Page last updated: 2024-12-05

adenosine phosphosulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Adenosine phosphosulfate (APS) is a key intermediate in the biosynthesis of various sulfur-containing compounds, including sulfolipids, sulfated polysaccharides, and steroid sulfates. It is synthesized from adenosine triphosphate (ATP) and inorganic sulfate by the enzyme ATP sulfurylase. APS plays a crucial role in the sulfur assimilation pathway, enabling the incorporation of sulfate into organic molecules. It is also involved in the detoxification of xenobiotics by catalyzing the sulfation of various compounds. The study of APS is important for understanding the regulation of sulfur metabolism, the biosynthesis of essential sulfur-containing biomolecules, and the detoxification processes in living organisms.'

Adenosine Phosphosulfate: 5'-Adenylic acid, monoanhydride with sulfuric acid. The initial compound formed by the action of ATP sulfurylase on sulfate ions after sulfate uptake. Synonyms: adenosine sulfatophosphate; APS. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

5'-adenylyl sulfate : An adenosine 5'-phosphate having a sulfo group attached to one the phosphate OH groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID10238
CHEMBL ID572546
CHEBI ID17709
SCHEMBL ID163762
MeSH IDM0000390

Synonyms (41)

Synonym
adenosine sulfatophosphate
adenosine 5'-sulfatophosphate
amps
brn 0067726
5'-adenylyl hydrogen sulfate
adenosine-5'-phosphosulfate
adenylylsulfate
CHEBI:17709 ,
5'-adenylic acid, monoanhydride with sulfuric acid
[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl sulfo hydrogen phosphate
amp-s, brn-0067726
adenosine phosphosulfate (aps)
[({[(2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]sulfonic acid
bdbm25461
adenosine 5-phosphosulfate
ADX ,
C00224
adenylyl sulfate
5'-adenylyl sulfate
adenosine phosphosulfate
485-84-7
adenosine 5'-phosphosulfate
DB03708
57D51844-70A4-4E5C-A9EF-DF05C8DC73A2
CHEMBL572546
4-26-00-03628 (beilstein handbook reference)
SCHEMBL163762
IRLPACMLTUPBCL-KQYNXXCUSA-N
adenosine-5'-phosphosulfate sodium salt
adenylic acid monoanhydride with sulfurate
adenylic acid monoanhydride with sulfuric acid
sulfatophosphate
phosphosulfate
adenylyl-sulphate
adenylyl sulphate
adenosine 5'-phosphosulphate
phosphosulphate
adenosine phosphosulphate
5'-o-[(s)-hydroxy(sulfooxy)phosphoryl]adenosine
Q356138
(((2r,3s,4r,5r)-5-(6-amino-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphoric) sulfuric anhydride

Research Excerpts

Overview

Adenosine phosphosulfate is a potent inhibitor of adenylylsulfate kinase. concentration for maximal reaction is dependent on the ATP concentration.

ExcerptReferenceRelevance
"Adenosine phosphosulfate is a potent inhibitor of adenylylsulfate kinase, but the adenosine phosphosulfate concentration for maximal reaction is dependent on the ATP concentration."( Purification and some properties of liver adenylylsulfate kinase.
Hommes, FA; Moss, L; Touchton, J, 1987
)
0.99
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
adenosine 5'-phosphate
acyl monophosphateAn organic phosphate ester or anhydride formed by condensation of phosphoric acid with a carboxylic acid.
acyl sulfate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (19)

PathwayProteinsCompounds
Sulfate/Sulfite Metabolism620
Sulfite Oxidase Deficiency620
Cysteine Biosynthesis1329
Sulfur Metabolism2833
Sulfur Metabolism (Butanesulfonate)2834
Sulfur Metabolism (Propanesulfonate)2834
Sulfur Metabolism (Ethanesulfonate)2834
Sulfur Metabolism (Isethionate)2834
Sulfur Metabolism (Methanesulfonate)2834
Monobactam Biosynthesis718
Purine nucleotides and Nucleosides metabolism ( Purine nucleotides and Nucleosides metabolism )10577
Mycobacterium tuberculosis biological processes3962
Sulfur compound metabolism1929
Sulfate assimilation712
Cysteine synthesis from O-acetylserine715
sulfate assimilation011
Sulfate assimilation and copper detoxification020
Sulfur degradation05
Biochemical pathways: part I0466
Sulfation biotransformation reaction010

Bioassays (1)

Assay IDTitleYearJournalArticle
AID440574Binding affinity to Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase assessed as S-sulfocysteine formation at pH 5.5 by single turnover method in absence of thioredoxin2009Journal of medicinal chemistry, Sep-10, Volume: 52, Issue:17
Identification of critical ligand binding determinants in Mycobacterium tuberculosis adenosine-5'-phosphosulfate reductase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (106)

TimeframeStudies, This Drug (%)All Drugs %
pre-199031 (29.25)18.7374
1990's21 (19.81)18.2507
2000's31 (29.25)29.6817
2010's21 (19.81)24.3611
2020's2 (1.89)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 34.73

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index34.73 (24.57)
Research Supply Index4.70 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index46.20 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (34.73)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews8 (7.34%)6.00%
Case Studies1 (0.92%)4.05%
Observational0 (0.00%)0.25%
Other100 (91.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]