dihydroisotanshinone i

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dihydroisotanshinone I (DHTS-I) is a natural compound isolated from the root of the medicinal herb Salvia miltiorrhiza (Danshen), traditionally used in Traditional Chinese Medicine for the treatment of cardiovascular diseases. It has garnered significant research interest due to its diverse pharmacological activities, including antioxidant, anti-inflammatory, anti-cancer, and neuroprotective effects. DHTS-I has been shown to inhibit the production of reactive oxygen species (ROS), reduce inflammation by suppressing the production of pro-inflammatory cytokines, and induce apoptosis in cancer cells. It is also reported to protect neurons from damage caused by oxidative stress. The mechanism of action of DHTS-I involves multiple targets, including the activation of Nrf2, a key transcription factor involved in antioxidant defense, and the inhibition of various signaling pathways associated with inflammation and cancer development. DHTS-I is currently under investigation for its potential therapeutic applications in various diseases, including cardiovascular diseases, cancer, neurodegenerative disorders, and inflammatory conditions.'

dihydroisotanshinone I: isolated from the root of Salvia miltiorrhiza Bunge; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Salvia	genus	A genus in the mint family (LAMIACEAE).[MeSH]	Lamiaceae	The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Salvia miltiorrhiza	species	A plant species which is known as an Oriental traditional medicinal plant.[MeSH]	Lamiaceae	The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID Source	ID
PubMed CID	89406
SCHEMBL ID	13568194
MeSH ID	M0135498

Synonyms (18)

Synonym
dihydroisotanshinone i
4,8-dimethyl-8,9-dihydronaphtho[2,1-f][1]benzofuran-7,11-dione
20958-18-3
phenanthro(3,2-b)furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-
4,8-dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione
SCHEMBL13568194
AC-35146
4,8-dimethyl-8,9-dihydrophenanthro[3,2-b]furan-7,11-dione #
phenanthro[3,2-b]furan-7,11-dione, 8,9-dihydro-4,8-dimethyl-
KXNYCALHDXGJSF-UHFFFAOYSA-N
AKOS028109839
CS-6505
HY-B1919
FT-0766994
DTXSID60943247
4,8-dimethyl-7h,8h,9h,11h-phenanthro[3,2-b]furan-7,11-dione
PD078596
FS-6927

Research Excerpts

Overview

Dihydroisotanshinone I is a phenanthrenequinone derivative isolated from the roots of Salvia trijuga Diels.

Excerpt	Reference	Relevance
"Dihydroisotanshinone I is a phenanthrenequinone derivative isolated from the roots of Salvia trijuga Diels. "	( Dihydroisotanshinone I protects against menadione-induced toxicity in a primary culture of rat hepatocytes. Che, CT; Ip, SP; Sun, HD; Yang, H, 2002)	3.2

Compound-Compound Interactions

Excerpt	Reference	Relevance
" Despite that sophisticated techniques of radiotherapy and radiation combined with chemotherapy were applied to the patients, some tumors may recur."	( Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway. Cheng, YC; Lee, IY; Lin, CL; Lin, WY; Lin, YS; Lin, YY; Shu, LH; Wu, CY; Yang, YH, 2018)	1.92

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (11.11)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (11.11)	29.6817
2010's	4 (44.44)	24.3611
2020's	3 (33.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.82 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	5.12 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.82)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	2.01	1	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.01	1	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
oxidopamine Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.. oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).	2.6	1	benzenetriol; catecholamine; primary amino compound	drug metabolite; human metabolite; neurotoxin
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.47	2	dialdehyde	biomarker
1,7-phenanthroline [no description available]	1.96	1	phenanthroline
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.01	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	3.57	8

Condition	Relationship Strength	Studies
Idiopathic Parkinson Disease [description not available]	2.6	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.6	1
Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)	2.6	1
Cancer of Lung [description not available]	2.31	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.31	1
Carcinoma, Squamous Cell of Head and Neck [description not available]	2.31	1
Cancer of Head [description not available]	2.31	1
Squamous Cell Carcinoma of Head and Neck The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.	2.31	1
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	2.31	1
Cancer of Colon [description not available]	2.15	1
Experimental Neoplasms [description not available]	2.15	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.15	1
Cancer of Prostate [description not available]	2.57	2
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.57	2
Cancer of Cervix [description not available]	2.07	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.07	1

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