Page last updated: 2024-09-27

Costello Syndrome

Rare congenital disorder with multiple anomalies including: characteristic dysmorphic craniofacial features, musculoskeletal abnormalities, neurocognitive delay, and high prevalence of cancer. Germline mutations in H-Ras protein can cause Costello syndrome. Costello syndrome shows early phenotypic overlap with other disorders that involve MAP KINASE SIGNALING SYSTEM (e.g., NOONAN SYNDROME and cardiofaciocutaneous syndrome).

Synonyms(3)

Synonym
Faciocutaneoskeletal Syndrome
Costello Syndrome
FCS Syndrome

Research Excerpts

Overview

ExcerptReference
"Costello syndrome is a pediatric genetic disorder linked to oncogenic germline mutations in the HRAS gene."( Hinek, A; Klüppel, M; Liu, K; Samavarchi-Tehrani, P; Wrana, JL, 2012)
"Costello Syndrome is a rare multiple congenital anomaly disorder caused by de novo heterozygous mutations in the v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS) gene."( Brown, P; Capone, F; Di Lazzaro, V; Dileone, M; Leoni, C; Pilato, F; Profice, P; Ranieri, F; Tartaglia, M; Zampino, G, 2012)
"Costello syndrome is a rare genetic condition characterized by coarse facies, short stature, loose folds of skin especially on hands and feet, severe feeding difficulties and failure to thrive."( Anichini, C; Buonocore, G; Felici, C; Lo Rizzo, C; Longini, M; Lotti, F; Pietrini, A; Proietti, F, 2013)
"Costello syndrome is linked to activating mutations of a residue in the p-loop or the NKCD/SAK motifs of Harvey Ras (HRas)."( Heo, J; Jeong, SS; Kim, J; Lee, J; Wey, M, 2013)
"Costello syndrome is a rare genetic disorder characterized by mental and growth retardation and distinctive coarse facies."( Hashimoto, A; Imamachi, N; Saito, Y; Ugata, K, 2019)
"Costello syndrome is an autosomal dominant disorder that is caused by germline HRAS mutations."( Abe, T; Aiba, S; Aoki, Y; Asao, A; Inoue, SI; Inoue-Shibui, A; Ishii, N; Katata, Y; Kobayashi, S; Kure, S; Niihori, T; Terui, H, 2020)

Research

Studies (17)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (5.88)18.1394
2010's13 (76.47)28.8240
2020's3 (17.65)9.53
DrugIndicatedRelationship StrengthStudiesTrials
amiodarone0low10
fentanyl0low10
midazolam0low10
pd 980590low10
propranolol0low10
diphenylamine0low10
glutamic acid0low10
coenzyme a0low10
pyridinoline0low10
deoxypyridinoline0low10
elastin0low20
digoxin0low10
alprostadil0low10
acitretin0low20
sirolimus0low10
25-hydroxyvitamin d 20low10
pd 03259010low10
ribose0low10
chondroitin0low10
ascorbic acid0low10
guanosine diphosphate0low10
guanosine triphosphate0low10

Protein Targets (770)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase4004
USP1 protein, partial3003
TDP1 protein100010
Microtubule-associated protein tau2002
AR protein9009
aldehyde dehydrogenase 1 family, member A14004
glucocorticoid receptor [Homo sapiens]5005
estrogen nuclear receptor alpha8008
peroxisome proliferator activated receptor gamma4004
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform 25005
flap endonuclease 12002
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a1001
DNA polymerase eta isoform 11001
geminin7007
peripheral myelin protein 223003
survival motor neuron protein isoform d4004
histone acetyltransferase KAT2A isoform 11001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40405
Bile salt export pump0202
Bile salt export pump0707
Rap guanine nucleotide exchange factor 31001
Cellular tumor antigen p535005
Rap guanine nucleotide exchange factor 41001
Thromboxane-A synthase 0101
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP1 subtype0101
Prostacyclin receptor0112
Nuclear receptor subfamily 4 group A member 20011
Solute carrier organic anion transporter family member 2A10001
Nuclear receptor subfamily 4 group A member 20011
Nuclear receptor subfamily 4 group A member 20011
Prostaglandin E2 receptor EP2 subtype0112
Canalicular multispecific organic anion transporter 10303
Solute carrier organic anion transporter family member 2A10001
Solute carrier organic anion transporter family member 2B10101
Solute carrier organic anion transporter family member 3A10001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
acetylcholinesterase2002
phosphopantetheinyl transferase3003
hypoxia-inducible factor 1 alpha subunit2002
RAR-related orphan receptor gamma4004
SMAD family member 23003
ATAD5 protein, partial3003
Fumarate hydratase1001
NFKB1 protein, partial1001
PPM1D protein2002
SMAD family member 33003
Thrombopoietin2002
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
thyroid stimulating hormone receptor2002
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 33003
progesterone receptor3003
EWS/FLI fusion protein3003
retinoic acid nuclear receptor alpha variant 14004
retinoid X nuclear receptor alpha3003
estrogen-related nuclear receptor alpha5005
farnesoid X nuclear receptor3003
pregnane X nuclear receptor4004
G2002
cytochrome P450 2D62002
polyprotein1001
peroxisome proliferator-activated receptor delta2002
caspase-31001
thyroid stimulating hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
cytochrome P450 2D6 isoform 12002
cellular tumor antigen p53 isoform a3003
cytochrome P450 2C9 precursor2002
D(1A) dopamine receptor2002
chromobox protein homolog 13003
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
heat shock protein beta-11001
huntingtin isoform 21001
mitogen-activated protein kinase 12002
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 14004
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 14004
cytochrome P450 3A4 isoform 12002
muscarinic acetylcholine receptor M12002
lethal factor (plasmid)4004
lamin isoform A-delta103003
Gamma-aminobutyric acid receptor subunit pi2316
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent L-type calcium channel subunit alpha-1F0101
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Integrin beta-33014
Tyrosine-protein kinase Fyn0123
ATP-dependent translocase ABCB10303
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20314
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB108110
Integrin alpha-IIb3014
Beta-1 adrenergic receptor0415
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0326
Adenosine receptor A30314
Cytochrome P450 2C80202
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M10314
Beta-3 adrenergic receptor0415
D(2) dopamine receptor0415
Androgen receptor0202
Gamma-aminobutyric acid receptor subunit beta-12316
Alpha-1B adrenergic receptor0314
Lethal factor0101
Alpha-2B adrenergic receptor0225
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta2316
Gamma-aminobutyric acid receptor subunit gamma-22316
Gamma-aminobutyric acid receptor subunit alpha-52316
Gamma-aminobutyric acid receptor subunit alpha-32316
Muscarinic acetylcholine receptor M30314
ATP-dependent translocase ABCB10303
Substance-K receptor0202
D(1A) dopamine receptor0314
D(4) dopamine receptor0303
Gamma-aminobutyric acid receptor subunit gamma-12316
Gamma-aminobutyric acid receptor subunit alpha-22316
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Endothelin-1 receptor0314
5-hydroxytryptamine receptor 2A0415
5-hydroxytryptamine receptor 2C0415
Gamma-aminobutyric acid receptor subunit alpha-42316
Gamma-aminobutyric acid receptor subunit gamma-32316
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-62316
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0527
D(3) dopamine receptor0303
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0516
Kappa-type opioid receptor0516
5-hydroxytryptamine receptor 2B0415
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0314
Histamine H2 receptor2002
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60415
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein2002
Gamma-aminobutyric acid receptor subunit alpha-12316
Gamma-aminobutyric acid receptor subunit beta-32316
Gamma-aminobutyric acid receptor subunit beta-22316
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sodium channel protein type 5 subunit alpha0202
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit2316
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 12002
Sodium channel protein type 2 subunit alpha0101
Ataxin-24004
Sigma non-opioid intracellular receptor 10606
Gamma-aminobutyric acid receptor subunit epsilon2316
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial2002
ATP-dependent phosphofructokinase2002
Chain A, Hyaluronidase, phage associated0101
GLI family zinc finger 33003
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 43003
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
IDH12002
nuclear factor erythroid 2-related factor 2 isoform 22002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Choline O-acetyltransferase0101
Histone acetyltransferase p3000101
Histone acetyltransferase KAT2B0101
Histone acetyltransferase KAT50101
N-alpha-acetyltransferase 500011
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
Chain A, Beta-lactamase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain1001
interleukin 81001
PAX80001
STAT3, partial0101
Smad32002
regulator of G-protein signaling 44004
67.9K protein3003
alpha-galactosidase1001
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
NPC intracellular cholesterol transporter 1 precursor2002
tumor necrosis factor1001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
ras-related protein Rab-9A2002
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Voltage-dependent calcium channel gamma-2 subunit1001
Sodium/potassium-transporting ATPase subunit alpha-1 0202
Sodium/potassium-transporting ATPase subunit beta-10202
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Cytochrome P450 3A40404
Replicase polyprotein 1ab0101
Sodium/potassium-transporting ATPase subunit alpha-30101
Sodium/potassium-transporting ATPase subunit beta-20101
Glutamate receptor 21214
Sodium/potassium-transporting ATPase subunit alpha-20202
Sodium/potassium-transporting ATPase subunit alpha-10101
Nuclear receptor ROR-gamma1113
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit gamma0101
Sodium/potassium-transporting ATPase subunit alpha-40101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4C10001
ATPase family AAA domain-containing protein 51001
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1B30101
Solute carrier organic anion transporter family member 1B10202
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
ClpP1001
Glycoprotein hormones alpha chain1001
UDP-glucuronosyltransferase 1A40102
Solute carrier family 22 member 1 0303
Nuclear receptor subfamily 1 group I member 20022
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Delta-type opioid receptor0202
Delta-type opioid receptor0202
Mu-type opioid receptor0213
Kappa-type opioid receptor0101
Histamine H1 receptor0101
Kappa-type opioid receptor0202
Mu-type opioid receptor0101
Mu-type opioid receptor0202
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial1001
thioredoxin reductase3003
GLS protein2002
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Carbonic anhydrase 10001
Carbonic anhydrase 20001
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0213
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0213
Glutamate receptor ionotropic, NMDA 2C0213
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0213
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0213
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0213
Chain A, ELONGATION FACTOR TU (EF-TU)0011
Chain A, Elongation Factor G0011
Chain A, ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 30011
Chain A, Eukaryotic peptide chain release factor GTP-binding subunit0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, ras-related C3 botulinum toxin substrate 1 isoform Rac1b0011
Chain A, interferon-inducible GTPase0011
Chain A, interferon-inducible GTPase0011
Chain A, Elongation factor 20011
Chain A, Guanine nucleotide-binding protein G(i), alpha-1 subunit0011
72 kDa type IV collagenase0101
Matrilysin0101
2-dehydropantoate 2-reductase0022
Ras-related protein Rab-7a0022
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Disintegrin and metalloproteinase domain-containing protein 170101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT50101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
P2Y purinoceptor 60011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90404
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
Translocator protein0101
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 2B10 0101
aryl hydrocarbon receptor1001
Bone morphogenetic protein receptor type-1B0022
Membrane-associated progesterone receptor component 10011
Serine/threonine-protein kinase PLK40022
ATP-dependent RNA helicase DDX3X0022
Pyridoxal kinase0022
Citron Rho-interacting kinase0022
Serine/threonine-protein kinase Chk10022
Aurora kinase A0022
Cyclin-G-associated kinase0022
Ephrin type-B receptor 60022
Peroxisomal acyl-coenzyme A oxidase 30022
Receptor-interacting serine/threonine-protein kinase 20022
Mitotic checkpoint serine/threonine-protein kinase BUB10022
Dynamin-like 120 kDa protein, mitochondrial0022
Tyrosine-protein kinase JAK20022
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20022
Serine/threonine-protein kinase ULK10022
Serine/threonine-protein kinase/endoribonuclease IRE10022
Ribosomal protein S6 kinase alpha-50022
U5 small nuclear ribonucleoprotein 200 kDa helicase0022
Ribosomal protein S6 kinase alpha-40022
Serine/threonine-protein kinase 160022
Serine/threonine-protein kinase 100022
Serine/threonine-protein kinase D30022
Structural maintenance of chromosomes protein 20022
Mitogen-activated protein kinase kinase kinase 60022
Mitogen-activated protein kinase kinase kinase kinase 40022
Serine/threonine-protein kinase LATS10022
Serine/threonine-protein kinase PAK 40022
Tyrosine-protein kinase ABL10022
Epidermal growth factor receptor0022
High affinity nerve growth factor receptor0022
ADP/ATP translocase 20022
Cytochrome P450 1A20202
Protein kinase C beta type0022
Insulin receptor0022
Tyrosine-protein kinase Lck0022
Cyclin-dependent kinase 10022
Glycogen phosphorylase, liver form0022
Tyrosine-protein kinase Fes/Fps0022
Adenine phosphoribosyltransferase0022
Tyrosine-protein kinase Yes0022
Tyrosine-protein kinase Lyn0022
Proto-oncogene tyrosine-protein kinase receptor Ret0022
Insulin-like growth factor 1 receptor0022
Signal recognition particle receptor subunit alpha0022
Cytochrome c1, heme protein, mitochondrial0022
Hepatocyte growth factor receptor0022
Tyrosine-protein kinase HCK0022
Platelet-derived growth factor receptor beta0022
Tyrosine-protein kinase Fgr0022
Serine/threonine-protein kinase A-Raf0022
Cytochrome P450 2D60202
Glycogen phosphorylase, brain form0022
Breakpoint cluster region protein0022
Serine/threonine-protein kinase pim-10022
Fibroblast growth factor receptor 10022
DNA topoisomerase 2-alpha0022
Cyclin-dependent kinase 40022
ADP/ATP translocase 30022
Inosine-5'-monophosphate dehydrogenase 20022
Proto-oncogene tyrosine-protein kinase Src0022
cAMP-dependent protein kinase type II-alpha regulatory subunit0022
Serine/threonine-protein kinase B-raf0123
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0022
Ribosyldihydronicotinamide dehydrogenase [quinone]0022
Tyrosine-protein kinase Fer0022
Protein kinase C alpha type0022
cAMP-dependent protein kinase catalytic subunit alpha0022
General transcription and DNA repair factor IIH helicase subunit XPD0022
Casein kinase II subunit alpha'0022
Ras-related protein Rab-6A0022
Ephrin type-A receptor 10022
Multifunctional protein ADE20022
cAMP-dependent protein kinase catalytic subunit gamma0011
cAMP-dependent protein kinase catalytic subunit beta0022
Ferrochelatase, mitochondrial0022
Ribosomal protein S6 kinase beta-10022
Tyrosine-protein kinase JAK10022
Cyclin-dependent kinase 20022
Beta-adrenergic receptor kinase 10022
Probable ATP-dependent RNA helicase DDX60022
Mitogen-activated protein kinase 3 0023
MAP/microtubule affinity-regulating kinase 30022
Deoxycytidine kinase0022
Mitogen-activated protein kinase 10224
Ephrin type-A receptor 20022
Ephrin type-B receptor 20022
Non-receptor tyrosine-protein kinase TYK20022
Wee1-like protein kinase0022
Heme oxygenase 20022
DnaJ homolog subfamily A member 10022
RAC-alpha serine/threonine-protein kinase0022
RAC-beta serine/threonine-protein kinase0022
Dual specificity mitogen-activated protein kinase kinase 10101
Dual specificity protein kinase TTK0022
DNA replication licensing factor MCM40022
Myosin-100022
Dual specificity mitogen-activated protein kinase kinase 20123
Receptor-type tyrosine-protein kinase FLT30022
Bone morphogenetic protein receptor type-1A0022
Activin receptor type-1B0022
TGF-beta receptor type-10022
Serine/threonine-protein kinase receptor R30022
TGF-beta receptor type-20022
Electron transfer flavoprotein subunit beta0022
Tyrosine-protein kinase CSK0022
Glycine--tRNA ligase0022
Mitogen-activated protein kinase kinase kinase 80101
Protein kinase C iota type0022
Exosome RNA helicase MTR40022
Tyrosine-protein kinase Tec0022
Tyrosine-protein kinase ABL20022
Tyrosine-protein kinase FRK0022
G protein-coupled receptor kinase 60022
Tyrosine-protein kinase SYK0022
26S proteasome regulatory subunit 6B0022
Mitogen-activated protein kinase 80022
Mitogen-activated protein kinase 90022
Dual specificity mitogen-activated protein kinase kinase 40011
Dual specificity mitogen-activated protein kinase kinase 30022
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0022
Casein kinase I isoform alpha0022
Casein kinase I isoform delta0022
MAP kinase-activated protein kinase 20022
Elongation factor Tu, mitochondrial0022
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0022
Casein kinase I isoform epsilon0022
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0022
Dual specificity protein kinase CLK10022
Dual specificity protein kinase CLK20022
Dual specificity protein kinase CLK30022
Glycogen synthase kinase-3 alpha0022
Glycogen synthase kinase-3 beta0022
Cyclin-dependent kinase 70022
Cyclin-dependent kinase 90022
Ras-related protein Rab-27A0022
Interleukin-1 receptor-associated kinase 10022
Ribosomal protein S6 kinase alpha-30022
Serine/threonine-protein kinase Nek20022
Serine/threonine-protein kinase Nek30022
Dual specificity mitogen-activated protein kinase kinase 60022
Serine/threonine-protein kinase PLK10022
LIM domain kinase 10022
LIM domain kinase 20022
Mitogen-activated protein kinase 100022
Tyrosine--tRNA ligase, cytoplasmic0022
5'-AMP-activated protein kinase subunit gamma-10022
Ephrin type-B receptor 30022
Ephrin type-A receptor 50022
Ephrin type-B receptor 40022
Ephrin type-A receptor 40022
Adenylate kinase 2, mitochondrial0022
Adenosine kinase0022
Ras-related protein Rab-100022
Actin-related protein 30022
Actin-related protein 20022
GTP-binding nuclear protein Ran0022
Casein kinase I isoform gamma-20022
Cyclin-dependent kinase 30011
Cyclin-dependent kinase 60022
Cyclin-dependent-like kinase 5 0022
Cyclin-dependent kinase 160022
Cyclin-dependent kinase 170022
ATP-dependent 6-phosphofructokinase, platelet type0022
Dual specificity mitogen-activated protein kinase kinase 10224
DNA topoisomerase 2-beta0022
Protein kinase C theta type0022
Activin receptor type-10022
Macrophage-stimulating protein receptor0022
Focal adhesion kinase 10022
Protein kinase C delta type0022
Tyrosine-protein kinase BTK0022
Activated CDC42 kinase 10022
Epithelial discoidin domain-containing receptor 10022
Mitogen-activated protein kinase kinase kinase kinase 20022
Tyrosine-protein kinase Mer0022
Serine/threonine-protein kinase 40022
5'-AMP-activated protein kinase catalytic subunit alpha-10022
Dual specificity mitogen-activated protein kinase kinase 50022
Mitogen-activated protein kinase 70022
Serine/threonine-protein kinase PAK 20022
Serine/threonine-protein kinase 30022
Mitogen-activated protein kinase kinase kinase 10022
Integrin-linked protein kinase0022
Rho-associated protein kinase 10022
Non-receptor tyrosine-protein kinase TNK10022
Calcium/calmodulin-dependent protein kinase type II subunit gamma0022
Calcium/calmodulin-dependent protein kinase type II subunit delta0022
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0022
Activin receptor type-2B0022
Bone morphogenetic protein receptor type-20022
Protein-tyrosine kinase 60022
cGMP-dependent protein kinase 1 0022
Cyclin-dependent kinase 130022
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0022
Protein-tyrosine kinase 2-beta0022
Maternal embryonic leucine zipper kinase0022
Structural maintenance of chromosomes protein 1A0022
Chromodomain-helicase-DNA-binding protein 40022
Peroxisomal acyl-coenzyme A oxidase 10022
Delta(24)-sterol reductase0022
Ribosomal protein S6 kinase alpha-10022
Dual specificity testis-specific protein kinase 10022
Myosin light chain kinase, smooth muscle0022
Mitogen-activated protein kinase 110022
Serine/threonine-protein kinase STK110022
Serine/threonine-protein kinase N10022
Serine/threonine-protein kinase N20022
Mitogen-activated protein kinase 140022
Calcium/calmodulin-dependent protein kinase type IV0022
Mitogen-activated protein kinase kinase kinase 110022
MAP kinase-activated protein kinase 30011
Discoidin domain-containing receptor 20022
AP2-associated protein kinase 10022
Myosin light chain kinase 30022
Uncharacterized aarF domain-containing protein kinase 50022
Putative heat shock protein HSP 90-beta 20022
Rab-like protein 30011
Serine/threonine-protein kinase MRCK alpha0022
Serine/threonine-protein kinase MRCK gamma0022
Acyl-CoA dehydrogenase family member 100022
Serine/threonine-protein kinase N30022
Serine/threonine-protein kinase ULK30022
Uncharacterized protein FLJ452520022
Acyl-CoA dehydrogenase family member 110022
Serine/threonine-protein kinase/endoribonuclease IRE20022
Serine/threonine-protein kinase MARK20022
ATP-dependent RNA helicase DHX300022
Serine/threonine-protein kinase TAO10022
STE20-related kinase adapter protein alpha0022
Myosin-140022
AarF domain-containing protein kinase 10022
ATP-dependent RNA helicase DDX420011
Mitogen-activated protein kinase kinase kinase kinase 30022
MAP kinase-activated protein kinase 50022
Misshapen-like kinase 10022
Atypical kinase COQ8A, mitochondrial0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0022
Mitogen-activated protein kinase 150022
Serine/threonine-protein kinase Nek90022
Serine/threonine-protein kinase Nek70011
ATP-dependent RNA helicase DDX10022
Mitogen-activated protein kinase kinase kinase kinase 10022
Aurora kinase B0022
MAP/microtubule affinity-regulating kinase 40022
Serine/threonine-protein kinase Nek10022
PAS domain-containing serine/threonine-protein kinase0022
Calcium/calmodulin-dependent protein kinase kinase 20022
EKC/KEOPS complex subunit TP53RK0022
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0022
Mitogen-activated protein kinase kinase kinase 50022
Mitogen-activated protein kinase kinase kinase 30022
Eukaryotic translation initiation factor 2-alpha kinase 10022
Nucleolar GTP-binding protein 10022
Serine/threonine-protein kinase D20022
NUAK family SNF1-like kinase 20011
RNA cytidine acetyltransferase0022
Serine/threonine-protein kinase SIK20022
STE20-like serine/threonine-protein kinase 0022
Serine/threonine-protein kinase TAO30022
dCTP pyrophosphatase 10022
Dual specificity protein kinase CLK40022
Casein kinase I isoform gamma-10022
Serine/threonine-protein kinase PAK 60011
Phenylalanine--tRNA ligase beta subunit0022
BMP-2-inducible protein kinase0022
Obg-like ATPase 10022
Interleukin-1 receptor-associated kinase 40022
Mitogen-activated protein kinase kinase kinase 200022
Cyclin-dependent kinase 120022
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130011
Serine/threonine-protein kinase pim-20011
Serine/threonine-protein kinase 260022
Serine/threonine-protein kinase NLK0022
5'-AMP-activated protein kinase subunit gamma-20022
Serine/threonine-protein kinase TBK10022
Septin-90022
Ribosomal protein S6 kinase alpha-60022
TRAF2 and NCK-interacting protein kinase0022
Serine/threonine-protein kinase TAO20022
Serine/threonine-protein kinase ICK0022
RAC-gamma serine/threonine-protein kinase0022
Serine/threonine-protein kinase SIK30022
Mitogen-activated protein kinase kinase kinase 20022
Thyroid hormone receptor-associated protein 30022
Mitogen-activated protein kinase kinase kinase kinase 50022
Receptor-interacting serine/threonine-protein kinase 30022
Serine/threonine-protein kinase MRCK beta0022
Interleukin-1 receptor-associated kinase 30022
Serine/threonine-protein kinase 240022
Casein kinase I isoform gamma-30022
Mitogen-activated protein kinase kinase kinase 40022
15-lipoxygenase, partial1001
nonstructural protein 11001
glucocerebrosidase1001
Parkin1001
arylsulfatase A2002
pyruvate kinase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
atrial natriuretic peptide receptor 2 precursor1001
muscleblind-like protein 1 isoform 11001
pyruvate kinase PKM isoform b1001
RAF proto-oncogene serine/threonine-protein kinase0101
Luciferin 4-monooxygenase0101
Ornithine decarboxylase1001
Amine oxidase [flavin-containing] B0101
Prostaglandin G/H synthase 10101
Dual specificity mitogen-activated protein kinase kinase 2 0101
Dual specificity mitogen-activated protein kinase kinase 1 0101
Beta-1 adrenergic receptor 0113
Albumin0011
Beta-2 adrenergic receptor0213
5-hydroxytryptamine receptor 1A0101
Beta-2 adrenergic receptor0203
Cytochrome P450 2C9 0202
Beta-1 adrenergic receptor0214
Alpha-2C adrenergic receptor0124
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0214
Alpha-2B adrenergic receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Alpha-2C adrenergic receptor0011
Alpha-2A adrenergic receptor0011
Alpha-1D adrenergic receptor0112
Alpha-1D adrenergic receptor0012
Beta-3 adrenergic receptor0202
5-hydroxytryptamine receptor 1B0213
5-hydroxytryptamine receptor 1B0202
Adenosine receptor A2a0112
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Cytochrome P450 2C190202
5-hydroxytryptamine receptor 70112
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0124
Alpha-1B adrenergic receptor0012
Vasopressin V1a receptor0112
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Beta-2 adrenergic receptor0113
Nuclear receptor subfamily 2 group E member 10022
Cell division cycle 7-related protein kinase0011
Cyclin-dependent kinase-like 50011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
S-adenosylmethionine synthase isoform type-20011
Alpha-synuclein1001
Serine/threonine-protein kinase mTOR0112
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Protein kinase C zeta type0011
Cyclin-dependent kinase 180011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Programmed cell death protein 40011
Regulatory-associated protein of mTOR0101
Calcium/calmodulin-dependent protein kinase type 1G0011
Dual specificity testis-specific protein kinase 20011
Target of rapamycin complex subunit LST80101
Serine/threonine-protein kinase mTOR 0101
Isoleucine--tRNA ligase, mitochondrial0011
Midasin0011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]