.4446 | 1 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | IC50 | 20.1350 | 2 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | Ki | 12.2000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 63.2557 | 107 | 108 |
| Polyphenol oxidase 2 | Agaricus bisporus | Ki | 82.3278 | 9 | 9 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 52.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 16.0660 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 1.7000 | 1 | 1 |
| Protein-lysine 6-oxidase | Homo sapiens (human) | IC50 | 0.3200 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 15.3833 | 2 | 3 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 9.3500 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 6.3094 | 9 | 10 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 3.7100 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 3.7100 | 1 | 1 |
| Retinal dehydrogenase 1 | Homo sapiens (human) | IC50 | 0.1300 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 4.6370 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 3.6840 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 70.3700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 69.8120 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 9.3500 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 9.3500 | 1 | 1 |
| TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | Homo sapiens (human) | IC50 | 0.0087 | 3 | 3 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 23.9833 | 3 | 3 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 9.3500 | 1 | 1 |
| type-1 angiotensin II receptor | Homo sapiens (human) | IC50 | 6.6370 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 1,014.7415 | 19 | 20 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 716.9000 | 3 | 3 |
| Tyrosinase | Priestia megaterium | IC50 | 52.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 5,500.0000 | 1 | 1 |
| Tyrosinase | Danio rerio (zebrafish) | IC50 | 12,550.0000 | 2 | 2 |
| Uncharacterized protein YOR062C | Saccharomyces cerevisiae S288C | IC50 | 19.0000 | 1 | 1 |