Roles > inhibitor
Page last updated: 2024-08-05 14:36:29

inhibitor

A substance that diminishes the rate of a chemical reaction.

ChEBI ID: 35222

Members (9)

MemberDefinitionClass
2-furoic acidA furoic acid having the carboxylic acid group located at position 2.2-furoic acid
ARS-1620A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals.ARS-1620
beta-alanineA naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.beta-alanine zwitterion; beta-alanine
blisterA pyrroloquinoline that is 1,2,3,3a-tetrahydro-H-pyrrolo[2,3-b]quinolin-4-one substituted by a hydroxy group at position 3a, a methyl group at position 6 and a phenyl group at position 1. It acts as an inhibitor of ATPase activity of non-muscle myosin II.blebbistatin
glafenineA carboxylic ester that is 2,3-dihydroxypropyl anthranilate in which the amino group is substituted by a 7-chloroquinolin-4-yl group. A non-steroidal anti-inflammatory drug, glafenine and its hydrochloride salt were used for the relief of all types of pain, but high incidence of anaphylactic reactions resulted in their withdrawal from the market.glafenine
limoninlimonin
medroxyprogesterone acetateAn acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.medroxyprogesterone acetate
parthenolideA sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).parthenolide
succinyl-coenzyme aAn omega-carboxyacyl-CoA having succinoyl as the S-acyl component.succinyl-CoA

Research

Studies (8,910)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,469 (16.49)18.7374
1990's1,649 (18.51)18.2507
2000's2,109 (23.67)29.6817
2010's3,104 (34.84)24.3611
2020's579 (6.50)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,333 (14.17%)5.53%
Reviews950 (10.10%)6.00%
Case Studies597 (6.35%)4.05%
Observational34 (0.36%)0.25%
Other6,490 (69.01%)84.16%

Protein Targets (153)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency35.481311
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency28.007613
Alpha-synucleinHomo sapiens (human)Potency5.623411
AR proteinHomo sapiens (human)Potency2.77181227
ATAD5 protein, partialHomo sapiens (human)Potency29.081011
Cellular tumor antigen p53Homo sapiens (human)Potency36.109312
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency35.481311
Chain A, Beta-lactamaseEscherichia coli K-12Potency26.632012
Chain A, CruzipainTrypanosoma cruziPotency35.716812
Chain A, Ferritin light chainEquus caballus (horse)Potency25.118911
Chain A, HADH2 proteinHomo sapiens (human)Potency31.622811
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency17.782811
Chain B, HADH2 proteinHomo sapiens (human)Potency31.622811
chromobox protein homolog 1Homo sapiens (human)Potency79.432811
cytochrome P450 2C9, partialHomo sapiens (human)Potency3.090111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency11.896124
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency9.595313
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency1.785013
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency7.079511
estrogen nuclear receptor alphaHomo sapiens (human)Potency5.0456711
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency20.8735613
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency6.818413
farnesoid X nuclear receptorHomo sapiens (human)Potency24.846445
GVesicular stomatitis virusPotency3.090111
GABA theta subunitRattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency11.896112
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency11.896112
gemininHomo sapiens (human)Potency12.859725
GLI family zinc finger 3Homo sapiens (human)Potency19.211424
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency1.5197512
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.048812
Guanine nucleotide-binding protein GHomo sapiens (human)Potency19.702012
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency3.090111
IDH1Homo sapiens (human)Potency19.146512
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency3.090112
Interferon betaHomo sapiens (human)Potency11.827824
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency35.481311
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.589311
Microtubule-associated protein tauHomo sapiens (human)Potency12.863112
mitogen-activated protein kinase 1Homo sapiens (human)Potency15.848911
neuropeptide S receptor isoform AHomo sapiens (human)Potency2.511911
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency7.943311
Nrf2Homo sapiens (human)Potency15.848911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency38.065935
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency0.221412
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.095212
Nuclear receptor ROR-gammaHomo sapiens (human)Potency16.785511
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency1.258911
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency51.005722
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency19.952611
ParkinHomo sapiens (human)Potency40.870812
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.422222
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency21.875057
PINK1Homo sapiens (human)Potency40.870812
plasminogen precursorMus musculus (house mouse)Potency1.122011
PPM1D proteinHomo sapiens (human)Potency14.740312
pregnane X nuclear receptorHomo sapiens (human)Potency6.471034
pregnane X receptorRattus norvegicus (Norway rat)Potency2.436212
progesterone receptorHomo sapiens (human)Potency7.463224
RAR-related orphan receptor gammaMus musculus (house mouse)Potency21.709024
regulator of G-protein signaling 4Homo sapiens (human)Potency13.587913
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.646634
retinoid X nuclear receptor alphaHomo sapiens (human)Potency16.698647
SMAD family member 2Homo sapiens (human)Potency6.858323
SMAD family member 3Homo sapiens (human)Potency6.858323
Smad3Homo sapiens (human)Potency12.589311
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency24.905412
TDP1 proteinHomo sapiens (human)Potency10.6307213
thioredoxin reductaseRattus norvegicus (Norway rat)Potency56.234111
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency8.821624
thyroid stimulating hormone receptorHomo sapiens (human)Potency16.785511
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency25.118911
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency1.122011
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency1.122011
USP1 protein, partialHomo sapiens (human)Potency50.118711
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency17.582324
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency18.741323
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency22.387211
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.048812

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC501.197011
Aldo-keto reductase family 1 member C1Homo sapiens (human)IC501.800011
Aldo-keto reductase family 1 member C2 Homo sapiens (human)IC504.040522
Aldo-keto reductase family 1 member C3Homo sapiens (human)IC501.405922
Androgen receptorHomo sapiens (human)IC500.006122
Androgen receptorRattus norvegicus (Norway rat)IC500.279023
Androgen receptorHomo sapiens (human)Ki0.002955
Androgen receptorRattus norvegicus (Norway rat)Ki0.004811
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
ATP-dependent translocase ABCB1Homo sapiens (human)IC5019.140011
Bile salt export pumpHomo sapiens (human)IC5017.643333
Bile salt export pumpRattus norvegicus (Norway rat)IC5032.200011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Cytochrome P450 2C19Homo sapiens (human)IC50150.000011
Cytochrome P450 3A4Homo sapiens (human)IC502,818.380011
Cytochrome P450 3A4Homo sapiens (human)Ki23.200011
Estrogen receptorHomo sapiens (human)IC500.924022
Estrogen receptor betaHomo sapiens (human)IC500.924022
Glucocorticoid receptorHomo sapiens (human)IC500.013033
Glucocorticoid receptorHomo sapiens (human)Ki0.012466
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC5011.600012
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC5011.600011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC5011.600011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC5011.600011
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)IC5011.600011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)IC5011.600011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)IC5011.600011
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)Ki0.008611
Glycine receptor subunit betaRattus norvegicus (Norway rat)IC500.019011
Glycine receptor subunit betaRattus norvegicus (Norway rat)Ki0.008611
GTPase KRasHomo sapiens (human)IC500.900066
GTPase KRasHomo sapiens (human)Ki47.500022
Heme oxygenase 2Homo sapiens (human)IC507.640011
Histamine H2 receptorHomo sapiens (human)IC5027.920011
Histamine H2 receptorHomo sapiens (human)Ki27.453011
Mineralocorticoid receptor Homo sapiens (human)IC501.197033
Multidrug resistance-associated protein 4Homo sapiens (human)IC5022.500011
Myosin heavy chain, non-muscleDrosophila melanogaster (fruit fly)IC50200.000011
Myosin IC heavy chainAcanthamoeba castellaniiIC50150.000011
Myosin-10Homo sapiens (human)IC504.600011
Myosin-14Mus musculus (house mouse)IC503.200011
Myosin-2 heavy chainDictyostelium discoideumIC504.900011
Myosin-2 heavy chain, non muscleAcanthamoeba castellaniiIC5083.000011
Myosin-4Oryctolagus cuniculus (rabbit)IC500.220011
Myosin-7Sus scrofa (pig)IC501.200011
Myosin-9Homo sapiens (human)IC504.000011
Nonmuscle myosin heavy chainGallus gallus (chicken)IC501.800011
Progesterone receptorHomo sapiens (human)IC502.508144
Progesterone receptorHomo sapiens (human)Ki0.000588
Proton-coupled amino acid transporter 1Homo sapiens (human)Ki2,400.000011
Quinone oxidoreductaseHomo sapiens (human)IC508.440011
Reticulon-4Homo sapiens (human)IC5014.610011
Sodium- and chloride-dependent betaine transporterMus musculus (house mouse)IC50331.131011
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)IC502,779.996733
Sodium- and chloride-dependent GABA transporter 2Homo sapiens (human)IC50154.500022
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)IC50378.889544
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)IC5041.200022
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)IC5055.399833
Synaptic vesicle membrane protein VAT-1 homologHomo sapiens (human)IC504.510022
Toll-like receptor 4Homo sapiens (human)IC501.400011
Unconventional myosin-IbRattus norvegicus (Norway rat)IC50150.000011
Unconventional myosin-VaMus musculus (house mouse)IC50150.000011
Unconventional myosin-XBos taurus (cattle)IC50150.000011
Unconventional myosin-XVHomo sapiens (human)IC50100.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Androgen receptorHomo sapiens (human)EC500.006111
Androgen receptorMus musculus (house mouse)EC500.006122
Androgen receptorHomo sapiens (human)Kd0.001011
Estrogen receptorHomo sapiens (human)EC500.924011
Estrogen receptor betaHomo sapiens (human)EC500.924011
Glucocorticoid receptorHomo sapiens (human)EC500.010033
Progesterone receptorHomo sapiens (human)EC500.62521616
Sex hormone-binding globulinHomo sapiens (human)Kd0.631011