Roles > mycoestrogen
Page last updated: 2024-08-05 15:45:36

mycoestrogen

Any compound produced by a fungus that happens to have estrogenic activity.

ChEBI ID: 76990

Members (1)

MemberDefinitionClass
zearalenoneA macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.zearalenone

Research

Studies (2,234)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990283 (12.67)18.7374
1990's148 (6.62)18.2507
2000's400 (17.91)29.6817
2010's857 (38.36)24.3611
2020's546 (24.44)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials41 (1.74%)5.53%
Reviews132 (5.60%)6.00%
Case Studies8 (0.34%)4.05%
Observational0 (0.00%)0.25%
Other2,175 (92.32%)84.16%

Protein Targets (80)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency9.937513
15-lipoxygenase, partialHomo sapiens (human)Potency31.622811
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency13.444813
AR proteinHomo sapiens (human)Potency27.0281916
aryl hydrocarbon receptorHomo sapiens (human)Potency23.439011
ATAD5 protein, partialHomo sapiens (human)Potency20.596222
Ataxin-2Homo sapiens (human)Potency16.593511
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency16.593511
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency58.876011
caspase-3Homo sapiens (human)Potency58.876011
Cellular tumor antigen p53Homo sapiens (human)Potency19.252235
Chain A, CruzipainTrypanosoma cruziPotency39.810711
Chain A, HADH2 proteinHomo sapiens (human)Potency35.716812
Chain B, HADH2 proteinHomo sapiens (human)Potency35.716812
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency0.365325
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency11.721512
estrogen nuclear receptor alphaHomo sapiens (human)Potency16.11941124
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency20.989924
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.3285612
farnesoid X nuclear receptorHomo sapiens (human)Potency32.404335
GABA theta subunitRattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency0.370813
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency0.370813
GLI family zinc finger 3Homo sapiens (human)Potency16.444135
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency26.072847
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency24.296512
heat shock protein beta-1Homo sapiens (human)Potency13.584324
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency47.199511
interleukin 8Homo sapiens (human)Potency67.267612
lamin isoform A-delta10Homo sapiens (human)Potency17.782811
lethal factor (plasmid)Bacillus anthracis str. A2012Potency15.848911
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency50.118722
mitogen-activated protein kinase 1Homo sapiens (human)Potency32.464812
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency50.118711
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Potency50.118711
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency10.000011
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency40.026246
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency52.958711
Nuclear receptor ROR-gammaHomo sapiens (human)Potency58.570612
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency33.552012
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency24.625924
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency40.402133
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency35.116836
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency48.022412
pregnane X nuclear receptorHomo sapiens (human)Potency7.589625
progesterone receptorHomo sapiens (human)Potency21.851423
RAR-related orphan receptor gammaMus musculus (house mouse)Potency29.451822
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency29.981834
retinoid X nuclear receptor alphaHomo sapiens (human)Potency22.814922
SMAD family member 2Homo sapiens (human)Potency31.574922
SMAD family member 3Homo sapiens (human)Potency31.574922
survival motor neuron protein isoform dHomo sapiens (human)Potency16.325312
TAR DNA-binding protein 43Homo sapiens (human)Potency2.818411
TDP1 proteinHomo sapiens (human)Potency2.059611
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency19.676124
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency39.810711
thyroid stimulating hormone receptorHomo sapiens (human)Potency25.118922
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency47.199511
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency32.050455
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency24.296512

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
90-kda heat shock protein beta HSP90 beta, partialHomo sapiens (human)IC502.402011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)IC502.402011
PTK2B protein tyrosine kinase 2 betaHomo sapiens (human)IC506.922011
Seed linoleate 13S-lipoxygenase-1Glycine max (soybean)IC5051.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Estrogen receptor betaHomo sapiens (human)EC500.110011
glycogen synthase kinase-3 beta isoform 1Homo sapiens (human)EC505.449011
serine/threonine-protein kinase 33 isoform aHomo sapiens (human)EC5044.560011