A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake.
| Member | Definition | Class |
|---|
| 1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine | A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and benzothiophen-2-yl groups attached at position 1. A potent dopamine re-uptake inhibitor with a behavioral profile different from that of phencyclidine (PCP) and similar to that of cocaine. | 1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine |
| 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride | A hydrochloride salt that is obtained by reaction of 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine with two equivalents of hydrogen chloride. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes). | 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride |
| amineptin | A carbocyclic fatty acid that is 5-aminoheptanoic acid in which one of the hydrogens attached to the nitrogen is replaced by a 10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl group. A tricyclic antidepressant, it was never approved in the US and was withdrawn from the French market in 1999 due to concerns over abuse, dependence and severe acne. | amineptine |
| amperozide | A member of the class of ureas that is urea in which three of the four hydrogens are replaced by ethyl and 4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl groups. An atypical antipsychotic which was in clinical development for the treatment of schizophrenia and substance-related disorders. It is a potent 5-HT2A antagonist and used in veterinary medicine because of its sedative effect on pigs. | amperozide |
| amperozide hydrochloride | The hydrochloride salt of amperozide. | amperozide hydrochloride |
| benzphetamine | Dextroamphetamine in which the the hydrogens attached to the amino group are substituted by a methyl and a benzyl group. A sympathomimetic agent with properties similar to dextroamphetamine, it is used as its hydrochloride salt in the treatment of obesity. | benzphetamine |
| cocaine | A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. | cocaine |
| dextroamphetamine | A 1-phenylpropan-2-amine that has S configuration. | (S)-amphetamine |
| gbr 12935 | An N-alkylpiperazine that consists of piperazine bearing 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent and selective inhibitor of dopamine uptake (KD = 5.5 nM in rat striatal membranes). | 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine |
| histidyl-proline diketopiperazine | A homodetic cyclic peptide resulting from the formal condensation of both the amino and acid groups of L-histidine with the acid and amino groups of L-proline. It is a metabolite of thyrotropin-releasing hormone (TRH). | cyclo(L-His-L-Pro) |
| minaprine | | minaprine |
| nomifensine | An N-methylated tetrahydroisoquinoline carrying phenyl and amino substituents at positions C-4 and C-8, respectively. | nomifensine |
| vanoxerine | An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. | vanoxerine |
| vanoxerine | A hydrochloride salt that is obtained by reaction of vanoxerine with two equivalents of hydrogen chloride. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. | vanoxerine dihydrochloride |
| venlafaxine | A tertiary amino compound that is N,N-dimethylethanamine substituted at position 1 by a 1-hydroxycyclohexyl and 4-methoxyphenyl group. | venlafaxine |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 16.8037 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 16.9409 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.9351 | 1 | 6 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 15.8489 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 15.4295 | 8 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 14.4393 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 8.9915 | 1 | 3 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.5810 | 3 | 6 |
| Ataxin-2 | Homo sapiens (human) | Potency | 19.3438 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 6.8763 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 8.4127 | 1 | 1 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 19.3117 | 1 | 2 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 17.4872 | 1 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 25.4793 | 2 | 6 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 23.7101 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 23.7101 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 22.5308 | 2 | 3 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 21.7459 | 2 | 6 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 12.6028 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 11.5190 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 26.8653 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 24.0146 | 1 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 12.6328 | 1 | 5 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 25.4533 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 11.2872 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 4.9890 | 1 | 9 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.0150 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.2248 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.0695 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 5.3415 | 3 | 7 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 16.5910 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 2.7164 | 1 | 2 |
| endonuclease IV | Escherichia coli | Potency | 22.2457 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 18.2920 | 8 | 17 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 20.4352 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 11.1813 | 10 | 21 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 21.7830 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 25.4218 | 4 | 11 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.4889 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.3866 | 1 | 4 |
| G | Vesicular stomatitis virus | Potency | 9.7717 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| GALC protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.0150 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 18.4503 | 4 | 8 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 12.1664 | 2 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 14.8211 | 1 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 27.0050 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.0824 | 3 | 6 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 21.2718 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.1083 | 2 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 21.4179 | 2 | 24 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 21.9741 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.7717 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 24.0731 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 21.0171 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.7717 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 7.4934 | 2 | 6 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 15.7142 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 15.7142 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 25.9553 | 3 | 5 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 10.3191 | 2 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 22.6130 | 1 | 5 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 24.5454 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 27.8025 | 1 | 5 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 33.4703 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 26.6357 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 8.9773 | 2 | 7 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 11.2947 | 2 | 4 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 12.6728 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.4334 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 24.0731 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 32.4784 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 31.6402 | 3 | 6 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 79.4328 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.4932 | 2 | 4 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 40.7775 | 1 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 7.5856 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 22.4110 | 3 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 76.1104 | 1 | 2 |
| polyprotein | Zika virus | Potency | 35.3866 | 1 | 4 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 17.3826 | 1 | 6 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 0.2234 | 1 | 4 |
| PPM1D protein | Homo sapiens (human) | Potency | 32.9993 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 26.7789 | 1 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.4278 | 2 | 4 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 9.0796 | 2 | 5 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 68.7404 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 22.1905 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 35.4427 | 3 | 7 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 13.7441 | 2 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 18.8926 | 4 | 7 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 16.4367 | 1 | 6 |
| TDP1 protein | Homo sapiens (human) | Potency | 12.2564 | 2 | 16 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 13.1943 | 3 | 6 |
| Thrombopoietin | Homo sapiens (human) | Potency | 15.9027 | 2 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.6426 | 3 | 8 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 20.9596 | 3 | 13 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 37.8958 | 1 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.2102 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 25.7140 | 2 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 21.2718 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.1635 | 2 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0855 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.3010 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 600.0000 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 85.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.7080 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.6850 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 14.4000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | Ki | 300.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 280.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 370.0000 | 2 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 0.3380 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | IC50 | 0.0270 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 653.6000 | 4 | 5 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | Ki | 1.1150 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0316 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| D | Rattus norvegicus (Norway rat) | IC50 | 3.7341 | 3 | 3 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0690 | 2 | 5 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 2.7240 | 2 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Fatty acid-binding protein, heart | Homo sapiens (human) | IC50 | 0.3670 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 0.8975 | 2 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 127.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 2 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 2.1400 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | Ki | 0.5240 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | Ki | 10.0000 | 1 | 2 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 3.5300 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 17.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 61.3985 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Sus scrofa (pig) | Ki | 0.2344 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 435.3333 | 2 | 3 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 400.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 8.6066 | 7 | 7 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C beta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C delta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C epsilon type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C eta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C gamma type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C iota type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C zeta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.3630 | 4 | 6 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 4.5740 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.1160 | 1 | 1 |
| Small conductance calcium-activated potassium channel protein 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1855 | 1 | 2 |
| Small conductance calcium-activated potassium channel protein 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1855 | 1 | 2 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 0.1855 | 1 | 2 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8540 | 69 | 111 |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | Ki | 0.8500 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 14.3897 | 36 | 72 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 0.9809 | 61 | 67 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4375 | 48 | 56 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.3203 | 37 | 42 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.3494 | 37 | 43 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.3335 | 36 | 41 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.8002 | 24 | 31 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.5961 | 39 | 47 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.4007 | 29 | 48 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 2.8724 | 17 | 19 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 2.5393 | 21 | 26 |
| Tryptophan 5-hydroxylase 1 | Rattus norvegicus (Norway rat) | Ki | 0.4900 | 1 | 1 |