Page last updated: 2024-12-11

thunberginol a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

thunberginol A: isolated from Hydrangeae dulcis folium; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5321948
CHEMBL ID68810
SCHEMBL ID12680535
MeSH IDM0211742

Synonyms (20)

Synonym
3-(3,4-dihydroxyphenyl)-8-hydroxy-1h-2-benzopyran-1-one
nsc 724383
unii-wk8zg6dzl6
wk8zg6dzl6 ,
1h-2-benzopyran-1-one, 3-(3,4-dihydroxyphenyl)-8-hydroxy-
147666-80-6
3-(3,4-dihydroxyphenyl)-8-hydroxyisocoumarin (thunberginol a)
nsc-724383
nsc724383
thunberginol a
smr001397330
MLS002473243
CHEMBL68810
3-(3,4-dihydroxyphenyl)-8-hydroxyisochromen-1-one
NCGC00247502-01
HMS2271A09
SCHEMBL12680535
DTXSID30163773
3-(3,4-dihydroxyphenyl)-8-hydroxyisocoumarin
Q7798878
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (22)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency89.12510.631035.7641100.0000AID504339
acid sphingomyelinaseHomo sapiens (human)Potency25.118914.125424.061339.8107AID504937
Nrf2Homo sapiens (human)Potency31.62280.09208.222223.1093AID624171
glp-1 receptor, partialHomo sapiens (human)Potency3.98110.01846.806014.1254AID624417
ClpPBacillus subtilisPotency31.62281.995322.673039.8107AID651965
WRNHomo sapiens (human)Potency35.48130.168331.2583100.0000AID651768
ATAD5 protein, partialHomo sapiens (human)Potency11.82920.004110.890331.5287AID504466; AID504467
GLS proteinHomo sapiens (human)Potency35.48130.35487.935539.8107AID624170
TDP1 proteinHomo sapiens (human)Potency18.35640.000811.382244.6684AID686978; AID686979
importin subunit beta-1 isoform 1Homo sapiens (human)Potency14.57635.804836.130665.1308AID540253; AID540263
flap endonuclease 1Homo sapiens (human)Potency44.66840.133725.412989.1251AID588795
snurportin-1Homo sapiens (human)Potency14.57635.804836.130665.1308AID540253; AID540263
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency79.43280.425612.059128.1838AID504891
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency9.20005.804816.996225.9290AID540253
DNA polymerase eta isoform 1Homo sapiens (human)Potency35.48130.100028.9256213.3130AID588591
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency70.79460.050127.073689.1251AID588590
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency2.81840.15855.287912.5893AID540303
plasminogen precursorMus musculus (house mouse)Potency2.81840.15855.287912.5893AID540303
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency2.81840.15855.287912.5893AID540303
gemininHomo sapiens (human)Potency11.83390.004611.374133.4983AID624296; AID624297
DNA polymerase kappa isoform 1Homo sapiens (human)Potency79.43280.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
rac GTPase-activating protein 1 isoform aHomo sapiens (human)IC50 (µMol)19.65007.390057.8904301.2400AID624330
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (43)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID209946Tested for inhibitory activity against T lymphocyte proliferation induced by Con A at 10e-6 to 10e-5 M; significantly suppressed the proliferation1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID168526Tested for in vivo inhibitory activity against asthmatic bronchoconstriction in rats induced by antigen-antibody reaction; showed inhibition1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1705065Inhibition of biotinylated 5-(4-((Z)-3-Carboxy-3-hydroxyacryloyl)-4-(4-chlorobenzyl)piperidine-1-carbonyl)-2-((13,35-dioxo-39-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-4-yl)-3,6,9,16,19,22,25,28,31-nonaoxa-12,34-diazanonatriacontyl)oxy)benzoi2020European journal of medicinal chemistry, Dec-15, Volume: 208Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors.
AID128375Tested for inhibitory activity against contact ear dermatitis in mice induced by dinitrofluorobenzene by consecutive oral administration in the primary sensitizing phase; showed inhibition1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1333409Inhibition of COX-2 mRNA expression in human HeLa cells at 50 uM by RT-PCR method2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333401Inhibition of mPGES1 in human HeLa cells assessed as reduction in TNF-alpha induced PGE2 production at 50 uM preincubated for 2 hrs followed by TNF-alpha addition for 24 hrs by ELISA2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333410Increase in IFN-gamma mRNA expression in human HeLa cells at 50 uM by RT-PCR method relative to control2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID308851Increase in triglyceride levels in mouse 3T3L1 cells at 3 uM2007Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
AID308852Increase in triglyceride levels in mouse 3T3L1 cells at 10 uM2007Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
AID1333418Increase in NFkappaB mRNA expression in human HeLa cells at 50 uM by RT-PCR method relative to control2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID204103Tested for inhibitory activity against hind paw edema sensitized with sheep red blood cells (SRBC) in both sensitizing and inflammatory phases after oral administration; showed reduction1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1333419Cytotoxicity against human HeLa cells assessed as cell proliferation at 50 uM after 24 hrs by MTT assay2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID308853Increase in triglyceride levels in mouse 3T3L1 cells at 30 uM2007Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
AID38026Tested for inhibitory activity against B lymphocyte proliferation induced by LPS at 10e-5 M; significantly suppressed the proliferation1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1333391Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 assessed as decrease in 5-HPETE production at 50 uM preincubated with enzyme followed by arachidonic acid substrate addition by UV-vis spectrophotometry2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333406Inhibition of COX-2/mPGES1 in human HeLa cells assessed as reduction in TNF-alpha induced PGE2 production at 50 uM preincubated for 15 mins followed by arachidonic acid addition for 15 mins by ELISA2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333416Increase in IL-6 mRNA expression in human HeLa cells at 50 uM by RT-PCR method relative to control2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID168525Tested for in vitro inhibitory activity against type 1 allergic reactions after oral administration; showed inhibition1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1333411Inhibition of mPGES1 mRNA expression in human HeLa cells at 50 uM by RT-PCR method2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID209949Tested for inhibitory activity against T lymphocyte proliferation induced by PHA; showed no suppressive effect1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID168527Tested for in vivo inhibitory activity against passive cutaneous anaphylaxis (PCA) reaction in rats; showed inhibition1998Bioorganic & medicinal chemistry letters, Feb-03, Volume: 8, Issue:3
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
AID1333405Inhibition of COX-2/mPGES1 in human HeLa cells assessed as reduction in TNF-alpha induced PGE2 production at 50 uM after 15 mins followed by ELISA2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333417Increase in TGF-beta3 mRNA expression in human HeLa cells at 50 uM by RT-PCR method relative to control2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID1333412Inhibition of COX-1 mRNA expression in human HeLa cells at 50 uM by RT-PCR method2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID308854Increase in triglyceride levels in mouse 3T3L1 cells at 100 uM2007Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
AID1333402Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 30 mins2016European journal of medicinal chemistry, Nov-29, Volume: 124Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
AID308850Increase in triglyceride levels in mouse 3T3L1 cells at 1 uM2007Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's9 (40.91)18.2507
2000's6 (27.27)29.6817
2010's4 (18.18)24.3611
2020's3 (13.64)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.19

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.19 (24.57)
Research Supply Index3.14 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.19)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other22 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]