Fukuhara Disease

A mitochondrial encephalomyopathy characterized clinically by a mixed seizure disorder, myoclonus, progressive ataxia, spasticity, and a mild myopathy. Dysarthria, optic atrophy, growth retardation, deafness, and dementia may also occur. This condition tends to present in childhood and to be transmitted via maternal lineage. Muscle biopsies reveal ragged-red fibers and respiratory chain enzymatic defects. (From Adams et al., Principles of Neurology, 6th ed, p986)

Synonym
Myoclonic Epilepsy with Ragged-Red Fibers
MERRF
Myoclonic Epilepsy with Ragged Red Fibers
Fukuhara Syndrome
Myoclonus with Epilepsy with Ragged Red Fibers
Myoclonic Epilepsy Associated with Ragged-Red Fibers
Fukuhara Disease
Myoencephalopathy Ragged-Red Fiber Disease
MERRF Syndrome
Myoclonic Epilepsy and Ragged Red Fibers

Excerpt	Reference
"Treatment of MELAS, LHON, and MERRF cells with cyclosporin A caused significant rescue from oxidant exposure, and in each case significantly greater rescue of mutant than control cells."	( Cortopassi, G; Wong, A, 1997)
"Treatment of MERRF cells with drugs affecting organellar Ca2+ transport mostly restored both the agonist-dependent mitochondrial Ca2+ uptake and the ensuing stimulation of ATP production."	( Brini, M; Davidson, M; King, MP; Pinton, P; Rizzuto, R; Schon, EA, 1999)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	27 (36.49)	12.5806
2000's	22 (29.73)	18.1394
2010's	20 (27.03)	28.8240
2020's	5 (6.76)	9.53

Drug	Relationship Strength	Studies	Trials
2-keto-4-methylvalerate	low	1	0
adenine	low	4	0
carnitine	low	1	0
choline	low	1	0
creatine	low	1	0
lactic acid	medium	3	1
glycine	low	2	0
histamine	low	1	0
taurine	low	1	0
thiamine	medium	2	1
cgp 37157	low	1	0
clonazepam	low	3	0
valproic acid	low	2	0
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	low	1	0
iofetamine	low	1	0
piracetam	low	3	0
sevoflurane	low	2	0
alanine	low	2	0
chloramphenicol	low	2	0
aspartic acid	low	2	0
lysine	low	1	0
adenosine diphosphate	low	1	0
uridine	low	2	0
tyrosine	low	1	0
cysteamine	low	1	0
lactose	low	1	0
methionine	low	1	0
phenylalanine	low	2	0
methylprednisolone	medium	1	1
thiamine pyrophosphate	medium	1	1
emetine	low	1	0
acetylcysteine	low	2	0
rhodamine 6g	low	1	0
d-alpha tocopherol	medium	2	1
gold	low	1	0
glutamic acid	low	1	0
zidovudine	low	1	0
adenosine	low	1	0
n-acetylaspartic acid	low	2	0
fluorodeoxyglucose f18	low	1	0
biotin	low	1	0
3-nitrotyrosine	low	1	0
riboflavin	medium	1	1
nadp	low	1	0
thiouridine	low	2	0
2-thiouridine	low	1	0
ubiquinone q2	low	1	0
ubiquinone 9	low	1	0
vitamin k semiquinone radical	medium	1	1
rottlerin	low	1	0
coenzyme q10	medium	5	1
levetiracetam	low	5	0
sirolimus	low	1	0
cysteine	low	1	0
cholestanol	low	1	0
i(3)so3-galactosylceramide	low	1	0
staurosporine	low	2	0
ubiquinol	low	1	0
cytochrome c-t	medium	1	1
anticodon	low	4	0
c-peptide	low	1	0
ubiquinone	medium	6	1
calpain	low	1	0
ascorbic acid	medium	1	1
oligomycins	low	1	0
cyclosporine	low	1	0
flavin mononucleotide	medium	2	1
5-taurinomethyluridine	low	2	0
guanine	low	4	0
guanosine	low	1	0

Protein Targets (1,097)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
Monocarboxylate transporter 2	0	1	0	1
Chain A, RNA polymerase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
phosphopantetheinyl transferase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	15	0	0	15
pyruvate kinase PKM isoform a	2	0	0	2
geminin	12	0	0	12
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Tubulin--tyrosine ligase	0	2	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
acetylcholinesterase	6	0	0	6
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	3	0	0	3
RAR-related orphan receptor gamma	9	0	0	9
USP1 protein, partial	6	0	0	6
NFKB1 protein, partial	1	0	0	1
Microtubule-associated protein tau	4	0	0	4
Thrombopoietin	1	0	0	1
AR protein	15	0	0	15
regulator of G-protein signaling 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	11	0	0	11
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	6	0	0	6
farnesoid X nuclear receptor	8	0	0	8
estrogen nuclear receptor alpha	18	0	0	18
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
arylsulfatase A	6	0	0	6
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	7	0	0	7
heat shock protein beta-1	6	0	0	6
flap endonuclease 1	6	0	0	6
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	4	0	0	4
muscarinic acetylcholine receptor M1	2	0	0	2
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	2
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	3	0	3
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	8	0	0	8
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	12	0	0	12
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
estrogen-related nuclear receptor alpha	12	0	0	12
pregnane X nuclear receptor	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Bile salt export pump	0	13	0	13
Cyclin-dependent kinase 1	0	1	1	2
Heat shock protein HSP 90-beta	0	2	1	4
Glutamate receptor 2	4	2	1	7
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	5	0	0	5
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
NPYLR7B	0	0	2	2
IDH1	5	0	0	5
Histone H2A.x	3	0	0	3
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	4	0	4
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	4	0	4
Rap guanine nucleotide exchange factor 3	4	0	0	4
Purine nucleoside phosphorylase	0	3	0	4
Epidermal growth factor receptor	0	1	1	2
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	1	2
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	2	2	5
Platelet-derived growth factor receptor beta	0	0	1	2
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	2	1	3
Heat shock cognate 71 kDa protein	0	0	2	2
Fibroblast growth factor receptor 1	0	0	1	2
Inosine-5'-monophosphate dehydrogenase 2	0	1	1	2
Endoplasmin	0	1	1	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	2	2
Adenosylhomocysteinase	0	1	0	3
Adenosine receptor A1	0	1	1	5
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenosine receptor A2a	0	1	1	5
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	4	0	5
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	1	2
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	4	0	4
Phosphatidylinositol 4-kinase type 2-beta	0	4	0	5
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Phosphatidylinositol 4-kinase type 2-alpha	0	4	0	5
Solute carrier family 28 member 3	0	4	0	4
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	4	0	5
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	2	0	2
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
P2Y purinoceptor 11	0	0	1	1
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Carbonic anhydrase 1	0	1	0	7
Carbonic anhydrase 2	0	1	0	8
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	3
Glutamate receptor ionotropic, NMDA 1	0	6	2	11
Proton-coupled amino acid transporter 1	0	4	0	4
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	7	0	0	7
thioredoxin glutathione reductase	2	0	0	2
chromobox protein homolog 1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	5	0	0	5
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	5	0	1	6
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
cytochrome P450 2C19 precursor	2	0	0	2
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	10
Glutamate receptor ionotropic, NMDA 2B	0	5	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	10
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	5
Glutamate receptor ionotropic, NMDA 2D	0	5	2	10
Glutamate receptor ionotropic, NMDA 3B	0	5	2	10
Glutamate receptor ionotropic, NMDA 3A	0	5	2	10
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
insulin-degrading enzyme isoform 1	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Cruzipain	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
cytochrome P450 3A4 isoform 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	3	1	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
Gamma-aminobutyric acid receptor subunit beta-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit delta	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	3	1	0	4
Gamma-aminobutyric acid receptor subunit gamma-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	3	1	0	4
Histamine H2 receptor	1	0	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-3	3	1	0	4
Gamma-aminobutyric acid receptor subunit beta-2	3	1	0	4
Hypoxia-inducible factor 1-alpha	0	2	0	3
GABA theta subunit	3	1	0	4
Endothelial PAS domain-containing protein 1	0	2	0	3
Gamma-aminobutyric acid receptor subunit epsilon	3	1	0	4
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	0	2
Mitochondrial sodium/calcium exchanger protein	0	1	0	1
interleukin 8	1	0	0	1
EWS/FLI fusion protein	4	0	0	4
G	2	0	0	2
cytochrome P450 2D6	3	0	0	3
peroxisome proliferator activated receptor gamma	6	0	0	6
aryl hydrocarbon receptor	4	0	0	4
activating transcription factor 6	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
DNA polymerase iota isoform a (long)	6	0	0	6
streptokinase A precursor	0	0	1	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	6
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	8	0	0	8
Cytochrome P450 3A4	0	2	0	2
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	1	0	4
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	3	0	5
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
thioredoxin reductase	7	0	0	7
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
NS5	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
ATAD5 protein, partial	3	0	0	3
PPM1D protein	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
progesterone receptor	4	0	0	4
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Serine hydrolase RBBP9	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	3
Alpha-2A adrenergic receptor	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Dihydroorotate dehydrogenase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	5	0	5
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	1	0	0	1
GLS protein	4	0	0	4
beta-2 adrenergic receptor	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	2	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	4	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	0	0	3
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 4	0	0	0	3
Carbonic anhydrase 6	0	1	0	4
Histamine H2 receptor	0	1	2	3
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Carbonic anhydrase 5A, mitochondrial	0	0	0	3
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 7	0	0	0	3
Carbonic anhydrase	0	0	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	0	0	3
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	0	0	4
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 15	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
Histamine H3 receptor	0	1	2	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
67.9K protein	2	0	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Luciferase	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Hsf1 protein	0	0	1	2
M-phase phosphoprotein 8	2	0	0	2
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
tumor necrosis factor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Fumarate hydratase	1	0	0	1
DNA polymerase III, partial	1	0	0	1
polyprotein	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Eukaryotic elongation factor 2 kinase	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Protein kinase C alpha type	0	1	1	2
Chymotrypsinogen B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
MAP kinase-activated protein kinase 2	0	1	1	2
Tyrosine-protein kinase JAK3	0	1	0	1
Protein kinase C delta type	0	1	1	2
Receptor-type tyrosine-protein phosphatase eta	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
MAP kinase-activated protein kinase 5	0	1	1	2
WD repeat-containing protein 48	0	1	0	1
RuvB-like 1	0	1	0	1
Smad3	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cytochrome P450 2C9	0	1	0	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Alpha-synuclein	1	0	0	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
glucocerebrosidase	1	0	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Acetylcholinesterase	0	1	0	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Cytidine deaminase	0	1	0	1
Protein cereblon	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	3
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Nuclear receptor ROR-gamma	1	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Albumin	0	0	1	1
Thymidine kinase, cytosolic	0	2	0	3
DNA polymerase beta	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Thymidylate kinase	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Reverse transcriptase/RNaseH	0	1	2	6
Protease	0	1	1	2
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(10)

Research Excerpts

Treatment

Research

Studies (74)

Protein Targets (1,097)

Fukuhara Disease

Synonyms(10)

Research Excerpts

Treatment

Research

Studies (74)

Drugs Studied (81)

Protein Targets (1,097)