ascorbic-acid and Wilms-Tumor

ascorbic-acid has been researched along with Wilms-Tumor* in 2 studies

Other Studies

2 other study(ies) available for ascorbic-acid and Wilms-Tumor

Article	Year
[Ways of antioxidative prevention of complications in immediate postoperative period in children with nephroblastoma]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 2000, Issue:6 The parameters of the activity of the antioxidative system (AOS) were studied in 85 patients aged 1 to 14 years who had nephroblastoma in the immediate postoperative period. They were compared with those in healthy children. To prevent AOS failure, Group 1 patients with nephroblastoma received ascorbic acid (AA) in a dose of 15 mg. Group 2 patients took a larger dose (25-30 mg) in combination with alpha-tocopherol. It was ascertained that the small dose of AA did not prevent AOS failure in the postoperative period while its larger doses prevented significant manifestations of antioxidative protective deficit, by reducing the incidence and severity of postoperative trophic complications. Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Kidney Neoplasms; Lipid Peroxidation; Nephrectomy; Postoperative Complications; Postoperative Period; Prognosis; Time Factors; Vitamin E; Wilms Tumor	2000
[Antioxidant defense status of children in the early post-operative period in Wilms' tumor] . Voprosy onkologii, 2000, Volume: 46, Issue:4 Lipid peroxidation (LP) was studied in 85 patients, aged 1-14, with Wilms tumor (stage II-IV). In addition to standard infusions, patients of group I received ascorbic acid (AA) 15 mg/body weight postoperatively while, in group II, AA 25-35 mg/body was supplemented with alpha-tocopherol 1.4-1.9 mg/body. LP was evaluated by assaying malonic dialdehyde (MDA) and--such enzymes A3 superoxide dismutase--SOD; catalase--CA and nonenzymatic components (AA and blood-alpha-tocopherol) for status of antioxidant defense. Medium mass molecules (MMM) were used as markers of endogenous intoxication. Said procedures were carried out before surgery and on days 1, 3 and 5 after operation. A significant decrease in endogenous AA and alpha-tocopherol was established, as compared with healthy children, while a significant increase was registered in MDA, MMM, SOD and CA levels. The LP investigation confirmed the systemic impact of tumor. Surgical stress contributed to the rise of LP thus compromising antioxidant defense. Postoperative administration of high doses of AA in combination with alpha-tocopherol reduced the rates of LP processes. Topics: Adolescent; Antioxidants; Ascorbic Acid; Catalase; Child; Child, Preschool; Female; Humans; Infant; Kidney Neoplasms; Lipid Peroxidation; Male; Malondialdehyde; Nephrectomy; Superoxide Dismutase; Time Factors; Vitamin E; Wilms Tumor	2000

Article

Year

[Ways of antioxidative prevention of complications in immediate postoperative period in children with nephroblastoma].

Vestnik Rossiiskoi akademii meditsinskikh nauk, 2000, Issue:6

The parameters of the activity of the antioxidative system (AOS) were studied in 85 patients aged 1 to 14 years who had nephroblastoma in the immediate postoperative period. They were compared with those in healthy children. To prevent AOS failure, Group 1 patients with nephroblastoma received ascorbic acid (AA) in a dose of 15 mg. Group 2 patients took a larger dose (25-30 mg) in combination with alpha-tocopherol. It was ascertained that the small dose of AA did not prevent AOS failure in the postoperative period while its larger doses prevented significant manifestations of antioxidative protective deficit, by reducing the incidence and severity of postoperative trophic complications.

Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Child, Preschool; Drug Therapy, Combination; Humans; Infant; Kidney Neoplasms; Lipid Peroxidation; Nephrectomy; Postoperative Complications; Postoperative Period; Prognosis; Time Factors; Vitamin E; Wilms Tumor

2000

[Antioxidant defense status of children in the early post-operative period in Wilms' tumor] .

Voprosy onkologii, 2000, Volume: 46, Issue:4

Lipid peroxidation (LP) was studied in 85 patients, aged 1-14, with Wilms tumor (stage II-IV). In addition to standard infusions, patients of group I received ascorbic acid (AA) 15 mg/body weight postoperatively while, in group II, AA 25-35 mg/body was supplemented with alpha-tocopherol 1.4-1.9 mg/body. LP was evaluated by assaying malonic dialdehyde (MDA) and--such enzymes A3 superoxide dismutase--SOD; catalase--CA and nonenzymatic components (AA and blood-alpha-tocopherol) for status of antioxidant defense. Medium mass molecules (MMM) were used as markers of endogenous intoxication. Said procedures were carried out before surgery and on days 1, 3 and 5 after operation. A significant decrease in endogenous AA and alpha-tocopherol was established, as compared with healthy children, while a significant increase was registered in MDA, MMM, SOD and CA levels. The LP investigation confirmed the systemic impact of tumor. Surgical stress contributed to the rise of LP thus compromising antioxidant defense. Postoperative administration of high doses of AA in combination with alpha-tocopherol reduced the rates of LP processes.

Topics: Adolescent; Antioxidants; Ascorbic Acid; Catalase; Child; Child, Preschool; Female; Humans; Infant; Kidney Neoplasms; Lipid Peroxidation; Male; Malondialdehyde; Nephrectomy; Superoxide Dismutase; Time Factors; Vitamin E; Wilms Tumor

2000