Any compound that induces or regulates osteogenesis.
ChEBI ID: 63054
| Member | Definition | Class |
|---|---|---|
| jte 013 | A semicarbazide derivative that is semicarbazide in which the amino group at position 2 is replaced by a [1,3-dimethyl-4-(propan-2-yl)-1H-pyrazolo[3,4-b]pyridin-6-yl]amino group and the amino group adjacent to the carbonyl is replaced by a (2,6-dichloropyridin-4-yl)amino group. It is a potent S1P2 antagonist (IC50 = 17.6 nM). | JTE-013 |
| purmorphamine | A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group. | purmorphamine |
| quercetin 3-o-glucopyranoside | A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells | quercetin 3-O-beta-D-glucopyranoside |
| salvianolic acid B | A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza | salvianolic acid B |
| u 0126 | An aryl sulfide that is (2Z,3Z)-bis[amino(sulfanyl)methylidene]butanedinitrile in which the sulfanyl hydrogens are replaced by 2-aminophenyl groups. An inhibitor of mitogen-activated protein kinase that also exhibits anti-cancer properties. | U0126 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (0.60) | 18.2507 |
| 2000's | 1,581 (42.86) | 29.6817 |
| 2010's | 1,818 (49.28) | 24.3611 |
| 2020's | 268 (7.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4 (0.11%) | 5.53% |
| Reviews | 33 (0.88%) | 6.00% |
| Case Studies | 2 (0.05%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,705 (98.96%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.0990 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 26.8545 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 31.6228 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 4.7724 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 1.7783 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 12.5917 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0019 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 4.7724 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 4.7724 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 4.7724 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 5.0119 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 4.7724 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 23.7260 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 15.8489 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 36.0415 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 2.9935 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 18.2563 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 5.3930 | 2 | 4 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 11.2202 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 31.0990 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 4.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 16.0000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 7.1050 | 2 | 2 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.0700 | 1 | 5 |
| Arginase | Leishmania amazonensis | IC50 | 2.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 10.7000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 28.4300 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.1110 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 3.3106 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.0757 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0038 | 1 | 1 |
| Chymotrypsinogen B | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Dual specificity mitogen-activated protein kinase kinase 1 | Homo sapiens (human) | IC50 | 2.9168 | 14 | 14 |
| Dual specificity mitogen-activated protein kinase kinase 2 | Homo sapiens (human) | IC50 | 2.7334 | 10 | 10 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 1.6600 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 0.3900 | 3 | 3 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Malate dehydrogenase | Thermus thermophilus | IC50 | 100.0000 | 1 | 1 |
| MAP kinase-activated protein kinase 5 | Homo sapiens (human) | IC50 | 50.0000 | 2 | 2 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 41.4333 | 1 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 44.8250 | 2 | 4 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 423.6500 | 2 | 2 |
| P2Y purinoceptor 12 | Homo sapiens (human) | Ki | 36.4000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 60.0000 | 1 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 0.2900 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Smoothened homolog | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | IC50 | 1.0000 | 2 | 2 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | IC50 | 0.0401 | 6 | 6 |
| Sphingosine 1-phosphate receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | IC50 | 1.0000 | 2 | 2 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 25.9700 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 15.8000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | EC50 | 0.0013 | 1 | 1 |
| Smoothened homolog | Mus musculus (house mouse) | EC50 | 0.8000 | 1 | 1 |
| Sonic hedgehog protein | Mus musculus (house mouse) | EC50 | 1.0000 | 1 | 1 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | Kd | 1.9600 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Arginase | Leishmania amazonensis | Kis | 6.9000 | 1 | 1 |
| interferon gamma precursor | Homo sapiens (human) | AC50 | 14.5550 | 2 | 2 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | Activity | 1.7500 | 1 | 1 |