A substance used to destroy pests of the phylum Nematoda (roundworms).
| Member | Definition | Class |
|---|
| (2e)-decenal | A dec-2-enal in which the olefinic double bond has E configuration. | (2E)-dec-2-enal |
| 1,3-dichloropropane | A chloroalkane that is propane in which a hydrogen from each of the terminal methyl groups has been replaced by a chlorine. | 1,3-dichloropropane |
| 2,4-decadienal | A polyunsaturated fatty aldehyde that is decanal which has undergone formal dehydrogenation to introduce trans- double bonds at the 2-3 and 4-5 positions. A product of lipid peroxidation in cell membranes and a component of cooking oil fumes. | (2E,4E)-deca-2,4-dienal |
| 5-hydroxymethyl-2-furoic acid | A member of the class of furoic acids that is 2-furoic acid substituted at position 5 by a hydroxymethyl group. | 5-hydroxymethyl-2-furoic acid |
| cadusafos | | cadusafos |
| carbofuran | | carbofuran |
| chloropicrin | A C-nitro compound that is nitromethane in which all three hydrogens are replaced by chlorines. It is a severe irritant, and can cause immediate, severe inflammation of the eyes, nose and throat, and significant injuries to the upper and lower respiratory tract. Formerly stockpiled as a chemical warfare agent, it has been widely used in the US as a soil fumigant, particularly for strawberry crops. It is not approved for use within the European Union. | chloropicrin |
| dazomet | A dithiocarbamic ester that is 1,3,5-thiadiazinane with a thione moiety at position 2 and in which the hydrogens attached to the nitrogens are replaced by methyl groups. A fungicide, herbicide and nematicide, it is used prior to sowing or planting for the control of soil fungi, nematodes, bacteria and germinating weeds, and as fumigant for poultry litter and eggs to control Salmonella. It is a non-ozone-depleting alternative to methyl bromide. | dazomet |
| diazinon | A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4. | diazinon |
| dibutylaminosulfenylcarbofuran | | carbosulfan |
| fensulfothion | | fensulfothion |
| flavone | The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2. | flavone |
| fluazaindolizine | A member of the class of imidazopyridines that is the amide formed from the formal condensation of the carboxy group of 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylic acid with the sulfonamide nitrogen of 2-chloro-5-methoxybenzene-1-sulfonamide. | fluazaindolizine |
| fluensulfone | A member of the class of 1,3-thiazoles carrying 3,4,4-trifluorobut-3-ene-1-sulfonyl and chloro substituents at positions 2 and 5 respectively. A nematicide that is effective against a number of plant parasitic nematodes in a range of agricultural and horticultural crops. | fluensulfone |
| fosthiazate | | fosthiazate |
| iprodione | An imidazolidine-2,4-dione in which the nitrogen at position 1 is substituted by an N-(isopropyl)carboxamide group while that at position 3 is substituted by a 3,5-dichlorophenyl group. A contact fungicide, it blocks the growth of the fungal mycelium and inhibits the germination of fungal spores. It is used on fruit and vegetable crops affected by various fungal diseases. It is also used as a nematicide. | iprodione |
| menthofuran | A monoterpenoid that is 4,5,6,7-tetrahydro-1-benzofuran substituted by methyl groups at positions 3 and 6. | menthofuran |
| methomyl | A carbamate ester obtained by the formal condensation of methylcarbamic acid with the hydroxy group of 1-(methylsulfanyl)acetaldoxime. | methomyl |
| methyl cinnamate | The E (trans) isomer of methyl cinnamate. | methyl trans-cinnamate |
| methyl isothiocyanate | An isothiocyanate having a methyl group attached to the nitrogen. It is also the active nematicide of the pronematicide metam-sodium. | methyl isothiocyanate |
| monepantel | A secondary carboxamide resulting from the formal condensation of the carboxy group of p-[(trifluoromethyl)sulfanyl]benzoic acid with the amino group of (2S)-2-amino-3-hydroxy-2-methylpropanenitrile in which the hydroxy group has been converted to the corresponding 5-cyano-2-(trifluoromethyl)phenyl ether. A broad-spectrum nematicide, it is used to control gastrointestinal roundworms in sheep and goats. | monepantel |
| oligomycin a | An oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents. | oligomycin A |
| salicylaldehyde | A hydroxybenzaldehyde carrying a hydroxy substituent at position 2. | salicylaldehyde |
| terbufos | | terbufos |
| tioxazafen | A 1,2,4-oxadizole in which the hydrogens at positions 3 and 5 have been replaced by phenyl and thiophen-2-yl groups, respectively. It is used as a broad spectrum nematicidal seed treatment. | tioxazafen |
| triazophos | | triazophos |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 31.7252 | 4 | 37 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.7612 | 2 | 6 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 28.2095 | 1 | 7 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 17.7828 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 29.8017 | 11 | 52 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 18.6791 | 3 | 23 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.5814 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 34.8640 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 29.3104 | 2 | 5 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 37.2047 | 1 | 3 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 45.3012 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 37.2047 | 1 | 3 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 45.3012 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 45.4983 | 3 | 14 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 0.0050 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 35.4813 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 12.7604 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 8.0687 | 1 | 2 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 12.7604 | 1 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 5.9593 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 25.0409 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.8006 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 14.5368 | 1 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.2148 | 1 | 8 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.3783 | 11 | 68 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 26.3717 | 2 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 27.8836 | 10 | 59 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 36.9751 | 2 | 10 |
| G | Vesicular stomatitis virus | Potency | 5.9593 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 8.8006 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 5.7314 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 25.9775 | 3 | 24 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 16.2710 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 21.5635 | 5 | 18 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 38.6584 | 1 | 5 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 29.5816 | 2 | 13 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 19.1728 | 2 | 4 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 82.2183 | 2 | 11 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 5.9593 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 22.0891 | 1 | 4 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 5.9593 | 1 | 4 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.0050 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.0050 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 21.9492 | 2 | 3 |
| interleukin 8 | Homo sapiens (human) | Potency | 72.2601 | 1 | 3 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 45.1489 | 3 | 9 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 7.6922 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 30.9973 | 4 | 23 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 5.8235 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.2836 | 1 | 5 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 9.1840 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.3979 | 3 | 47 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 52.6978 | 4 | 11 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.5734 | 5 | 18 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 53.8820 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 39.8301 | 2 | 30 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 44.7275 | 1 | 6 |
| progesterone receptor | Homo sapiens (human) | Potency | 48.9848 | 2 | 11 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 24.6737 | 2 | 25 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 29.4796 | 3 | 33 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.4426 | 4 | 30 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 15.3917 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 15.3917 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 2.3109 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 12.5893 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 30.4167 | 2 | 5 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 37.3998 | 3 | 27 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 4.3152 | 1 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 27.9293 | 6 | 26 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 18.2200 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 21.8503 | 4 | 13 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 38.6584 | 1 | 5 |