A class of neuro-active insecticides that act at the nicotinic acetylcholine receptor.
ChEBI ID: 25540
| Member | Definition | Class |
|---|---|---|
| clothianidin | A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety. | (E)-clothianidin; clothianidin |
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. | (E)-clothianidin; clothianidin |
| clothianidin | A clothiadin that has E configuration at the C=N bond of the nitroguanidine moiety. | (E)-clothianidin; clothianidin |
| clothianidin | An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3. | (E)-clothianidin; clothianidin |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| imidacloprid | An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1. | (E)-imidacloprid; (Z)-imidacloprid; imidacloprid |
| prizes | A carboxamidine that is acetamidine in which the amino hydrogens are substituted by a (6-chloropyridin-3-yl)methyl and a methyl group while the hydrogen attached to the imino nitrogen is replaced by a cyano group. | acetamiprid |
| scorpions | (E)-dinotefuran; dinotefuran | |
| thiacloprid | A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen. | thiacloprid |
| thiamethoxam | An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively. | thiamethoxam |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 32 (0.95) | 18.2507 |
| 2000's | 595 (17.69) | 29.6817 |
| 2010's | 1,719 (51.10) | 24.3611 |
| 2020's | 1,018 (30.26) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 107 (2.57%) | 5.53% |
| Reviews | 52 (1.25%) | 6.00% |
| Case Studies | 53 (1.27%) | 4.05% |
| Observational | 2 (0.05%) | 0.25% |
| Other | 3,949 (94.86%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 40.1798 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 26.4922 | 3 | 4 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 2.8184 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 52.2759 | 1 | 4 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.3993 | 2 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0089 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 3.0480 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 54.2002 | 2 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.3332 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 38.8952 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 8.1129 | 2 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 0.6113 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 1.1220 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholine receptor subunit alpha | Homo sapiens (human) | IC50 | 210.0000 | 1 | 2 |
| Acetylcholine receptor subunit alpha-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit alpha-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 1 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | IC50 | 0.0030 | 2 | 4 |
| Acetylcholine receptor subunit beta-like 2 | Drosophila melanogaster (fruit fly) | Ki | 0.0034 | 2 | 4 |
| Acetylcholine-binding protein | Lymnaea stagnalis (great pond snail) | Ki | 0.7967 | 1 | 3 |
| Forkhead box protein A2-A | Xenopus laevis (African clawed frog) | Ki | 0.0019 | 1 | 1 |
| Liver carboxylesterase B-1 | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor DM1 | Drosophila melanogaster (fruit fly) | Ki | 100.0000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | IC50 | 1.7300 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Mus musculus (house mouse) | IC50 | 1.7300 | 1 | 2 |
| Neuronal acetylcholine receptor subunit alpha-4 | Gallus gallus (chicken) | Ki | 0.6300 | 1 | 3 |
| Neuronal acetylcholine receptor subunit alpha-4 | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-7 | Homo sapiens (human) | IC50 | 185.0000 | 1 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Homo sapiens (human) | Ki | 0.7200 | 1 | 1 |
| Nicotinic acetyl choline receptor alpha-subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 3 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 4 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha 5 subunit | Musca domestica (house fly) | Ki | 0.0046 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha3, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha4, isoform D | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha5, isoform B | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor alpha6, isoform E | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor beta 3 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor Dalpha7 | Drosophila melanogaster (fruit fly) | Ki | 0.0021 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha5 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-1 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Nicotinic acetylcholine receptor, alpha7-2 subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,148.0000 | 1 | 5 |
| Putative nicotinic acetylcholine receptor subunit | Myzus persicae (green peach aphid) | Ki | 0.0019 | 1 | 1 |
| Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Ki | 0.0183 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Kd | 0.0140 | 1 | 2 |
| Chain E, Soluble acetylcholine receptor | Aplysia californica (California sea hare) | Kd | 0.0140 | 1 | 2 |