Polymyalgia Rheumatica

A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.

Synonym
Polymyalgia Rheumatica

Excerpt	Reference
"The polymyalgia rheumatica is characterized by periarticular pain which is mostly symmetrical and accentuated in the shoulder girdle."	( Mumenthaler, M, 1978)
"Polymyalgia rheumatica is probably a stage of the same disease."	( Sochocky, S, 1977)
"Early diagnosis of polymyalgia rheumatica is often difficult."	( Sewell, JR, 1986)
"Polymyalgia rheumatica is a relatively common syndrome of older patients, mostly white, manifested by aching and morning stiffness of the pelvic and shoulder girdles and accompanied by a rapid erythrocyte sedimentation rate."	( Healey, LA; Wilske, KR, 1984)
"Polymyalgia rheumatica is a heterogeneous disease with variations in the treatment duration and dose of corticosteroids required for suppression of symptoms."	( Evans, JM; Fulbright, JW; Goronzy, JJ; Hunder, GG; Weyand, CM, 1999)
"Polymyalgia rheumatica is characterized by muscular pain and stiffness developing almost exclusively in individuals older than 50 years."	( Gran, JT, 1999)
"Polymyalgia rheumatica is often diagnosed and treated in general practice."	( Bratland, B, 2001)
"Polymyalgia rheumatica is uncommon in young women and remains a diagnostic challenge for pregnant women."	( Maruo, T; Ohara, N; Sasaki, H; Washio, M, 2005)
"The diagnosis of polymyalgia rheumatica is important to properly manage pregnancy."	( Maruo, T; Ohara, N; Sasaki, H; Washio, M, 2005)
"Polymyalgia rheumatica is infrequently the initial manifestation of underlying malignancy."	( Gilliland, WR; Keith, MP, 2006)
"Polymyalgia rheumatica is treated with prednisolone."	( Tereshchenko, IV, 2006)
"Polymyalgia rheumatica is frequently associated with giant cell arteritis."	( Zimmermann-Górska, I, 2008)
"Polymyalgia rheumatica is a clinical diagnosis without a 'gold standard' serological or histological test and there are other conditions that may mimic PMR."	( Charlton, R, 2008)
"Polymyalgia rheumatica is characterized by bilateral pain in the shoulder and pelvic girdles, malaise, morning stiffness and weight loss."	( Schmidt, WA, 2013)
"Polymyalgia rheumatica is characterized by aching and stiffness of the shoulder, the pelvic girdles and the neck."	( Manovitch, Z; Mouallem, M, 2014)
"Polymyalgia rheumatica is treated with glucocorticoids (GC) in an initial dosage of up to 20 mg per day."	( Hellmich, B, 2016)
"Polymyalgia rheumatica is an inflammatory disease that affects the shoulder, the pelvic girdles, and the neck, usually in individuals older than 50 years."	( Castañeda, S; González-Gay, MA; Matteson, EL, 2017)
"Polymyalgia rheumatica is the most common inflammatory rheumatic disease in elderly people, usually develops in patients older than 50 years, more frequently in females."	( Allegri, V; Fanti, S; Lanzafame, H; Mulè, R; Zanoni, L, 2022)
"Polymyalgia rheumatica is more common and typically presents with constitutional symptoms, proximal muscle pain, and elevated inflammatory markers."	( Darrow, HJ; Raleigh, MF; Stoddard, J, 2022)

Excerpt	Reference
"After steroid treatment, the polymyalgia rheumatica and dementia rapidly resolved and the CT scan and EEG became normal."	( Bates, D; Nightingale, S; Venables, GS, 1982)
"Steroids are the only treatment of polymyalgia rheumatica (PMR)."	( Bartoli, E; Casatta, L; De Vita, S; Ferraccioli, G; Salaffi, F, 1996)
"MP) with oral prednisolone (OP) in the treatment of polymyalgia rheumatica (PMR), a common steroid-treated illness where prolonged therapy can lead to steroid side-effects."	( Dasgupta, B; Dolan, AL; Fernandes, L; Panayi, GS, 1998)
"Steroids are the standard treatment for polymyalgia rheumatica."	( Caporali, R; Cimmino, MA; Ferraccioli, G; Gerli, R; Klersy, C; Montecucco, C; Salvarani, C, 2004)
"If untreated, polymyalgia rheumatica may result in significant disability."	( Gilliland, W; Unwin, B; Williams, CM, 2006)
"A reliable alternative to steroids for treating polymyalgia rheumatica has not yet been identified."	( Boiardi, L; Cantini, F; Catanoso, MG; Cimmino, M; Gerli, R; Hunder, GG; Klersy, C; Macchioni, P; Manganelli, P; Manzini, C; Paolazzi, G; Salvarani, C; Trotta, A, 2007)
"A 60-year-old male who had been treated for polymyalgia rheumatica (PMR) with Raynaud's phenomenon was admitted to our hospital with acrocyanosis and rapid progressive anemia."	( Eguchi, K; Hayashi, T; Ida, H; Kamihira, S; Kamiya-Matsumoto, K; Kawakami, A; Nakamura, H; Sato, S, 2009)
"He had been taking prednisolone for the treatment of polymyalgia rheumatica since 2000."	( Arakaki, O; Asato, Y; Hagiwara, K; Hosokawa, A; Kayo, S; Nonaka, K; Taira, K; Uezato, H; Yagi, N; Yamamoto, Y, 2010)
"the mainstay of treatment of polymyalgia rheumatica (PMR) is oral glucocorticoids, but randomized controlled trials of treatment are lacking."	( Caporali, R; Cimmino, MA; Montecucco, C; Parodi, M, 2011)
"Glucocorticoids are the cornerstone treatment of polymyalgia rheumatica (PMR) but induce adverse events."	( Berthelot, JM; Cornec, D; De Bandt, M; Devauchelle-Pensec, V; Garrigues, F; Gouillou, M; Jousse-Joulin, S; Marhadour, T; Querellou, S; Renaudineau, Y; Saraux, A, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	297 (34.66)	23.3326
1990's	158 (18.44)	12.5806
2000's	149 (17.39)	18.1394
2010's	166 (19.37)	28.8240
2020's	87 (10.15)	9.53

Drug	Relationship Strength	Studies	Trials
salicylic acid	low	5	0
lactic acid	medium	2	1
melatonin	low	1	0
pyruvic acid	medium	2	1
thiamine	low	1	0
uric acid	low	1	0
acetaminophen	low	2	0
alendronate	low	1	0
diatrizoic acid	low	1	0
antipyrine	low	1	0
aspirin	medium	17	1
azathioprine	medium	8	1
caffeine	low	1	0
carbamazepine	low	1	0
carprofen	medium	1	1
celecoxib	low	1	0
chlorambucil	low	1	0
chloroquine	low	3	0
dapsone	medium	10	1
dibucaine	low	1	0
diclofenac	medium	2	2
dipyridamole	low	1	0
valproic acid	low	1	0
etidronate	medium	2	2
flufenamic acid	low	1	0
hydralazine	low	2	0
hydroxychloroquine	low	3	0
ibuprofen	medium	4	2
lidocaine	low	1	0
indomethacin	medium	20	2
isoniazid	low	2	0
2-propanol	low	1	0
ketoprofen	medium	1	1
mefenamic acid	low	1	0
metoprolol	low	1	0
minoxidil	low	1	0
oxyphenbutazone	low	4	0
phenacetin	low	1	0
phenobarbital	low	1	0
phenylbutazone	medium	8	1
pridinol	low	1	0
probenecid	low	1	0
procainamide	low	2	0
procaine	low	1	0
sulfamethoxazole	low	1	0
sulfasalazine	low	3	0
sulfisoxazole	low	1	0
sulfobromophthalein	low	1	0
trimethoprim	low	1	0
corticosterone	low	4	0
thymidine	low	3	0
hydroxyproline	medium	2	1
thyroxine	low	2	0
penicillamine	low	4	0
paramethasone	low	1	0
methylprednisolone acetate	medium	1	1
dehydroepiandrosterone	low	4	0
penicillin g	low	2	0
pilocarpine	low	1	0
alanine	low	1	0
aminopyrine	low	1	0
adenosine monophosphate	low	1	0
leucine	medium	1	1
androstenedione	medium	3	1
colchicine	low	1	0
cycloserine	low	2	0
17-alpha-hydroxyprogesterone	medium	4	1
ampicillin	low	1	0
methandrostenolone	low	1	0
methylprednisolone	medium	31	9
pyrroles	low	1	0
ergotamine	low	1	0
isoxazoles	low	3	0
citrulline	low	1	0
betamethasone	low	2	0
fluorometholone	low	1	0
fluorobenzenes	low	1	0
homocystine	low	1	0
congo red	low	1	0
benzydamine	low	1	0
dehydroepiandrosterone sulfate	medium	5	1
ethambutol	low	1	0
streptomycin	low	1	0
floxacillin	low	1	0
technetium	low	4	0
gold	low	7	0
calcium pyrophosphate	low	2	0
trolamine salicylate	low	80	0
triamcinolone	low	3	0
fludrocortisone	low	1	0
transferrin	low	1	0
glutamic acid	medium	1	1
gallium citrate	low	1	0
metsulfuron methyl	low	1	0
lovastatin	low	1	0
pravastatin	low	1	0
finasteride	low	1	0
tenidap	medium	1	1
atorvastatin	low	1	0
fluorodeoxyglucose f18	medium	70	4
lonazolac	low	1	0
zoledronic acid	low	1	0
6-amino-1-hydroxyhexane-1,1-diphosphonate	medium	1	1
clarithromycin	low	2	0
fibrinogen	low	7	0
lopinavir	low	1	0
quinidine gluconate	low	1	0
tritium oxide	medium	1	1
pyridinoline	medium	3	2
deoxypyridinoline	medium	3	2
methotrexate	medium	58	4
naproxen	medium	1	1
atropine	low	1	0
erlotinib hydrochloride	low	1	0
deflazacort	medium	12	6
sorafenib	low	1	0
cortisone	low	7	0
ritonavir	low	1	0
glycogen	low	2	0
fibrin	low	1	0
bradykinin	medium	1	1
elastin	low	3	0
cortodoxone	low	1	0
strychnine	low	1	0
quinidine	low	1	0
arachidonic acid	low	1	0
cerivastatin	low	1	0
melphalan	low	1	0
dipyrone	low	1	0
bromochloroacetic acid	low	2	0
mercaptopurine	low	1	0
terbinafine	low	1	0
ethionamide	low	2	0
osteoprotegerin	low	1	0
dinoprostone	medium	1	1
alprostadil	low	1	0
vitamin d 2	low	1	0
clobetasol	low	1	0
gallium	low	1	0
enalapril	low	2	0
phosphorus	low	3	0
pregabalin	low	1	0
limaprost	low	1	0
nitrofurantoin	low	1	0
phosphocreatine	low	1	0
technetium tc 99m diphosphonate	low	1	0
mocetinostat	low	1	0
idelalisib	low	1	0
acid phosphatase	low	1	0
jaw	low	4	0
nad	low	1	0
calcitonin	medium	2	2
atrial natriuretic factor	low	1	0
gdc-0973	low	2	0
piperidines	medium	5	2
interleukin-8	medium	3	1
heparitin sulfate	low	1	0
ascorbic acid	low	1	0
minocycline	low	1	0
salicylates	low	7	0
piroxicam	medium	4	4
mobiflex	medium	4	4
warfarin	low	1	0
calca protein, human	low	1	0
hyaluronoglucosaminidase	low	1	0
vitamin b 12	low	3	0
s 8932	low	1	0
cyclosporine	low	1	0
thromboplastin	low	1	0
muramidase	low	2	0
amyloid beta-peptides	medium	1	1
chondroitin sulfates	low	1	0
levoleucovorin	medium	2	1
folic acid	low	2	0
rifampin	low	1	0
allopurinol	low	1	0
inosine pranobex	low	1	0
concanavalin a	low	3	0
leptin	low	3	0

Protein Targets (1,817)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
acetylcholinesterase	17	0	0	17
pregnane X receptor	10	0	0	10
SMAD family member 2	22	0	0	22
SMAD family member 3	22	0	0	22
TDP1 protein	58	0	0	58
GLI family zinc finger 3	58	0	0	58
Microtubule-associated protein tau	25	0	0	25
AR protein	76	0	0	76
progesterone receptor	42	0	0	42
glucocorticoid receptor [Homo sapiens]	63	0	0	63
retinoic acid nuclear receptor alpha variant 1	53	0	0	53
retinoid X nuclear receptor alpha	46	0	0	46
estrogen-related nuclear receptor alpha	63	0	0	63
farnesoid X nuclear receptor	33	0	0	33
pregnane X nuclear receptor	50	0	0	50
estrogen nuclear receptor alpha	88	0	0	88
G	30	0	0	30
vitamin D (1,25- dihydroxyvitamin D3) receptor	42	0	0	42
arylsulfatase A	9	0	0	9
euchromatic histone-lysine N-methyltransferase 2	50	0	0	50
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	43	0	0	43
activating transcription factor 6	21	0	0	21
nuclear receptor subfamily 1, group I, member 2	12	0	0	12
chromobox protein homolog 1	28	0	0	28
nuclear factor erythroid 2-related factor 2 isoform 1	54	0	0	54
geminin	58	0	0	58
survival motor neuron protein isoform d	25	0	0	25
histone acetyltransferase KAT2A isoform 1	21	0	0	21
lamin isoform A-delta10	48	0	0	48
Voltage-dependent calcium channel gamma-2 subunit	27	0	0	27
Interferon beta	40	0	0	40
HLA class I histocompatibility antigen, B alpha chain	30	0	0	30
Glucocorticoid receptor	0	16	2	23
Sex hormone-binding globulin	0	0	6	6
Glycine receptor subunit alpha-1	0	17	0	17
Corticosteroid-binding globulin	0	7	0	7
Adenosine receptor A3	0	5	0	5
Replicase polyprotein 1ab	0	8	4	12
Androgen receptor	0	14	0	14
Alpha-1B adrenergic receptor	0	6	0	6
Glutamate receptor 2	27	2	1	30
Glycine receptor subunit beta	0	16	0	16
Glycine receptor subunit alpha-2	0	16	0	16
Glycine receptor subunit alpha-3	0	16	0	16
Mitogen-activated protein kinase 3	0	2	4	6
Alpha-1A adrenergic receptor	0	7	0	7
Sodium-dependent dopamine transporter	0	10	0	10
TAR DNA-binding protein 43	16	0	0	16
Inositol hexakisphosphate kinase 1	30	0	0	30
cytochrome P450 2C9, partial	30	0	0	30
ATP-dependent phosphofructokinase	19	0	0	19
hypoxia-inducible factor 1 alpha subunit	15	0	0	15
RAR-related orphan receptor gamma	55	0	0	55
aldehyde dehydrogenase 1 family, member A1	34	0	0	34
peroxisome proliferator-activated receptor delta	35	0	0	35
v-jun sarcoma virus 17 oncogene homolog (avian)	24	0	0	24
Histone H2A.x	17	0	0	17
thyroid hormone receptor beta isoform a	19	0	0	19
heat shock protein beta-1	14	0	0	14
Geranylgeranyl pyrophosphate synthase	0	4	0	5
Farnesyl pyrophosphate synthase	0	6	0	6
ATAD5 protein, partial	20	0	0	20
GLS protein	22	0	0	22
Smad3	15	0	0	15
thyroid stimulating hormone receptor	26	0	0	26
nuclear receptor subfamily 1, group I, member 3	40	0	0	40
EWS/FLI fusion protein	32	0	0	32
peroxisome proliferator activated receptor gamma	39	0	0	39
aryl hydrocarbon receptor	27	0	0	27
thyroid hormone receptor beta isoform 2	51	0	0	51
peripheral myelin protein 22	27	0	0	27
cytochrome P450 3A4 isoform 1	30	0	0	30
Gamma-aminobutyric acid receptor subunit pi	30	0	1	31
ATP-binding cassette sub-family C member 3	0	54	0	54
Multidrug resistance-associated protein 4	0	55	0	60
Solute carrier family 22 member 6	0	13	0	13
Carbonic anhydrase 12	0	6	0	6
UDP-glucuronosyltransferase 1A9	0	2	0	5
Bile salt export pump	0	18	0	18
Bile salt export pump	0	77	0	77
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	18	0	20
Carbonic anhydrase 2	0	18	1	21
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	7	0	9
Prostaglandin G/H synthase 1	0	15	0	16
Carbonic anhydrase 3	0	3	0	3
Cytochrome P450 3A4	0	16	1	18
Cytochrome P450 2D6	0	12	0	12
Cytochrome P450 2C9	0	28	0	29
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	30	0	1	31
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	30	0	1	31
Gamma-aminobutyric acid receptor subunit gamma-2	30	0	1	31
UDP-glucuronosyltransferase 1-6	0	5	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	30	0	1	31
Gamma-aminobutyric acid receptor subunit alpha-3	30	0	1	31
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	7	0	8
Carbonic anhydrase 4	0	3	0	3
Prostaglandin G/H synthase 1	0	18	0	19
Carbonic anhydrase 6	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	30	0	1	31
Gamma-aminobutyric acid receptor subunit alpha-2	30	0	1	31
Gamma-aminobutyric acid receptor subunit alpha-4	30	0	1	31
Gamma-aminobutyric acid receptor subunit gamma-3	30	0	1	31
Gamma-aminobutyric acid receptor subunit alpha-6	30	0	1	31
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	23	5	31
Carbonic anhydrase 7	0	4	0	4
Nuclear receptor ROR-gamma	18	0	0	18
Cytochrome P450 2J2	0	18	0	18
Gamma-aminobutyric acid receptor subunit alpha-1	30	2	1	33
Gamma-aminobutyric acid receptor subunit beta-3	30	0	1	31
Gamma-aminobutyric acid receptor subunit beta-2	30	0	1	31
Carbonic anhydrase 9	0	9	0	9
GABA theta subunit	30	0	1	31
Canalicular multispecific organic anion transporter 1	0	54	0	54
Carbonic anhydrase 15	0	3	0	3
Carbonic anhydrase 13	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	30	0	1	31
Carbonic anhydrase 14	0	4	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	3
toxin B	0	0	0	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
regulator of G-protein signaling 4	11	0	0	11
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	3	3
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	2
Transient receptor potential cation channel subfamily M member 2	0	3	0	3
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	2
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	4	6
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	2	0	2
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	3	2	7
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	6	7
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	3	4
Adenylate kinase 2, mitochondrial	0	0	4	5
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	6	7
Adenosine deaminase-like protein	0	0	0	1
Protease	0	6	4	12
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	5	6
5'-AMP-activated protein kinase subunit beta-1	0	0	2	3
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	31	0	0	31
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	20	0	0	20
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	2	6
Proton-coupled amino acid transporter 1	0	4	0	5
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	3	0	4
Chain A, farnesyl pyrophosphate synthase	0	1	0	1
Acetylcholinesterase	0	8	0	8
Hypoxanthine-guanine phosphoribosyltransferase	0	1	0	1
Farnesyl pyrophosphate synthase	0	3	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
interleukin 8	14	0	0	14
estrogen receptor 2 (ER beta)	26	0	0	26
IDH1	22	0	0	22
Bloom syndrome protein isoform 1	17	0	0	17
transcriptional regulator ERG isoform 3	5	0	0	5
ras-related protein Rab-9A	8	0	0	8
Polyphenol oxidase 2	0	5	0	7
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Cellular tumor antigen p53	39	0	0	39
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	2	2	5
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Purine nucleoside phosphorylase	0	0	2	2
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	2
Thromboxane-A synthase	0	5	0	5
Prostaglandin E2 receptor EP3 subtype	0	3	0	3
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin E2 receptor EP1 subtype	0	3	0	3
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Solute carrier organic anion transporter family member 2A1	0	0	0	3
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, Ferritin light chain	10	0	0	10
Luciferase	25	0	0	25
thioredoxin reductase	28	0	0	28
15-lipoxygenase, partial	9	0	0	9
cytochrome P450 family 3 subfamily A polypeptide 4	39	0	0	39
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	13	0	0	13
histone deacetylase 9 isoform 3	6	0	0	6
Nicotinate phosphoribosyltransferase	0	9	0	9
ORF73	0	0	2	2
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	17	0	0	17
Chain A, 2-oxoglutarate Oxygenase	25	0	0	25
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Cruzipain	10	0	0	10
Beta-lactamase	0	0	0	2
acid sphingomyelinase	5	0	0	5
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	18	0	0	18
DNA polymerase beta	6	0	0	6
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	13	0	0	13
DNA polymerase kappa isoform 1	13	0	0	13
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	2	0	2
Spike glycoprotein	26	1	4	31
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	1	3	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	2
Chain A, HADH2 protein	18	0	0	18
Chain B, HADH2 protein	18	0	0	18
nonstructural protein 1	11	0	0	11
Caspase-7	5	0	0	5
peripheral myelin protein 22 isoform 1	11	0	0	11
potassium voltage-gated channel subfamily H member 2 isoform d	17	0	0	17
caspase-3	5	0	0	5
importin subunit beta-1 isoform 1	7	0	0	7
mitogen-activated protein kinase 1	13	0	0	13
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
snurportin-1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
nuclear receptor ROR-gamma isoform 1	22	0	0	22
muscleblind-like protein 1 isoform 1	15	0	0	15
neuropeptide S receptor isoform A	7	0	0	7
Beta-glucuronidase	0	2	0	2
Cholinesterase	0	5	0	5
Aromatase	0	6	0	8
Gastrin/cholecystokinin type B receptor	0	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Alpha-synuclein	5	2	0	7
USP1 protein, partial	29	0	0	29
67.9K protein	15	0	0	15
nuclear factor erythroid 2-related factor 2 isoform 2	21	0	0	22
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
phosphopantetheinyl transferase	22	0	0	22
thioredoxin glutathione reductase	13	0	0	13
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cellular tumor antigen p53 isoform a	9	0	0	9
vitamin D3 receptor isoform VDRA	21	0	0	21
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	4	0	0	4
Fatty-acid amide hydrolase 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Prostaglandin G/H synthase 1	0	7	0	9
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
60 kDa chaperonin	0	2	0	2
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Histamine H2 receptor	21	0	0	22
Calmodulin	0	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Prostaglandin G/H synthase 2	0	11	0	12
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Lanosterol 14-alpha demethylase	0	3	0	3
Solute carrier organic anion transporter family member 1B3	0	15	0	19
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	16	0	21
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal factor (plasmid)	8	0	0	8
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	6	1	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	3	3
ras protein, partial	0	0	3	3
hypothetical protein, conserved	2	0	0	2
cytochrome P450 2D6	22	0	0	22
glucocerebrosidase	7	0	0	7
Rac1 protein	0	0	3	3
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	3	3
muscarinic acetylcholine receptor M1	17	0	0	17
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 2	0	5	0	6
Epidermal growth factor receptor	0	7	4	11
Fatty acid-binding protein, liver	0	4	0	4
Integrin beta-3	5	1	1	7
Myeloperoxidase	0	7	0	7
Seed linoleate 13S-lipoxygenase-1	0	3	0	3
Integrin alpha-IIb	5	1	1	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Adenosine receptor A1	0	7	0	8
Adenosine receptor A2a	0	6	0	8
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	2	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	3	3
Rho-associated protein kinase 2	0	2	0	2
Solute carrier family 22 member 20	0	7	0	7
Solute carrier family 22 member 6	0	7	0	7
Sigma non-opioid intracellular receptor 1	0	5	2	7
Sigma non-opioid intracellular receptor 1	0	0	2	2
caspase 7, apoptosis-related cysteine protease	7	0	0	7
caspase-3	7	0	0	7
Solute carrier organic anion transporter family member 2B1	0	10	0	12
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	5	0	5
ATP-dependent translocase ABCB1	0	14	1	19
Insulin receptor	0	4	0	4
Dipeptidyl peptidase 4	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	4	0	4
Histone deacetylase 1	0	7	0	7
Histone deacetylase 2	0	7	0	7
Histone deacetylase 6	0	6	0	6
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	10	0	11
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	2	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	11	0	15
5-hydroxytryptamine receptor 4	0	4	0	4
Muscarinic acetylcholine receptor M2	0	6	2	11
Muscarinic acetylcholine receptor M4	0	4	1	7
Muscarinic acetylcholine receptor M1	0	4	1	8
Muscarinic acetylcholine receptor M3	0	4	1	8
Muscarinic acetylcholine receptor M4	0	4	1	8
Muscarinic acetylcholine receptor M5	0	4	1	8
Muscarinic acetylcholine receptor M5	0	5	1	8
Muscarinic acetylcholine receptor M2	0	4	1	9
Muscarinic acetylcholine receptor M1	0	5	3	11
Muscarinic acetylcholine receptor M1	0	0	1	2
Muscarinic acetylcholine receptor M3	0	4	1	7
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 2C	0	5	0	5
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	3
Fumarate hydratase	11	0	0	11
polyprotein	11	0	0	11
P53	2	0	0	2
thyroid stimulating hormone receptor	13	0	0	13
hemoglobin subunit beta	2	0	0	2
M-phase phosphoprotein 8	9	0	0	9
ATPase family AAA domain-containing protein 5	20	0	0	20
Ataxin-2	22	0	0	22
Protein-arginine deiminase type-4	0	9	0	9
cytochrome P450 2D6 isoform 1	11	0	0	11
Guanylate cyclase soluble subunit beta-2	0	0	1	1
Guanylate cyclase soluble subunit alpha-2	0	0	1	1
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
galanin receptor type 3	0	1	0	1
Angiotensin-converting enzyme	0	1	0	2
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Potassium channel subfamily K member 2	0	1	2	3
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	4	4	8
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	2	0	3
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	5	2	7
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	3	2	5
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	4	5
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Phosphodiesterase	0	1	0	1
Guanine deaminase	0	2	0	2
Vpr	1	0	0	1
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	4	0	10
Cytochrome P450 2B6	0	0	2	2
Sodium channel protein type 4 subunit alpha	0	2	0	3
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Complement C5	0	0	1	1
Fatty-acid amide hydrolase 1	0	4	0	4
Chain A, Carbonic anhydrase II	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
glp-1 receptor, partial	10	0	0	10
PPM1D protein	11	0	0	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
interferon gamma precursor	0	0	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	2
Prostaglandin E synthase	0	2	0	2
Histone deacetylase 3	0	5	0	5
3-phosphoinositide-dependent protein kinase 1	0	1	2	3
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	4	0	4
Procathepsin L	0	4	4	8
Aldo-keto reductase family 1 member B1	0	9	0	9
Neuronal acetylcholine receptor subunit alpha-4	4	2	0	6
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Quinolone resistance protein NorA	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	4	2	0	6
Beta-3 adrenergic receptor	0	2	1	3
Calpain-2 catalytic subunit	0	1	0	1
5-hydroxytryptamine receptor 1A	0	6	1	7
D(1A) dopamine receptor	0	4	0	4
Prostaglandin G/H synthase 1	0	3	0	3
Sodium-dependent noradrenaline transporter	0	10	0	10
Cruzipain	0	1	0	1
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	3	0	3
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	1	1	2
Delta-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	3	0	3
Bifunctional epoxide hydrolase 2	0	3	0	3
Prostaglandin G/H synthase 2	0	8	0	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Histone deacetylase 4	0	4	0	4
D(2) dopamine receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	5
Mitogen-activated protein kinase 14	0	3	4	7
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	8	0	10
Carbonic anhydrase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Cyclooxygenase-2	0	2	0	2
Histone deacetylase 7	0	4	0	4
Rap guanine nucleotide exchange factor 4	3	0	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	4	0	4
P2Y purinoceptor 12	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	4	0	4
NFKB1 protein, partial	7	0	0	7
GALC protein	3	0	0	3
Thrombopoietin	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	15	0	0	15
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	2	0	2
Spike glycoprotein	0	1	4	5
Replicase polyprotein 1ab	0	1	5	6
glucose-6-phosphate 1-dehydrogenase isoform b	0	2	0	2
flap endonuclease 1	8	0	0	8
Transmembrane protease serine 2	0	1	4	5
Dihydrofolate reductase	0	3	0	3
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	0	3	0	3
Histidine-rich protein PFHRP-II	0	2	0	3
Alpha-2A adrenergic receptor	0	6	0	6
Replicase polyprotein 1a	0	1	4	5
Replicase polyprotein 1ab	0	1	4	5
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	4	7
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	2	4	6
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
streptokinase A precursor	0	0	3	3
endonuclease IV	6	0	0	6
PAX8	0	0	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C19 precursor	8	0	0	8
cytochrome P450 2C9 precursor	15	0	0	15
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
steroidogenic factor 1	0	1	0	1
Solute carrier family 22 member 3	0	5	0	5
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	4	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	8	0	10
Dihydrofolate reductase	0	4	0	4
Chymotrypsinogen A	0	1	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	0	0	2
5-hydroxytryptamine receptor 2A	0	3	0	4
Beta-galactosidase	0	1	0	2
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Solute carrier family 22 member 2	0	5	0	6
Solute carrier family 22 member 3	0	1	0	1
Mineralocorticoid receptor	0	2	2	4
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	5	0	8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Solute carrier family 22 member 1	0	8	0	9
Solute carrier family 22 member 2	0	8	0	8
dopamine D1 receptor	3	0	0	3
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	10	0	10
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	2	5
Glutamate receptor ionotropic, NMDA 2B	0	4	2	6
Glutamate receptor ionotropic, NMDA 2C	0	3	2	5
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	2	5
Glutamate receptor ionotropic, NMDA 3B	0	3	2	5
Glutamate receptor ionotropic, NMDA 3A	0	3	2	5
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Dihydrofolate reductase	0	6	0	7
5-hydroxytryptamine receptor 6	0	4	0	4
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	5	0	5
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	4	0	7
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	1	0	3
Solute carrier organic anion transporter family member 1A2	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	3	0	6
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier family 22 member 11	0	4	0	7
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	2
lysosomal alpha-glucosidase preproprotein	5	0	0	5
Aldo-keto reductase family 1 member B10	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	4	4
Transthyretin	0	2	2	7
Albumin	0	6	6	16
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	4	0	4
Aldo-keto reductase family 1 member B1	0	7	0	7
UDP-glucuronosyltransferase 1A4	0	3	0	4
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	3
UDP-glucuronosyltransferase 2B10	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Solute carrier family 22 member 6	0	12	0	15
UDP-glucuronosyltransferase 1A7	0	2	0	2
UDP-glucuronosyltransferase 1A10	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 7	0	3	0	6
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	11	0	13
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 7	0	3	0	4
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
DNA polymerase III, partial	1	0	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
NPYLR7B	0	0	1	1
serine-protein kinase ATM isoform a	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
tumor susceptibility gene 101 protein	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Caspase-7	3	0	0	3
Inositol monophosphatase 1	3	0	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	3	0	3
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Angiotensin-converting enzyme	0	1	0	1
Type-2 angiotensin II receptor	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	3	4	7
Tyrosine-protein kinase Fyn	0	1	4	5
Beta-2 adrenergic receptor	0	4	1	5
Beta-1 adrenergic receptor	0	4	1	5
D(2) dopamine receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	0	3
5-hydroxytryptamine receptor 1B	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 5A	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	2	5
Serine/threonine-protein kinase B-raf	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	5
Pantothenate synthetase	0	2	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
Cytochrome P450 2C19	0	6	0	6
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
Chain A, PROTEIN (TRANSTHYRETIN)	0	0	1	1
Chain B, PROTEIN (TRANSTHYRETIN)	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	13	0	0	13
Androgen receptor	0	3	2	5
Aldo-keto reductase family 1 member C4	0	4	0	4
Aldo-keto reductase family 1 member C3	0	8	0	8
Transcription factor SOX-18	0	1	0	1
Aldo-keto reductase family 1 member C2	0	5	0	5
Aldo-keto reductase family 1 member C1	0	5	0	5
Peroxisome proliferator-activated receptor alpha	2	0	0	2
Transcriptional enhancer factor TEF-3	0	1	1	2
Potassium channel subfamily K member 18	0	1	1	2
Acid-sensing ion channel 5	0	0	1	1
huntingtin isoform 2	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	6	6
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	6	0	0	6
Thymidylate synthase	0	5	0	5
Thymidylate synthase	0	3	0	4
Dihydrofolate reductase	0	4	3	7
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Bone morphogenetic protein receptor type-1B	0	0	4	4
Membrane-associated progesterone receptor component 1	0	0	4	4
Serine/threonine-protein kinase PLK4	0	1	4	5
ATP-dependent RNA helicase DDX3X	0	0	4	4
Pyridoxal kinase	0	0	4	4
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase Chk1	0	1	4	5
Aurora kinase A	0	1	4	5
Cyclin-G-associated kinase	0	0	4	4
Ephrin type-B receptor 6	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 3	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 2	0	1	4	5
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
Dynamin-like 120 kDa protein, mitochondrial	0	0	4	4
Eukaryotic translation initiation factor 5B	0	0	2	2
Rho-associated protein kinase 2	0	1	4	5
Serine/threonine-protein kinase ULK1	0	0	4	4
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	4	4
Ribosomal protein S6 kinase alpha-5	0	1	4	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	4	4
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 10	0	0	4	4
Serine/threonine-protein kinase D3	0	0	4	4
Structural maintenance of chromosomes protein 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 6	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Tyrosine-protein kinase ABL1	0	2	5	7
High affinity nerve growth factor receptor	0	0	4	4
ADP/ATP translocase 2	0	0	4	4
Protein kinase C beta type	0	0	4	4
Insulin receptor	0	2	4	6
Cyclin-dependent kinase 1	0	0	4	4
Glycogen phosphorylase, liver form	0	0	4	4
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Tyrosine-protein kinase Yes	0	0	4	4
Tyrosine-protein kinase Lyn	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	4	6
Insulin-like growth factor 1 receptor	0	0	4	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	4	4
Hepatocyte growth factor receptor	0	1	4	5
Tyrosine-protein kinase HCK	0	1	4	5
Platelet-derived growth factor receptor beta	0	1	4	5
Serine/threonine-protein kinase A-Raf	0	1	4	5
Glycogen phosphorylase, brain form	0	0	4	4
Breakpoint cluster region protein	0	1	4	5
Fibroblast growth factor receptor 1	0	1	4	5
DNA topoisomerase 2-alpha	0	0	4	4
Cyclin-dependent kinase 4	0	1	4	5
ADP/ATP translocase 3	0	0	4	4
Inosine-5'-monophosphate dehydrogenase 2	0	0	3	3
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	3	3
Serine/threonine-protein kinase B-raf	0	4	5	9
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Tyrosine-protein kinase Fer	0	0	4	4
Protein kinase C alpha type	0	1	4	5
cAMP-dependent protein kinase catalytic subunit alpha	0	0	4	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	4	4
Casein kinase II subunit alpha'	0	0	4	4
Ras-related protein Rab-6A	0	0	4	4
Ephrin type-A receptor 1	0	0	4	4
Multifunctional protein ADE2	0	0	4	4
cAMP-dependent protein kinase catalytic subunit gamma	0	0	4	4
cAMP-dependent protein kinase catalytic subunit beta	0	0	4	4
Ferrochelatase, mitochondrial	0	0	4	4
Tyrosine-protein kinase JAK1	0	3	5	10
Cyclin-dependent kinase 2	0	2	5	7
Beta-adrenergic receptor kinase 1	0	0	4	4
Probable ATP-dependent RNA helicase DDX6	0	0	4	4
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Deoxycytidine kinase	0	0	4	4
Mitogen-activated protein kinase 1	0	2	4	6
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-B receptor 2	0	0	4	4
Non-receptor tyrosine-protein kinase TYK2	0	3	5	10
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	4	4
S-adenosylmethionine synthase isoform type-2	0	0	4	4
DnaJ homolog subfamily A member 1	0	0	4	4
RAC-alpha serine/threonine-protein kinase	0	1	4	5
RAC-beta serine/threonine-protein kinase	0	0	4	4
DNA replication licensing factor MCM4	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 2	0	1	4	5
Receptor-type tyrosine-protein kinase FLT3	0	2	4	6
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Electron transfer flavoprotein subunit beta	0	0	3	3
Tyrosine-protein kinase CSK	0	1	4	5
Glycine--tRNA ligase	0	0	4	4
Protein kinase C iota type	0	0	4	4
Exosome RNA helicase MTR4	0	0	4	4
Tyrosine-protein kinase Tec	0	1	4	5
Tyrosine-protein kinase ABL2	0	0	4	4
Tyrosine-protein kinase FRK	0	0	4	4
Tyrosine-protein kinase SYK	0	0	4	4
26S proteasome regulatory subunit 6B	0	0	4	4
Mitogen-activated protein kinase 8	0	1	4	5
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	3	3
Casein kinase I isoform alpha	0	1	4	5
Casein kinase I isoform delta	0	0	4	4
MAP kinase-activated protein kinase 2	0	1	4	5
Elongation factor Tu, mitochondrial	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Casein kinase I isoform epsilon	0	0	4	4
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	4	4
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Glycogen synthase kinase-3 beta	0	2	4	6
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	3	3
Interleukin-1 receptor-associated kinase 1	0	0	4	4
Ribosomal protein S6 kinase alpha-3	0	1	4	5
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	1	4	5
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	4	4
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	1	4	5
Ephrin type-A receptor 4	0	0	4	4
Ras-related protein Rab-10	0	0	4	4
Actin-related protein 3	0	1	4	5
GTP-binding nuclear protein Ran	0	0	4	4
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Casein kinase I isoform gamma-2	0	0	4	4
Cyclin-dependent kinase 6	0	1	4	5
Cyclin-dependent-like kinase 5	0	1	4	5
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
ATP-dependent 6-phosphofructokinase, platelet type	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 1	0	2	4	6
DNA topoisomerase 2-beta	0	0	4	4
Protein kinase C theta type	0	0	4	4
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	0	4	4
Focal adhesion kinase 1	0	0	4	4
Protein kinase C delta type	0	0	4	4
Tyrosine-protein kinase BTK	0	1	4	5
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	4	4
Integrin-linked protein kinase	0	0	4	4
Rho-associated protein kinase 1	0	0	4	4
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	4	4
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
cGMP-dependent protein kinase 1	0	0	4	4
Cyclin-dependent kinase 13	0	0	4	4
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	3	3
Chromodomain-helicase-DNA-binding protein 4	0	0	4	4
Peroxisomal acyl-coenzyme A oxidase 1	0	0	3	3
Ephrin type-A receptor 7	0	0	4	4
Delta(24)-sterol reductase	0	0	3	3
Ribosomal protein S6 kinase alpha-1	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	4	4
Mitogen-activated protein kinase 11	0	1	4	5
Serine/threonine-protein kinase STK11	0	0	4	4
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
MAP kinase-activated protein kinase 3	0	0	3	3
Discoidin domain-containing receptor 2	0	1	4	5
AP2-associated protein kinase 1	0	0	4	4
Myosin light chain kinase 3	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	4	4
Rab-like protein 3	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	4	4
Serine/threonine-protein kinase N3	0	0	3	3
Serine/threonine-protein kinase ULK3	0	0	4	4
Uncharacterized protein FLJ45252	0	0	4	4
Acyl-CoA dehydrogenase family member 11	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	4	4
ATP-dependent RNA helicase DHX30	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	4	4
STE20-related kinase adapter protein alpha	0	0	4	4
Myosin-14	0	0	3	3
AarF domain-containing protein kinase 1	0	0	4	4
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
MAP kinase-activated protein kinase 5	0	1	4	5
Misshapen-like kinase 1	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	4	4
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	3	3
ATP-dependent RNA helicase DDX1	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Aurora kinase B	0	0	4	4
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	4	4
EKC/KEOPS complex subunit TP53RK	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	4	4
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Mitogen-activated protein kinase kinase kinase 3	0	0	4	4
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	4	4
Nucleolar GTP-binding protein 1	0	0	4	4
Serine/threonine-protein kinase D2	0	0	4	4
RNA cytidine acetyltransferase	0	0	4	4
Serine/threonine-protein kinase SIK2	0	0	4	4
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	4	4
dCTP pyrophosphatase 1	0	0	4	4
Dual specificity protein kinase CLK4	0	0	4	4
Casein kinase I isoform gamma-1	0	0	4	4
Serine/threonine-protein kinase PAK 6	0	0	4	4
Phenylalanine--tRNA ligase beta subunit	0	0	4	4
BMP-2-inducible protein kinase	0	0	4	4
Midasin	0	0	4	4
Interleukin-1 receptor-associated kinase 4	0	0	4	4
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	4	4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase 26	0	0	4	4
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	4	4
Serine/threonine-protein kinase TBK1	0	1	4	5
Septin-9	0	0	4	4
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO2	0	0	4	4
Long-chain-fatty-acid--CoA ligase 5	0	0	4	4
Serine/threonine-protein kinase ICK	0	0	4	4
RAC-gamma serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase 38-like	0	0	4	4
Serine/threonine-protein kinase SIK3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 2	0	0	4	4
Thyroid hormone receptor-associated protein 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	1	4	5
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	1	2	1	4
Glutamate receptor 3	1	2	1	4
Glutamate receptor 4	1	2	1	4
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	2
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Parkin	6	0	0	6
pyruvate kinase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	2	0	2
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	1	0	1
Genome polyprotein	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	5	0	9
Caspase-1	0	5	0	6
Caspase-3	0	3	0	3
Caspase-4	0	3	0	3
Caspase-5	0	3	0	3
Caspase-9	0	3	0	3
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	3	5
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	2	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
Adenine phosphoribosyltransferase	0	0	2	2
Tyrosine-protein kinase Fgr	0	0	3	3
Ribosomal protein S6 kinase beta-1	0	1	3	4
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	2	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	2	4
Phosphatidylinositol 4-kinase alpha	0	1	0	1
G protein-coupled receptor kinase 6	0	0	2	2
Adenosine kinase	0	0	3	3
Actin-related protein 2	0	0	2	2
Cyclin-dependent kinase 3	0	0	3	3
Serine/threonine-protein kinase 38	0	0	3	3
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	3	3
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	1	0	1
PAS domain-containing serine/threonine-protein kinase	0	0	3	3
NUAK family SNF1-like kinase 2	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	2	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	3	0	3
Nitric oxide synthase, inducible	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
C-X-C chemokine receptor type 3	0	1	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Prostaglandin D2 receptor	0	2	0	2
Lactoylglutathione lyase	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	4	1	5
Macrophage migration inhibitory factor	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Endonuclease 8-like 1	0	1	0	1
matrix metalloproteinase 1, partial	0	0	1	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	2	0	3
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Potassium voltage-gated channel subfamily D member 2	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, protease	0	0	1	1
Chain B, protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, PROTEASE RETROPEPSIN	0	1	0	1
Chain B, PROTEASE RETROPEPSIN	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Chain A, Protease Retropepsin	0	1	0	1
Chain B, Protease Retropepsin	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
CAAX prenyl protease 1 homolog	0	1	0	1
Plasmepsin V	0	2	0	2
Protease	0	4	3	7
Chain A, Antigen Cd11a (p180)	0	1	0	1
PINK1	1	0	0	1
bcl-2-related protein A1	0	1	0	1
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Integrin alpha-L	0	1	1	2
Substance-K receptor	0	4	0	4
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Myc proto-oncogene protein	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	3
Cytochrome P450 2C11	0	1	0	1
Acetylcholinesterase	0	2	0	2
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	3	0	4
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	4	0	5
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	3	0	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	3	0	5
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dihydrofolate reductase	0	2	0	3
Proton-coupled folate transporter	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Stromelysin-1	0	1	1	2
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Hormone-sensitive lipase	0	1	0	1
Interstitial collagenase	0	2	0	2
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Nrf2	1	0	0	1
Microphthalmia-associated transcription factor	0	0	0	1
caspase recruitment domain family, member 15	0	1	0	1
receptor-interacting serine/threonine-protein kinase 2 isoform 1	0	1	0	1
Beta lactamase (plasmid)	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Cystathionine gamma-lyase	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	4	0	6
Arylacetamide deacetylase	0	1	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Solute carrier family 22 member 4	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
NH(3)-dependent NAD(+) synthetase	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Vasopressin V1a receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Thromboxane-A synthase	0	0	0	1
Sodium/bile acid cotransporter	0	2	0	2
NS5	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	3
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Leukotriene C4 synthase	0	0	2	2
tyrosine-protein kinase Yes	2	0	0	2
melanocortin receptor 4	0	1	1	2
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase 25	0	0	2	2
Serine/threonine-protein kinase RIO3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 7	0	1	2	3
Peripheral plasma membrane protein CASK	0	0	2	2
Serine/threonine-protein kinase DCLK1	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	2	2
Mitogen-activated protein kinase 13	0	1	2	3
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	2	2
NUAK family SNF1-like kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	3	3	8
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	2	2
Serine/threonine-protein kinase 17B	0	0	2	2
Cyclin-dependent kinase 14	0	0	2	2
Serine/threonine-protein kinase OSR1	0	0	2	2
Serine/threonine-protein kinase Chk2	0	0	2	2
Tyrosine-protein kinase ABL1	0	1	0	1
RAF proto-oncogene serine/threonine-protein kinase	0	2	2	4
Platelet-derived growth factor receptor beta	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	2	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	2	2
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	1	2	3
Myosin light chain kinase, smooth muscle	0	0	2	2
Insulin receptor-related protein	0	0	2	2
Platelet-derived growth factor receptor alpha	0	1	2	3
Vascular endothelial growth factor receptor 1	0	1	2	3
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	2	2
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	2	2
Fibroblast growth factor receptor 2	0	0	2	2
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Fibroblast growth factor receptor 4	0	0	2	2
Fibroblast growth factor receptor 3	0	0	2	2
G1/S-specific cyclin-D1	0	1	0	1
Protein kinase C eta type	0	0	2	2
Cyclin-C	0	1	1	2
Activin receptor type-2A	0	0	2	2
Ephrin type-A receptor 3	0	0	2	2
Ephrin type-A receptor 8	0	0	2	2
Leukocyte tyrosine kinase receptor	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	0	2	2
Mitogen-activated protein kinase 4	0	0	2	2
G protein-coupled receptor kinase 4	0	0	2	2
Dual specificity protein kinase TTK	0	0	2	2
5-hydroxytryptamine receptor 7	0	1	0	1
Myosin-10	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	2	2
Vascular endothelial growth factor receptor 3	0	1	2	3
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Vascular endothelial growth factor receptor 2	0	2	3	6
Serine/threonine-protein kinase receptor R3	0	0	2	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase TXK	0	1	2	3
Tyrosine-protein kinase ZAP-70	0	0	2	2
Cyclin-dependent kinase 8	0	1	2	3
Dual specificity protein kinase CLK3	0	0	2	2
Tyrosine-protein kinase Blk	0	1	2	3
Cytoplasmic tyrosine-protein kinase BMX	0	1	2	3
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	2	2
Tyrosine-protein kinase JAK3	0	3	3	9
Death-associated protein kinase 1	0	0	2	2
Mitogen-activated protein kinase 12	0	1	2	3
Ephrin type-B receptor 1	0	0	2	2
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Cell division control protein 2 homolog	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
Tubulin alpha-1A chain	0	0	2	2
Casein kinase II subunit alpha	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	2	2
SRSF protein kinase 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 9	0	0	2	2
Protein delta homolog 1	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase-like 1	0	0	2	2
Protein kinase C epsilon type	0	0	2	2
Mitogen-activated protein kinase kinase kinase 10	0	0	2	2
Protein kinase C zeta type	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	2	2
Cyclin-dependent kinase 18	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	1	2	3
Myotonin-protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	1	2	3
Serine/threonine-protein kinase PAK 1	0	0	2	2
cGMP-dependent protein kinase 2	0	0	2	2
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	1	2	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1	0	0	2	2
Serine/threonine-protein kinase D1	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	1	2	3
Ribosomal protein S6 kinase alpha-2	0	0	2	2
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	2	2
BDNF/NT-3 growth factors receptor	0	0	2	2
Mitogen-activated protein kinase 6	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	2	2
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Serine/threonine-protein kinase TNNI3K	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase Nek5	0	0	2	2
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Serine/threonine-protein kinase tousled-like 2	0	0	2	2
Serine/threonine-protein kinase 32C	0	0	2	2
Serine/threonine-protein kinase pim-3	0	0	2	2
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	2	2
Homeodomain-interacting protein kinase 1	0	1	2	3
Calcium/calmodulin-dependent protein kinase type 1D	0	0	2	2
Cyclin-dependent kinase-like 3	0	0	2	2
Serine/threonine-protein kinase BRSK2	0	0	2	2
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Serine/threonine-protein kinase DCLK2	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	2	2
Casein kinase I isoform alpha-like	0	0	2	2
Homeodomain-interacting protein kinase 4	0	1	2	3
Myosin-IIIa	0	0	2	2
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	2	2
Serine/threonine-protein kinase Nek11	0	0	2	2
Serine/threonine-protein kinase BRSK1	0	0	2	2
Serine/threonine-protein kinase 35	0	0	2	2
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1G	0	0	2	2
Cyclin-dependent kinase 15	0	0	2	2
SRSF protein kinase 1	0	0	2	2
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	2	2
Serine/threonine-protein kinase RIO1	0	0	2	2
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	1	2	3
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase 33	0	0	2	2
Serine/threonine-protein kinase DCLK3	0	0	2	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	2	2
Poly [ADP-ribose] polymerase tankyrase-2	0	0	1	1
Homeodomain-interacting protein kinase 2	0	1	2	3
Tyrosine-protein kinase Srms	0	0	2	2
Homeodomain-interacting protein kinase 3	0	1	2	3
Serine/threonine-protein kinase PLK3	0	1	2	3
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	2	3
Serine/threonine-protein kinase Nek6	0	0	2	2
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	2	2
Serine/threonine-protein kinase 36	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	2	2
Serine/threonine-protein kinase PLK2	0	1	2	3
Serine/threonine-protein kinase MARK1	0	0	2	2
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	2	2
eIF-2-alpha kinase GCN2	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	2	2
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	2	2
Death-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase tousled-like 1	0	0	2	2
ALK tyrosine kinase receptor	0	0	2	2
SRSF protein kinase 3	0	0	2	2
Cyclin-dependent kinase 11A	0	0	2	2
Aurora kinase C	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit rho-2	0	0	0	1
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
Tumor necrosis factor	0	0	1	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Cystine/glutamate transporter	0	1	0	1
Endothelin-1 receptor	0	2	0	2
Hematopoietic prostaglandin D synthase	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Cocaine esterase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Vitamin D3 receptor	0	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Butyrophilin subfamily 3 member A1	0	0	1	2
72 kDa type IV collagenase	0	1	0	1
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Geranylgeranyl pyrophosphate synthase	0	2	0	2
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (857)

Protein Targets (1,817)

Polymyalgia Rheumatica

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (857)

Drugs Studied (208)

Protein Targets (1,817)