ascorbic-acid and Cholangitis

Topics: Adult; Ascorbic Acid; Cholangitis; Clinical Trials as Topic; Erythromycin; Female; Fungi; Humans; Infant; Infections; Male; Meningitis; Meningoencephalitis; Peritonitis; Pneumonia; Staphylococcal Infections; Urine

The change in hepatic antioxidant defense system with the development of alpha-naphthylisothiocyanate (ANIT)-induced liver injury was examined in rats injected once with the toxicant (75 mg/kg body weight). Liver injury with cholestasis did not occur 12 h after ANIT injection, but appeared at 24 h, progressed at 48 h, and recovered at 72 h, judging from the serum levels of marker enzymes and components. Liver lipid peroxide content increased 12 h after ANIT injection and further increased 24 and 48 h, but this increase was attenuated at 72 h. Liver superoxide dismutase and catalase activities decreased 24 and 48 h, respectively, after ANIT injection, although the catalase activity increased at 12 h, but these decreases were attenuated at 72 h. Liver Se-glutathione peroxidase activity remained unchanged 24, 48, and 72 h after ANIT injection, although the activity increased at 12 h. Liver reduced glutathione content increased 24 h after ANIT injection, but the increase was reduced time dependently thereafter. Liver ascorbic acid content increased 12 h after ANIT injection and further increased at 24 h, but the increase was reduced time dependently thereafter. These results indicate that the change in hepatic antioxidant defense system occurs before and with the development of ANIT-induced liver injury in rats, and suggest that the reduction of hepatic antioxidant defense system mediated by SOD and catalase could contribute to the liver injury development through an enhancement of hepatic lipid peroxidation.

Topics: 1-Naphthylisothiocyanate; Animals; Antioxidants; Ascorbic Acid; Bile Acids and Salts; Bilirubin; Cattle; Chemical and Drug Induced Liver Injury; Cholangitis; Drug Administration Schedule; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Liver; Male; Rats; Rats, Wistar; Selenium

The blood flow in the portal vein and hepatic artery was studied by means of ultrasonic Doppler flow measurement to investigate organic and regional hemodynamics of the liver in purulent cholangitis. The blood flow in the portal vein was found to be significantly diminished in patients with acute cholangitis and hepatic failure. Hepatic microcirculation was studied on a experimental model of obstructive jaundice and obstructive purulent cholangitis in rats by polarographic measurement of hydrogen clearance. Considerable reduction of the volume rate of the local blood flow was noted, and the degree of the reduction was related to the severity and duration of the disease. Decompression of the biliary tract by external drainage improved the local blood flow rate which, however, diminished again in prolonged external drainage. The use of pharmacological agents for correction of microcirculation in decompression of the biliary tract led to total and rapid correction of the volume rate of the local blood flow.

Topics: Acute Disease; Animals; Aprotinin; Ascorbic Acid; Aspirin; Cholangitis; Cholestasis; Dextrans; Dipyridamole; Drainage; Drug Combinations; Heparin; Humans; Liver Circulation; Male; Microcirculation; Pentoxifylline; Pyridinolcarbamate; Rats; Rutin; Suppuration; Ultrasonography; Xanthinol Niacinate

Topics: Adolescent; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Balneology; Cholangitis; Cholecystitis; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Vitamin B Complex; Vitamin B Deficiency

Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adrenal Glands; Ascorbic Acid; Child; Cholangitis; Cholecystitis; Gastritis; Humans