Any compound that inhibits the biosynthesis of any sterol.
| Member | Definition | Class |
|---|
| brassicasterol | An 3beta-sterol that is (22E)-ergosta-5,22-diene substituted by a hydroxy group at position 3beta. It is a phytosterol found in marine algae, fish, and rapeseed oil. | brassicasterol |
| n-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide | An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol. | fenhexamid |
| naftifine | A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections. | naftifine |
| spiroxamine | The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powdery mildew in the production of cereals, bananas and grapes. | spiroxamine |
| terbinafine | A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections. | terbinafine |
| u 18666a | A hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor. | 3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| activating transcription factor 6 | Homo sapiens (human) | Potency | 2.3914 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 35.6470 | 8 | 8 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 43.7116 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 0.0347 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 19.6877 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 68.5896 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 41.0989 | 6 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 24.3365 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 62.6224 | 5 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 18.4457 | 2 | 4 |
| G | Vesicular stomatitis virus | Potency | 13.8029 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 28.7092 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.4975 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 76.9588 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 25.1189 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9315 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.1949 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.8029 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 13.8029 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0158 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 39.4331 | 4 | 6 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 35.5826 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 14.1254 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 11.1868 | 3 | 4 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.3148 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 22.4348 | 3 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 30.3988 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 35.4760 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 7.5624 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.3431 | 2 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 42.3172 | 2 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 70.7946 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 36.9906 | 2 | 3 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0616 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 76.9588 | 1 | 1 |