Fibrodysplasia Ossificans Progressiva

Synonym
Myositis Ossificans Progressiva
Progressive Ossifying Myositis
Progressive Myositis Ossificans
Fibrodysplasia Ossificans Progressiva

Excerpt	Reference
"Fibrodysplasia ossificans progressiva is a serious and rare disease with a terrible development, leading to a sort of petrifaction of the patient."	( Biarese, V; Galvagno, G; Lovisetto, P; Manachino, D; Marchi, L, 1989)
"A new case of myositis ossificans progressiva is described."	( Delgado, A; Maturana, I; Sánchez, E, 1984)
"Fibrodysplasia ossificans progressiva is a rare hereditary variant of heterotropic bone formation that is often difficult to diagnose."	( Elgazzar, AH; Gelfand, MJ; Kriss, VM, 1995)
"Fibrodysplasia ossificans progressiva is a chronic progressive hereditary disease of unknown etiology and unfavourable prognosis."	( Hoffmann, R; Ketkar, H, 1999)
"Fibrodysplasia ossificans progressiva is a rare genetic disease characterized by widespread soft tissue ossification and congenital stigmata of the extremities."	( Camargo, EE; Moura-Ribeiro, MV; Nucci, A; Queiroz, LD; Santos, AD, 2000)
"Fibrodysplasia ossificans progressiva is a rare genetic disorder in which the joints of patients become disabled by the formation of heterotopic bone."	( Jones, G; Rocke, DM, 2002)
"Individuals with fibrodysplasia ossificans progressiva are born with malformations of the great toes and develop a heterotopic skeleton during childhood because of an identical heterozygous mutation in the glycine-serine activation domain of ACVR1, a bone morphogenetic protein type I receptor."	( Groppe, JC; Kaplan, FS; Shore, EM, 2007)
"Fibrodysplasia ossificans progressiva is characterized by extensive ossification within muscle tissues, and its molecular pathogenesis is responsible for the constitutively activating mutation (R206H) of the bone morphogenetic protein type 1 receptor, activin-like kinase 2 (ALK2)."	( Kaji, H; Kawao, N; Okada, K; Okumoto, K; Tamura, Y; Yano, M, 2014)
"Fibrodysplasia ossificans progressiva is a rare genetic disorder characterized by progressive heterotopic ossification."	( Bravenboer, N; Eekhoff, MEW; Micha, D; Netelenbos, C; Pals, G; Rustemeyer, T; Sistermans, EA; van Essen, HW; Voermans, E; Zandieh-Doulabi, B, 2016)
"Fibrodysplasia ossificans progressiva is a very rare heritable disease characterized by a progressive heterotopic endochondal ossification, occurring in the first decade of life, and leading thereafter to a severe ankylosis of the spine, limbs and jaw, with a progressive and severe functional disability."	( Audran, M; Bouvard, B; Legrand, E; Masson, C, 2016)
"Fibrodysplasia Ossificans Progressiva is a rare debilitating disorder of the musculoskeletal system affecting one in two million individuals."	( Baidoo, RO; Dayie, MS, 2016)
"Fibrodysplasia ossificans progressiva is a rare debilitating, connective tissue disease characterized by progressive extraosseous ossification with abnormal great toes."	( Belho, ES; Dey, S; Gupta, N; Verma, R, 2020)

Excerpt	Reference
"Two patients with fibrodysplasia ossificans progressiva (FOP) were treated with disodium etidronate, a disodium salt of ethane-1-hydroxy-1, 1-diphosphonic acid (EHPD) for two years; both had multiple ectopic ossifications of connective tissue."	( Asboe-Hansen, G; Hentzer, B; Jacobsen, HH, 1978)
"Two patients with fibrodysplasia ossificans progressiva who presented with jaw immobilization due to formation of bone between the maxilla and mandible were treated with surgical resection of their ectopic bone in conjunction with experimental, adjunctive medical therapy using isotretinoin."	( Brahim, JS; Crofford, LJ; Marini, JC; Zasloff, MA, 1990)
"There is no known effective therapy for fibrodysplasia ossificans progressiva."	( Brantus, JF; Meunier, PJ, 1998)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	171 (45.00)	23.3326
1990's	48 (12.63)	12.5806
2000's	39 (10.26)	18.1394
2010's	88 (23.16)	28.8240
2020's	34 (8.95)	9.53

Drug	Relationship Strength	Studies	Trials
acetic acid	low	1	0
salicylic acid	low	6	0
lactic acid	low	1	0
glycine	low	1	0
urea	low	1	0
3-methylcholanthrene	low	1	0
alendronate	low	2	0
baclofen	low	1	0
celecoxib	low	1	0
diazepam	low	1	0
diclofenac	low	1	0
dipyridamole	low	1	0
etidronate	medium	36	2
fendiline	low	1	0
glyphosate	low	1	0
ibuprofen	low	1	0
lidocaine	low	1	0
indomethacin	low	5	0
khellin	low	1	0
meclofenamic acid	low	1	0
metformin	low	1	0
activins	low	26	0
omeprazole	low	1	0
pamidronate	low	3	0
perhexiline	low	2	0
propidium	low	1	0
sodium fluoride	low	1	0
risedronic acid	low	1	0
imatinib	low	1	0
thalidomide	low	1	0
corticosterone	low	1	0
prednisolone	low	9	0
hydroxyproline	low	4	0
penicillamine	low	1	0
prednisone	low	5	0
triiodothyronine	low	1	0
aspartic acid	low	1	0
glutamine	low	1	0
edetic acid	low	6	0
tyrosine	low	1	0
methylene blue	low	1	0
histidine	low	1	0
arginine	low	1	0
methylprednisolone	low	2	0
quinazolines	medium	4	1
oxazoles	low	1	0
thiazoles	low	1	0
pyrazines	low	1	0
nandrolone	low	1	0
alpha-aminopyridine	low	1	0
copper gluconate	low	1	0
2-piperidone	low	1	0
digoxigenin	low	1	0
dysprosium	low	1	0
lanthanum	low	1	0
manganese	low	1	0
molybdenum	low	1	0
technetium	low	17	0
thulium	low	1	0
magnesium sulfate	low	1	0
tricalcium phosphate	low	2	0
fluorine	low	2	0
galactose	low	1	0
trolamine salicylate	low	10	0
clodronic acid	low	2	0
cromolyn sodium	low	1	0
fluorides	low	1	0
phenyl acetate	low	2	0
glutamic acid	low	1	0
gallium citrate	low	1	0
substance p	low	1	0
1-carboxyglutamic acid	low	1	0
propiconazole	low	3	0
antineoplaston a10	low	1	0
adenosine	low	1	0
triazoles	low	1	0
delphinidin	low	1	0
fluorodeoxyglucose f18	low	7	0
zoledronic acid	low	1	0
rosiglitazone	low	2	0
2-aminopyrazine	low	1	0
cobalt	low	1	0
7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one	low	1	0
imatinib mesylate	low	3	0
gefitinib	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	3	0
proline	low	1	0
sb 203580	low	1	0
erlotinib	low	1	0
organophosphonates	low	7	0
lapatinib	low	1	0
sorafenib	low	1	0
cortisone	low	6	0
fibrin	low	1	0
strychnine	low	1	0
tretinoin	low	1	0
tacrolimus	low	1	0
stilbenes	low	8	0
pyrophosphate	low	3	0
s 1033	low	1	0
propylthiouracil	low	1	0
hydroxylysine	low	1	0
dasatinib	low	1	0
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	low	1	0
calcitriol	low	1	0
vitamin k semiquinone radical	low	1	0
vitamin d 2	low	1	0
cholecalciferol	low	1	0
montelukast	low	1	0
etretinate	low	1	0
isotretinoin	medium	5	1
perhexiline maleate	low	2	0
sirolimus	low	5	0
lysophosphatidic acid	low	1	0
pd 161570	low	1	0
su 11248	low	1	0
barium	low	1	0
strontium	low	1	0
gallium	low	1	0
ecdysterone	low	1	0
phosphorus	low	10	0
heroin	low	1	0
strontium radioisotopes	low	2	0
technetium tc 99m pyrophosphate	low	2	0
gadolinium dtpa	low	1	0
phosphocreatine	low	1	0
technetium tc 99m diphosphonate	low	1	0
tofacitinib	low	1	0
dysidenin	low	1	0
pazopanib	low	1	0
gw 799388	low	1	0
palovarotene	low	10	0
saracatinib	medium	4	1
dorsomorphin	low	6	0
crizotinib	low	1	0
dihydrotachysterol	low	2	0
acid phosphatase	low	2	0
turkesterone	low	1	0
jaw	low	3	0
neuropeptide y	low	1	0
oligonucleotides	low	2	0
cellulose	low	1	0
technetium tc 99m sestamibi	low	3	0
incb-018424	low	1	0
ldn 193189	low	3	0
plx4032	low	1	0
piperidines	low	1	0
3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol	low	1	0
chondroitin	low	1	0
ascorbic acid	low	2	0
tetracycline	low	1	0
warfarin	low	2	0
transforming growth factor beta	low	22	0
ldn-212854	low	2	0
hyaluronoglucosaminidase	low	2	0
technetium tc 99m medronate	low	26	0
guanine	low	1	0
aprepitant	low	1	0

Protein Targets (1,718)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thioredoxin reductase	17	0	0	17
DNA polymerase kappa isoform 1	13	0	0	13
Heat shock protein HSP 90-alpha	0	1	3	4
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	1	3
cytochrome P450 family 3 subfamily A polypeptide 4	31	0	0	31
G	22	0	0	22
cytochrome P450 2D6	18	0	0	18
Interferon beta	36	0	0	36
HLA class I histocompatibility antigen, B alpha chain	22	0	0	22
Bone morphogenetic protein receptor type-1A	0	4	17	21
TGF-beta receptor type-1	0	8	18	26
Serine/threonine-protein kinase receptor R3	0	4	15	19
Activin receptor type-1	0	4	17	21
Inositol hexakisphosphate kinase 1	22	0	0	22
cytochrome P450 2C9, partial	22	0	0	22
Luciferase	14	0	0	14
pregnane X receptor	7	0	0	7
phosphopantetheinyl transferase	13	0	0	13
RAR-related orphan receptor gamma	33	0	0	33
SMAD family member 2	16	0	0	16
SMAD family member 3	16	0	0	16
TDP1 protein	44	0	0	44
Microtubule-associated protein tau	17	0	0	17
AR protein	48	0	0	48
caspase 7, apoptosis-related cysteine protease	9	0	0	9
aldehyde dehydrogenase 1 family, member A1	22	0	0	22
nuclear receptor subfamily 1, group I, member 3	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	30	0	0	30
estrogen-related nuclear receptor alpha	37	0	0	37
farnesoid X nuclear receptor	23	0	0	23
pregnane X nuclear receptor	33	0	0	33
estrogen nuclear receptor alpha	52	0	0	52
peroxisome proliferator-activated receptor delta	21	0	0	21
peroxisome proliferator activated receptor gamma	25	0	0	25
caspase-3	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	35	0	0	35
aryl hydrocarbon receptor	20	0	0	20
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
activating transcription factor 6	11	0	0	11
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
thyroid hormone receptor beta isoform a	18	0	0	18
heat shock protein beta-1	14	0	0	14
nuclear factor erythroid 2-related factor 2 isoform 1	33	0	0	33
Voltage-dependent calcium channel gamma-2 subunit	25	0	0	25
Cellular tumor antigen p53	31	0	0	31
Cytochrome P450 1A2	0	7	1	9
Tyrosine-protein kinase Lck	0	15	18	33
Tyrosine-protein kinase Fyn	0	6	18	24
Aldo-keto reductase family 1 member B1	0	8	0	8
Adenosine receptor A3	0	12	2	15
Alpha-1B adrenergic receptor	0	12	0	12
Glutamate receptor 2	25	2	1	28
Acetylcholinesterase	0	8	0	8
Sodium-dependent noradrenaline transporter	0	8	1	9
Aryl hydrocarbon receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	12	0	12
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, 2-oxoglutarate Oxygenase	14	0	0	14
Chain A, TGF-beta receptor type-1	0	1	0	1
USP1 protein, partial	25	0	0	25
EWS/FLI fusion protein	28	0	0	28
cytochrome P450 2D6 isoform 1	6	0	0	6
cytochrome P450 2C19 precursor	11	0	0	11
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
mitogen-activated protein kinase 1	9	0	0	9
tyrosine-protein kinase Yes	17	0	0	17
cytochrome P450 3A4 isoform 1	17	0	0	17
histone acetyltransferase KAT2A isoform 1	14	0	0	14
lethal factor (plasmid)	9	0	0	9
Serine/threonine-protein kinase PLK4	0	3	17	20
Serine/threonine-protein kinase 25	0	0	14	14
Gamma-aminobutyric acid receptor subunit pi	17	2	2	21
Citron Rho-interacting kinase	0	1	17	18
Serine/threonine-protein kinase RIO3	0	0	14	14
Serine/threonine-protein kinase Chk1	0	2	17	19
Aurora kinase A	0	4	17	21
Cyclin-G-associated kinase	0	4	17	21
Serine/threonine-protein kinase DCLK1	0	0	14	14
Muscle, skeletal receptor tyrosine-protein kinase	0	0	14	14
Polyunsaturated fatty acid lipoxygenase ALOX15B	10	0	0	10
3-phosphoinositide-dependent protein kinase 1	0	2	14	16
Death-associated protein kinase 3	0	0	14	14
Receptor-interacting serine/threonine-protein kinase 2	0	4	17	21
NUAK family SNF1-like kinase 1	0	1	14	15
Tyrosine-protein kinase JAK2	0	7	19	28
Ribosomal protein S6 kinase alpha-5	0	1	17	18
Ribosomal protein S6 kinase alpha-4	0	0	17	17
Serine/threonine-protein kinase 16	0	0	17	17
Serine/threonine-protein kinase PAK 3	0	0	14	14
Serine/threonine-protein kinase 17B	0	0	14	14
Serine/threonine-protein kinase 10	0	0	17	17
Serine/threonine-protein kinase D3	0	2	17	19
Cyclin-dependent kinase 14	0	0	14	14
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	17	17
Serine/threonine-protein kinase LATS1	0	0	17	17
Serine/threonine-protein kinase PAK 4	0	2	17	19
Tyrosine-protein kinase ABL1	0	17	21	39
Epidermal growth factor receptor	0	23	18	41
RAF proto-oncogene serine/threonine-protein kinase	0	7	15	23
Receptor tyrosine-protein kinase erbB-2	0	11	14	25
High affinity nerve growth factor receptor	0	1	17	18
Insulin receptor	0	9	17	27
Tyrosine-protein kinase Fes/Fps	0	0	17	17
Macrophage colony-stimulating factor 1 receptor	0	9	14	23
Tyrosine-protein kinase Yes	0	3	17	20
Tyrosine-protein kinase Lyn	0	3	17	20
Proto-oncogene tyrosine-protein kinase receptor Ret	0	6	17	23
Insulin-like growth factor 1 receptor	0	4	17	21
Hepatocyte growth factor receptor	0	6	17	23
Tyrosine-protein kinase HCK	0	7	17	24
Proto-oncogene tyrosine-protein kinase ROS	0	2	14	16
Platelet-derived growth factor receptor beta	0	17	17	35
Tyrosine-protein kinase Fgr	0	1	17	18
Mast/stem cell growth factor receptor Kit	0	12	16	28
Serine/threonine-protein kinase pim-1	0	0	17	17
Fibroblast growth factor receptor 1	0	7	17	25
Myosin light chain kinase, smooth muscle	0	0	11	11
Proto-oncogene tyrosine-protein kinase Src	0	16	17	33
Insulin receptor-related protein	0	0	14	14
Serine/threonine-protein kinase B-raf	0	8	19	28
Gamma-aminobutyric acid receptor subunit beta-1	17	2	2	21
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	17	17
Platelet-derived growth factor receptor alpha	0	14	16	30
Tyrosine-protein kinase Fer	0	0	17	17
cAMP-dependent protein kinase catalytic subunit alpha	0	2	17	19
Vascular endothelial growth factor receptor 1	0	8	14	22
Gamma-aminobutyric acid receptor subunit delta	17	2	2	21
Gamma-aminobutyric acid receptor subunit gamma-2	17	2	3	22
Interferon-induced, double-stranded RNA-activated protein kinase	0	1	14	15
Casein kinase II subunit alpha'	0	0	17	17
Gamma-aminobutyric acid receptor subunit alpha-5	17	2	2	21
Gamma-aminobutyric acid receptor subunit alpha-3	17	2	2	21
Cyclin-dependent kinase 11B	0	0	14	14
Ephrin type-A receptor 1	0	0	17	17
Fibroblast growth factor receptor 2	0	2	14	17
Fibroblast growth factor receptor 4	0	1	14	16
Fibroblast growth factor receptor 3	0	2	14	17
cAMP-dependent protein kinase catalytic subunit beta	0	2	17	19
Tyrosine-protein kinase JAK1	0	6	19	27
Gamma-aminobutyric acid receptor subunit gamma-1	17	2	2	21
Gamma-aminobutyric acid receptor subunit alpha-2	17	2	2	21
Protein kinase C eta type	0	2	14	16
Cyclin-dependent kinase 2	0	8	17	25
Activin receptor type-2A	0	0	14	14
Mitogen-activated protein kinase 3	0	1	17	18
MAP/microtubule affinity-regulating kinase 3	0	0	17	17
Gamma-aminobutyric acid receptor subunit alpha-4	17	2	2	21
Gamma-aminobutyric acid receptor subunit gamma-3	17	2	2	21
Mitogen-activated protein kinase 1	0	4	17	21
Ephrin type-A receptor 2	0	4	17	21
Ephrin type-A receptor 3	0	0	14	14
Ephrin type-A receptor 8	0	0	14	14
Ephrin type-B receptor 2	0	3	17	20
Leukocyte tyrosine kinase receptor	0	0	14	14
Non-receptor tyrosine-protein kinase TYK2	0	6	19	27
Gamma-aminobutyric acid receptor subunit alpha-6	17	2	2	21
Wee1-like protein kinase	0	0	17	17
Tyrosine-protein kinase receptor UFO	0	2	14	16
Mitogen-activated protein kinase 4	0	0	14	14
RAC-alpha serine/threonine-protein kinase	0	3	17	20
RAC-beta serine/threonine-protein kinase	0	2	17	19
Dual specificity protein kinase TTK	0	0	16	16
Tyrosine-protein kinase receptor Tie-1	0	0	14	14
Vascular endothelial growth factor receptor 3	0	6	14	20
Vascular endothelial growth factor receptor 2	0	19	15	35
Dual specificity mitogen-activated protein kinase kinase 2	0	4	17	21
Receptor-type tyrosine-protein kinase FLT3	0	8	17	26
Activin receptor type-1B	0	4	17	21
TGF-beta receptor type-2	0	4	17	21
Tyrosine-protein kinase CSK	0	3	17	20
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	5	14	19
Tyrosine-protein kinase Tec	0	2	17	19
Tyrosine-protein kinase TXK	0	2	14	16
Tyrosine-protein kinase ABL2	0	1	17	18
Tyrosine-protein kinase FRK	0	0	17	17
Tyrosine-protein kinase ZAP-70	0	0	14	14
Tyrosine-protein kinase SYK	0	3	17	20
Mitogen-activated protein kinase 8	0	2	17	19
Mitogen-activated protein kinase 9	0	2	17	19
Dual specificity mitogen-activated protein kinase kinase 4	0	0	16	16
Dual specificity mitogen-activated protein kinase kinase 3	0	0	17	17
Histamine H2 receptor	12	0	0	12
Casein kinase I isoform delta	0	1	17	18
MAP kinase-activated protein kinase 2	0	2	17	19
Cyclin-dependent kinase 8	0	1	14	15
Casein kinase I isoform epsilon	0	1	17	18
Dual specificity protein kinase CLK1	0	0	17	17
Dual specificity protein kinase CLK2	0	2	17	19
Dual specificity protein kinase CLK3	0	0	16	16
Glycogen synthase kinase-3 alpha	0	0	17	17
Glycogen synthase kinase-3 beta	0	4	17	21
Cyclin-dependent kinase 7	0	1	17	18
Cyclin-dependent kinase 9	0	0	17	17
Tyrosine-protein kinase Blk	0	4	14	18
Ribosomal protein S6 kinase alpha-3	0	3	17	20
Cytoplasmic tyrosine-protein kinase BMX	0	2	14	16
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	14	14
Serine/threonine-protein kinase Nek2	0	1	17	18
Tyrosine-protein kinase JAK3	0	7	15	25
Dual specificity mitogen-activated protein kinase kinase 6	0	0	17	17
Serine/threonine-protein kinase PLK1	0	6	17	23
Death-associated protein kinase 1	0	0	14	14
LIM domain kinase 1	0	1	17	18
LIM domain kinase 2	0	1	17	18
Mitogen-activated protein kinase 12	0	4	15	19
Mitogen-activated protein kinase 10	0	3	17	20
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	2	14	17
Ephrin type-B receptor 3	0	0	17	17
Ephrin type-A receptor 5	0	0	17	17
Ephrin type-B receptor 4	0	5	17	22
Ephrin type-B receptor 1	0	0	14	14
Ephrin type-A receptor 4	0	0	17	17
Serine/threonine-protein kinase SIK1	0	2	14	16
Gamma-aminobutyric acid receptor subunit alpha-1	17	3	3	23
Gamma-aminobutyric acid receptor subunit beta-3	17	2	2	21
Gamma-aminobutyric acid receptor subunit beta-2	17	2	3	22
Tubulin alpha-1A chain	0	0	11	11
Casein kinase II subunit alpha	0	0	14	14
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	14	14
SRSF protein kinase 2	0	0	14	14
Casein kinase I isoform gamma-2	0	0	17	17
Mitogen-activated protein kinase kinase kinase 9	0	0	14	14
Inositol monophosphatase 1	5	0	0	5
Cyclin-dependent kinase 3	0	0	16	16
Cyclin-dependent-like kinase 5	0	1	17	18
Cyclin-dependent kinase 16	0	0	17	17
Cyclin-dependent kinase 17	0	0	17	17
Protein kinase C epsilon type	0	2	14	16
Dual specificity mitogen-activated protein kinase kinase 1	0	5	17	22
Angiopoietin-1 receptor	0	4	14	18
Mitogen-activated protein kinase kinase kinase 10	0	0	14	14
Protein kinase C theta type	0	2	17	19
Focal adhesion kinase 1	0	3	17	20
Protein kinase C delta type	0	3	17	20
Tyrosine-protein kinase BTK	0	4	17	21
Tyrosine-protein kinase receptor TYRO3	0	1	14	15
Cyclin-dependent kinase 18	0	0	15	15
Activated CDC42 kinase 1	0	1	17	18
Epithelial discoidin domain-containing receptor 1	0	7	17	24
Tyrosine-protein kinase ITK/TSK	0	2	14	16
Myotonin-protein kinase	0	1	14	15
Tyrosine-protein kinase Mer	0	2	16	18
Serine/threonine-protein kinase 4	0	0	17	17
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	2	17	20
Serine/threonine-protein kinase PAK 1	0	0	14	14
Mitogen-activated protein kinase 7	0	0	17	17
Serine/threonine-protein kinase PAK 2	0	0	16	16
Serine/threonine-protein kinase 3	0	0	17	17
cGMP-dependent protein kinase 2	0	0	14	14
Non-receptor tyrosine-protein kinase TNK1	0	0	17	17
Receptor-interacting serine/threonine-protein kinase 1	0	2	14	16
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	14	14
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	17	17
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	17	17
Activin receptor type-2B	0	0	17	17
Bone morphogenetic protein receptor type-2	0	3	17	20
Protein-tyrosine kinase 6	0	1	17	18
cGMP-dependent protein kinase 1	0	0	18	18
Calcium/calmodulin-dependent protein kinase type 1	0	0	14	14
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	17	17
Protein-tyrosine kinase 2-beta	0	0	17	17
Maternal embryonic leucine zipper kinase	0	0	17	17
Serine/threonine-protein kinase D1	0	3	14	17
Ribosomal protein S6 kinase alpha-2	0	0	14	14
Ephrin type-A receptor 7	0	0	15	15
Ribosomal protein S6 kinase alpha-1	0	3	17	20
Dual specificity testis-specific protein kinase 1	0	0	16	16
Myosin light chain kinase, smooth muscle	0	0	17	17
Mitogen-activated protein kinase 11	0	4	18	22
Serine/threonine-protein kinase STK11	0	0	17	17
NT-3 growth factor receptor	0	0	14	14
Serine/threonine-protein kinase N1	0	0	17	17
Serine/threonine-protein kinase N2	0	1	17	18
Mitogen-activated protein kinase 14	0	11	20	31
Calcium/calmodulin-dependent protein kinase type IV	0	0	17	17
Mitogen-activated protein kinase kinase kinase 11	0	0	17	17
BDNF/NT-3 growth factors receptor	0	1	14	15
Mitogen-activated protein kinase 6	0	0	14	14
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	14	14
Discoidin domain-containing receptor 2	0	8	17	25
AP2-associated protein kinase 1	0	2	17	19
Serine/threonine-protein kinase TNNI3K	0	1	14	15
Serine/threonine-protein kinase MRCK alpha	0	0	17	17
Serine/threonine-protein kinase MRCK gamma	0	0	17	17
Serine/threonine-protein kinase Nek5	0	0	14	14
Serine/threonine-protein kinase MARK2	0	0	17	17
Serine/threonine-protein kinase tousled-like 2	0	0	14	14
Serine/threonine-protein kinase 32C	0	0	14	14
Serine/threonine-protein kinase pim-3	0	0	14	14
Myosin light chain kinase family member 4	0	0	14	14
Calcium/calmodulin-dependent protein kinase type 1D	0	0	14	14
Mitogen-activated protein kinase kinase kinase kinase 3	0	1	17	18
MAP kinase-activated protein kinase 5	0	1	17	18
Serine/threonine-protein kinase BRSK2	0	0	14	14
Serine/threonine-protein kinase DCLK2	0	0	14	14
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	14	14
Casein kinase I isoform alpha-like	0	0	14	14
Myosin-IIIa	0	0	14	14
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	14	14
Atypical kinase COQ8A, mitochondrial	0	0	17	17
Mitogen-activated protein kinase 15	0	0	17	17
Serine/threonine-protein kinase Nek9	0	0	17	17
Serine/threonine-protein kinase BRSK1	0	0	14	14
Serine/threonine-protein kinase Nek7	0	0	16	16
Myosin-IIIb	0	0	14	14
GABA theta subunit	17	2	2	21
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	17	17
Atypical kinase COQ8B, mitochondrial	0	0	14	14
Aurora kinase B	0	4	17	21
MAP/microtubule affinity-regulating kinase 4	0	0	17	17
Calcium/calmodulin-dependent protein kinase type 1G	0	0	15	15
Serine/threonine-protein kinase Nek1	0	0	17	17
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	17	17
SRSF protein kinase 1	0	0	14	14
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	4	17	21
Mitogen-activated protein kinase kinase kinase 5	0	0	17	17
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	14	14
Serine/threonine-protein kinase RIO1	0	0	14	14
MAP kinase-interacting serine/threonine-protein kinase 1	0	1	14	15
Cyclin-dependent kinase 19	0	1	14	15
Testis-specific serine/threonine-protein kinase 1	0	0	14	14
Serine/threonine-protein kinase 33	0	0	14	14
Serine/threonine-protein kinase D2	0	0	17	17
Serine/threonine-protein kinase DCLK3	0	0	14	14
Gamma-aminobutyric acid receptor subunit epsilon	17	2	2	21
NUAK family SNF1-like kinase 2	0	0	16	16
Serine/threonine-protein kinase SIK2	0	1	17	18
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	14	14
STE20-like serine/threonine-protein kinase	0	0	17	17
Tyrosine-protein kinase Srms	0	0	14	14
Serine/threonine-protein kinase PLK3	0	3	14	17
Dual specificity protein kinase CLK4	0	0	16	16
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	14	15
Serine/threonine-protein kinase Nek6	0	0	14	14
Casein kinase I isoform gamma-1	0	0	17	17
Serine/threonine-protein kinase PAK 6	0	1	15	16
Serine/threonine-protein kinase LATS2	0	0	14	14
Serine/threonine-protein kinase 36	0	1	14	15
BMP-2-inducible protein kinase	0	0	17	17
Serine/threonine-protein kinase 32B	0	0	14	14
Mitogen-activated protein kinase kinase kinase 20	0	1	17	18
Serine/threonine-protein kinase MARK1	0	0	14	14
Serine/threonine-protein kinase pim-2	0	0	16	16
Serine/threonine-protein kinase PAK 5	0	1	14	15
Serine/threonine-protein kinase 26	0	0	17	17
eIF-2-alpha kinase GCN2	0	0	14	14
Serine/threonine-protein kinase NLK	0	1	17	18
Serine/threonine-protein kinase 17A	0	0	14	14
Ephrin type-A receptor 6	0	0	14	14
Death-associated protein kinase 2	0	0	14	14
Ribosomal protein S6 kinase alpha-6	0	0	17	17
TRAF2 and NCK-interacting protein kinase	0	1	17	18
Serine/threonine-protein kinase tousled-like 1	0	0	14	14
ALK tyrosine kinase receptor	0	5	15	20
Cyclin-dependent kinase 11A	0	0	14	14
Aurora kinase C	0	1	14	15
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	14	14
RAC-gamma serine/threonine-protein kinase	0	1	17	18
Serine/threonine-protein kinase 38-like	0	0	15	15
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	16	16
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	17	17
Serine/threonine-protein kinase MRCK beta	0	0	17	17
Interleukin-1 receptor-associated kinase 3	0	0	17	17
Serine/threonine-protein kinase 24	0	0	16	16
Casein kinase I isoform gamma-3	0	0	17	17
Mitogen-activated protein kinase kinase kinase 4	0	0	17	17
thyroid stimulating hormone receptor	8	0	0	8
Substance-P receptor	0	5	2	7
Substance-P receptor	0	4	0	4
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	14	0	0	14
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	11	0	0	11
glucocorticoid receptor [Homo sapiens]	35	0	0	35
retinoid X nuclear receptor alpha	28	0	0	28
NPYLR7B	0	0	2	2
arylsulfatase A	7	0	0	7
IDH1	15	0	0	15
Histone H2A.x	12	0	0	12
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
flap endonuclease 1	12	0	0	12
nuclear receptor ROR-gamma isoform 1	14	0	0	14
peripheral myelin protein 22	19	0	0	19
survival motor neuron protein isoform d	11	0	0	11
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	14	14
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	8	0	0	8
Purine nucleoside phosphorylase	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Phosphoglycerate kinase 2	0	1	0	1
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	14	15
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	5	1	8
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	3	2	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	6	2	9
Adenosine receptor A2a	0	3	1	6
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	3	0	4
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	15	16
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	3	0	4
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	3	0	4
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	3	13	17
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	6	0	7
Farnesyl pyrophosphate synthase	0	8	0	8
Hypoxanthine-guanine phosphoribosyltransferase	0	2	0	2
Farnesyl pyrophosphate synthase	0	6	0	6
Farnesyl pyrophosphate synthase	0	3	0	3
thyroid stimulating hormone receptor	15	0	0	15
thyroid hormone receptor beta isoform 2	27	0	0	27
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Kappa-type opioid receptor	0	1	2	3
Mu-type opioid receptor	0	6	1	7
Tyrosine-protein kinase	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	14	0	0	14
GALC protein	6	0	0	6
GLI family zinc finger 3	31	0	0	31
estrogen receptor 2 (ER beta)	23	0	0	23
progesterone receptor	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
ATP-binding cassette sub-family C member 3	0	27	0	27
Multidrug resistance-associated protein 4	0	27	0	27
Bile salt export pump	0	46	0	46
Cytochrome P450 3A4	0	18	2	23
Neuromedin-K receptor	0	2	1	3
Spike glycoprotein	19	0	3	22
Substance-P receptor	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	26	0	26
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
NFKB1 protein, partial	5	0	0	5
GLS protein	11	0	0	11
alpha-galactosidase	1	0	0	1
chromobox protein homolog 1	17	0	0	17
DNA polymerase iota isoform a (long)	12	0	0	12
muscarinic acetylcholine receptor M1	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, inducible	0	1	0	2
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	12	0	0	12
thioredoxin glutathione reductase	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	12	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	40	0	0	40
lamin isoform A-delta10	25	0	0	25
Polyphenol oxidase 2	0	2	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	3
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	11	0	0	11
Bloom syndrome protein isoform 1	10	0	0	10
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	12	0	18
Carbonic anhydrase 2	0	14	0	20
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	6	3	11
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	9
Glutamate receptor ionotropic, NMDA 2B	0	6	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	9
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	5	2	9
Glutamate receptor ionotropic, NMDA 3B	0	5	2	9
Carbonic anhydrase 4	0	3	0	5
Glutamate receptor ionotropic, NMDA 3A	0	5	2	9
ATAD5 protein, partial	8	0	0	8
67.9K protein	11	0	0	11
D(1A) dopamine receptor	2	0	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Nuclear receptor ROR-gamma	6	1	1	8
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	11	0	0	11
Vitamin D3 receptor	0	0	1	1
PPM1D protein	20	0	0	20
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	5	1	6
Cytochrome P450 2D6	0	8	1	9
Vitamin D3 receptor	0	2	3	9
Cytochrome P450 2C9	0	14	2	18
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	3	5
Cytochrome P450 2C19	0	9	1	11
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Vpr	2	0	0	2
Bile salt export pump	0	5	0	5
Albumin	0	0	4	4
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	6
Cytochrome P450 2B6	0	1	1	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cytochrome P450 2J2	0	5	0	5
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Cruzipain	5	0	0	5
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	10	0	0	10
Smad3	9	0	0	9
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	5	0	0	5
Caspase-7	5	0	0	5
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	0	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
caspase-3	5	0	0	5
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	2	1	3
Carbonic anhydrase 12	0	5	0	7
Prostaglandin G/H synthase 1	0	4	0	5
Prostaglandin G/H synthase 2	0	3	0	4
cGMP-specific 3',5'-cyclic phosphodiesterase	0	4	0	4
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	3	0	3
Prostaglandin G/H synthase 1	0	9	0	10
Carbonic anhydrase 3	0	4	0	6
Procathepsin L	0	2	3	5
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	4	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Quinolone resistance protein NorA	0	3	0	3
Neuronal acetylcholine receptor subunit beta-2	2	4	0	6
Beta-3 adrenergic receptor	0	4	0	4
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	5	1	6
D(1A) dopamine receptor	0	2	0	2
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 4	0	5	0	7
Prostaglandin G/H synthase 1	0	7	0	8
Carbonic anhydrase 6	0	4	0	6
Cruzipain	0	4	0	4
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	2	1	3
Delta-type opioid receptor	0	3	1	4
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Bifunctional epoxide hydrolase 2	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Prostaglandin G/H synthase 2	0	10	15	26
Prostaglandin G/H synthase 2	0	5	0	6
Carbonic anhydrase	0	4	0	6
Carbonic anhydrase 7	0	5	0	7
Urotensin-2 receptor	0	1	0	1
Carbonic anhydrase	0	1	0	3
Histone deacetylase 4	0	2	1	3
Ras-related protein Rab-2A	0	0	1	1
D(2) dopamine receptor	0	1	1	2
Prostaglandin G/H synthase 2	0	8	0	8
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Prostaglandin G/H synthase 2	0	5	0	6
Histone deacetylase 1	0	3	1	4
Carbonic anhydrase 9	0	9	0	11
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	4	0	4
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	5	0	6
Carbonic anhydrase	0	1	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	2
Cyclooxygenase-2	0	1	0	1
Histone deacetylase 7	0	2	1	3
Rap guanine nucleotide exchange factor 4	4	0	0	4
Histone deacetylase 2	0	2	1	3
Polyamine deacetylase HDAC10	0	2	1	3
Histone deacetylase 11	0	2	1	3
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	14	0	0	14
Carbonic anhydrase 15	0	5	0	7
Histone deacetylase 8	0	2	1	3
P2Y purinoceptor 12	0	3	0	3
Histone deacetylase 6	0	4	1	5
Histone deacetylase 9	0	2	1	3
Carbonic anhydrase 14	0	5	0	7
Histone deacetylase 5	0	2	1	3
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
P2Y purinoceptor 12	0	2	0	2
Protein-arginine deiminase type-4	0	3	0	3
interleukin 8	3	0	0	3
15-lipoxygenase, partial	5	0	0	5
vitamin D3 receptor isoform VDRA	15	0	0	15
60 kDa chaperonin	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	3	0	3
Glycine receptor subunit alpha-1	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	3	0	3
Thiosulfate sulfurtransferase	0	3	0	3
60 kDa chaperonin	0	3	0	3
10 kDa chaperonin	0	3	0	3
Type IV secretion-like conjugative transfer relaxase protein TraI	0	2	0	2
72 kDa type IV collagenase	0	3	0	3
Stromelysin-1	0	2	1	3
Matrix metalloproteinase-9	0	2	0	2
Macrophage metalloelastase	0	1	0	1
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
nonstructural protein 1	8	0	0	8
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 1	0	8	0	8
Solute carrier family 22 member 3	0	3	0	3
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	3	3
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	2	2	4
Androgen receptor	0	6	0	6
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	2	0	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Solute carrier family 22 member 2	0	2	0	2
endonuclease IV	2	0	0	2
dopamine D1 receptor	2	0	0	2
peripheral myelin protein 22 isoform 1	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
M-phase phosphoprotein 8	5	0	0	5
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	9	0	9
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	6	0	0	6
Multidrug and toxin extrusion protein 1	0	7	0	7
Leukotriene C4 synthase	0	0	13	13
Fumarate hydratase	18	0	0	18
polyprotein	18	0	0	18
Bone morphogenetic protein receptor type-1B	0	3	16	19
Membrane-associated progesterone receptor component 1	0	0	10	10
Cell division cycle 7-related protein kinase	0	0	9	9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	4	13	17
ATP-dependent RNA helicase DDX3X	0	0	15	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	13	13
Pyridoxal kinase	0	0	15	15
Dual specificity mitogen-activated protein kinase kinase 7	0	1	13	14
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	13	15
Peripheral plasma membrane protein CASK	0	0	13	13
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	13	14
Ephrin type-B receptor 6	0	0	16	16
Peroxisomal acyl-coenzyme A oxidase 3	0	0	15	15
Mitogen-activated protein kinase 13	0	4	14	18
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	13	13
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	15	15
Dynamin-like 120 kDa protein, mitochondrial	0	0	15	15
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	13	13
Eukaryotic translation initiation factor 5B	0	0	8	8
Rho-associated protein kinase 2	0	1	16	17
Serine/threonine-protein kinase ULK1	0	0	16	16
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	16	16
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	15	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	13	13
Cyclin-dependent kinase-like 5	0	0	14	14
Structural maintenance of chromosomes protein 2	0	0	14	14
Mitogen-activated protein kinase kinase kinase 6	0	0	16	16
Sodium-dependent phosphate transport protein 2B	0	1	0	1
Serine/threonine-protein kinase OSR1	0	0	13	13
Serine/threonine-protein kinase Chk2	0	1	13	14
Tyrosine-protein kinase ABL1	0	4	0	4
HLA class II histocompatibility antigen gamma chain	0	1	0	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	11	11
ADP/ATP translocase 2	0	0	15	15
Protein kinase C beta type	0	2	15	17
Cyclin-dependent kinase 1	0	2	15	17
Glycogen phosphorylase, liver form	0	0	15	15
Nucleophosmin	0	2	0	2
Adenine phosphoribosyltransferase	0	0	10	10
Signal recognition particle receptor subunit alpha	0	0	11	11
Cytochrome c1, heme protein, mitochondrial	0	0	15	15
Wee1-like protein kinase 2	0	0	13	13
Uncharacterized serine/threonine-protein kinase SBK3	0	0	13	13
Serine/threonine-protein kinase A-Raf	0	2	15	17
Glycogen phosphorylase, brain form	0	0	15	15
Breakpoint cluster region protein	0	8	19	28
DNA topoisomerase 2-alpha	0	0	13	13
Cyclin-dependent kinase 4	0	2	16	18
ADP/ATP translocase 3	0	0	15	15
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	14	14
G2/mitotic-specific cyclin-B1	0	2	0	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	15	19
Protein kinase C alpha type	0	5	15	20
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	15	15
Ras-related protein Rab-6A	0	0	13	13
Serine/threonine-protein kinase MAK	0	0	13	13
Receptor tyrosine-protein kinase erbB-3	0	3	13	16
Multifunctional protein ADE2	0	0	15	15
cAMP-dependent protein kinase catalytic subunit gamma	0	2	12	14
Ferrochelatase, mitochondrial	0	0	16	16
Ribosomal protein S6 kinase beta-1	0	2	16	18
Beta-adrenergic receptor kinase 1	0	0	15	15
Probable ATP-dependent RNA helicase DDX6	0	0	15	15
Deoxycytidine kinase	0	0	15	15
UMP-CMP kinase	0	0	9	9
Phosphatidylethanolamine-binding protein 1	0	0	12	12
Heme oxygenase 2	0	0	15	15
S-adenosylmethionine synthase isoform type-2	0	0	15	15
DnaJ homolog subfamily A member 1	0	0	15	15
G protein-coupled receptor kinase 4	0	0	13	13
DNA replication licensing factor MCM4	0	0	14	14
Myosin-10	0	0	11	11
Electron transfer flavoprotein subunit beta	0	0	10	10
Glycine--tRNA ligase	0	0	15	15
Protein kinase C iota type	0	2	16	18
Exosome RNA helicase MTR4	0	0	15	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	4	13	17
Serine/threonine-protein kinase mTOR	0	6	14	20
Megakaryocyte-associated tyrosine-protein kinase	0	0	13	13
G protein-coupled receptor kinase 6	0	0	12	12
26S proteasome regulatory subunit 6B	0	0	15	15
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	13	13
Casein kinase I isoform alpha	0	4	16	20
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	4	13	17
Elongation factor Tu, mitochondrial	0	0	15	15
Choline-phosphate cytidylyltransferase A	0	0	7	7
Cysteine--tRNA ligase, cytoplasmic	0	0	13	13
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	15	15
Ras-related protein Rab-27A	0	0	14	14
Interleukin-1 receptor-associated kinase 1	0	0	16	16
Serine/threonine-protein kinase Nek3	0	0	16	16
Serine/threonine-protein kinase Nek4	0	0	13	13
Tyrosine--tRNA ligase, cytoplasmic	0	0	15	15
5'-AMP-activated protein kinase subunit gamma-1	0	2	15	18
Adenylate kinase 2, mitochondrial	0	0	15	15
Hormonally up-regulated neu tumor-associated kinase	0	0	13	13
Receptor-interacting serine/threonine-protein kinase 4	0	0	13	13
Ras-related protein Rab-10	0	0	15	15
Cell division control protein 2 homolog	0	0	13	13
Actin-related protein 3	0	0	15	15
Actin-related protein 2	0	0	14	14
Calcium-dependent protein kinase 1	0	0	13	13
GTP-binding nuclear protein Ran	0	0	15	15
ALK tyrosine kinase receptor	0	1	0	1
Serine/threonine-protein kinase PknB	0	0	13	13
Cyclin-dependent kinase-like 1	0	0	13	13
Cyclin-dependent kinase 6	0	1	15	16
ATP-dependent 6-phosphofructokinase, platelet type	0	0	15	15
Angiopoietin-1 receptor	0	1	0	1
DNA topoisomerase 2-beta	0	0	15	15
Macrophage-stimulating protein receptor	0	1	16	17
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	16	16
Mitogen-activated protein kinase kinase kinase 12	0	0	13	13
Dual specificity mitogen-activated protein kinase kinase 5	0	0	16	16
Mitogen-activated protein kinase kinase kinase 1	0	0	16	16
Integrin-linked protein kinase	0	0	15	15
Rho-associated protein kinase 1	0	0	16	16
Serine/threonine-protein kinase PRP4 homolog	0	0	13	13
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	16	16
Cyclin-dependent kinase 13	0	0	16	16
Structural maintenance of chromosomes protein 1A	0	0	13	13
Chromodomain-helicase-DNA-binding protein 4	0	0	15	15
Lysine--tRNA ligase	0	1	1	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	13	13
Cyclin-dependent kinase 10	0	0	6	6
Serine/threonine-protein kinase 38	0	0	13	13
Receptor tyrosine-protein kinase erbB-4	0	5	13	18
Delta(24)-sterol reductase	0	0	14	14
Rhodopsin kinase GRK1	0	0	13	13
Myosin light chain kinase 3	0	0	16	16
Uncharacterized aarF domain-containing protein kinase 5	0	0	10	10
Serine/threonine-protein kinase SBK1	0	0	13	13
Mitogen-activated protein kinase kinase kinase 19	0	0	13	13
Putative heat shock protein HSP 90-beta 2	0	0	14	14
Rab-like protein 3	0	0	10	10
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	13	15
Macrophage-stimulating protein receptor	0	1	0	1
Acyl-CoA dehydrogenase family member 10	0	0	13	13
Serine/threonine-protein kinase N3	0	0	14	14
Serine/threonine-protein kinase ULK3	0	0	16	16
Dual serine/threonine and tyrosine protein kinase	0	0	13	13
Mitogen-activated protein kinase kinase kinase 15	0	0	13	13
Uncharacterized protein FLJ45252	0	0	15	15
Acyl-CoA dehydrogenase family member 11	0	0	14	14
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	14	14
ATP-dependent RNA helicase DHX30	0	0	10	10
Serine/threonine-protein kinase TAO1	0	0	16	16
STE20-related kinase adapter protein alpha	0	0	15	15
Myosin-14	0	0	15	15
AarF domain-containing protein kinase 1	0	0	15	15
ATP-dependent RNA helicase DDX42	0	0	8	8
Serine/threonine-protein kinase VRK2	0	0	13	13
Homeodomain-interacting protein kinase 1	0	1	13	14
Cyclin-dependent kinase-like 3	0	0	13	13
Serine/threonine-protein kinase NIM1	0	0	13	13
Serine/threonine-protein kinase ULK2	0	0	13	13
Misshapen-like kinase 1	0	0	15	15
Mixed lineage kinase domain-like protein	0	0	1	1
Homeodomain-interacting protein kinase 4	0	1	13	14
Serine/threonine-protein kinase Nek11	0	0	13	13
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	16	16
Serine/threonine-protein kinase 35	0	0	13	13
Rhodopsin kinase GRK7	0	0	13	13
Serine/threonine-protein kinase 32A	0	0	13	13
ATP-dependent RNA helicase DDX1	0	0	15	15
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	13	13
Cyclin-dependent kinase-like 2	0	0	13	13
Serine/threonine-protein kinase Sgk3	0	0	13	13
Cyclin-dependent kinase 15	0	0	13	13
PAS domain-containing serine/threonine-protein kinase	0	0	13	13
EKC/KEOPS complex subunit TP53RK	0	0	15	15
Dual specificity testis-specific protein kinase 2	0	0	8	8
Mitogen-activated protein kinase kinase kinase 3	0	0	16	16
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	16	16
Serine/threonine-protein kinase RIO2	0	0	13	13
Transient receptor potential cation channel subfamily M member 6	0	0	13	13
Nucleolar GTP-binding protein 1	0	0	14	14
RNA cytidine acetyltransferase	0	0	15	15
Serine/threonine-protein kinase TAO3	0	0	16	16
Homeodomain-interacting protein kinase 2	0	1	13	14
Homeodomain-interacting protein kinase 3	0	1	13	14
dCTP pyrophosphatase 1	0	0	15	15
Echinoderm microtubule-associated protein-like 4	0	1	0	1
SNF-related serine/threonine-protein kinase	0	0	13	13
Phenylalanine--tRNA ligase beta subunit	0	0	15	15
Isoleucine--tRNA ligase, mitochondrial	0	0	10	10
Obg-like ATPase 1	0	0	11	11
Midasin	0	0	15	15
Aurora kinase A-interacting protein	0	1	0	1
Interleukin-1 receptor-associated kinase 4	0	0	16	16
Cyclin-dependent kinase 12	0	0	15	15
Serine/threonine-protein kinase PLK2	0	3	13	16
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	14	14
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	13	13
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	13	13
5'-AMP-activated protein kinase subunit gamma-2	0	1	15	17
Serine/threonine-protein kinase TBK1	0	3	16	19
Septin-9	0	0	15	15
Serine/threonine-protein kinase TAO2	0	0	16	16
Long-chain-fatty-acid--CoA ligase 5	0	0	12	12
SRSF protein kinase 3	0	0	13	13
Serine/threonine-protein kinase ICK	0	0	16	16
Microtubule-associated serine/threonine-protein kinase 1	0	0	13	13
Serine/threonine-protein kinase SIK3	0	1	16	17
Mitogen-activated protein kinase kinase kinase 2	0	0	16	16
Thyroid hormone receptor-associated protein 3	0	0	13	13
Receptor-interacting serine/threonine-protein kinase 3	0	1	15	16
Alkaline phosphatase, germ cell type	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
G-protein coupled receptor 35	0	0	1	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Spike glycoprotein	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
huntingtin isoform 2	5	0	0	5
Transmembrane protease serine 2	0	0	3	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Proto-oncogene tyrosine-protein kinase Src	0	5	3	8
Transthyretin	0	0	3	6
Neuronal proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Replicase polyprotein 1a	0	0	4	4
Replicase polyprotein 1ab	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Replicase polyprotein 1ab	0	1	3	4
Cytochrome P450 2A6	0	2	0	2
Angiotensin-converting enzyme	0	3	0	3
Potassium voltage-gated channel subfamily E member 1	0	4	0	4
Tyrosine-protein kinase Blk	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	4	0	4
DNA-dependent protein kinase catalytic subunit	0	4	0	4
Myelin transcription factor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Protein kinase C zeta type	0	3	10	13
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	5	0	5
Breakpoint cluster region protein	0	1	0	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	6	6
Protein cereblon	0	2	2	6
Angiotensin-converting enzyme 2	0	0	3	3
Potassium voltage-gated channel subfamily D member 3	0	3	0	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	12	3	15
NF-kappa-B essential modulator	0	1	0	1
Alpha-synuclein	4	3	0	7
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
Gamma-aminobutyric acid	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Fatty acid-binding protein, liver	0	5	0	5
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	4	6	11
ATP-dependent translocase ABCB1	0	7	3	11
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	2	5
Translocator protein	0	2	1	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	3	1	4
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-2	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	3	0	3
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	3	0	3
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Solute carrier family 22 member 6	0	4	0	4
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Chain A, DigA16	0	0	1	1
Chain A, DigA16	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
PAX8	0	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
ras-related protein Rab-9A	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	2	0	0	2
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
serine-protein kinase ATM isoform a	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
cytochrome P450 2C9 precursor	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
serine/threonine-protein kinase PLK1	4	0	0	4
eyes absent homolog 2 isoform a	4	0	0	4
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
snurportin-1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	2	1	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
neuropeptide S receptor isoform A	5	0	0	5
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	1	0	2
Bone morphogenetic protein 4	0	2	0	2
5'-AMP-activated protein kinase subunit gamma-3	0	1	0	2
5'-AMP-activated protein kinase subunit beta-1	0	3	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Ultraspiracle	0	2	0	2
20-hydroxy-ecdysone receptor	0	2	0	2
Ecdysone receptor	0	1	0	1
Protein ultraspiracle	0	1	0	1
Ecdysone receptor	0	1	0	1
Ultraspiracle	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
Ultraspiracle protein	0	1	0	1
20-hydroxy-ecdysone receptor	0	1	0	1
Eyes absent homolog 2	0	2	0	2
Amyloid-beta precursor protein	0	3	0	3
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
streptokinase A precursor	0	0	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1	1	0	0	1
RAF proto-oncogene serine/threonine-protein kinase isoform b	1	0	0	1
epidermal growth factor receptor isoform a precursor	2	2	0	4
dual specificity protein kinase CLK4	1	0	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Serine/threonine-protein kinase B-raf	0	3	0	3
D(1A) dopamine receptor	0	2	0	2
Fatty-acid amide hydrolase 1	0	4	0	4
Synaptic vesicular amine transporter	0	2	0	2
Serine/threonine-protein kinase ATR	0	0	7	7
Serine/threonine-protein kinase ULK3	0	0	3	3
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Alpha-1A adrenergic receptor	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	6	0	7
apical membrane antigen 1, AMA1	4	0	0	4
Transcriptional activator protein LuxR	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
Extracellular calcium-sensing receptor	0	0	1	1
5-hydroxytryptamine receptor 2B	0	8	0	8
Calmodulin	0	0	1	1
Cytochrome P450 2E1	0	1	0	1
Cytochrome P450 2C8	0	3	0	4
Type-1 angiotensin II receptor	0	1	0	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Beta-secretase 1	0	1	0	1
Transcription factor p65	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	1	2
Glutamate receptor ionotropic, NMDA 3B	0	1	1	2
Glutathione reductase, mitochondrial	0	3	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
Integrin beta-3	2	1	1	4
Integrin alpha-IIb	2	1	1	4
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
Glutamate receptor ionotropic, NMDA 2A	0	1	1	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	1	2
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	1	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	1	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	3	0	3
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	3	0	3
Amino acid transporter	0	3	0	3
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
Proton-coupled amino acid transporter 1	0	3	0	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	1	2	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Glutamine synthetase	0	1	0	1
Cytochrome P450 71B1	0	1	0	2
Glutamine synthetase	0	1	0	1
2-dehydro-3-deoxyphosphooctonate aldolase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Liver carboxylesterase 1	0	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	2
Histidine-binding periplasmic protein	0	0	1	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Glutamine synthetase	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Solute carrier family 22 member 6	0	3	0	3
Cholinesterase	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	5
Caspase-1	0	1	0	2
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Solute carrier family 22 member 6	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL	0	1	0	1
Chain A, Tyrosine-protein kinase SYK	0	1	0	1
BCR/ABL p210 fusion protein	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	2	0	2
Platelet-derived growth factor receptor beta	0	4	0	4
Muscarinic acetylcholine receptor M1	0	1	1	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Thromboxane-A synthase	0	5	0	5
G1/S-specific cyclin-E1	0	2	0	2
Histamine H2 receptor	0	2	0	2
Platelet-derived growth factor receptor alpha	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
Platelet-derived growth factor receptor beta	0	2	0	2
C-terminal-binding protein 1	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Cytochrome P450 3A5	0	2	1	4
Oxysterols receptor LXR-beta	0	1	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	8	0	0	8
glucocerebrosidase	3	0	0	3
Parkin	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	2	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	2	5	8
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	2	0	2
Guanine nucleotide-binding protein G	3	0	0	3
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Aldo-keto reductase family 1 member C1	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
DNA polymerase eta isoform 1	3	0	0	3
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Chymotrypsinogen A	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
Chain A, Epidermal growth factor receptor	0	1	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Activin receptor type-1	0	0	1	1
Bone morphogenetic protein 4	0	1	0	1
ACVR1 protein	0	1	0	1
Bone morphogenetic protein 4	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Lysophosphatidic acid receptor 6	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 1	0	0	2	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 5	0	0	1	1
Lysophosphatidic acid receptor 2	0	0	1	1
Lysophosphatidic acid receptor 3	0	0	1	1
Transcription factor SOX-18	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
luciferase	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
histone deacetylase 9 isoform 3	2	0	0	2
pyruvate kinase PKM isoform a	2	0	0	2
DNA polymerase beta	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	1	1
Glutathione reductase	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Microtubule-associated protein tau	0	1	1	2
Amine oxidase [flavin-containing] A	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-2 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M1	0	6	0	6
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	4	0	4
Substance-K receptor	0	4	0	4
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Leukotriene C4 synthase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	2	1	3
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	2	0	2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
ClpP	1	0	0	1
Mcl-1	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Fatty acid synthase	0	2	0	2
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Muscarinic acetylcholine receptor	0	1	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Receptor protein-tyrosine kinase	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Platelet-derived growth factor receptor alpha	0	1	0	1
Cystathionine gamma-lyase	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
D	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Carnitine O-palmitoyltransferase 2, mitochondrial	0	2	0	2
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, liver isoform	0	2	0	2
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Microphthalmia-associated transcription factor	0	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
G-protein coupled receptor 55	0	1	0	1
NACHT, LRR and PYD domains-containing protein 1 isoform 1	0	1	0	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Pirin	0	1	0	1
GTPase KRas	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Heat shock factor protein 1	0	1	0	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Glutamate 5-kinase	0	0	0	1
heat shock protein 90, putative	0	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
NADH-cytochrome b5 reductase 3	0	1	0	1
Myeloperoxidase	0	2	0	2
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
Chain A, dATP pyrophosphohydrolase	0	1	0	1
Chain A, Adenylate cyclase type 5	0	1	0	1
Chain B, Adenylate cyclase type 2	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	2	3
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
H	0	2	0	2
Phosphotransferase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	1	0	1
Free fatty acid receptor 1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Catechol O-methyltransferase	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Amine oxidase [flavin-containing] B	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
C-C chemokine receptor type 2	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	2	1	3
Peroxisome proliferator-activated receptor alpha	0	2	1	3
ATP-binding cassette sub-family C member 8	0	1	0	1
ATP-sensitive inward rectifier potassium channel 11	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Thrombin	0	0	1	1
CDGSH iron-sulfur domain-containing protein 2	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Estrogen receptor beta	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Chain A, Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Nucleoside diphosphate kinase B	0	0	1	1
Chain A, Erk2	0	1	0	1
Mitogen-activated protein kinase 2	0	1	0	1
Neutrophil elastase	0	1	0	1
Tyrosinase	0	2	0	2
Cholesteryl ester transfer protein	0	1	0	1
Mitogen-activated protein kinase 14	0	1	1	2
Mitogen-activated protein kinase 1	0	1	0	1
P2X purinoceptor 7	0	1	0	1
P2X purinoceptor 7	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Carbonic anhydrase	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Aromatase	0	2	0	2
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-C	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Protein delta homolog 1	0	1	2	3
MAP kinase-activated protein kinase 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Beta-adrenergic receptor kinase 1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	2	0	2
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Cereblon isoform 4	0	2	0	2
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Thyroid hormone receptor alpha	0	2	2	4
Thyroid hormone receptor beta	0	2	2	4
Proliferating cell nuclear antigen	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
SLC16A10 protein	0	0	0	1
Tubulin--tyrosine ligase	0	1	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Fibrodysplasia Ossificans Progressiva

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (380)

Protein Targets (1,718)

Fibrodysplasia Ossificans Progressiva

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (380)

Drugs Studied (178)

Protein Targets (1,718)