A drug that prevent fibrinolysis or lysis of a blood clot or thrombus.
ChEBI ID: 48675
| Member | Definition | Class |
|---|---|---|
| aminocaproic acid | An epsilon-amino acid comprising hexanoic acid carrying an amino substituent at position C-6. Used to control postoperative bleeding, and to treat overdose effects of the thrombolytic agents streptokinase and tissue plasminogen activator. | 6-aminohexanoic acid zwitterion; 6-aminohexanoic acid |
| bl 4162a | A 1,5-dihydroimidazo[2,1-]quinazoline having an oxo substituent at the 2-position and chloro substituents at the 6- and 7-positions. | anagrelide |
| camostat | A benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients. | camostat |
| camostat mesylate | A methanesulfonate (mesylate) salt prepared from equimolar amounts of camostat and methanesulfonic acid. It is a serine protease inhibitor approved and marketed in Japan in 1985 for the alleviation of acute symptoms associated with chronic pancreatitis. In 1994, it was approved for the treatment of postoperative reflux esophagitis. | camostat mesylate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 848 (37.96) | 18.7374 |
| 1990's | 434 (19.43) | 18.2507 |
| 2000's | 416 (18.62) | 29.6817 |
| 2010's | 384 (17.19) | 24.3611 |
| 2020's | 152 (6.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 187 (7.56%) | 5.53% |
| Reviews | 259 (10.48%) | 6.00% |
| Case Studies | 279 (11.29%) | 4.05% |
| Observational | 11 (0.44%) | 0.25% |
| Other | 1,736 (70.23%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.0050 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.3381 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 2.5918 | 1 | 1 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 44.6684 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 2.2387 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 94.5626 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.1380 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.1299 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.0493 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 16.3888 | 4 | 11 |
| geminin | Homo sapiens (human) | Potency | 0.2060 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 16.4784 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 5.7413 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 0.1518 | 2 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 0.0829 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 1.2589 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 10.0000 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 19.0115 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0829 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.4224 | 1 | 1 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.3981 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cathepsin G | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | IC50 | 34.0000 | 2 | 2 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | IC50 | 0.2327 | 6 | 6 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | IC50 | 0.2327 | 6 | 6 |
| Chymotrypsinogen A | Bos taurus (cattle) | IC50 | 100.0000 | 1 | 1 |
| Furin | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| Furin | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Hepatocyte growth factor activator | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Kallikrein-1 | Homo sapiens (human) | IC50 | 34.1000 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 12.7000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | IC50 | 105.0000 | 1 | 1 |
| Plasminogen | Homo sapiens (human) | Ki | 53,000.0000 | 1 | 1 |
| Plasminogen | Rattus norvegicus (Norway rat) | IC50 | 2.6200 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Prothrombin | Homo sapiens (human) | IC50 | 10.7993 | 3 | 3 |
| Prothrombin | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 35,000.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 35.0000 | 2 | 2 |
| Serine protease hepsin | Homo sapiens (human) | IC50 | 0.0235 | 2 | 2 |
| Serine protease hepsin | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 16.5000 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Transmembrane protease serine 6 | Homo sapiens (human) | IC50 | 0.0180 | 1 | 1 |
| Transmembrane protease serine 6 | Homo sapiens (human) | Ki | 3.4394 | 1 | 6 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 0.0270 | 2 | 2 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 0.0035 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 2 |
| Chain A, Apolipoprotein | Homo sapiens (human) | Kd | 20.0000 | 1 | 1 |
| Chain A, PLASMINOGEN | Homo sapiens (human) | Kd | 11.0000 | 1 | 2 |
| Plasminogen | Homo sapiens (human) | Kd | 9.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 10.0000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 6.6703 | 2 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 10.0000 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 2 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 7.0000 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Liver carboxylesterase 1 | Homo sapiens (human) | Km | 707.0000 | 1 | 1 |