ascorbic-acid and magnolol

Interference rejection in amperometric biosensors can be more effective introducing some modifiers during electro-deposition of permselective film. Addition of β-cyclodextrin (βCD), a cyclic oligosaccharide composed of seven glucose units, to the ortho-phenylendiamine (oPD) monomer were already demonstrated to provide an enhancement in ascorbic acid (AA) rejection. Here we evaluated the improvement in permselectivity of poly-eugenol and poly-magnolol films electro-polymerized in presence of different amounts of βCD or eugenol-βCD inclusion complex for amperometric biosensor application. Starting from Pt-Ir wire as transducer several microsensors were covered with polymeric films doped with βCD-based modifiers through constant potential amperometry. Characterization of modified polymers was achieved by scanning electron microscopy and permselectivity analysis. Poly-magnolol film in combination with βCD showed a worsening in permselectivity compared to poly-magnolol alone. In contrast, the introduction of βCD-based modifier enhanced the interference rejection toward the archetypal interferent AA, while slightly affecting permeability toward H

Topics: Ascorbic Acid; beta-Cyclodextrins; Biosensing Techniques; Biphenyl Compounds; Electrochemical Techniques; Eugenol; Glutamic Acid; Lignans; Polymers

Topics: Acetylcholine; Acetylcholinesterase; Alcohol Oxidoreductases; Ascorbic Acid; Biosensing Techniques; Biphenyl Compounds; Electrochemical Techniques; Eugenol; Lignans; Microscopy, Electron, Scanning; Phenols; Phenylenediamines; Polymerization; Polymers; Reproducibility of Results