Compounds > 2-tert-butyl-4-methylphenol
Page last updated: 2024-09-22

2-tert-butyl-4-methylphenol

Description

2-tert-butyl-4-methylphenol: RN given refers to cpd with locants [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID17004
CHEMBL ID281976
SCHEMBL ID270433
MeSH IDM0153915

Synonyms (73)

Synonym
LS-13987
phenol, 2-(1,1-dimethylethyl)-4-methyl-
2-(1,1-dimethylethyl)-4-methylphenol
hsdb 5875
einecs 219-314-6
2-terc.butyl-p-kresol [czech]
2-t-butyl-4-methylphenol
2-t-butyl-p-cresol
ccris 4045
4-methyl-2-t-butylphenol
nsc 60301
4-methyl-6-t-butylphenol
4-methyl-2-(1,1-dimethylethyl)phenol
brn 1817645
2409-55-4
nsc60301
2-tert-butyl-4-methyl-1-phenol
2-tert-butyl-4-methylphenol
4-methyl-2-tert-butylphenol
1-hydroxy-2-tert-butyl-4-methylbenzene
o-tert-butyl-p-cresol
phenol,1-dimethylethyl)-4-methyl-
2-tert-butyl-p-cresol
wln: qr d1 bx1&1&1
2-terc.butyl-p-kresol
nsc-60301
p-cresol, 2-tert-butyl-
TIMTEC1_002162
inchi=1/c11h16o/c1-8-5-6-10(12)9(7-8)11(2,3)4/h5-7,12h,1-4h
STK367442
2-tert-butyl-4-methylphenol, 99%
HMS1540C06
B0910
CHEMBL281976
BRD-K22403246-001-01-7
AKOS000120238
NCGC00249138-01
ec 219-314-6
unii-y9vvu7g7j4
y9vvu7g7j4 ,
4-06-00-03397 (beilstein handbook reference)
tox21_303003
cas-2409-55-4
dtxsid2020212 ,
dtxcid00212
NCGC00256616-01
NCGC00259487-01
tox21_201938
25567-40-2
einecs 247-108-6
phenol, (1,1-dimethylethyl)-4-methyl-
2-(tert-butyl)-4-methylphenol
FT-0613429
butyl-4-methylphenol, 2-tert-
2-t-butyl-4-methylphenol [hsdb]
t-butyl p-cresol [inci]
AB00443915-03
SCHEMBL270433
mono-tert-butyl-p-cresol
2-tert-butyl-4-methyl-phenol
2-tertiarybutyl-4-methylphenol
2-tert-butyl-4-cresol
2-(1,1-dimethylethyl)-4-methyl-phenol
W-107351
mfcd00002381
D84620
F0001-0824
NCGC00249138-02
EN300-20370
Q27294416
CS-W016085
?2-tert-butyl-4-methylphenol
Z104477904

Protein Targets (25)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
SMAD family member 2Homo sapiens (human)Potency57.14240.173734.304761.8120AID1346859; AID1346924
SMAD family member 3Homo sapiens (human)Potency57.14240.173734.304761.8120AID1346859; AID1346924
GLI family zinc finger 3Homo sapiens (human)Potency54.38350.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency42.12660.000221.22318,912.5098AID743035; AID743036; AID743042; AID743054; AID743063
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency57.74450.013326.981070.7614AID1346978
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency76.80230.000657.913322,387.1992AID1259378
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency40.25010.000214.376460.0339AID720691; AID720692
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency32.93340.001530.607315,848.9004AID1224848; AID1224849; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency59.34140.375827.485161.6524AID743217; AID743220
estrogen nuclear receptor alphaHomo sapiens (human)Potency35.42700.000229.305416,493.5996AID743069; AID743075; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency54.84020.001024.504861.6448AID743212; AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency55.20410.001019.414170.9645AID743094; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency34.30770.023723.228263.5986AID743222; AID743223
caspase-3Homo sapiens (human)Potency57.74450.013326.981070.7614AID1346978
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency15.32410.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency17.19390.001628.015177.1139AID1224843
activating transcription factor 6Homo sapiens (human)Potency48.87640.143427.612159.8106AID1159516
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency54.893919.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency50.41520.057821.109761.2679AID1159526; AID1159528
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency38.01530.000323.4451159.6830AID743065; AID743067
heat shock protein beta-1Homo sapiens (human)Potency24.49620.042027.378961.6448AID743210
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency29.29670.000627.21521,122.0200AID743202; AID743219
Cellular tumor antigen p53Homo sapiens (human)Potency52.28210.002319.595674.0614AID651631; AID720552
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency54.37190.011917.942071.5630AID651632
Ataxin-2Homo sapiens (human)Potency54.37190.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (141)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (40)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (26)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID114268Hypnotic activity was measured as dose which causes loss of righting reflex for a minimum period of 30s in 50% of mice1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents.
AID282835Cytotoxicity against mouse L1210 cells2005Journal of medicinal chemistry, Nov-17, Volume: 48, Issue:23
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
AID116727Acute toxicity measured as median lethal dose in mice; Range is 100-1201980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Synthesis, biological evaluation, and preliminary structure-activity considerations of a series of alkylphenols as intravenous anesthetic agents.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (33.33)18.7374
1990's4 (26.67)18.2507
2000's1 (6.67)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
phenol[no description available]medium20phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
propofol[no description available]medium20phenolsanticonvulsant;
antiemetic;
intravenous anaesthetic;
radical scavenger;
sedative
2-isopropylphenol[no description available]medium20phenols
2-sec-butylphenol[no description available]medium10phenols
thymol[no description available]medium20monoterpenoid;
phenols		volatile oil component
2,4-di-tert-butylphenol[no description available]medium20alkylbenzene;
phenols		antioxidant;
bacterial metabolite;
marine metabolite
4-isopropylphenol[no description available]medium10phenolsflavouring agent
2,4-dimethylphenol[no description available]medium20aromatic fungicide;
phenols		disinfectant;
volatile oil component
carvacrol[no description available]medium10botanical anti-fungal agent;
p-menthane monoterpenoid;
phenols		agrochemical;
antimicrobial agent;
flavouring agent;
TRPA1 channel agonist;
volatile oil component
2,6-xylenol[no description available]medium20hydroxytoluene
butylated hydroxytoluene[no description available]medium20phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
2,6-di-tert-butylphenol[no description available]medium20alkylbenzene;
phenols		antioxidant
etomidate[no description available]medium10ethyl ester;
imidazoles		intravenous anaesthetic;
sedative
thiopental sodium[no description available]medium10organic sodium saltintravenous anaesthetic
4-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
catechol[no description available]medium40catecholsallelochemical;
genotoxin;
plant metabolite
2-cresol[no description available]medium10cresolhuman xenobiotic metabolite
3-cresol[no description available]medium10cresolhuman xenobiotic metabolite
guaiacol[no description available]medium10guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
hydroquinone[no description available]medium30benzenediol;
hydroquinones		antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent
4-nitrophenol[no description available]medium104-nitrophenolshuman xenobiotic metabolite;
mouse metabolite
4-nonylphenol[no description available]medium10phenolsenvironmental contaminant
acetaminophen[no description available]medium10acetamides;
phenols		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
4-cresol[no description available]medium10cresolEscherichia coli metabolite;
human metabolite;
uremic toxin
4-chlorophenol[no description available]medium10monochlorophenol
resorcinol[no description available]medium30benzenediol;
phenolic donor;
resorcinols		erythropoietin inhibitor;
sensitiser
salicyl alcohol[no description available]medium10aromatic primary alcohol;
hydroxybenzyl alcohol		human urinary metabolite
2-aminophenol[no description available]medium10aminophenolbacterial metabolite
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
2-tert-butylphenol[no description available]medium10alkylbenzene
2,6-di-tert-butyl-4-hydroxymethylphenol[no description available]medium10alkylbenzene
2-nitrophenol[no description available]medium102-nitrophenols
2-ethylphenol[no description available]medium10phenols
pyrogallol 1,3-dimethyl ether[no description available]medium10dimethoxybenzene;
phenols		plant metabolite
2-bromophenol[no description available]medium10bromophenolmarine metabolite
2-chlorophenol[no description available]medium102-halophenol;
monochlorophenol
2-amino-4-methylphenol[no description available]medium10
butylphen[no description available]medium20phenolsallergen
3-dimethylaminophenol[no description available]medium10
4-hydroxyacetophenone[no description available]medium10monohydroxyacetophenonefungal metabolite;
mouse metabolite;
plant metabolite
4-bromophenol[no description available]medium10bromophenolhuman urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite
3-chlorophenol[no description available]medium10monochlorophenol
syringaldehyde[no description available]medium10dimethoxybenzene;
hydroxybenzaldehyde		hypoglycemic agent;
plant metabolite
3-hydroxyanisole[no description available]medium10monomethoxybenzene;
phenols
mequinol[no description available]medium20methoxybenzenes;
phenols		metabolite
2-fluorophenol[no description available]medium10
4-fluorophenol[no description available]medium10fluorophenol;
monofluorobenzenes
3-fluorophenol[no description available]medium10
4-methylcatechol[no description available]medium10methylcatecholantioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite
topanol 354[no description available]medium10methoxybenzenes;
phenols
2,4,6-trimethylphenol[no description available]medium10hydroxytoluene
2-iodophenol[no description available]medium102-halophenol;
iodophenol
4-iodophenol[no description available]medium10iodophenol
3-nitrophenol[no description available]medium103-nitrophenols
3-bromophenol[no description available]medium10
3-aminophenol[no description available]medium10aminophenol
2-cyanophenol[no description available]medium10benzenes;
nitrile
3-ethylphenol[no description available]medium10phenols
3-hydroxyacetanilide[no description available]medium10acetamides;
phenols		non-narcotic analgesic
4-Ethoxyphenol[no description available]medium10aromatic ether;
phenols
2-propylphenol[no description available]medium10phenolsflavouring agent;
plant metabolite
4-propylphenol[no description available]medium10alkylbenzene
2,4,6-tri-tert-butylphenol[no description available]medium10
4-cyanophenol[no description available]medium10phenolsEC 1.4.3.4 (monoamine oxidase) inhibitor
4-phenoxyphenol[no description available]medium10phenoxyphenol
4-n-Butylphenol[no description available]medium10phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
acetosyringone[no description available]medium10acetophenones;
dimethoxybenzene;
phenols		anti-asthmatic drug;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite
butylated hydroxyanisole[no description available]medium10
4-n-Pentylphenol[no description available]medium10phenols
4-ethylphenol[no description available]medium10phenolsfungal xenobiotic metabolite
4-hydroxybenzamide[no description available]medium10
guaethol[no description available]medium10aromatic ether;
phenols;
volatile organic compound		flavouring agent
2,6-di-tert-butyl-4-nitrophenol[no description available]medium10
3,5-di-tert-butyl-4-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehyde
equilenin[no description available]medium1017-oxo steroid;
3-hydroxy steroid		antioxidant;
mammalian metabolite
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
2-amino-4-nitrophenol[no description available]medium104-nitrophenols
sinapaldehyde[no description available]medium10cinnamaldehydes;
dimethoxybenzene;
phenols		antifungal agent;
plant metabolite
baclofen[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
phenoxy radical[no description available]medium10organic radical
isoeugenol[no description available]medium10isoeugenolplant metabolite
dithionitrobenzoic acid[no description available]medium10nitrobenzoic acid;
organic disulfide		indicator
ascorbic acid[no description available]medium10ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
propyl gallate[no description available]medium20trihydroxybenzoic acid
d-alpha tocopherol[no description available]medium20alpha-tocopherolalgal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite
1-hydroxyethyl radical[no description available]medium10organic anionhuman metabolite;
Saccharomyces cerevisiae metabolite
methylnitronitrosoguanidine[no description available]medium20nitroso compoundalkylating agent
propylparaben[no description available]medium20benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
potassium hydroxide[no description available]medium10alkali metal hydroxide
anthralin[no description available]medium10anthracenesantipsoriatic
thiodipropionic acid[no description available]medium10dicarboxylic acid
2-tert-butylhydroquinone[no description available]medium10hydroquinonesfood antioxidant
9,10-dimethyl-1,2-benzanthracene[no description available]medium10ortho-fused polycyclic arene;
tetraphenes		carcinogenic agent
caffeic acid[no description available]medium10caffeic acidgeroprotector;
mouse metabolite
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
ConditionIndicatedRelationship StrengthStudiesTrials
Auricular Cancer0low10
Auricular Neoplasms0low10
Bladder Cancer0low10
Bladder Neoplasms0low10
Bladder Tumors0low10
Body Weight0low10
Cancer of Bladder0low10
Cancer of Ear0low10
Cancer of Ear Auricle0low10
Cancer of Stomach0low40
Cancer of the Bladder0low10
Cancer of the Ear0low10
Cancer of the Stomach0low40
Carcinoma in Situ0low10
Carcinoma, Epidermoid0low10
Carcinoma, Intraepithelial0low10
Carcinoma, Planocellular0low10
Carcinoma, Preinvasive0low10
Carcinoma, Squamous0low10
Carcinoma, Squamous Cell0low10
Ear Cancer0low10
Ear Neoplasms0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Experimental Mammary Neoplasms0low10
Gastric Cancer0low40
Gastric Cancer, Familial Diffuse0low40
Gastric Neoplasms0low40
Hyperplasia0low10
Infantile Paralysis0low10
Intraepithelial Neoplasms0low10
Malignant Tumor of Urinary Bladder0low10
Mammary Neoplasms, Experimental0low10
Neoplasms of Ear Auricle0low10
Neoplasms, Auricular0low10
Neoplasms, Bladder0low10
Neoplasms, Ear0low10
Neoplasms, Experimental Mammary0low10
Neoplasms, Gastric0low40
Neoplasms, Intraepithelial0low10
Neoplasms, Stomach0low40
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Squamous Cell Carcinoma0low10
Stomach Cancer0low40
Stomach Neoplasms0low40
Urinary Bladder Cancer0low10
Urinary Bladder Neoplasms0low10

Research Highlights

Safety/Toxicity (1)

ArticleYear
Cellular apoptosis and cytotoxicity of phenolic compounds: a quantitative structure-activity relationship study.
Journal of medicinal chemistry, Nov-17, Volume: 48, Issue: 23		2005
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]