An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that interferes with the action of alcohol dehydrogenase (EC 1.1.1.1).
ChEBI ID: 50269
| Member | Definition | Class |
|---|---|---|
| dodecanedioic acid | An alpha,omega-dicarboxylic acid that is dodecane in which the methyl groups have been oxidised to the corresponding carboxylic acids. | dodecanedioic acid |
| fomepizole | A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4. | fomepizole |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 120 (20.13) | 18.7374 |
| 1990's | 132 (22.15) | 18.2507 |
| 2000's | 169 (28.36) | 29.6817 |
| 2010's | 119 (19.97) | 24.3611 |
| 2020's | 56 (9.40) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 26 (4.04%) | 5.53% |
| Reviews | 56 (8.70%) | 6.00% |
| Case Studies | 95 (14.75%) | 4.05% |
| Observational | 3 (0.47%) | 0.25% |
| Other | 464 (72.05%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 14.7464 | 3 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 24.5346 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 24.5346 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 27.2225 | 3 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 38.5404 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.8876 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.0294 | 4 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 70.9009 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 19.8957 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.0010 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 0.1549 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 0.1549 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 0.1412 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Kd | 0.0130 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Kd | 0.0130 | 1 | 1 |