Roles > fibrin modulating drug
Page last updated: 2024-08-05 15:16:05

fibrin modulating drug

A drug that affects the function of fibrin in blood coagulation.

ChEBI ID: 48676

Members (3)

MemberDefinitionClass
cilostazolA lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.cilostazol
ticlopidineA thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.ticlopidine
tirofibanA member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group.tirofiban

Research

Studies (12,092)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990335 (2.77)18.7374
1990's963 (7.96)18.2507
2000's4,194 (34.68)29.6817
2010's6,073 (50.22)24.3611
2020's527 (4.36)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials2,504 (19.25%)5.53%
Reviews2,155 (16.57%)6.00%
Case Studies1,299 (9.99%)4.05%
Observational223 (1.71%)0.25%
Other6,826 (52.48%)84.16%

Protein Targets (116)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency16.426024
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.540614
AR proteinHomo sapiens (human)Potency21.287035
ATAD5 protein, partialHomo sapiens (human)Potency29.081011
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency7.568611
Bloom syndrome protein isoform 1Homo sapiens (human)Potency0.100022
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency79.432811
Chain A, Ferritin light chainEquus caballus (horse)Potency11.220212
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.118711
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency5.972811
chromobox protein homolog 1Homo sapiens (human)Potency56.234111
cytochrome P450 2C19 precursorHomo sapiens (human)Potency0.039811
cytochrome P450 2C9 precursorHomo sapiens (human)Potency39.810711
cytochrome P450 2C9, partialHomo sapiens (human)Potency5.531512
cytochrome P450 2D6Homo sapiens (human)Potency0.549511
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency0.398111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency12.780827
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency17.754712
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)Potency10.000011
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency19.952611
DNA polymerase kappa isoform 1Homo sapiens (human)Potency8.436811
endonuclease IVEscherichia coliPotency12.589311
estrogen nuclear receptor alphaHomo sapiens (human)Potency20.606066
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency13.368655
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency8.904012
EWS/FLI fusion proteinHomo sapiens (human)Potency0.065112
GVesicular stomatitis virusPotency5.531512
GABA theta subunitRattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency12.756914
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency12.756914
gemininHomo sapiens (human)Potency23.109311
GLI family zinc finger 3Homo sapiens (human)Potency12.222822
glp-1 receptor, partialHomo sapiens (human)Potency7.943311
GLS proteinHomo sapiens (human)Potency5.623411
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency8.740222
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency21.131711
Guanine nucleotide-binding protein GHomo sapiens (human)Potency5.011911
heat shock protein beta-1Homo sapiens (human)Potency21.130011
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency39.810713
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency5.531512
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency5.531514
Interferon betaHomo sapiens (human)Potency5.531512
lamin isoform A-delta10Homo sapiens (human)Potency12.924412
LuciferasePhotinus pyralis (common eastern firefly)Potency8.709011
M-phase phosphoprotein 8Homo sapiens (human)Potency1.000011
mitogen-activated protein kinase 1Homo sapiens (human)Potency3.548111
neuropeptide S receptor isoform AHomo sapiens (human)Potency19.952611
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency18.832211
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency20.596211
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency26.832511
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency9.270624
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency18.101335
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency32.196811
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency84.921411
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency14.125411
pregnane X nuclear receptorHomo sapiens (human)Potency23.412412
progesterone receptorHomo sapiens (human)Potency18.833611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency29.849311
retinoid X nuclear receptor alphaHomo sapiens (human)Potency5.236322
SMAD family member 2Homo sapiens (human)Potency21.313811
SMAD family member 3Homo sapiens (human)Potency21.313811
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency29.881612
survival motor neuron protein isoform dHomo sapiens (human)Potency7.508412
TDP1 proteinHomo sapiens (human)Potency26.992827
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.446711
ThrombopoietinHomo sapiens (human)Potency15.848922
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency29.849322
thyroid stimulating hormone receptorHomo sapiens (human)Potency22.436058
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency10.000011
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency25.373522
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency21.131711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.382011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.143011
Alpha-2B adrenergic receptorHomo sapiens (human)IC500.304011
Alpha-2B adrenergic receptorHomo sapiens (human)Ki0.139011
Alpha-2C adrenergic receptorHomo sapiens (human)IC501.175011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.171011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC5077.983333
Bile salt export pumpRattus norvegicus (Norway rat)IC5049.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)IC501,000.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)IC501,000.000011
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)IC501,000.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)IC500.328544
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)IC500.436733
Cytochrome P450 2B6Homo sapiens (human)IC500.405022
Cytochrome P450 2B6Homo sapiens (human)Ki0.800012
Cytochrome P450 2C19Homo sapiens (human)IC500.667811
Cytochrome P450 2C19Homo sapiens (human)Ki45.150022
Cytochrome P450 2C8Homo sapiens (human)Ki30.366733
Cytochrome P450 2C9 Homo sapiens (human)IC5015.900022
Cytochrome P450 2D6Homo sapiens (human)IC506.292811
Cytochrome P450 2J2Homo sapiens (human)IC5021.800011
Integrin alpha-5Homo sapiens (human)IC50300.000022
Integrin alpha-IIbHomo sapiens (human)IC500.12252426
Integrin alpha-V Homo sapiens (human)IC50113.835266
Integrin beta-1Homo sapiens (human)IC50300.000022
Integrin beta-3Homo sapiens (human)IC5021.44373032
Integrin beta-3 Rattus norvegicus (Norway rat)IC500.130011
Integrin subunit alpha 2bRattus norvegicus (Norway rat)IC500.130011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5016.600011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)IC500.426011
Sigma non-opioid intracellular receptor 1Homo sapiens (human)Ki0.179011
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)IC5091.200011
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)IC5091.200011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Integrin alpha-IIbHomo sapiens (human)Kd0.010033
Integrin beta-3Homo sapiens (human)Kd0.010033

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Integrin alpha-IIbHomo sapiens (human)ED500.001011
Integrin beta-3Homo sapiens (human)ED500.001011