Page last updated: 2024-08-05 15:06:50
bronchoconstrictor agent
A drug which causes a narrowing of the lumen of a bronchus or bronchiole.
ChEBI ID: 50141
Members (7)
| Member | Definition | Class |
|---|---|---|
| 1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine | A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has octadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. | 2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine |
| 1-hexadecyl-2-acetyl-glycero-3-phosphocholine | A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis. | 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine |
| 8-epi-prostaglandin f2alpha | An isoprostane that is prostaglandin F2alpha having inverted stereochemistry at the 8-position. | 8-epi-prostaglandin F2alpha |
| 8-isoprostaglandin e2 | A prostanoid that is prostaglandin E2 having inverted stereochemistry at the 8-position. | 8-epi-prostaglandin E2 |
| leukotriene c4 | A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage. | leukotriene C4 |
| leukotriene d4 | A leukotriene that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 5 (5S) and a L-cysteinylglycinyl group at position 6 (6R). | leukotriene D4 |
| methacholine | A quaternary ammonium ion in which the nitrogen is substituted with three methyl groups and a 2-acetoxypropyl group. Parasympathomimetic bronchoconstrictor drug used in clinical diagnosis. | methacholine |
Research
Studies (12,275)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,316 (18.87) | 18.7374 |
| 1990's | 5,343 (43.53) | 18.2507 |
| 2000's | 2,853 (23.24) | 29.6817 |
| 2010's | 1,556 (12.68) | 24.3611 |
| 2020's | 207 (1.69) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 521 (3.99%) | 5.53% |
| Reviews | 1,097 (8.40%) | 6.00% |
| Case Studies | 71 (0.54%) | 4.05% |
| Observational | 19 (0.15%) | 0.25% |
| Other | 11,357 (86.93%) | 84.16% |
Protein Targets (26)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 42.5615 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 2.2387 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 6.9058 | 1 | 4 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 5.4800 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 0.0038 | 2 | 2 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Ki | 0.0004 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 0.0007 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Ki | 0.0003 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 2.7900 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 3.5933 | 2 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.0590 | 1 | 1 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0590 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 1.6000 | 1 | 1 |
| Platelet-activating factor receptor | Homo sapiens (human) | IC50 | 0.0003 | 1 | 1 |
| Platelet-activating factor receptor | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | EC50 | 0.0219 | 1 | 2 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | EC50 | 0.0066 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | EC50 | 0.4000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | EC50 | 0.1200 | 1 | 1 |
| NPYLR7B | Aedes aegypti (yellow fever mosquito) | EC50 | 20.0000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Km | 1.5000 | 1 | 1 |