An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of aldehyde reductase (EC 1.1.1.21).
| Member | Definition | Class |
|---|
| berberine | | berberine |
| butein | A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'. | butein |
| curcumin | A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. | curcumin |
| epalrestat | A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy. | epalrestat |
| eriodictyol 7-glucuronide | A beta-D-glucosiduronic acid that is the 7-O-glucuronide of (2R)-eriodictyol. Isolated from the flowers of Chrysanthemum indicum, it exhibits inhibitory activity for rat lens aldose reductase. | (2R)-eriodictoyl-7-O-beta-D-glucopyranosiduronic acid |
| n-methylhippuric acid | An N-acylglycine that is N-methylglycine in which the hydrogen of the amino group is substituted by a benzoyl group. | N-methylhippuric acid |
| nigerloxin | A member of the class of benzoic acids that is benzoic acid which is substituted at positions 2, 3, 4, 5, and 6 by carbamoyl, hydroxy, E)-prop-1-en-1-yl, methyl, and methoxy groups, respectively. Obtained from solid-state fermentation of Aspergillus niger CFR-W-105, it inhibits soy bean lipoxygenase-1 (LOX-1) and rat lens aldose reductase (RLAR). It also shows free radical scavenging activity. | nigerloxin |
| patuletin | A trimethoxyflavone that is quercetagetin methylated at position 6. | patuletin |
| quercitrin | A quercetin O-glycoside that is quercetin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage. | quercitrin |
| rosmarinic acid | The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid. | rosmarinic acid |
| semilicoisoflavone b | A member of the class of 7-hydroxyisoflavones that is 2',2'-dimethyl-2'H,4H-3,6'-bichromen-4-one substituted by hydroxy groups at positions 5, 7 and 8'. It has been isolated from Glycyrrhiza uralensis. | semilicoisoflavone B |
| sorbinil | An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring. | sorbinil |
| tolrestat | | tolrestat |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.4411 | 1 | 3 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 63.6740 | 3 | 4 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 35.6534 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 27.2549 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 7.0795 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 24.7551 | 9 | 21 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 31.5724 | 3 | 6 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.7209 | 1 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 44.1534 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 10.9852 | 4 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 48.3696 | 2 | 4 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 27.4727 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 27.4727 | 1 | 1 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 18.2861 | 3 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.0156 | 1 | 4 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 100.0000 | 1 | 1 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 7.0795 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 17.1509 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 40.0686 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.4038 | 1 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.5249 | 1 | 6 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 13.9344 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 17.1509 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 28.2141 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 13.6758 | 2 | 6 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 34.4925 | 1 | 3 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 27.2454 | 2 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 23.3318 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 33.2060 | 2 | 4 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 31.7853 | 2 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 26.5929 | 1 | 7 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 42.9745 | 8 | 14 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 27.4727 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.6616 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.0687 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 8.3572 | 4 | 4 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 4.7763 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 46.9791 | 4 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 52.7107 | 1 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 13.6758 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 18.6172 | 2 | 7 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.7033 | 3 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 33.6569 | 1 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 24.9765 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 43.2943 | 3 | 4 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 77.4286 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 31.2256 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 27.3162 | 2 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 4 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 25.3333 | 1 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 101.3910 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 31.6228 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 52.2970 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.4108 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 56.8352 | 2 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 13.6045 | 2 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 10.4353 | 1 | 3 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 22.9608 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.0794 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 21.0677 | 3 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 20.7510 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 8.1884 | 2 | 6 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 35.7168 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 21.6407 | 4 | 4 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 3.4895 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 24.3888 | 2 | 8 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 62.3531 | 3 | 3 |
| P53 | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.7954 | 2 | 4 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 27.0962 | 5 | 8 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.5047 | 5 | 5 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 10.9472 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 60.8578 | 1 | 4 |
| PINK1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.8146 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 37.3019 | 2 | 2 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 79.4328 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 39.8396 | 2 | 2 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 29.5262 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 47.0389 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 9.2176 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 30.7735 | 4 | 4 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 41.5410 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 41.5410 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 28.9342 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 56.8352 | 2 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 17.6530 | 2 | 12 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 37.6460 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 26.2910 | 2 | 6 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 52.1315 | 3 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 23.3155 | 5 | 6 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.7247 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 3.9811 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 7.5506 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 13.9840 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 39.5969 | 5 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 53.3595 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 77.4286 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 9.6995 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 4.5150 | 1 | 2 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 53.3216 | 5 | 5 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 306.4500 | 4 | 4 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | IC50 | 2.8014 | 6 | 9 |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | IC50 | 1.1198 | 3 | 4 |
| Aldo-keto reductase family 1 member A1 | Sus scrofa (pig) | IC50 | 2.0260 | 4 | 5 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 1.4269 | 18 | 22 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 66.4639 | 42 | 55 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.4686 | 51 | 66 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 4.2862 | 3 | 4 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | IC50 | 0.9960 | 8 | 11 |
| Aldo-keto reductase family 1 member B10 | Homo sapiens (human) | Ki | 0.0500 | 1 | 1 |
| Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | IC50 | 1.1980 | 1 | 1 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 6.7100 | 1 | 1 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | IC50 | 40.6500 | 1 | 2 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | Ki | 22.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.3344 | 2 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.4000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 81.0100 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 3.5000 | 3 | 3 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 2.5733 | 3 | 3 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 15.5000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 9.8541 | 30 | 30 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 243,576.9100 | 3 | 3 |
| Arginase | Leishmania amazonensis | IC50 | 12.2000 | 1 | 1 |
| Arginase | Leishmania amazonensis | Ki | 7.9000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 45.8000 | 1 | 1 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 7.7510 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 172.6850 | 2 | 2 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | Ki | 39.6000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 111.0500 | 2 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.6300 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 84.4000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 2.3600 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 86.4500 | 4 | 4 |
| Cholinesterase | Homo sapiens (human) | IC50 | 12.2633 | 3 | 3 |
| CREB-binding protein | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 7.7500 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.9747 | 3 | 3 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0440 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0850 | 1 | 1 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 1.0700 | 2 | 2 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | IC50 | 200.0000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] FabI | Escherichia coli K-12 | IC50 | 30.0000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 12.5000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 2.8280 | 3 | 3 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 12.0000 | 2 | 2 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 69.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 17.9500 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.0660 | 1 | 1 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 7.9635 | 2 | 2 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 21.9167 | 6 | 6 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 50.7900 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 97.6700 | 1 | 1 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 64.9800 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| hypothetical protein SA1422 | Staphylococcus aureus subsp. aureus N315 | IC50 | 42.9000 | 2 | 2 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 19.9763 | 2 | 2 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 5.9158 | 2 | 4 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 18.7000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 5.9158 | 2 | 4 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 8.2850 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 54.8750 | 4 | 4 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 31.3750 | 1 | 4 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 31.3750 | 1 | 4 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 5.7100 | 2 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 6.5000 | 1 | 1 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 24.2000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 75.2250 | 4 | 4 |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 14.3000 | 1 | 1 |
| Neuronal proto-oncogene tyrosine-protein kinase Src | Mus musculus (house mouse) | IC50 | 2.2000 | 1 | 1 |
| Non-structural protein 1 | Dengue virus | IC50 | 1.7000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 38.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 38.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 9.1670 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 10.2320 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 6.4000 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 11.1000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 187.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 125.0000 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 0.0046 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 66.0693 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 143.5000 | 2 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 1.8000 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 63.8350 | 1 | 2 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2,000.0000 | 3 | 3 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 63.8350 | 1 | 2 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 2,000.0000 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 65.0000 | 2 | 2 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 31.7500 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 31.7500 | 1 | 2 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 3.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Rattus norvegicus (Norway rat) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | Ki | 8.6000 | 1 | 1 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| Serine/threonine-protein kinase pim-2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Sorbitol dehydrogenase | Homo sapiens (human) | IC50 | 67.7000 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 10.2000 | 1 | 1 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 0.0132 | 1 | 1 |
| toll-like receptor 9 | Homo sapiens (human) | IC50 | 8.3620 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 19.7000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 38.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 1.3000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 57.3700 | 2 | 2 |