A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system.
| Member | Definition | Class |
|---|
| acetosyringone | A member of the class of acetophenones that is 1-phenylethanone substituted by a hydroxy group at position 4 and methoxy groups at positions 3 and 5. | acetosyringone |
| acetovanillone | An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3. | apocynin |
| alfentanil | A member of the class of piperidines that is piperidine having a 2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl group at the 1-position as well as N-phenylpropanamido- and methoxymethyl groups at the 4-position. | alfentanil |
| ampyrone | A pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. | 4-aminoantipyrine |
| aprepitant | A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. | aprepitant |
| chloroprocaine | Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. | chloroprocaine |
| dipyrone | A pyrazole that is antiipyrine substituted at C-4 by a methyl(sulfomethyl)amino group, the sodium salt of which, metamizole sodium, was widely used as a powerful analgesic and antipyretic, but withdrawn from many markets from the 1970s due to a risk of causing risk of causing agranulocytosis. | metamizole |
| dipyrone | An organic sodium salt of antipyrine substituted at C-4 by a methyl(sulfonatomethyl)amino group, commonly used as a powerful analgesic and antipyretic. | metamizole sodium |
| ecgonine methyl ester | The O-debenzoyl analogue of cocaine. | ecgonine methyl ester |
| methyldopa | A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. | alpha-methyl-L-dopa |
| nicotine | A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. | (S)-nicotine |
| noramidopyrine | A member of the class of pyrazoles that is antipyrine substituted at C-4 by a methylamino group. It is a metabolite of aminopyrine and of metamizole. | 4-(methylamino)antipyrine |
| parthenolide | A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium). | parthenolide |
| phenacetin | A member of the class of acetamides that is acetamide in which one of the hydrogens attached to the nitrogen is substituted by a 4-ethoxyphenyl group. | phenacetin |
| phenylbutazone | A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position. | phenylbutazone |
| procaine | A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol. | procaine |
| propionylcarnitine | An O-acylcarnitine compound having propanoyl as the acyl substituent. | O-propanoylcarnitine |
| propyphenazone | A pyrazolone derivative that is antipyrine substituted at C-4 by an isopropyl group. | propyphenazone |
| rosmarinic acid | The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid. | rosmarinic acid |
| suprofen | An aromatic ketone that is thiophene substituted at C-2 by a 4-(1-carboxyethyl)benzoyl group. | suprofen |
| suxibuzone | A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses. | suxibuzone |
| zardaverine | A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4. | zardaverine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 27.5371 | 1 | 8 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 12.9890 | 1 | 3 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 37.9330 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 54.9792 | 2 | 7 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0120 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 20.0090 | 1 | 10 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 11.2202 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 30.5777 | 8 | 14 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 34.0915 | 2 | 3 |
| arylsulfatase A | Homo sapiens (human) | Potency | 20.1632 | 1 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 32.2837 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 11.3542 | 4 | 8 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 29.2657 | 2 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 3.5563 | 2 | 7 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 27.8298 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 22.0412 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 22.0412 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.2155 | 3 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 16.9270 | 1 | 7 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 4.9472 | 2 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 43.9099 | 2 | 5 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 6.3790 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 16.2710 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 7.3116 | 2 | 8 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 13.4797 | 1 | 5 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 6.3618 | 1 | 7 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 6.3790 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 66.5298 | 2 | 10 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 16.3114 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 16.8401 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 8.6124 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 24.9054 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.2191 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.4955 | 1 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 53.4040 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.5329 | 1 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 23.2809 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 1.5099 | 1 | 3 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 5.5809 | 2 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 5.9000 | 2 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 3.2690 | 1 | 6 |
| endonuclease IV | Escherichia coli | Potency | 31.6228 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.1600 | 8 | 28 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 39.7969 | 9 | 24 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 12.9034 | 1 | 9 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 4.7763 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 29.8470 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 36.7453 | 3 | 5 |
| G | Vesicular stomatitis virus | Potency | 16.8401 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| GALC protein | Homo sapiens (human) | Potency | 0.6310 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 9.3351 | 2 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 24.0393 | 2 | 13 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 5.9976 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 19.5681 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 17.3934 | 4 | 10 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 24.4465 | 1 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 17.3285 | 2 | 10 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 17.0090 | 1 | 8 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 29.8493 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.6592 | 2 | 5 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 16.8401 | 1 | 4 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 22.5410 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 29.5599 | 1 | 3 |
| IDH1 | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 89.9056 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 16.8401 | 1 | 8 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 17.7161 | 2 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 15.1045 | 3 | 10 |
| interleukin 8 | Homo sapiens (human) | Potency | 47.3079 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.4755 | 2 | 8 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 22.1060 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 9.5283 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 2.7717 | 1 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 33.9735 | 1 | 4 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 20.2415 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.9211 | 1 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 40.3444 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 52.5784 | 1 | 3 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 0.3162 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.0039 | 3 | 5 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 35.4813 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 29.7938 | 3 | 11 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 54.5388 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.7252 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 80.3039 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 40.8359 | 3 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 26.7067 | 2 | 3 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 8.0092 | 3 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 53.9421 | 2 | 7 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 14.7403 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 22.3259 | 2 | 9 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 25.6643 | 3 | 4 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 0.7943 | 2 | 3 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 24.7794 | 2 | 3 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 17.5394 | 1 | 6 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 27.7858 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 8.4332 | 2 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 23.0014 | 4 | 4 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 38.7383 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 38.7383 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 4.5167 | 1 | 6 |
| snurportin-1 | Homo sapiens (human) | Potency | 89.9056 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 6.4643 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 30.3803 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.7232 | 2 | 16 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 35.9957 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.1026 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.8709 | 3 | 5 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.0018 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.6362 | 4 | 5 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 49.2885 | 1 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 26.8325 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 45.3708 | 3 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 62.9847 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 24.4465 | 1 | 4 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 71.0000 | 1 | 2 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | IC50 | 11.0000 | 2 | 2 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 | 4.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | Ki | 2.7000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | IC50 | 0.0025 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | Ki | 3.3139 | 4 | 4 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | Ki | 8.1350 | 2 | 2 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 0.2236 | 7 | 8 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 1,220.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 112.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 527.6364 | 4 | 11 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A | Bos taurus (cattle) | IC50 | 10.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Bos taurus (cattle) | IC50 | 10.0000 | 1 | 1 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | IC50 | 99.7820 | 1 | 10 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | IC50 | 99.7820 | 1 | 10 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | IC50 | 0.4723 | 3 | 3 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 71.4748 | 5 | 14 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | IC50 | 0.4723 | 3 | 3 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 50.1985 | 11 | 22 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | IC50 | 0.2100 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 7B | Homo sapiens (human) | IC50 | 99.7820 | 1 | 10 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 375.5000 | 1 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 375.5000 | 1 | 2 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 84.5246 | 2 | 13 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 14.7068 | 5 | 7 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 71.4120 | 5 | 14 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 79.2014 | 3 | 14 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 0.3900 | 1 | 7 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.3900 | 1 | 4 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 0.3900 | 1 | 2 |
| Chain A, Phosphodiesterase 4D | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| Cyclooxygenase-2 | Canis lupus familiaris (dog) | IC50 | 3.7900 | 1 | 1 |
| Cystathionine gamma-lyase | Homo sapiens (human) | IC50 | 3,000.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 1,366.6858 | 3 | 3 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Ki | 72.0000 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 159.9560 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 210.6763 | 2 | 3 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 46.2667 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 22.5667 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 13.1730 | 2 | 2 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.4400 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens (human) | IC50 | 99.7820 | 1 | 10 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 5.2280 | 1 | 1 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 2 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| fMet-Leu-Phe receptor | Homo sapiens (human) | IC50 | 5.3000 | 1 | 1 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | IC50 | 84.5246 | 2 | 13 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 3.5596 | 2 | 2 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 3 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 3.5596 | 2 | 2 |
| Liver carboxylesterase B-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0450 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0150 | 1 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0389 | 1 | 1 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.2260 | 2 | 2 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.2241 | 2 | 2 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Mus musculus (house mouse) | Ki | 2.1100 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 1.0597 | 2 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 360.0000 | 1 | 1 |
| Neuromedin-K receptor | Homo sapiens (human) | Ki | 0.4541 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Homo sapiens (human) | Ki | 0.0595 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 0.0438 | 27 | 28 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 0.3899 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | Ki | 0.3763 | 20 | 20 |
| Neuronal acetylcholine receptor subunit alpha-3 | Mus musculus (house mouse) | Ki | 0.0841 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 0.2178 | 37 | 42 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 0.3456 | 10 | 12 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 0.0055 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | Ki | 0.0019 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.3444 | 30 | 30 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0204 | 72 | 85 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-5 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 14.3000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | IC50 | 0.0087 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Ki | 5.9317 | 17 | 19 |
| Neuronal acetylcholine receptor subunit alpha-7 | Mus musculus (house mouse) | Ki | 0.2406 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Ki | 3.1729 | 16 | 20 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | IC50 | 0.0041 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | IC50 | 0.3256 | 11 | 13 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.3399 | 30 | 30 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | Ki | 0.0024 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 0.0124 | 76 | 85 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | IC50 | 0.0848 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0050 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Mus musculus (house mouse) | Ki | 0.0012 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 0.0070 | 3 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | IC50 | 0.7150 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | IC50 | 5.0025 | 4 | 4 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | Ki | 0.3463 | 22 | 22 |
| Neuronal acetylcholine receptor subunit beta-4 | Mus musculus (house mouse) | Ki | 0.0572 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Ki | 0.1748 | 54 | 63 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.1260 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 269.6219 | 6 | 7 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 209.0000 | 3 | 4 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 163.0000 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 15.0000 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Ki | 1.0466 | 3 | 3 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | IC50 | 151,600.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 64.3000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 50.5000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 488.0000 | 1 | 1 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 34.7000 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | IC50 | 0.0002 | 10 | 10 |
| Substance-P receptor | Meriones unguiculatus (Mongolian gerbil) | IC50 | 0.0001 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | Ki | 0.0013 | 3 | 3 |
| Toll-like receptor 4 | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 0.5063 | 2 | 4 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 5.5000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 5.1760 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 7 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 7 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 7 |
| UDP-glucuronosyltransferase 2B10 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 7 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 7 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 5.3360 | 1 | 1 |
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | EC50 | 25.3333 | 3 | 3 |
| Acetylcholine receptor subunit alpha | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit beta | Homo sapiens (human) | EC50 | 29.0000 | 3 | 3 |
| Acetylcholine receptor subunit beta | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine receptor subunit delta | Homo sapiens (human) | EC50 | 33.0000 | 2 | 2 |
| Acetylcholine receptor subunit delta | Tetronarce californica (Pacific electric ray) | EC50 | 110.0000 | 2 | 2 |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | EC50 | 65.0000 | 1 | 1 |
| Acetylcholine receptor subunit gamma | Homo sapiens (human) | EC50 | 33.0000 | 2 | 2 |
| Acetylcholine receptor subunit gamma | Tetronarce californica (Pacific electric ray) | EC50 | 60.0000 | 1 | 1 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Kd | 0.2931 | 3 | 5 |
| cGMP-dependent protein kinase 1 | Homo sapiens (human) | EC50 | 200.0000 | 1 | 1 |
| Cytochrome P450 2A13 | Homo sapiens (human) | Kd | 54.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Kd | 470.0000 | 1 | 1 |
| Glycoprotein IIb | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| Integrin beta | Oryctolagus cuniculus (rabbit) | EC50 | 1.5068 | 1 | 4 |
| mu-type opioid receptor isoform MOR-1 | Homo sapiens (human) | EC50 | 92.5900 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | EC50 | 40.6667 | 2 | 3 |
| Neuronal acetylcholine receptor subunit alpha-10 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | EC50 | 21.3260 | 14 | 15 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 30.2517 | 7 | 8 |
| Neuronal acetylcholine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | EC50 | 3.1424 | 20 | 24 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 10.7398 | 12 | 12 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-5 | Homo sapiens (human) | EC50 | 30.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-6 | Homo sapiens (human) | EC50 | 0.1270 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | EC50 | 55.2158 | 6 | 6 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | EC50 | 3,948.0836 | 10 | 11 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | Kd | 0.0011 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-9 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | EC50 | 9.3127 | 23 | 27 |
| Neuronal acetylcholine receptor subunit beta-2 | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 10.7398 | 12 | 12 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-3 | Homo sapiens (human) | EC50 | 10.5635 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 35.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| Neuronal acetylcholine receptor subunit beta-4 | Homo sapiens (human) | EC50 | 13.6576 | 14 | 15 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | EC50 | 30.2517 | 7 | 8 |
| Neuronal acetylcholine receptor subunit beta-4 | Rattus norvegicus (Norway rat) | Kd | 14,352.0000 | 3 | 3 |
| POsterior Segregation | Caenorhabditis elegans | EC50 | 13.6040 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | EC50 | 8.7510 | 1 | 1 |
| Substance-P receptor | Homo sapiens (human) | Kd | 0.0083 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 152,369.0000 | 2 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Mus musculus (house mouse) | EC50 | 10.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | EC50 | 51.0000 | 1 | 1 |
| Zinc finger protein mex-5 | Caenorhabditis elegans | EC50 | 8.7510 | 1 | 1 |