Page last updated: 2024-09-28

Hypervitaminosis A

A symptom complex resulting from ingesting excessive amounts of VITAMIN A.

Synonyms(1)

Synonym
Hypervitaminosis A

Research Excerpts

Overview

ExcerptReference
"Although hypervitaminosis A is not uncommon, fatal cases are rare."( Bush, ME; Dahms, BB, 1984)
"Hypervitaminosis A is sometimes associated with abnormalities of calcium metabolism and bone mineral status."( Ballew, C; Galuska, D; Gillespie, C, 2001)
"Chronic hypervitaminosis A is induced after daily doses of 2 mg retinol/kg in oil-based preparations for many months or years."( Blomhoff, R; Bøhn, SK; Carlsen, MH; Laake, P; Myhre, AM; Wold, HL, 2003)
"Hypervitaminosis A is increasingly a public health concern, and thus noninvasive quantitative methods merit exploration."( Escaron, AL; Green, MH; Howe, JA; Tanumihardjo, SA, 2009)
"Hypervitaminosis A is well-described but overlooked in chronic kidney disease (CKD) and has been associated with hypercalcemia, contributing to mineral bone disease."( Erkan, E; Harris, M; Nehus, ST; Taylor, V; Varnell, C; Zhang, B, 2022)

Context

ExcerptReference
"Hypervitaminosis A has not been previously reported in this setting, and awareness of the condition is important in centers where this treatment is contemplated."( Griffin, GC; Grissom, LE; Mandell, GA, 1996)

Research

Studies (407)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990234 (57.49)23.3326
1990's64 (15.72)12.5806
2000's54 (13.27)18.1394
2010's46 (11.30)28.8240
2020's9 (2.21)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dinitrochlorobenzene0low10
iodine0low10
nickel0low10
niacin0low20
palmitic acid0low10
pyridoxine0low10
uric acid0medium11
urea0low10
1-anilino-8-naphthalenesulfonate0low20
acetaminophen0low10
acetazolamide0low20
valproic acid0low10
furosemide0low10
isoniazid0low10
neostigmine0low10
phenobarbital0low10
sulfanilamide0low10
sulfobromophthalein0low10
urethane0low10
prednisolone0low10
hydroxyproline0low30
thyroxine0low10
prednisone0low10
triiodothyronine0low10
ethinyl estradiol0low10
uridine monophosphate0low10
carbostyril0low20
phenylalanine0low10
colchicine0low20
cycloheximide0low10
norethindrone0low10
dinitrofluorobenzene0low10
n,n'-diphenyl-4-phenylenediamine0low10
thymol0low10
thiamine pyrophosphate0low10
d-alpha tocopherol0low100
tocopherols0low20
fucose0low10
sabinene0low10
deuterium0low10
ethinyl estradiol-norgestrel combination0low10
galactose0low10
trolamine salicylate0low40
tiletamine hydrochloride0low10
4-methoxyamphetamine0low10
paclitaxel0low10
methyldopa0low10
methotrexate0low10
cortisone0low40
norethindrone enanthate0low10
glycogen0low10
betadex0low30
tretinoin0low160
retinol0medium3446
oleic acid0low10
cocaine0low10
isomethyleugenol0low10
retinol acetate0low30
hydroxypropyl-gamma-cyclodextrin0low10
alpha-carotene0low10
linoleic acid0low10
calcitriol0low10
vitamin k semiquinone radical0low70
beta carotene0low120
11-cis-retinal0low10
retinol palmitate0low130
vitamin d 20low20
etretinate0low30
isotretinoin0low80
acitretin0low10
vitamin k 10low10
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid0low10
thallium0low10
phosphorus0low40
25-hydroxyvitamin d 20low20
tetrodotoxin0low10
temarotene0low10
retinyl stearate0low10
plethoryl0low10
smr 20low10
i(3)so3-galactosylceramide0low10
retinol oleate0low10
acid phosphatase0low40
mefloquine0low10
vx-7700low20
glycolipids0low10
chondroitin0low20
ascorbic acid0low80
transforming growth factor beta0low10
technetium tc 99m sulfur colloid0low10
vitamin b 120low10
norgestrel0low10
chondroitin sulfates0low10
folic acid0low30
trypan blue0low20
eye0low30

Protein Targets (849)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A8008
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase3003
thioredoxin reductase150015
USP1 protein, partial230023
TDP1 protein300030
vitamin D3 receptor isoform VDRA110011
importin subunit beta-1 isoform 15005
flap endonuclease 16006
serine/threonine-protein kinase PLK16006
snurportin-15005
peptidyl-prolyl cis-trans isomerase NIMA-interacting 17007
GTP-binding nuclear protein Ran isoform 13003
DNA polymerase eta isoform 18008
DNA polymerase iota isoform a (long)110011
urokinase-type plasminogen activator precursor6006
plasminogen precursor6006
urokinase plasminogen activator surface receptor precursor6006
geminin340034
DNA polymerase kappa isoform 1100010
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0114
Fatty acid-binding protein, intestinal0213
Fatty acid-binding protein, adipocyte0729
Cyclin-A20101
Cannabinoid receptor 10112
Cyclin-dependent kinase 20123
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G3003
Fatty acid-binding protein 50426
Fatty acid-binding protein 50011
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140202
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinoic acid receptor beta0011
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, HADH2 protein120012
Chain B, HADH2 protein120012
Chain A, 2-oxoglutarate Oxygenase7007
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Ferritin light chain9009
Chain A, Cruzipain5005
Luciferase160016
endonuclease IV4004
ATAD5 protein, partial9009
NFKB1 protein, partial2002
Thrombopoietin3003
aldehyde dehydrogenase 1 family, member A1240024
estrogen receptor 2 (ER beta)180018
progesterone receptor180018
glucocorticoid receptor [Homo sapiens]330033
retinoid X nuclear receptor alpha270027
estrogen-related nuclear receptor alpha340034
farnesoid X nuclear receptor220022
pregnane X nuclear receptor240024
estrogen nuclear receptor alpha440044
peroxisome proliferator-activated receptor delta180018
euchromatic histone-lysine N-methyltransferase 2200020
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor100010
thyrotropin-releasing hormone receptor4004
Bloom syndrome protein isoform 17007
cytochrome P450 2D6 isoform 13003
NPC intracellular cholesterol transporter 1 precursor3003
peripheral myelin protein 22 isoform 14004
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C19 precursor2002
thyroid hormone receptor beta isoform a140014
DNA polymerase beta4004
nuclear factor NF-kappa-B p105 subunit isoform 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
ras-related protein Rab-9A3003
serine/threonine-protein kinase mTOR isoform 14004
nuclear factor erythroid 2-related factor 2 isoform 1330033
nuclear receptor ROR-gamma isoform 1120012
survival motor neuron protein isoform d9009
M-phase phosphoprotein 85005
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)7007
lamin isoform A-delta10140014
neuropeptide S receptor isoform A3003
Voltage-dependent calcium channel gamma-2 subunit170017
Cellular tumor antigen p53300030
Integrin beta-32103
Integrin alpha-IIb2002
Ornithine decarboxylase0002
Retinoic acid receptor alpha04311
Retinoic acid receptor beta04311
Retinoic acid receptor gamma 04412
Glutamate receptor 2170017
Retinoic acid receptor RXR-alpha03610
Retinoic acid receptor RXR-beta0336
Cellular retinoic acid-binding protein 10204
Retinoic acid receptor RXR-gamma0336
Nuclear receptor ROR-gamma111214
Inositol monophosphatase 12002
Peroxisome proliferator-activated receptor alpha4026
ATP-dependent phosphofructokinase8008
5-hydroxytryptamine receptor 2C0618
5-hydroxytryptamine receptor 2A0617
5-hydroxytryptamine receptor 1A0314
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1D0213
5-hydroxytryptamine receptor 1F0213
5-hydroxytryptamine receptor 2B0516
5-hydroxytryptamine receptor 60112
Sodium-dependent serotonin transporter0617
Sodium-dependent serotonin transporter0405
5-hydroxytryptamine receptor 7 0112
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
5-hydroxytryptamine receptor 3A0112
5-hydroxytryptamine receptor 4 0112
5-hydroxytryptamine receptor 3B0112
RAR-related orphan receptor gamma290029
GLS protein7007
Microtubule-associated protein tau140014
Smad35005
thyroid stimulating hormone receptor9009
nuclear receptor subfamily 1, group I, member 3200020
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 1330033
peroxisome proliferator activated receptor gamma220022
aryl hydrocarbon receptor160016
chromobox protein homolog 1150015
thyroid hormone receptor beta isoform 2300030
peripheral myelin protein 22170017
cytochrome P450 3A4 isoform 1120012
Gamma-aminobutyric acid receptor subunit pi121114
ATP-binding cassette sub-family C member 3016016
Multidrug resistance-associated protein 4016018
Solute carrier family 22 member 60303
Carbonic anhydrase 1206111
UDP-glucuronosyltransferase 1A90002
Bile salt export pump0808
Bile salt export pump028028
Cytochrome P450 2B10102
Cytochrome P450 1A10001
Carbonic anhydrase 108116
Carbonic anhydrase 208317
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20316
Prostaglandin G/H synthase 10101
Carbonic anhydrase 306110
Cytochrome P450 3A408110
Cytochrome P450 2D60415
Cytochrome P450 2C9 07210
Polyunsaturated fatty acid lipoxygenase ALOX150404
Gamma-aminobutyric acid receptor subunit beta-1121114
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta121114
Gamma-aminobutyric acid receptor subunit gamma-2121114
UDP-glucuronosyltransferase 1-60103
Gamma-aminobutyric acid receptor subunit alpha-5121114
Gamma-aminobutyric acid receptor subunit alpha-3121114
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0305
Carbonic anhydrase 407111
Prostaglandin G/H synthase 10303
Carbonic anhydrase 607111
Gamma-aminobutyric acid receptor subunit gamma-1121114
Gamma-aminobutyric acid receptor subunit alpha-2121114
Gamma-aminobutyric acid receptor subunit alpha-4121114
Gamma-aminobutyric acid receptor subunit gamma-3121114
Gamma-aminobutyric acid receptor subunit alpha-6121114
Carbonic anhydrase 5A, mitochondrial07113
Prostaglandin G/H synthase 20203
Carbonic anhydrase 706110
Cytochrome P450 2J20303
Gamma-aminobutyric acid receptor subunit alpha-1121114
Gamma-aminobutyric acid receptor subunit beta-3121114
Gamma-aminobutyric acid receptor subunit beta-2121114
Carbonic anhydrase 907112
GABA theta subunit121114
Canalicular multispecific organic anion transporter 1015015
Carbonic anhydrase 150406
Carbonic anhydrase 130508
Gamma-aminobutyric acid receptor subunit epsilon121114
Carbonic anhydrase 1406111
Carbonic anhydrase 5B, mitochondrial06112
toxin B0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase9009
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0002
Carbonic anhydrase 0202
GALC protein3003
GLI family zinc finger 3260026
cytochrome P450 family 3 subfamily A polypeptide 4190019
Carbonic anhydrase 0202
Carbonic anhydrase 0202
arylsulfatase A3003
Carbonic anhydrase0202
muscleblind-like protein 1 isoform 15005
Carbonic anhydrase0202
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 20314
Cathepsin B0101
Steryl-sulfatase0101
Polyunsaturated fatty acid 5-lipoxygenase0202
Cytochrome P450 2C80202
Cytochrome P450 2A60303
Androgen receptor0808
Translocator protein0101
Cytochrome P450 2B60202
Carbonic anhydrase 5A, mitochondrial0202
Adenosine receptor A10203
Serum paraoxonase/arylesterase 10303
Dipeptidyl peptidase 40001
Endochitinase0101
Adenosine receptor A2a0102
Delta-type opioid receptor0202
Cytochrome P450 2C190415
Delta-type opioid receptor0303
Mu-type opioid receptor0303
Carbonic anhydrase0304
Kappa-type opioid receptor0112
Carbonic anhydrase0101
D(1A) dopamine receptor1102
Corticosteroid 11-beta-dehydrogenase isozyme 10202
Carbonic anhydrase0203
D(2) dopamine receptor0202
Cholinesterase0303
Carbonic anhydrase 0202
Mu-type opioid receptor0202
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Glutamate receptor ionotropic, NMDA 2B0203
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0203
Carbonic anhydrase 30101
Carbonic anhydrase0204
Carbonic anhydrase0204
Carbonic anhydrase 0202
Sigma intracellular receptor 20101
Delta carbonic anhydrase0202
Sigma non-opioid intracellular receptor 10213
Renin0101
Carbonic anhydrase 0203
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130417
Carbonic anhydrase 40303
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 0101
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
AR protein370037
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a230023
eyes absent homolog 2 isoform a2002
histone acetyltransferase KAT2A isoform 1100010
Rap guanine nucleotide exchange factor 3110011
Rap guanine nucleotide exchange factor 43003
nuclear factor erythroid 2-related factor 2 isoform 2120012
Sex hormone-binding globulin0066
Corticosteroid-binding globulin0505
Mineralocorticoid receptor 0347
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10102
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase9009
thioredoxin glutathione reductase100010
vitamin D (1,25- dihydroxyvitamin D3) receptor230023
IDH19009
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Polyphenol oxidase 20404
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0213
Spike glycoprotein4015
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
core protein, partial0101
Solute carrier organic anion transporter family member 1B30608
Solute carrier organic anion transporter family member 1B10608
Chain A, D-MALTODEXTRIN BINDING PROTEIN0011
Chain A, Limit Dextrinase0011
Chain A, Solute-binding protein0011
Chain A, Solute-binding protein0011
Chain B, SusD0011
Chain A, SusD0011
Chain A, SusD0011
Chain A, Alpha-hemolysin0011
Chain B, Alpha-hemolysin0011
Chain C, Alpha-hemolysin0011
Chain D, Alpha-hemolysin0011
Chain E, Alpha-hemolysin0011
Chain F, Alpha-hemolysin0011
Chain G, Alpha-hemolysin0011
phosphopantetheinyl transferase8008
activating transcription factor 6140014
potassium voltage-gated channel subfamily H member 2 isoform d7007
Chain A, Vitamin D Nuclear Receptor0011
Vitamin D3 receptor0011
PPM1D protein5005
mitogen-activated protein kinase 15005
Interferon beta150015
Vitamin D-binding protein0011
Androgen receptor0404
Vitamin D3 receptor0125
Vitamin D3 receptor0113
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Chain A, serum paraoxonase0101
Neutrophil cytosol factor 10101
Poly [ADP-ribose] polymerase tankyrase-20101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Amyloid-beta precursor protein0404
Fatty acid-binding protein, heart0303
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
D0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10102
Sodium-dependent noradrenaline transporter 0606
Sodium-dependent dopamine transporter0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30202
Gamma-aminobutyric acid receptor subunit alpha-50202
Gamma-aminobutyric acid receptor subunit alpha-30202
Glutamate receptor ionotropic, NMDA 1 0102
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit epsilon0202
Glutamate receptor ionotropic, NMDA 2A 0102
Glutamate receptor ionotropic, NMDA 2C0102
Sodium-dependent dopamine transporter 0404
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20202
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60202
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0102
Gamma-aminobutyric acid receptor subunit gamma-10202
Glutamate receptor ionotropic, NMDA 3B0102
Sigma non-opioid intracellular receptor 10303
Gamma-aminobutyric acid receptor subunit gamma-30202
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0102
Gamma-aminobutyric acid receptor subunit theta0202
Transporter0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
interleukin 86006
PAX80001
pregnane X receptor130013
hypoxia-inducible factor 1 alpha subunit130013
Fumarate hydratase3003
polyprotein3003
67.9K protein8008
glucocerebrosidase3003
v-jun sarcoma virus 17 oncogene homolog (avian)150015
nuclear receptor subfamily 1, group I, member 25005
nuclear receptor subfamily 0 group B member 10101
cytochrome P450 2C9 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
steroidogenic factor 10101
caspase-1 isoform alpha precursor2002
Solute carrier family 22 member 30202
Tubulin alpha-1A chain0225
Tubulin beta chain0224
Plasma kallikrein0002
Tubulin beta-4A chain0338
ATP-dependent translocase ABCB10101
Tubulin beta chain0338
ATP-dependent translocase ABCB10205
Tubulin alpha-3C chain0338
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10202
Histamine H2 receptor2002
Tubulin alpha-1B chain0338
Tubulin alpha-4A chain0338
Tubulin beta-4B chain0338
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0439
Tubulin beta-2A chain0338
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0338
Tubulin beta-2B chain0215
Tubulin alpha-3E chain0338
Tubulin alpha-1A chain0338
Similar to alpha-tubulin isoform 1 0114
Similar to alpha-tubulin isoform 1 0103
CREB-binding protein1001
ATPase family AAA domain-containing protein 59009
Ataxin-2100010
Tubulin alpha-1C chain0338
Tubulin beta-6 chain0338
Tubulin beta-2B chain0338
Tubulin beta-1 chain0338
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
nonstructural protein 12002
G9009
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a120012
heat shock protein beta-1160016
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0202
Solute carrier family 22 member 30202
HLA class I histocompatibility antigen, B alpha chain 9009
C-8 sterol isomerase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10202
Inositol hexakisphosphate kinase 19009
Solute carrier family 22 member 20303
cytochrome P450 2C9, partial9009
dopamine D1 receptor2002
regulator of G-protein signaling 47007
atrial natriuretic peptide receptor 1 precursor1001
Glucocorticoid receptor010217
Glycine receptor subunit alpha-1010010
Glycine receptor subunit beta010010
Glycine receptor subunit alpha-2010010
Glycine receptor subunit alpha-3010010
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 436006
Multidrug and toxin extrusion protein 10404
glp-1 receptor, partial5005
P531001
RPL19A0011
Histone H2A.x7007
Spike glycoprotein0011
Replicase polyprotein 1ab0011
heat shock protein HSP 90-alpha isoform 20001
transactivating tegument protein VP16 [Human herpesvirus 1]0202
COUP transcription factor 2 isoform a0101
Transmembrane protease serine 20011
Glucose transporter0101
Hexose transporter 1 0101
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0112
Solute carrier family 2, facilitated glucose transporter member 10101
Alpha-synuclein3306
Eukaryotic initiation factor 4A-I0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0202
Peptidyl-prolyl cis-trans isomerase FKBP30101
Peptidyl-prolyl cis-trans isomerase FKBP40101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10314
Hypoxia-inducible factor 1-alpha0101
Endothelial PAS domain-containing protein 10101
Angiotensin-converting enzyme 2 0011
Peptidyl-prolyl cis-trans isomerase FKBP140101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 40101
heat shock protein 90, putative0001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
SMAD family member 28008
SMAD family member 38008
apical membrane antigen 1, AMA15005
caspase 7, apoptosis-related cysteine protease5005
caspase-35005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor5005
Vpr2002
Glutathione S-transferase omega-10101
histone deacetylase 9 isoform 32002
lysosomal alpha-glucosidase preproprotein4004
Estrogen receptor0617
Aldo-keto reductase family 1 member B10505
Neuronal acetylcholine receptor subunit alpha-42002
Adenosine receptor A30606
Neuronal acetylcholine receptor subunit beta-22002
Alpha-1B adrenergic receptor0606
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Adenosine receptor A2a0202
Mu-type opioid receptor0202
Kappa-type opioid receptor0202
Alpha-1A adrenergic receptor0606
Sulfotransferase 1A10214
Aldehyde oxidase0101
Nuclear receptor subfamily 1 group I member 3 0101
Multidrug and toxin extrusion protein 20101
Estrogen receptor beta0314
cytochrome P450 2D63003
Chain A, Dihydrofolate reductase0011
alpha-galactosidase2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
Thymidylate synthase0404
Thymidylate synthase0303
Dihydrofolate reductase0235
Aldo-keto reductase family 1 member B10101
Folylpolyglutamate synthase, mitochondrial0104
Solute carrier organic anion transporter family member 1A30104
Folylpolyglutamate synthase, mitochondrial0104
Multidrug resistance associated protein0103
Fucose-binding lectin PA-IIL0101
CD209 antigen0202
Albumin0101
Glucose-6-phosphate 1-dehydrogenase0202
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Adenosine receptor A10101
6-phosphogluconate dehydrogenase, decarboxylating0202
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20102
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Proton-coupled amino acid transporter 10101
Amino acid transporter0101
bromodomain adjacent to zinc finger domain 2B5005
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
N-glycosylase/DNA lyase0101
Myeloperoxidase0101
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0202
Endonuclease 8-like 10101
Parkin2002
Caspase-73003
caspase-33003
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Mitogen-activated protein kinase 10202
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
5-hydroxytryptamine receptor 2B0606
Cellular retinoic acid-binding protein 10022
Olfactory receptor 51E20123
15-lipoxygenase, partial6006
Free fatty acid receptor 10011
Prostaglandin G/H synthase 1 0303
Sterol O-acyltransferase 10202
Trypsin0202
Seed linoleate 13S-lipoxygenase-10202
Coagulation factor VII0202
Aromatase0202
Tissue factor0303
Tyrosine-protein phosphatase non-receptor type 70101
Sterol O-acyltransferase 10202
Aldo-keto reductase family 1 member C30101
Nuclear receptor subfamily 4 group A member 20022
Dual specificity protein phosphatase 30101
Prostaglandin G/H synthase 20303
Free fatty acid receptor 40011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
ClpP2002
Thymidylate synthase 0101
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX122002
transcriptional regulator ERG isoform 31001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10112
Bifunctional dihydrofolate reductase-thymidylate synthase0101
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Kappa-type opioid receptor0101
Reduced folate transporter0202
Caspase-71001
Pteridine reductase 10101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Solute carrier family 22 member 60002
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Caspase 6, apoptosis-related cysteine peptidase0001
hypothetical protein, conserved1001
pyruvate kinase1001
estrogen receptor beta isoform 10101
Epidermal growth factor receptor0202
Tyrosine-protein kinase Fyn0202
Cystathionine gamma-lyase0101
Solute carrier family 15 member 10101
phosphoglycerate kinase1001
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Acetylcholinesterase0404
Cholinesterase0303
Acetylcholinesterase0303
Cholesteryl ester transfer protein0101
D-amino-acid oxidase0101
Xanthine dehydrogenase/oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Estrogen receptor0011
Progesterone receptor0427
Estrogen receptor beta0011
Chain A, Adipocyte Lipid-binding Protein0011
Chain A, SERUM ALBUMIN0011
Chain A, SERUM ALBUMIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, BCL-2-RELATED PROTEIN A10011
putative potassium channel subunit0011
serine-protein kinase ATM isoform a1001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
bcl-2-like protein 11 isoform 10011
Fatty-acid amide hydrolase 10101
Fatty acid-binding protein, liver0202
Fatty acid-binding protein, liver0011
DNA topoisomerase 10101
Protein kinase C alpha type0001
Tyrosine-protein phosphatase non-receptor type 10202
Peroxisome proliferator-activated receptor delta0001
Transient receptor potential cation channel subfamily V member 20202
Genome polyprotein 0101
Receptor tyrosine-protein kinase erbB-20101
Integrin alpha-V 0101
60 kDa chaperonin0303
Botulinum neurotoxin type A 0101
Apoptosis regulator Bcl-20101
60 kDa heat shock protein, mitochondrial0303
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0101
UDP-glucuronosyltransferase 2B70203
Substance-K receptor0202
UDP-glucuronosyltransferase 1A40101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Delta-type opioid receptor0202
10 kDa heat shock protein, mitochondrial0303
Bcl-2-like protein 10101
Tyrosine-protein kinase Mer0101
Thiosulfate sulfurtransferase0303
Beta-tubulin 0101
60 kDa chaperonin 0303
10 kDa chaperonin 0303
Nucleotide-binding oligomerization domain-containing protein 20101
Chain A, Fatty acid-binding protein, adipocyte0101
Toll-like receptor 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Alkaline phosphatase, tissue-nonspecific isozyme 0101
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
E3 ubiquitin-protein ligase XIAP0101
Large neutral amino acids transporter small subunit 10102
SLC16A10 protein0001
Carbonic anhydrase-like protein, putative0001
Large neutral amino acids transporter small subunit 1 0101
Monocarboxylate transporter 100001
Phospholipase A-2-activating protein0101
luciferase0001
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Pyridoxal kinase0001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Disintegrin and metalloproteinase domain-containing protein 172002
Protein argonaute-20022
Hematopoietic prostaglandin D synthase0101
Sodium channel protein type 9 subunit alpha0101
1-deoxy-D-xylulose-5-phosphate synthase0011
1-deoxy-D-xylulose-5-phosphate synthase0011
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain B, Odorant-binding Protein0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Transient receptor potential cation channel subfamily A member 10011
Secreted chorismate mutase0101
Heat sensitive channel TRPV30011
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily M member 80112
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
Solute carrier organic anion transporter family member 1A40103
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Thyroid hormone receptor alpha0235
Thyroid hormone receptor beta0235
Proliferating cell nuclear antigen0202
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Nuclear Receptor ROR-beta0101
Alpha-1A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Prothrombin0011
Thyroid hormone receptor beta0101
Adenosine receptor A10202
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Urease subunit alpha0101
Urease subunit beta0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain B, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine 5'-monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain A, orotidine monophosphate decarboxylase0101
Chain B, orotidine monophosphate decarboxylase0101
Chain B, PyrR bifunctional protein0011
Orotidine 5'-phosphate decarboxylase0101
Uridine 5'-monophosphate synthase0101
UMP-CMP kinase 0001
Orotidine 5'-phosphate decarboxylase 0101
Protein cereblon0101
Cocaine esterase0101
Histone deacetylase 30202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Histone deacetylase 40202
Histone deacetylase 10202
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
Cytochrome P450 2E10101
Cystic fibrosis transmembrane conductance regulator0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]