A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
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| "Evidence of hyperparathyroidism is relatively common in association with both the ulcerogenic and the diarrheogenic tumor syndromes." | ( Zollinger, RM, 1975) |
| "Thus, primary hyperparathyroidism is accompanied by normal steady-state concentrations of circulating calcitonin, and normal-to-blunted C-cell responses to pentagastrin or induced hypercalcemia, the response to calcium generally increasing after successful parathyroid surgery." | ( Heath, H; Lambert, PW; Sizemore, GW, 1979) |
| "Primary hyperparathyroidism is a major cause of calcium urolithiasis and is easily recognised when it is classically manifested." | ( Barilla, DE; Pak, CY, 1979) |
| "Primitive hyperparathyroidism is for several respects an excellent disease model for testing "mass screening"." | ( Adami, S; Bianchi, I; Cinti, S; Cominacini, L; Galvanini, G; Lo Cascio, V; Scuro, LA, 1976) |
| "A case of primary hyperparathyroidism is described that presented unusual features." | ( Fransen, H, 1975) |
| "Mild hyperparathyroidism is present in renal tubular acidosis and reverses with alkali treatment." | ( Coe, FL; Firpo, JJ, 1975) |
| "Hyperparathyroidism is an important cause of calculous disease." | ( Drago, JR; Rohner, TJ; Sanford, EJ; Santen, RE, 1976) |
| "Primary hyperparathyroidism is caused by defects in the parathyroid gland." | ( Marx, SJ, 1991) |
| "Neonatal primary hyperparathyroidism is a life-threatening disease because of marked hypercalcemia and severe respiratory distress caused by the hypoplastic thorax and occasional rib fractures." | ( Fujimoto, Y; Hazama, H; Oku, K, 1990) |
| "Secondary hyperparathyroidism is common in chronic renal failure and is due to inadequate synthesis of calcitriol, the active metabolite of vitamin D." | ( Althoff, P; Fellström, B; Ljunghall, S; Marjanovic, B; Nisell, J; Weiss, L; Wide, L, 1990) |
| "Primary hyperparathyroidism is a common disorder and one that can usually (approximately 95%) be successfully treated by parathyroidectomy." | ( Clark, OH; Duh, QY, 1989) |
| "Acute primary hyperparathyroidism is a rare disease with a high mortality rate in some series." | ( Desportes, L; Dubost, C; Gossot, D; Sarfati, E, 1989) |
| "Underlying primary hyperparathyroidism is diagnosed in approximately 1 to 5 per cent of the patients with calcium stone disease." | ( Broadus, AE, 1989) |
| "Hyperparathyroidism is rare during pregnancy and often remains asymptomatic." | ( Magnien, J, 1986) |
| "Hyperparathyroidism is uncommonly associated with AP and when it is other aetiological factors must be excluded." | ( Imrie, CW; Shearer, MG, 1986) |
| "Primary hyperparathyroidism is usually associated with normal or elevated serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] levels." | ( Brown, EM; Haddad, JG; Posillico, JT; Wortsman, J, 1986) |
| "Acute primary hyperparathyroidism is an unusual form of primary hyperparathyroidism characterized by life-threatening hypercalcemia." | ( Bilezikian, JP; Fitzpatrick, LA, 1987) |
| "Hyperparathyroidism is a heterogeneous disease, and therapy must be individualized to each patient." | ( Clerkin, EP; ReMine, SG; Rossi, RL, 1985) |
| "Primary hyperparathyroidism is one of the most significant pathogenesis of urolithiasis and determination of serum Ca level is valuable in screening for primary hyperparathyroidism." | ( Fukushige, M; Kinoshita, H; Nakamoto, T; Usui, A, 1985) |
| "This degree of hyperparathyroidism is similar to that seen in patients with hyperparathyroidism and normal renal function." | ( Bellorin-Font, E; Martin, KJ; Tamayo, J, 1983) |
| "Primary hyperparathyroidism is generally treated by primary neck exploration." | ( Doppman, JL; Geelhoed, GW; Krudy, AG, 1983) |
| "Secondary hyperparathyroidism is one of the major complications encountered in patients on maintenance dialysis." | ( Bernheim, J; Erez, I; Korzets, Z; Kraus, L; Magen, H, 1983) |
| "Hyperparathyroidism is caused by hyperphosphataemia, hypocalcaemia and possibly, a lack of 1,25-dihydroxycholecalciferol." | ( Chan, YL; Posen, S, 1982) |
| "A case of primary hyperparathyroidism is described, in which the level of circulating parathyroid hormone and hypercalcaemia remain entirely unaffected by cimetidine." | ( Benton, KG; Mallett, RB; Sainsbury, R, 1981) |
| "Lithium-induced hyperparathyroidism is characterized by a reduction in parathyroid sensitivity to changes in extracellular calcium (Ca2+)." | ( McHenry, CR; Racke, F; Stenger, DB, 1995) |
| "Primary hyperparathyroidism is a syndrome with variable clinical expression, presenting as asymptomatic hypercalcaemia in Western countries and with predominant bone disease in developing countries." | ( Gupta, N; Harinarayan, CV; Kochupillai, N, 1995) |
| "Secondary hyperparathyroidism is found in a large proportion, but not all patients on dialysis." | ( Mehls, O; Ritz, E, 1995) |
| "Primary hyperparathyroidism is a more frequently recognized entity." | ( Atallah, C; Gannage, MH; Halaby, G; Jambart, S; Medlej, R; Nemr, E, 1994) |
| "Hyperparathyroidism is being increasingly recognized by the detection of hypercalcemia on routine blood chemistry." | ( Beck, J; Gillott, AR; Lundgren, EC; Wiseman, JS, 1995) |
| "Hyperparathyroidism is a rare cause of pancreatic inflammatory disease." | ( Kazantsev, GB; Nash, DW; Prinz, RA, 1994) |
| "Surgery for primary hyperparathyroidism is successful in 95% of patients, but ectopic glands and anatomic variations in location are causes of surgical failure." | ( Burke, GJ; Casas, AT; Mansberger, AR; Wei, JP, 1993) |
| "Primary hyperparathyroidism is usually associated with normal or elevated serum 1,25-dihydroxyvitamin D [1,25(OH)2D] levels." | ( Brossard, JH; D'Amour, P; Garon, J; Gascon-Barré, M; Lepage, R, 1993) |
| "Hyperparathyroidism is often detected in the asymptomatic stage at the present time with the advent of mass screening for hypercalcemia." | ( Anarayana, S; Merritt, RM; Wei, JP, 1993) |
| "Primary hyperparathyroidism is the most frequent cause of hypercalcemia in the general population." | ( Cohen-Solal, M; Sebert, JL, 1993) |
| "Primary hyperparathyroidism is a common condition due to either a parathyroid adenoma or, less commonly, parathyroid hyperplasia, whose treatment is essentially surgical." | ( Besser, GM; Britton, KE; Carroll, MJ; Grossman, AB; Johnston, LB; Lowe, DG; Shand, W, 1996) |
| "Hyperparathyroidism is a rare condition although recently the incidence has increased, particularly the asymptomatic form, as a result of routine serum calcium measurements." | ( Berjaud, J; Dahan, M; Esquerre, JP; Giron, J; Ouhayoun, E; Railhac, JJ; Senac, JP, 1996) |
| "Hyperparathyroidism is a common finding in patients with renal failure." | ( Almaden, Y; Hernandez, A; Rodriguez, M; Torres, A, 1996) |
| "Primary hyperparathyroidism is the most prevalent cause of hypercalcemia." | ( Rude, RK, 1996) |
| "Primary hyperparathyroidism is caused by an ectopically located parathyroid adenoma in a small percentage of cases." | ( Burke, GJ; Gadacz, TR; Wei, JP; Weisner, LF, 1995) |
| "Primary hyperparathyroidism is an underdiagnosed disorder in Iraq, and most patients present with advanced disease." | ( Safar, SB; Sawa, TE, 1996) |
| "Tertiary hyperparathyroidism is thus a potential complication of long-term phosphorus supplementation in vitamin D-resistant osteomalacia." | ( Goupille, P; Lecomte, P; Valat, JP; Vedere, V, 1996) |
| "Hypercalcaemia and hyperparathyroidism are sometimes aetiologically related to reduced renal function in long-term lithium patients." | ( Bendz, H; Berglund, K; Sjödin, I; Toss, G, 1996) |
| "Hyperparathyroidism is due to enlargement of one or more parathyroid glands and is most often treated by surgical resection." | ( Hodin, RA; Silen, WW, 1997) |
| "Although hyperparathyroidism is a common feature in renal transplant recipients, the long-term course of parathyroid hormone (PTH) secretion in these patients is not well established, and the actual contribution of PTH to posttransplant bone disease remains incompletely understood." | ( Bouhaddi, M; Bresson, C; Chalopin, JM; Dumoulin, G; Fournier, V; Hory, B; Nguyen, NU; Regnard, J; Saint-Hillier, Y, 1997) |
| "Primary hyperparathyroidism is a disease best managed surgically; resection of the lesion(s) is curative." | ( Palestro, CJ; Patel, M; Serchuk, LS; Tomas, MB, 1997) |
| "Hyperparathyroidism is a relatively frequent condition mostly due to a solitary parathyroid adenoma." | ( Alak, MC; Arébalo-Cross, G; Bruno, OD; Castellanos, AA; Curutchet, HP; Degrossi, OJ; García del Río, H; García, AJ; Mezzadri, NA; Montesinos, M, 1996) |
| "Since hyperparathyroidism is present in nearly 95-100% of patients with MEN 1 and frequently is the first condition to be identified, the study was limited to the identification of patients with hyperparathyroidism while the screening for gastroenteropancreatic (GEP) lesions was carried out in patients with both pituitary and parathyroid lesions." | ( Beck-Peccoz, P; Corbetta, S; Faglia, G; Peracchi, M; Pizzocaro, A; Spada, A, 1997) |
| "Thus secondary hyperparathyroidism is responsible for impaired LPL expression in experimental CRF." | ( Liang, K; Vaziri, ND; Wang, XQ, 1997) |
| "Primary hyperparathyroidism is seldom associated with other autoimmune disorders." | ( Abikaram, G; Awada, H; Gannage, MH; Nasr, F, 1998) |
| "Primary hyperparathyroidism is a disease of uncertain etiology that results from hypersecretion of parathyroid hormone (PTH) by the parathyroid gland." | ( Klieger, P; O'Mara, R, 1998) |
| "Primary hyperparathyroidism is unusual in children." | ( Bornemann, M, 1998) |
| "Although primary hyperparathyroidism is a physiologic disease, surgeons rely on anatomical characteristics (gross and histologic) to determine appropriate operative decisions." | ( Murphy, C; Norman, J, 1999) |
| "Recurrent hyperparathyroidism is uncommon." | ( Alexander, HR; Bartlett, DL; Feldman, AL; Fraker, DL; Libutti, SK; Marx, SJ; Norton, JA; Sharaf, RN; Skarulis, MC; Weinstein, LS, 1999) |
| "Primary hyperparathyroidism is rarely caused by carcinoma." | ( Abrahams, TG; Hanks, P; Jones, M, 2000) |
| "Primary hyperparathyroidism is now increasingly being detected during the asymptomatic phase." | ( Bilezikian, J; Khan, A, 2000) |
| "Primary hyperparathyroidism is a not so infrequent disease that is often overlooked by physicians." | ( Beckers, A; Dubois, B; Godon, E; Godon, JP; Janssens, L; Petrossians, P; Verbeke, V, 2000) |
| "Primary hyperparathyroidism is a recognized though relatively rare cause of multiple limbs fractures." | ( Alonge, TO; Ayantunde, A; Omololu, AB, 2000) |
| "It is known that hyperparathyroidism is connected with stimulation of gastrin synthesis as well with increased acidity of gastric juice." | ( Baranowicz-Gaszczyk, I; Bednarek-Skublewska, A; Ksiazek, A; Majdan, M; Schabowski, J, 2001) |
| "Primary hyperparathyroidism is the main cause of hypercalcemia in ambulatory patients." | ( Avalos, N; Marín, L; Morales, B; Valenzuela, MA, 2001) |
| "Primary hyperparathyroidism is a commonly encountered illness that can usually be treated successfully with surgery." | ( Baker, MZ; Howell, P; Kariampuzha, S; Kipgen, W; Scofield, RH; Tytle, TL; Williams, GR, 2001) |
| "Hyperparathyroidism is the most common presenting symptom in patients with MEN1 syndrome." | ( Johnson, LW; Norton, KS; Zibari, GB, 2001) |
| "Familial primary hyperparathyroidism is associated with tumor-susceptibility syndromes, which are unrelated to mutations in the calcium receptor gene." | ( Carling, T; Hellman, P; Lundgren, E; Rastad, J; Szabo, E, 2002) |
| "Juvenile primary hyperparathyroidism is rare, and raises diagnostic and prognostic problems." | ( Berger, N; Causeret, S; Lapras, V; Lifante, JC; Monneuse, O; Peix, JL, 2002) |
| "The effect of mild hyperparathyroidism is a nonspecific increase in bone turnover, of which the best index is the bone formation rate measured by double tetracycline labeling expressed per unit of bone surface." | ( Parfitt, AM, 2003) |
| "Hyperparathyroidism is one of the most frequent aetiological factors in benign hypercalcaemia, but it is usually not considered in oncology patients." | ( Barutca, S; Erdogan, S; Kacar, F; Kadikoylu, G; Yurekli, Y, 2003) |
| "Hyperparathyroidism is a disease characterized by hypercalcemia with hypophosphoremia resulting from increased secretion of parathyroid hormone (PTH)." | ( Bernasconi, S; Bona, G; Bozzola, M; Buzi, F; De Sanctis, C; De Sanctis, V; Radetti, G; Rigon, F; Tatò, L; Tonini, G, 2004) |
| "Early diagnosis of hyperparathyroidism is crucial." | ( Boumdin, H; Hadri, L; Hassikou, H; Messary, A; Safi, S; Zouhair, A, 2004) |
| "Hyperparathyroidism is usually associated with hypercalcemia." | ( Demir, D; Emin, AH; Karatay, MC; Süoğlu, Y, 2004) |
| "Tertiary hyperparathyroidism is usually due to multiple hyperplastic parathyroid glands, and patients who have initial limited parathyroidectomy have a higher risk of persistent or recurrent THPT." | ( Clark, OH; Duh, QY; Kebebew, E, 2004) |
| "Primary hyperparathyroidism is a hypercalcemic condition generated as a result of overproduction of parathyroid hormone (PTH) by one or more of the parathyroid glands." | ( De Manicor, NA, 2004) |
| "Secondary hyperparathyroidism is defined as autonomic secretion of parathormon (PTH) whose 1-84 fraction level is up to 60 ng/l." | ( Diouf, B; Ka, EF; Leye, A; Moreira-Diop, T; Ndongo, S; Niang, A; Pouye, A, 2004) |
| "Usually hyperparathyroidism is the first and most frequent symptom while in our patient the first symptom was transient hyponatremia secondary to the pituitary tumor, 2." | ( Czarkowski, M; Dabrowska, J, 2005) |
| "Primary hyperparathyroidism is rare in childhood." | ( Abish, S; Albuquerque, P; Alyaarubi, S; Gale, M; Jabado, N; Krishnamoorthy, P, 2006) |
| "Hyperparathyroidism is a parameter predictive of rHuEPO hyporesponsiveness in dialysis patients." | ( Al-Hilali, N; Al-Humoud, H; Johny, KV; Nampoory, MR; Ninan, VT; Puliyclil, MA, 2007) |
| "Primary hyperparathyroidism is usually caused by a single parathyroid adenoma, rarely by multiple adenomas or hyperplasia and in 1-2% of cases by carcinoma." | ( Darvas, K; Duffek, L; Györke, T; Horányi, J; Lakatos, P; Miklós, T; Szlávik, R, 2006) |
| "Secondary hyperparathyroidism is a common complication in children receiving hemodialysis." | ( Amdahl, M; Benador, N; Goldstein, SL; Greenbaum, LA; Mattingly, S; Melnick, JZ; Paredes, A; Salusky, IB; Williams, LA, 2007) |
| "Primary hyperparathyroidism is a common endocrine disorder, affecting approximately 1 in 500 women and 1 in 2,000 men." | ( Al-Nahhas, A; Shah, S; Win, Z, 2008) |
| "Primary hyperparathyroidism is an endocrine disorder with high prevalence, typically caused by a solitary parathyroid adenoma, less frequently (about 15%) by multiple parathyroid gland disease (MGD) and rarely (1%) by parathyroid carcinoma." | ( Fuster, D; Grassetto, G; Gulec, SA; Hindié, E; Kettle, A; O'Doherty, M; Pons, F; Rubello, D; Ugur, O; Ureña, P, 2009) |
| "Hyperparathyroidism is a condition with elevated parathyroid hormone (PTH)." | ( Thomsen, Sv; Vestergaard, P, 2011) |
| "Hyperparathyroidism is a rare finding in children." | ( Mitskevich, NG; Willig, RP, 2011) |
| "Hyperparathyroidism is also more common among kidney transplant recipients compared with CKD patients." | ( Chatsrisak, K; Disthabanchong, S; Ingsathit, A; Kantachuvesiri, S; Radinahamed, P; Sirilak, S; Stitchantrakul, W; Sumethkul, V, 2012) |
| "Hyperparathyroidism is much more common in women and therefore may represent different diseases in men and women." | ( Chen, H; Mazeh, H; Sippel, RS, 2012) |
| "Primary hyperparathyroidism is the third most common endocrine disorder." | ( Bellamy, J; Janklewicz, P; Rostoker, G, 2011) |
| "Primary hyperparathyroidism is supposed to be the third most common endocrine disorder." | ( Kerschan-Schindl, K, 2013) |
| "Hyperparathyroidism is present in up to 50% of transplant recipients 1 year after transplant, often despite good graft function." | ( Balk, EM; Cohen, JB; Francis, JM; Gordon, CE, 2012) |
| "Hyperparathyroidism is a common complication of chronic renal failure." | ( Burgos, FJ; Fernández, A; Galeano, C; Jimenez, S; Marcén, R; Quereda, C; Villafruela, JJ, 2012) |
| "Primary hyperparathyroidism is diagnosed by the presence of hypercalcemia, hypercalciuria and elevated serum levels of parathyroid hormone and is treated surgically by removal of the enlarged gland." | ( Delorme, S; Haberkorn, U; Zechmann, C, 2013) |
| "Persistent hyperparathyroidism is common after kidney transplantation." | ( Deng, H; Kopyt, N; Mannon, RB; Vincenti, F; Von Visger, J; Weir, MR; Wolf, M; Yue, S, 2016) |
| "Hyperparathyroidism is a complex clinical syndrome characterized by dysfunction in the metabolism of bone, calcium and phosphorus." | ( Aboutorabi, RB; Rezaieyazdi, Z; Salari, M, 2015) |
| "Normocalcaemic hyperparathyroidism is a common biochemical finding, usually identified during an assessment of bone or renal health." | ( Crowley, RK; Gittoes, NJ, 2016) |
| "Hyperparathyroidism is common in end-stage renal disease." | ( Aitken, E; Al-Moasseb, Z, 2016) |
| "Primary hyperparathyroidism is primarily due to a solitary parathyroid adenoma but multi-gland disease, parathyroid carcinoma, and ectopic parathyroid hormone production can occur." | ( Arnold, A, 2016) |
| "Hyperparathyroidism is common in patients undergoing kidney transplantation." | ( Cheunsuchon, B; Sritippayawan, S, 2017) |
| "Hyperparathyroidism is a common complication in chronic kidney disease and might persist in up to 25% of patients after transplantation." | ( Frazão, J; Martins, P; Meng, C; Pestana, M, 2017) |
| "The prevalence of hyperparathyroidism is 0." | ( Sullivan, SA, 2019) |
| "Primary hyperparathyroidism is uncommon in equids." | ( Bertin, FR; Carslake, H; Costa, LRR; Cruz Villagrán, C; Durward-Akhurst, SA; Frank, N; Gorenberg, EB; Johnson, AL; Magdesian, KG; Theelen, MJP; Tomlinson, JE, 2020) |
| "Hyperparathyroidism is a common endocrine disorder with potential complications of bone, renal, neurocognitive and cardiovascular system." | ( Brkic, F; Jakubovic-Cičkisic, A; Ramas, A; Sulejmanovic, M; Umihanic, S, 2019) |
| "Pathophysiology of hyperparathyroidism is only partially understood but FGF23 excess and deficient production of calcitriol likely contributes to its development." | ( Brandi, ML; Kamenický, P; Lecoq, AL; Linglart, A, 2020) |
| "Hyperparathyroidism is a common endocrine disorder." | ( Boulagnon, C; Deguelte, S; Dejust, S; Delemer, B; Lalire, P; Ly, S; Morland, D; Papathanassiou, D; Richard, C; Zalzali, M, 2020) |
| "Hyperparathyroidism is a frequent complication in XLH adult patients." | ( Blanchard, A; Boros, E; Brailly-Tabard, S; Briot, K; Chanson, P; Chaumet-Riffaud, P; Dupeux, M; Durand, E; Francou, B; Kamenický, P; Lambert, B; Lecoq, AL; Linglart, A; Piketty, M; Rothenbuhler, A; Silve, C, 2020) |
| "Secondary hyperparathyroidism is a complication of chronic renal failure that is associated with cardiovascular disease." | ( Chen, CH; Chen, CY; Hsieh, HL; Hsu, SC; Huang, PH; Lin, FY; Liu, CT; Shih, CM; Shiu, YT; Sue, YM, 2021) |
| "Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II." | ( Alpay, H; Amouzegar, A; Ariceta, G; Atmis, B; Bacchetta, J; Bárány, P; Baron, S; Bayrakci, US; Belge, H; Besouw, M; Blanchard, A; Bockenhauer, D; Bökenkamp, A; Boyer, O; Burgmaier, K; Calò, LA; Conti, VS; Decramer, S; Devuyst, O; Emma, F; Ferraro, PM; Fila, M; Francisco, T; Ghiggeri, GM; Gondra, L; Guarino, S; Hooman, N; Hoorn, EJ; Houillier, P; Kamperis, K; Kari, JA; Konrad, M; Levtchenko, E; Lucchetti, L; Lugani, F; Marzuillo, P; Mohidin, B; Neuhaus, TJ; Nijenhuis, T; Osman, A; Papizh, S; Perelló, M; Rookmaaker, MB; Santos, F; Sawaf, G; Serdaroglu, E; Szczepanska, M; Taroni, F; Topaloglu, R; Trepiccione, F; van Dyck, M; Vargas-Poussou, R; Verploegen, MFA; Vidal, E; Walsh, SB; Wan, ER; Weber, L; Yildirim, ZY; Yüksel, S; Zlatanova, G, 2022) |
| "Hyperparathyroidism is one of the most common endocrine disorders worldwide." | ( Gomes, CC; Gomez, RS; Guimarães, LM; Rebelo Pontes, HA; Valeriano, AT, 2022) |
| "Primary hyperparathyroidism is the most common cause of hypercalcemia, accounting for about 90% of all cases." | ( Goldenberg, D; Kulkarni, P, 2024) |