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7alpha-hydroxy steroid
A 7-hydroxy steroid in which the hydroxy group at position 7 has an alpha-configuration.
ChEBI ID: 36843
Members (16)
| Member | Definition | Role |
|---|---|---|
| 3,7,12-trihydroxycholestan-26-oic acid | A steroid acid that is 5beta-cholestan-26-oic acid which is substituted by hydroxy groups as the 3alpha, 7alpha, and 12alpha positions. | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oic acid |
| 3,7,12-trihydroxycoprostane | 5beta-cholestane-3alpha,7alpha,12alpha-triol | |
| 3,7,12-trihydroxycoprostanic acid | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane-5-carboxylic acid | |
| 3,7,12,24-tetrahydroxycholestanoic acid | 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid | |
| 7 alpha-hydroxy-4-cholesten-3-one | A cholestanoid consisting of a cholesterol core having an oxo group at the 3-position, a C=C bond at the 4,5-position and an alpha-hydroxy group at the 7-position. | 7alpha-hydroxycholest-4-en-3-one |
| 7-hydroxydehydroepiandrosterone | An androstanoid that is dehydroepiandrosterone carrying an additional hydroxy substituent at the 7alpha-position. | 7alpha-hydroxydehydroepiandrosterone |
| allocholic acid | An allo-bile acid that is 5alpha-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12. | allocholic acid |
| androstane-3,7,17-triol | A 3beta sterol that is 5alpha-androstane which is substituted by beta-hydroxy groups at positions 3 and 17 and by an alpha-hydroxy group at position 7. | 5alpha-androstane-3beta,7alpha,17beta-triol |
| cholest-5-en-3 beta,7 alpha-diol | The 7alpha-hydroxy derivative of cholesterol. | 7alpha-hydroxycholesterol |
| cholestane-3,7,12,26-tetrol | 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol | |
| cholic acid | A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12. | cholic acid |
| dihydroxycoprostane | 5beta-cholestane-3alpha,7alpha-diol | |
| glycochenodeoxycholate-3-sulfate | A steroid sulfate that is the 3-O-sulfo derivative of glycochenodeoxycholic acid. | sulfoglycochenodeoxycholic acid |
| hydroxysitosterol | A 3beta-hydroxy steroid that is sitosterol substituted by an additional alpha-hydroxy group at position 7. It has been isolated from the roots of Breynia fruticosa. | stigmast-5-ene-3beta,7alpha-diol |
| obeticholic acid | A dihydroxy-5beta-cholanic acid that is chenodeoxycholic acid carrying an additional ethyl substituent at the 6alpha-position. A semi-synthetic bile acid which acts as a farnesoid X receptor agonist and is used for treatment of primary biliary cholangitis. | obeticholic acid |
| scymnol | 5beta-scymnol |
Research
Studies (2,491)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 529 (21.24) | 18.7374 |
| 1990's | 495 (19.87) | 18.2507 |
| 2000's | 468 (18.79) | 29.6817 |
| 2010's | 751 (30.15) | 24.3611 |
| 2020's | 248 (9.96) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 97 (3.69%) | 5.53% |
| Reviews | 143 (5.44%) | 6.00% |
| Case Studies | 36 (1.37%) | 4.05% |
| Observational | 4 (0.15%) | 0.25% |
| Other | 2,350 (89.35%) | 84.16% |