An oral contraceptive which owes its effectiveness to synthetic preparation.
| Member | Definition | Class |
|---|
| desogestrel | | desogestrel |
| dienogest | A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive. | dienogest |
| ethynodiol diacetate | | ethynodiol diacetate |
| gamendazole | A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug. | gamendazole |
| levonorgestrel | | levonorgestrel |
| medroxyprogesterone | A 3-oxo Delta(4)-steroid that is pregn-4-ene-3,20-dione substituted by an alpha-hydroxy group at position 17 and a methyl group at position 6. | medroxyprogesterone |
| medroxyprogesterone acetate | An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control. | medroxyprogesterone acetate |
| megestrol | A 3-oxo Delta(4)-steroid that is pregna-4,6-diene-3,20-dione substituted by a methyl group at position 6 and a hydroxy group at position 17. | megestrol |
| megestrol acetate | A steroid ester resulting from the formal condensation of the hydroxy group of megestrol with the carboxy group of acetic acid. It is an appetite stimulant used for the treatment of anorexia and cachexia. Also used for birth control and for the treatment of breast cancer. | megestrol acetate |
| mifepristone | | mifepristone |
| norethindrone | A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen. | norethisterone |
| norethindrone acetate | A 3-oxo Delta(4)-steroid that is norethisterone in which the hydroxy group has been converted to its acetate ester. | norethisterone acetate |
| norgestimate | | norgestimate |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Androgen receptor | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 4.0544 | 12 | 153 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.1324 | 3 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 28.6008 | 2 | 7 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0060 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.7099 | 2 | 7 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 36.9629 | 2 | 16 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 44.4620 | 2 | 6 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 37.0814 | 1 | 3 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 24.8033 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 49.5275 | 2 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.1217 | 1 | 9 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 15.7008 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.4274 | 2 | 8 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 10.6911 | 1 | 11 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 2.3108 | 1 | 1 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 11.6681 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 85.3973 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 23.5272 | 1 | 5 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0103 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.5347 | 12 | 110 |
| Estrogen receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 12.6304 | 3 | 14 |
| Estrogen receptor beta | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 30.6308 | 10 | 82 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 12.3391 | 1 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.2828 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.4758 | 4 | 14 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 18.5772 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 9.1217 | 1 | 9 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 20.2593 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 13.5484 | 2 | 13 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.0795 | 2 | 29 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Potency | 0.0008 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 7.0581 | 5 | 38 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 33.8150 | 1 | 8 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 24.9618 | 1 | 3 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 19.3755 | 2 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 60.3634 | 2 | 10 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.1217 | 1 | 9 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 19.8384 | 2 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 32.4354 | 2 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 4.0114 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.1217 | 1 | 18 |
| Interferon beta | Homo sapiens (human) | Potency | 11.6682 | 2 | 13 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.1990 | 1 | 5 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 11.9173 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 17.0157 | 1 | 2 |
| Mineralocorticoid receptor | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.5612 | 1 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 11.0344 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 23.3085 | 3 | 29 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 8.1286 | 1 | 5 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 22.1723 | 1 | 7 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 16.7855 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 12.0208 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 8.5742 | 1 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 46.6740 | 3 | 16 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 75.0594 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 43.9534 | 1 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 21.2106 | 1 | 4 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 16.1083 | 5 | 15 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 19.0212 | 5 | 17 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.4328 | 1 | 1 |
| PINK1 | Homo sapiens (human) | Potency | 43.9534 | 1 | 3 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| polyprotein | Zika virus | Potency | 18.5772 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.9445 | 3 | 21 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 4.2719 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 10.4898 | 3 | 28 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 25.7411 | 2 | 26 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.0030 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 27.3981 | 3 | 31 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 16.9202 | 4 | 23 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.4745 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 20.6502 | 2 | 14 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 20.6502 | 2 | 14 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 32.3580 | 1 | 4 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 9.5209 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 19.8600 | 2 | 25 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 12.3807 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 17.4193 | 3 | 35 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 26.2778 | 4 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 13.0051 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.9125 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 43.9593 | 1 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 19.0983 | 2 | 9 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 23.8795 | 5 | 13 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 33.8150 | 1 | 8 |