B-Raf inhibitor

A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf)

ChEBI ID: 75047

Members (7)

Member	Definition	Class
dabrafenib	An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.	dabrafenib
GDC-0879	A member of the class of pyrazoles that is 1-(2-hydroxyethyl)pyrazole carrying additional 4-pyridyl and 1-(hydroxyimino)indan-5-yl substituents at positions 3 and 4 respectively.	GDC-0879
ly3009120	A member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties.	LY3009120
plx 4720	A pyrrolopyridine that is vemurafenib in which the p-chlorophenyl group has been replaced by chlorine. It is a potent and selective inhibitor of the Raf kinase B-Raf(V600E).	PLX-4720
plx4032	A pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases.	vemurafenib
TAK-580	A 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults.	TAK-580
tak-632	A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively.	TAK-632

Research

Studies (2,356)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (0.17)	29.6817
2010's	1,797 (76.27)	24.3611
2020's	555 (23.56)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	211 (7.79%)	5.53%
Reviews	340 (12.55%)	6.00%
Case Studies	618 (22.81%)	4.05%
Observational	27 (1.00%)	0.25%
Other	1,513 (55.85%)	84.16%

Protein Targets (514)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	9.4655	1	3
cytochrome P450 2D6	Homo sapiens (human)	Potency	2.3919	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	7.5637	1	1
EWS/FLI fusion protein	Homo sapiens (human)	Potency	17.4389	4	16
Fumarate hydratase	Homo sapiens (human)	Potency	13.2066	1	1
G	Vesicular stomatitis virus	Potency	9.4655	1	3
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	9.4655	1	3
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	9.4655	1	6
Interferon beta	Homo sapiens (human)	Potency	6.9944	2	12
polyprotein	Zika virus	Potency	13.2066	1	1
PPM1D protein	Homo sapiens (human)	Potency	6.1708	1	6
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	39.8107	1	1
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	0.7732	1	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	0.7400	1	1
Aspartyl/asparaginyl beta-hydroxylase	Homo sapiens (human)	IC50	13.8500	4	4
Aurora kinase A	Homo sapiens (human)	IC50	1.8466	1	8
Aurora kinase B	Homo sapiens (human)	IC50	0.0660	1	1
Casein kinase I isoform delta	Homo sapiens (human)	IC50	10.0000	1	1
Chain A, AKAP9-BRAF fusion protein	Homo sapiens (human)	IC50	0.0310	1	1
Chain A, B-Raf proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	0.1600	1	1
Chain A, Basic fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	0.1600	1	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	Homo sapiens (human)	IC50	0.1600	1	1
Cyclin-A2	Homo sapiens (human)	IC50	0.5800	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	0.7900	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	0.5800	1	1
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	IC50	29.3500	1	1
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	11.3000	2	4
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	IC50	13.8333	1	3
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	IC50	0.8000	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	IC50	0.4500	1	1
Ephrin type-A receptor 2	Homo sapiens (human)	IC50	0.0200	1	1
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	0.1000	1	1
Epidermal growth factor receptor	Homo sapiens (human)	IC50	10.0000	2	2
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	1.8466	1	8
Fibroblast growth factor receptor 3	Homo sapiens (human)	IC50	0.2800	1	1
Focal adhesion kinase 1	Homo sapiens (human)	IC50	1.8466	1	8
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	0.7900	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	0.5000	1	1
GTPase KRas	Homo sapiens (human)	IC50	7.5433	1	3
Heat shock factor protein 1	Homo sapiens (human)	IC50	10.0000	1	4
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	IC50	3.7000	1	1
Insulin receptor	Homo sapiens (human)	IC50	10.0000	1	1
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	IC50	0.3900	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50	1.8466	1	8
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	10.0000	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	0.0630	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	0.4700	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	IC50	0.0610	1	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	IC50	0.0610	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	IC50	0.0610	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	0.3305	2	2
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50	5.0315	2	2
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50	5.2350	2	2
Mitogen-activated protein kinase 9	Homo sapiens (human)	IC50	0.4700	1	1
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	IC50	5.0490	2	2
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	IC50	0.0311	3	3
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	IC50	1.8466	1	8
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	IC50	0.9700	1	1
Pirin	Homo sapiens (human)	IC50	8.1340	1	5
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	0.1200	1	1
Platelet-derived growth factor subunit A	Homo sapiens (human)	IC50	0.6100	1	1
Protein kinase C theta type	Homo sapiens (human)	IC50	10.0000	1	1
Protein-tyrosine kinase 6	Homo sapiens (human)	IC50	1.3575	1	4
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	2.6233	3	6
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	1.2385	11	17
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Ki	0.0010	3	4
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	10.0000	1	1
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	53.2000	1	1
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.0770	1	1
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	IC50	0.1260	2	2
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	IC50	0.2749	4	8
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	GI50	0.0140	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	0.2402	77	117
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Ki	0.0011	5	7
Serine/threonine-protein kinase B-raf	Mus musculus (house mouse)	IC50	0.0300	1	1
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	IC50	1.4000	1	1
TGF-beta receptor type-1	Homo sapiens (human)	IC50	3.7000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	0.3800	1	1
Tyrosine-protein kinase CSK	Homo sapiens (human)	IC50	1.6737	2	9
Tyrosine-protein kinase FRK	Homo sapiens (human)	IC50	1.3575	1	4
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	0.0910	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	1.4071	3	7

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	3
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	22.0000	2	5
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	1	2
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	3
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	3
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	5
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	20.2200	2	5
Activin receptor type-1	Homo sapiens (human)	Kd	22.0000	2	5
Activin receptor type-1B	Homo sapiens (human)	Kd	17.1668	2	6
Activin receptor type-2A	Homo sapiens (human)	Kd	10.0000	1	2
Activin receptor type-2B	Homo sapiens (human)	Kd	20.6400	2	5
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	3
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	2
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	3
Adenosine kinase	Homo sapiens (human)	Kd	30.0000	1	3
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	4
ADP/ATP translocase 3	Homo sapiens (human)	Kd	30.0000	1	3
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	1	2
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	10.0000	1	2
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	10.0000	1	2
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	22.0000	2	5
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	30.0000	1	3
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	4
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	2
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	23.3333	2	6
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	10.0000	1	2
Aurora kinase A	Homo sapiens (human)	Kd	22.0000	2	5
Aurora kinase B	Homo sapiens (human)	Kd	20.4600	2	5
Aurora kinase C	Homo sapiens (human)	Kd	6.2500	1	2
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	10.0000	1	2
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	3
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	22.0000	2	5
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	23.3333	2	6
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	18.9800	2	5
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	22.0000	2	5
Breakpoint cluster region protein	Homo sapiens (human)	Kd	20.0987	1	3
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	5.0008	1	2
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	22.0000	2	5
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	5.9500	1	2
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	22.0000	2	5
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	22.0000	2	5
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	16.4548	2	5
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	22.0000	2	5
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	22.0000	2	5
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	2
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	1	2
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	3
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	22.0000	2	5
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	10.0000	1	2
Casein kinase I isoform delta	Homo sapiens (human)	Kd	20.2800	2	5
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	20.0260	2	5
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	22.0000	2	5
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	20.8200	2	5
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	22.0000	2	5
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	1	2
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	22.0000	2	5
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	2
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	2
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	23.3333	2	6
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	2
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	3
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	20.7000	2	5
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	20.1213	1	3
Cyclin-dependent kinase 10	Homo sapiens (human)	Kd	30.0000	1	4
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	3
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	22.0000	2	5
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	18.3355	2	6
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	16.0072	2	5
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	5.3500	1	2
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	16.0038	2	5
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	23.3333	2	6
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	14.3037	3	7
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	20.1060	1	3
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	22.0000	2	5
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	5.9500	1	2
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	22.0000	2	5
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	10.0000	1	2
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	20.0000	2	4
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	16.2136	2	5
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	22.0000	2	5
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	3
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	10.0000	1	2
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	3
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	2
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	3
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	3
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	14.8654	2	5
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	3
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	30.0000	1	3
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	4
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	3
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	20.1100	2	5
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	20.2200	2	5
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	14.0672	2	5
Dual specificity mitogen-activated protein kinase kinase 4	Mus musculus (house mouse)	Kd	0.0082	1	1
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	7.6256	2	5
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	22.0000	2	5
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	2
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	15.5084	2	5
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	20.5200	2	5
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	22.0000	2	5
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	22.0000	2	5
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	20.0000	2	4
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	17.8750	2	4
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	30.0000	1	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	16.6436	2	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	23.3333	2	6
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	6.3500	1	2
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	5.6500	1	2
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	3
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	2
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	3
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	10.3544	2	5
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	13.5485	3	6
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	10.0000	1	2
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	22.0000	2	5
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	23.3333	2	6
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	10.0000	1	2
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	23.3333	2	6
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	10.0000	1	2
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	10.0000	1	2
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	22.0000	2	5
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	22.0000	2	5
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	17.8868	2	5
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	8.9232	2	5
Epidermal growth factor receptor	Homo sapiens (human)	Kd	12.8571	13	28
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	14.4926	2	5
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	2
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	16.1898	2	5
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	1
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	3
Ferrochelatase, mitochondrial	Homo sapiens (human)	EC50	5.0119	1	1
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	15.6798	2	4
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	22.5500	2	6
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	6.5500	1	2
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	2	4
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	10.0000	1	2
Focal adhesion kinase 1	Homo sapiens (human)	Kd	22.0000	2	5
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	10.0000	1	2
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	4
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	3
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	4
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	3
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	23.3333	2	6
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	22.0000	2	5
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	3
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	4
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	13.5149	4	9
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	22.0000	2	5
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	7.7500	1	2
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	7.5000	1	2
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	9.8500	1	2
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	7.7000	1	2
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	22.0000	2	5
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	3
Insulin receptor	Homo sapiens (human)	Kd	22.0000	2	5
Insulin receptor-related protein	Homo sapiens (human)	Kd	10.0000	1	2
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	24.2857	2	7
Integrin-linked protein kinase	Homo sapiens (human)	Kd	30.0000	1	3
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	16.3128	2	5
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	22.0000	2	5
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	2	4
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	10.0000	1	2
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	2
LIM domain kinase 1	Homo sapiens (human)	Kd	8.6908	2	5
LIM domain kinase 2	Homo sapiens (human)	Kd	14.1404	2	5
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	6.3500	1	2
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	22.0000	2	5
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	22.0000	2	5
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	1
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	22.0000	2	5
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	23.3333	2	6
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	7.1449	8	16
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	16.3632	2	5
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	22.0000	2	5
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
Midasin	Homo sapiens (human)	Kd	30.0000	1	3
Misshapen-like kinase 1	Homo sapiens (human)	Kd	17.0250	2	4
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	24.2857	2	7
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	20.5000	2	5
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	16.1368	2	5
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	16.0716	2	5
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	23.3333	2	6
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	16.4180	2	5
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	16.2022	2	5
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	5.4550	1	2
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	2.1982	2	5
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	10.0000	1	2
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	22.0000	2	5
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	23.3333	2	6
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	20.4600	2	5
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	15.0000	2	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	3
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	4
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	10.0000	1	2
Myosin light chain kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	6.7000	1	2
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	16.8812	2	5
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	3
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	3
Myosin-IIIa	Homo sapiens (human)	Kd	10.0000	1	2
Myosin-IIIb	Homo sapiens (human)	Kd	10.0000	1	2
Myotonin-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	4
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	16.0132	2	5
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	18.5714	3	7
NT-3 growth factor receptor	Homo sapiens (human)	Kd	10.0000	1	2
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	20.0000	2	4
Nuclear receptor subfamily 1 group I member 2	Homo sapiens (human)	EC50	0.0871	2	2
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	3
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	3
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	2
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	10.0000	1	2
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	30.0000	1	2
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	30.0000	1	3
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	5.6000	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	10	20
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	1	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	23.3333	2	6
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	22.0000	2	5
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	10.0000	1	2
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	5.0950	1	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	16.2614	2	5
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	2
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	10.0000	1	2
Protein kinase C alpha type	Homo sapiens (human)	Kd	30.0000	1	3
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	3
Protein kinase C delta type	Homo sapiens (human)	Kd	23.3333	2	6
Protein kinase C epsilon type	Homo sapiens (human)	Kd	10.0000	1	2
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	1	2
Protein kinase C iota type	Homo sapiens (human)	Kd	22.0000	2	5
Protein kinase C theta type	Homo sapiens (human)	Kd	22.0000	2	5
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	2
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	22.0000	2	5
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	12.1455	2	6
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	16.6667	5	12
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	10.0000	1	2
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	22.4500	2	6
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	5
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	3
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	3
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.0000	2	5
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.0000	2	5
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	22.0000	2	5
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	EC50	0.6010	1	1
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	0.0883	1	2
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	3
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	4
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	3
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	10.0000	1	2
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	6.1500	1	2
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	10.0000	1	2
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	4.0150	3	4
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	6.6926	2	5
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	0.8744	3	5
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	10.0000	1	2
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	12.1778	8	18
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	22.0000	2	5
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	22.0000	2	5
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	1	2
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	10.0000	1	2
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	18.5714	3	7
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	10.0000	2	4
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	22.0000	2	5
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	18.5714	3	7
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	18.5714	3	7
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	18.5714	3	7
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	22.0000	2	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	30.0000	1	3
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	4
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	3
Septin-9	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	20.2600	2	5
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	20.3800	2	5
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	20.0000	2	4
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	6.4500	1	2
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	20.0000	2	4
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	10.7283	1	3
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	2
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	EC50	0.8430	4	5
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	0.8577	5	9
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	16.0068	2	5
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	16.0240	2	5
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	9.0500	1	2
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	6.2500	1	2
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	23.3333	2	6
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	3
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	16.0954	2	5
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	5.0950	1	2
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	21.0000	2	5
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	16.6667	2	3
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	16.0106	2	5
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	6.9500	1	2
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	5.7000	1	2
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	10.0000	1	2
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	20.0000	2	4
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	14.8040	2	5
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	16.6667	2	3
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	0.9850	1	2
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	8.6000	1	2
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	5.2600	1	2
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	14.5098	2	5
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	18.6675	2	6
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	22.0000	2	5
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	23.3333	2	6
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	23.3333	2	6
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	16.0376	2	5
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	18.5800	2	6
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	10.0000	1	2
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	16.2906	2	5
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	20.0387	1	3
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	1
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
SRSF protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2
SRSF protein kinase 3	Homo sapiens (human)	Kd	10.0000	1	2
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.2800	2	5
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	3
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	10.0000	1	2
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	3
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	2
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	10.0000	1	2
TGF-beta receptor type-1	Homo sapiens (human)	Kd	17.8807	2	6
TGF-beta receptor type-2	Homo sapiens (human)	Kd	3.6922	2	5
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	3
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	18.9600	2	5
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	3
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	6.9592	16	33
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	8.6208	2	5
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	5.5500	1	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	22.0000	2	5
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	17.1752	2	6
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	22.0000	2	5
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	20.7200	2	5
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	10.4028	2	4
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	12.1332	2	6
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	14.6234	2	5
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	14.8692	2	5
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	18.2571	3	7
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	13.3058	2	4
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	14.5166	2	5
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	14.4906	2	5
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	22.0000	2	5
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	5.0105	1	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	22.0000	2	5
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	22.0000	2	5
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	10.0000	1	2
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	14.6152	2	5
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	10.0000	1	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	3
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	2
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	30.0000	1	3
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	30.0000	1	3
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	10.0000	1	2
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	5.9500	1	2
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	6.0500	1	2
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	10.0000	1	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	4
Wee1-like protein kinase	Homo sapiens (human)	Kd	16.0504	2	5
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	10.0000	1	2

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	INH	0.0270	1	2
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	INH	0.0342	2	4