An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly.
| Member | Definition | Class |
|---|
| amprenavir | | amprenavir |
| atazanavir | A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV). | atazanavir |
| darunavir | An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors. | darunavir |
| indinavir sulfate | | indinavir |
| isovanillin | A member of the class of benzaldehydes that is 4-methoxybenzaldehyde substituted by a hydroxy group at position 3. It is an inhibitor of aldehyde oxidase. | isovanillin |
| lopinavir | A dicarboxylic acid diamide that is amphetamine is substituted on nitrogen by a (2,6-dimethylphenoxy)acetyl group and on the carbon alpha- to nitrogen by a (1S,3S)-1-hydroxy-3-{[(2S)-3-methyl-2-(2-oxotetrahydropyrimidin-1-yl)butanoyl]amino}-4-phenylbutyl group. An antiretroviral of the protease inhibitor class, it is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir. | lopinavir |
| nelfinavir | An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties. | nelfinavir |
| nelfinavir mesylate | A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties. | nelfinavir mesylate |
| ritonavir | An L-valine derivative that is L-valinamide in which alpha-amino group has been acylated by a [(2-isopropyl-1,3-thiazol-4-yl)methyl]methylcarbamoyl group and in which a hydrogen of the carboxamide amino group has been replaced by a (2R,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl group. A CYP3A inhibitor and antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS, it is often used as a fixed-dose combination with another protease inhibitor, lopinavir. Also used in combination with dasabuvir sodium hydrate, ombitasvir and paritaprevir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as cirrhosis of the liver. | ritonavir |
| salvin | An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity. | carnosic acid |
| saquinavir | An aspartic acid derivative obtained by formal condensation of the primary amino group of (2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-ylamine with the carboxy group of N(2)(-quinolin-2-ylcarbonyl)-L-asparagine. An inhibitor of HIV-1 protease. | saquinavir |
| tipranavir | A pyridine-2-sulfonamide substituted at C-5 by a trifluoromethyl group and at the sulfonamide nitrogen by a dihydropyrone-containing m-tolyl substituent. It is an HIV-1 protease inhibitor. | tipranavir |
| xv 638 | A member of the class of diazepanones that is 1,3-diazepane which is substituted by a 3-(1,3-thiazol-2-ylcarbamoyl)benzyl group at positions 1 and 3, oxo group at position 2, hydroxy groups at positions 5S and 6S, and benzyl groups at positions 4R and 7R. It is a potent HIV-1 protease inhibitor. | XV638 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 10.0241 | 2 | 6 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 26.8325 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.2094 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 31.3540 | 2 | 2 |
| AR protein | Homo sapiens (human) | Potency | 25.8545 | 9 | 17 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 23.4124 | 1 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 16.5746 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 16.5746 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 15.7776 | 1 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 23.0925 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 35.7168 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 22.8817 | 1 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 9.9763 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 106.1010 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 12.1467 | 1 | 6 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 22.1837 | 1 | 6 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 1.5849 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 0.7807 | 2 | 7 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 33.4915 | 1 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.1413 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 47.0685 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 23.0601 | 7 | 19 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 20.5613 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 20.9417 | 8 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 14.4182 | 4 | 12 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 23.6090 | 4 | 5 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 36.6412 | 1 | 3 |
| G | Vesicular stomatitis virus | Potency | 12.1467 | 1 | 6 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 1.5849 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 15.4169 | 2 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 17.0765 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 19.4458 | 1 | 3 |
| GLS protein | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 16.8751 | 4 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 33.4915 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 39.1512 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 0.3548 | 1 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 27.8474 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 12.1467 | 1 | 6 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 18.9003 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 12.1467 | 1 | 12 |
| Interferon beta | Homo sapiens (human) | Potency | 12.1467 | 1 | 6 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 19.6932 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 21.3120 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 1.9912 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 19.9526 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.8227 | 4 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 28.0383 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 8.4127 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.0574 | 2 | 6 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 16.8037 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 26.2887 | 2 | 3 |
| Parkin | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.9242 | 2 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 15.7905 | 5 | 11 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 10.0485 | 3 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 2.0262 | 2 | 2 |
| PINK1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 8.3409 | 1 | 3 |
| polyprotein | Zika virus | Potency | 36.6412 | 1 | 3 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 28.9342 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 10.9606 | 3 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 25.4741 | 2 | 3 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 19.9990 | 2 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 3.7827 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 14.0880 | 4 | 6 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 23.9145 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 23.9145 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 21.6380 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 0.7079 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.3012 | 2 | 15 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 63.0957 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 22.8818 | 2 | 9 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 23.7434 | 2 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 8.3409 | 1 | 3 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 8.3409 | 1 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 42.5231 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 33.4915 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 4.2730 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 2.4420 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 4.2730 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 2.4420 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 14.7960 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 8.3630 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 8.8520 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 8.7790 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 61.3773 | 2 | 9 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 8.3630 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 61.3773 | 2 | 9 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 8.3630 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 67.2000 | 1 | 8 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 36.3890 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 24.2590 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 70.5167 | 1 | 6 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 25.8952 | 12 | 31 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 40.4600 | 4 | 10 |
| B-cell CLL/lymphoma 9 protein | Homo sapiens (human) | IC50 | 5.2130 | 1 | 1 |
| B-cell CLL/lymphoma 9 protein | Homo sapiens (human) | Ki | 4.8780 | 3 | 3 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 34.0800 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 25.5660 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 14.3232 | 6 | 19 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 42.6500 | 3 | 8 |
| CAAX prenyl protease 1 homolog | Mus musculus (house mouse) | IC50 | 9.8000 | 1 | 2 |
| Cadherin-1 | Homo sapiens (human) | Ki | 387.2000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 6 |
| Catenin beta-1 | Homo sapiens (human) | IC50 | 5.2130 | 1 | 1 |
| Catenin beta-1 | Homo sapiens (human) | Ki | 4.8780 | 3 | 3 |
| Cathepsin D | Homo sapiens (human) | IC50 | 15.2000 | 1 | 1 |
| Cathepsin D | Homo sapiens (human) | Ki | 15.0000 | 1 | 1 |
| Cathepsin E | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| Chain A, ASPARTYLPROTEASE | Human immunodeficiency virus 1 | Ki | 0.0020 | 1 | 1 |
| Chain A, Endothiapepsin | Cryphonectria parasitica (chestnut blight fungus) | Ki | 0.0150 | 1 | 2 |
| Chain A, gag-pro-pol polyprotein | DG-75 Murine leukemia virus | Ki | 0.0002 | 1 | 3 |
| Chain A, HIV-1 protease | Human immunodeficiency virus 1 | IC50 | 0.0028 | 1 | 2 |
| Chain A, HIV-1 Protease | Human immunodeficiency virus 1 | Ki | 0.0046 | 1 | 24 |
| Chain A, HIV-1 Protease | Human immunodeficiency virus type 1 (BH5 ISOLATE) | Ki | 0.0079 | 1 | 9 |
| Chain A, HIV-1 protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Ki | 0.0001 | 1 | 1 |
| Chain A, Hiv-1 Protease | Human immunodeficiency virus type 1 (CLONE 12) | Ki | 0.0001 | 1 | 1 |
| Chain A, HIV-II PROTEASE | Human immunodeficiency virus 1 | Ki | 0.0004 | 1 | 2 |
| Chain A, Pol polyprotein | Human immunodeficiency virus 1 | Ki | 0.4354 | 1 | 24 |
| Chain A, Pol polyprotein | Human immunodeficiency virus type 1 (BH5 ISOLATE) | Ki | 0.0096 | 1 | 3 |
| Chain A, Protease | Human immunodeficiency virus 1 | Ki | 0.0013 | 1 | 77 |
| Chain A, Protease | Human immunodeficiency virus 2 | Ki | 0.0016 | 1 | 4 |
| Chain A, Protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Ki | 0.0019 | 1 | 2 |
| Chain A, Protease Retropepsin | Human immunodeficiency virus 1 | Ki | 0.0019 | 1 | 14 |
| Chain A, PROTEIN (HIV-1 PROTEASE) | Human immunodeficiency virus 1 | Ki | 0.0010 | 1 | 13 |
| Chain A, PROTEIN (PROTEASE) | Human immunodeficiency virus 1 | Ki | 0.0003 | 1 | 2 |
| Chain B, ASPARTYLPROTEASE | Human immunodeficiency virus 1 | Ki | 0.0020 | 1 | 1 |
| Chain B, gag-pro-pol polyprotein | DG-75 Murine leukemia virus | Ki | 0.0002 | 1 | 3 |
| Chain B, HIV-1 protease | Human immunodeficiency virus 1 | IC50 | 0.0028 | 1 | 2 |
| Chain B, HIV-1 Protease | Human immunodeficiency virus 1 | Ki | 0.0046 | 1 | 24 |
| Chain B, HIV-1 Protease | Human immunodeficiency virus type 1 (BH5 ISOLATE) | Ki | 0.0079 | 1 | 9 |
| Chain B, HIV-1 protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Ki | 0.0001 | 1 | 1 |
| Chain B, Hiv-1 Protease | Human immunodeficiency virus type 1 (CLONE 12) | Ki | 0.0001 | 1 | 1 |
| Chain B, HIV-II PROTEASE | Human immunodeficiency virus 1 | Ki | 0.0004 | 1 | 2 |
| Chain B, Pol Polyprotein | Human immunodeficiency virus 1 | Ki | 0.4972 | 1 | 21 |
| Chain B, Pol polyprotein | Human immunodeficiency virus type 1 (BH5 ISOLATE) | Ki | 0.0096 | 1 | 3 |
| Chain B, Protease | Human immunodeficiency virus 1 | Ki | 0.0013 | 1 | 77 |
| Chain B, Protease | Human immunodeficiency virus 2 | Ki | 0.0016 | 1 | 4 |
| Chain B, Protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Ki | 0.0019 | 1 | 2 |
| Chain B, protease RETROPEPSIN | Human immunodeficiency virus 1 | Ki | 0.0019 | 1 | 14 |
| Chain B, PROTEIN (HIV-1 PROTEASE) | Human immunodeficiency virus 1 | Ki | 0.0010 | 1 | 13 |
| Chain B, PROTEIN (PROTEASE) | Human immunodeficiency virus 1 | Ki | 0.0003 | 1 | 2 |
| Chloroquine resistance transporter | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 13.0000 | 2 | 2 |
| Cruzipain | Trypanosoma cruzi | IC50 | 222.0000 | 2 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 12.7000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.4580 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 9.2000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 28.0750 | 4 | 4 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.4491 | 9 | 16 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.8111 | 4 | 9 |
| Cytochrome P450 3A5 | Homo sapiens (human) | Ki | 0.2967 | 2 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 12.9350 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 6.4670 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 15.3660 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 5.2190 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 47.1585 | 1 | 2 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 16.6245 | 1 | 2 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 55.6290 | 1 | 1 |
| Exoribonuclease H | Human immunodeficiency virus 2 | IC50 | 0.0005 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Gag polyprotein | HIV-1 M:B_MN | IC50 | 0.0154 | 1 | 3 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (BRU ISOLATE) | IC50 | 0.0145 | 2 | 3 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | IC50 | 0.0288 | 10 | 19 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 2 (ISOLATE ROD) | IC50 | 0.0055 | 1 | 2 |
| Gag-Pol polyprotein | HIV-1 M:B_ARV2/SF2 | Ki | 0.0109 | 2 | 17 |
| Gag-Pol polyprotein | HIV-1 M:B_HXB2R | Ki | 0.4046 | 5 | 55 |
| Gag-Pol polyprotein | HIV-1 M:K_96CM-MP535 | Ki | 0.0001 | 1 | 4 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (BRU ISOLATE) | Ki | 0.0248 | 10 | 92 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | Ki | 0.0051 | 5 | 17 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (RF/HAT ISOLATE) | Ki | 0.0505 | 1 | 42 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (STRAIN UGANDAN / ISOLATE U455) | Ki | 0.0505 | 1 | 42 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 2 (ISOLATE ROD) | Ki | 0.0020 | 1 | 10 |
| Genome polyprotein | Human rhinovirus sp. | IC50 | 0.0005 | 1 | 1 |
| Genome polyprotein | Human rhinovirus sp. | Ki | 0.0033 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| Kappa-type opioid receptor | Homo sapiens (human) | IC50 | 18.8673 | 1 | 3 |
| Kappa-type opioid receptor | Homo sapiens (human) | Ki | 7.5467 | 1 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 18.2240 | 1 | 1 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 22.5030 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 29.8663 | 1 | 3 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 12.1240 | 1 | 3 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 2.9967 | 3 | 6 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 133.9750 | 2 | 4 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 83.8333 | 1 | 6 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 86.0740 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 61.8400 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Pepsin A-5 | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| Plasmepsin V | Plasmodium falciparum 3D7 | IC50 | 20.0000 | 1 | 2 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 500.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 13.7970 | 1 | 1 |
| Potassium voltage-gated channel subfamily D member 3 | Homo sapiens (human) | IC50 | 2,555.9350 | 2 | 2 |
| Potassium voltage-gated channel subfamily E member 1 | Homo sapiens (human) | IC50 | 148.5932 | 3 | 3 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 4,062.0840 | 8 | 8 |
| Potassium voltage-gated channel subfamily KQT member 1 | Homo sapiens (human) | IC50 | 148.5932 | 3 | 3 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 0.1573 | 82 | 91 |
| Protease | Human immunodeficiency virus | Ki | 0.0004 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0110 | 126 | 266 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 41.5000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 20.7775 | 4 | 8 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 28.8533 | 2 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 266.5000 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 266.5000 | 1 | 2 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 0.0260 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 180.1076 | 4 | 4 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 25.3110 | 1 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 20.1100 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 8.8520 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 8.7790 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | Ki | 18.4000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 30.5867 | 1 | 3 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 120.9500 | 1 | 2 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 83.4000 | 1 | 2 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | IC50 | 400.0000 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 1.8800 | 4 | 5 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 1.3000 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 2.4000 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 2.1850 | 1 | 2 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 5.6500 | 1 | 2 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 5.5000 | 1 | 2 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 10.8292 | 1 | 4 |
| Substance-K receptor | Homo sapiens (human) | Ki | 3.6095 | 1 | 4 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 6.3892 | 1 | 5 |
| Transcription factor 7-like 2 | Homo sapiens (human) | Ki | 387.2000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 7.9710 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 79.1660 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 1.0333 | 5 | 6 |
| UDP-glucuronosyltransferase 1A1 | Rattus norvegicus (Norway rat) | IC50 | 4.2000 | 1 | 1 |
| Vasopressin V1a receptor | Homo sapiens (human) | IC50 | 14.9690 | 1 | 2 |
| Vasopressin V1a receptor | Homo sapiens (human) | Ki | 6.0055 | 1 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 793.3950 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 12.8200 | 1 | 5 |
| Catenin beta-1 | Homo sapiens (human) | Kd | 20.0000 | 1 | 1 |
| Chain A, HIV-1 Protease | HIV-1 M:B_ARV2/SF2 | Kd | 0.0000 | 1 | 3 |
| Chain A, HIV-1 protease | Human immunodeficiency virus 1 | Kd | 0.0000 | 1 | 6 |
| Chain A, POL polyprotein | Human immunodeficiency virus 1 | Kd | 0.0268 | 1 | 5 |
| Chain A, Protease | HIV-1 M:B_ARV2/SF2 | Kd | 0.0006 | 1 | 36 |
| Chain A, Protease | Human immunodeficiency virus 1 | Kd | 0.0640 | 1 | 25 |
| Chain A, Protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Kd | 5.4000 | 1 | 1 |
| Chain A, Protease (Retropepsin) | Human immunodeficiency virus 1 | Kd | 3.2000 | 1 | 2 |
| Chain B, HIV-1 Protease | HIV-1 M:B_ARV2/SF2 | Kd | 0.0000 | 1 | 3 |
| Chain B, HIV-1 protease | Human immunodeficiency virus 1 | Kd | 0.0000 | 1 | 6 |
| Chain B, POL polyprotein | Human immunodeficiency virus 1 | Kd | 0.0268 | 1 | 5 |
| Chain B, Protease | HIV-1 M:B_ARV2/SF2 | Kd | 0.0006 | 1 | 36 |
| Chain B, Protease | Human immunodeficiency virus 1 | Kd | 0.0640 | 1 | 25 |
| Chain B, Protease | Human immunodeficiency virus type 1 (BRU ISOLATE) | Kd | 5.4000 | 1 | 1 |
| Chain B, Protease (Retropepsin) | Human immunodeficiency virus 1 | Kd | 3.2000 | 1 | 2 |
| Gag-Pol polyprotein | Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE) | EC50 | 0.0038 | 1 | 12 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 4.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 12.8200 | 1 | 5 |
| Protease | Human immunodeficiency virus 1 | EC50 | 0.2871 | 5 | 5 |
| Protease | Human immunodeficiency virus 1 | Kd | 0.0056 | 8 | 24 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.8200 | 1 | 5 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 12.8200 | 1 | 5 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 12.8200 | 1 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 12.8200 | 1 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.8200 | 1 | 5 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 12.8200 | 1 | 5 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 12.8200 | 1 | 5 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 12.8200 | 1 | 5 |