Page last updated: 2024-08-05 11:24:10
dihydrochalcones
Any ketone that is 1,3-diphenylpropanone and its derivatives obtained by substitution.
ChEBI ID: 71230
Members (14)
| Member | Definition | Role |
|---|---|---|
| 2',6'-dihydroxy-4'-methoxydihydrochalcone | A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 2' and 6' and a methoxy group at position 4' respectively. | 2',6'-dihydroxy-4'-methoxydihydrochalcone |
| 3-(4-methoxyphenyl)-3-(4-methylphenyl)sulfonyl-1-phenyl-1-propanone | 3-(4-methoxyphenyl)-3-(4-methylphenyl)sulfonyl-1-phenyl-1-propanone | |
| 3-(benzenesulfonyl)-3-(4-methoxyphenyl)-1-phenyl-1-propanone | 3-(benzenesulfonyl)-3-(4-methoxyphenyl)-1-phenyl-1-propanone | |
| asebogenin | A member of the class of dihydrochalcones that is the 4'-methyl ether derivative of phloretin. | asebogenin |
| aspalathin | A member of the class of dihydrochalcones that is the 2-C-beta-D-glucopyranide of phloroglucinol and which is substituted at position 4 by a 3-(3,4-dihydroxyphenyl)propanoyl group. A metabolite of red bush, Aspalathus linearis (and present in the herbal tea made from the leaves), aspalathin exhibits significant hypoglycemic activity. | aspalathin |
| avobenzone | avobenzone | |
| davidigenin | A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', and 4' respectively. | davidigenin |
| dihydrochalcone | A member of the class of dihydrochalcones that is acetophenone in which one of the hydrogens of the methyl group is replaced by a benzyl group. | dihydrochalcone |
| dihydroxanthohumol | A member of the class of dihydrochalcones that is the alpha,beta-dihydro derivative of xanthohumol. Isolated from Humulus lupulus, it exhibits inhibition of NO production. | dihydroxanthohumol |
| neohesperidin dihydrochalcone | A member of the dihydrochalcones that is 3,2',4',6'-tetrahydroxy-4-methoxydihydrochalcone attached to a neohesperidosyl residue at position 4' via glycosidic linkage. It is found in sweet orange. | neohesperidin dihydrochalcone |
| phloretin | A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'. | phloretin |
| phlorhizin | An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage. | phlorizin |
| trilobatin | An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage. It is isolated from the leaves of the Chinese sweet tea Lithocarpus polystachyus and exhibits significant anti-hyperglycemic, anti-oxidative and anti-inflammatory properties. | trilobatin |
| uvaretin | A member of the class of dihydrochalcones that is 1,3-diphenylpropan-1-one in which the phenyl group that is bonded to the carbonyl group is substituted by hydroxy groups at positions 2 and 4, an o-hydroxybenzyl group at position 3, and a methoxy group at position 6. A cytotoxic natural product found particularly in Uvaria acuminata and Uvaria chamae. | uvaretin |
Research
Studies (3,173)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1,434 (45.19) | 18.7374 |
| 1990's | 420 (13.24) | 18.2507 |
| 2000's | 450 (14.18) | 29.6817 |
| 2010's | 612 (19.29) | 24.3611 |
| 2020's | 257 (8.10) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 27 (0.75%) | 5.53% |
| Reviews | 110 (3.06%) | 6.00% |
| Case Studies | 10 (0.28%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,450 (95.91%) | 84.16% |