thiazolidinediones

A thiadiazolidine in which the 1,3-thiazolidine ring is substituted by two oxo groups.

ChEBI ID: 50990

Members (5)

Member	Definition	Role
2-[2,4-dioxo-3-(phenylmethyl)-5-thiazolidinyl]acetic acid		2-[2,4-dioxo-3-(phenylmethyl)-5-thiazolidinyl]acetic acid
as 605240	A quinoxaline derivative that is quinoxaline in which the hydrogen at position 6 is replaced by a (2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl group. It is a potent inhibitor of the PI3Kgamma, with an IC50 of 8 nM and inhibits the progression of joint inflammation and damage in both lymphocyte-independent and dependent mouse models of rheumatoid arthritis.	(5Z)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione
hydroxypioglitazone	A member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone.	hydroxypioglitazone
pioglitazone	A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.	pioglitazone
rosiglitazone		rosiglitazone