Page last updated: 2024-09-27

Posterior Vitreous Detachment

Detachment of the corpus vitreum (VITREOUS BODY) from its normal attachments, especially the retina, due to shrinkage from degenerative or inflammatory conditions, trauma, myopia, or senility.

Synonyms(2)

Synonym
Posterior Vitreous Detachment
Vitreous Detachment

Research Excerpts

Treatment

ExcerptReference
"Our study suggests that posterior vitreous detachment may play a role in the efficacy of intravitreal bevacizumab during the treatment of neovascular age-related macular degeneration."( Aragon, AV; Rush, RB; Simunovic, MP; Vandiver, L; Ysasaga, JE, 2014)

Research

Studies (108)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (0.93)23.3326
1990's3 (2.78)12.5806
2000's43 (39.81)18.1394
2010's47 (43.52)28.8240
2020's14 (12.96)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0medium11
nitrites0low10
aspirin0low10
cetylpyridinium0low10
fentanyl0medium11
hydrochlorothiazide0low10
meperidine0medium11
ticlopidine0low10
thyroxine0low10
pilocarpine0low20
lysine0low10
arginine0low10
perfluoroethane0low20
perflutren0medium211
triamcinolone acetonide0low120
diphenhydramine hydrochloride0medium11
perfluorooctane0low30
sulfur hexafluoride0low120
trolamine salicylate0low50
phenyl acetate0low10
etoposide0low10
propiconazole0low20
clopidogrel0low10
zanamivir0low10
nsc-1727550low10
fibrinogen0low10
arginyl-glycyl-aspartic acid0low10
vitamin b 60low10
pentosidine0low10
angiotensin ii0low10
alpha-chymotrypsin0low10
sphingosine0low10
sphingosine 1-phosphate0low10
indocyanine green0low60
ascorbic acid0low10
warfarin0low10
budesonide, formoterol fumarate drug combination0low10
nattokinase0low20
hyaluronoglucosaminidase0low150
eye0low80

Protein Targets (431)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
glucocerebrosidase3003
DNA polymerase kappa isoform 16006
histone acetyltransferase KAT2A isoform 11001
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase6006
phosphopantetheinyl transferase3003
NFKB1 protein, partial2002
GLS protein3003
thyroid stimulating hormone receptor2002
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 2110011
cytochrome P450 2C19 precursor3003
chromobox protein homolog 1110011
flap endonuclease 12002
DNA polymerase iota isoform a (long)7007
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)3003
Cytochrome P450 3A40203
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
ATP-dependent phosphofructokinase3003
Integrin beta-30202
Integrin beta-10101
Integrin alpha-V 0101
Integrin alpha-IIb0202
Integrin alpha-50101
Integrin beta-50101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase4004
RAR-related orphan receptor gamma110011
GLI family zinc finger 3100010
AR protein100010
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 49009
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 1110011
estrogen-related nuclear receptor alpha130013
estrogen nuclear receptor alpha150015
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
IDH14004
nuclear factor erythroid 2-related factor 2 isoform 25005
thyroid hormone receptor beta isoform 28008
nuclear factor erythroid 2-related factor 2 isoform 16006
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin7007
lamin isoform A-delta109009
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0213
Spike glycoprotein4004
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain A, Phospholipase A2 isoform 30011
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase3003
GTP-binding protein (rab7)0011
ras protein, partial0011
interleukin 81001
aldehyde dehydrogenase 1 family, member A14004
hypothetical protein, conserved1001
EWS/FLI fusion protein5005
cytochrome P450 2D63003
peroxisome proliferator-activated receptor delta6006
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Bloom syndrome protein isoform 13003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Prostaglandin-H2 D-isomerase0101
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0707
Epidermal growth factor receptor0101
Carbonic anhydrase 10404
Carbonic anhydrase 20505
Fatty acid-binding protein, liver0202
Myeloperoxidase0101
Prostaglandin G/H synthase 10101
Seed linoleate 13S-lipoxygenase-10101
Glutathione hydrolase 1 proenzyme0101
Prostaglandin G/H synthase 10202
Adenosine receptor A10101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin G/H synthase 20303
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma1001
Ras-related protein Rab-2A0011
Gamma-aminobutyric acid receptor subunit alpha-13104
Prostaglandin G/H synthase 20101
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Canalicular multispecific organic anion transporter 10607
Sigma non-opioid intracellular receptor 10415
Sigma non-opioid intracellular receptor 10112
TDP1 protein9009
Smad32002
67.9K protein2002
interferon gamma precursor0001
Alpha-synuclein2002
nonstructural protein 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
Cytochrome P450 2C80202
Cytochrome P450 2B60303
Liver carboxylesterase 10002
Sodium-dependent serotonin transporter0314
Cytochrome P450 2C190303
Rap guanine nucleotide exchange factor 41001
P2Y purinoceptor 120101
endonuclease IV2002
nuclear receptor subfamily 1, group I, member 36006
retinoid X nuclear receptor alpha8008
pregnane X nuclear receptor120012
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)7007
peripheral myelin protein 22 isoform 13003
thyroid hormone receptor beta isoform a6006
potassium voltage-gated channel subfamily H member 2 isoform d5005
mitogen-activated protein kinase 12002
eyes absent homolog 2 isoform a1001
survival motor neuron protein isoform d2002
Cellular tumor antigen p538008
Inositol monophosphatase 11001
TAR DNA-binding protein 433003
glp-1 receptor, partial4004
hypoxia-inducible factor 1 alpha subunit4004
SMAD family member 24004
SMAD family member 34004
caspase 7, apoptosis-related cysteine protease1001
progesterone receptor8008
peroxisome proliferator activated receptor gamma5005
caspase-31001
LMP1 [Human herpesvirus 4]0001
activating transcription factor 63003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x1001
heat shock protein beta-14004
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Voltage-dependent calcium channel gamma-2 subunit5005
Prothrombin0001
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10304
DNA topoisomerase 10102
DNA topoisomerase 2-alpha0117
Cytochrome P450 2C9 0606
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
Glutamate receptor 25005
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0102
Serum paraoxonase/arylesterase 10101
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta0118
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0202
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
ATPase family AAA domain-containing protein 55005
Ataxin-25005
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
Luciferase4004
Solute carrier family 22 member 1 0202
Nuclear receptor subfamily 1 group I member 20022
D(2) dopamine receptor0101
Amine oxidase [flavin-containing] A0101
D(4) dopamine receptor0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0404
Delta-type opioid receptor0303
Mu-type opioid receptor0314
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Mu-type opioid receptor0325
D(3) dopamine receptor0101
Delta-type opioid receptor0303
Kappa-type opioid receptor0202
Kappa-type opioid receptor0303
Mu-type opioid receptor0202
Mu-type opioid receptor0404
Potassium voltage-gated channel subfamily H member 20202
Sigma non-opioid intracellular receptor 10202
Carbonic anhydrase 0101
ATAD5 protein, partial5005
Hsf1 protein0011
G3003
Carbonic anhydrase 0101
arylsulfatase A3003
cytochrome P450 2C9 precursor2002
Carbonic anhydrase 120101
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0112
Carbonic anhydrase 30101
Carbonic anhydrase 40202
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
Histamine H2 receptor3003
Cytochrome P450 2J20404
Guanine nucleotide-binding protein G2002
Carbonic anhydrase 90101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Inositol hexakisphosphate kinase 13003
Carbonic anhydrase 130101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
cytochrome P450 2C9, partial3003
aryl hydrocarbon receptor6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
histone deacetylase 9 isoform 31001
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Sodium-dependent dopamine transporter0101
Sodium-dependent serotonin transporter0101
Kappa-type opioid receptor0101
estrogen receptor 2 (ER beta)2002
Carbonic anhydrase0101
Carbonic anhydrase 150101
regulator of G-protein signaling 41001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
Muscarinic acetylcholine receptor M20112
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10123
Cytochrome P450 2A60112
Muscarinic acetylcholine receptor M10011
Gamma-aminobutyric acid receptor subunit beta-13003
Muscarinic acetylcholine receptor DM10101
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Cytochrome P450 2A130112
GABA theta subunit3003
Gamma-aminobutyric acid receptor subunit epsilon3003
luciferase0001
nuclear receptor subfamily 1, group I, member 22002
Estrogen receptor0202
Glucocorticoid receptor06112
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10606
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Histamine H1 receptor0112
Nociceptin receptor0011
Estrogen receptor beta0202
Chain A, Beta-lactamase3003
Chain A, Ferritin light chain3003
pregnane X receptor1001
farnesoid X nuclear receptor1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA2002
heat shock protein HSP 90-alpha isoform 20001
nuclear receptor ROR-gamma isoform 12002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
heat shock protein 90, putative0001
Chain A, Cruzipain1001
acid sphingomyelinase1001
USP1 protein, partial2002
Microtubule-associated protein tau1001
apical membrane antigen 1, AMA12002
C-X-C chemokine receptor type 5 isoform 10101
DNA polymerase beta1001
ubiquitin-conjugating enzyme E2 N0101
C-C chemokine receptor type 60101
apelin receptor0101
DNA polymerase eta isoform 12002
bcl-2-related protein A10101
streptokinase A precursor0011
Endoglycoceramidase II 0001
Protein kinase C alpha type0101
Estrogen receptor0011
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
cAMP-dependent protein kinase catalytic subunit alpha 0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Estrogen receptor beta0011
Protein kinase C eta type0101
Sphingosine kinase 20101
Sphingosine kinase 10101
Protein kinase C theta type0101
Sphingosine 1-phosphate receptor 20112
Sphingosine 1-phosphate receptor 40112
Sphingosine 1-phosphate receptor 10112
Sphingosine 1-phosphate receptor 30112
Sphingosine 1-phosphate receptor 50112
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
cytochrome P450 2D6 isoform 11001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Bile salt export pump0101
Alpha-2A adrenergic receptor0202
Cytochrome P450 2D60101
Alpha-2C adrenergic receptor0202
Disintegrin and metalloproteinase domain-containing protein 171001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
procathepsin L isoform 1 preproprotein0101
muscleblind-like protein 1 isoform 11001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
PPM1D protein1001
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
Chain A, Neuraminidase0101
Chain A, Neuraminidase0101
Chain A, Neuraminidase0101
Chain A, Neuraminidase0101
Chain A, Neuraminidase0101
Chain A, Neuraminidase0101
Chain A, NEURAMINIDASE0101
Chain A, Neuraminidase0101
Neuraminidase 0202
GALC protein1001
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase 0101
Sialidase-10101
Neuraminidase0101
Neuraminidase0101
Neuraminidase0101
Neuraminidase0202
Neuraminidase0112
Acyl-CoA desaturase 10101
Neuraminidase0101
D(2) dopamine receptor0101
Sialidase A0101
Neuraminidase0101
Neuraminidase 0101
Neuraminidase 0101
Neuraminidase 0202
Neuraminidase 0101
Neuraminidase 0202
Neuraminidase0101
Neuraminidase0101
Neuraminidase0101
Sialidase-40202
Sialidase-10101
Sialidase-30202
Sialidase-20202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]