nicotinic antagonist

An antagonist at the nicotinic cholinergic receptor.

ChEBI ID: 48878

Members (17)

Member	Definition	Class
atracurium	A diester compound consisting of pentane-1,5-diol with both hydroxyls bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups.	atracurium
atracurium besylate	The bisbenzenesulfonate salt of atracurium.	atracurium besylate
cisatracurium	A diester that is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium, a quaternary ammonium ion consisting of pentane-1,5-diol with both hydroxy functions bearing 3-[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolinium-2(1H)-yl]propanoyl groups. The active species in the skeletal muscle relaxant cisatracurium besylate.	cisatracurium
dihydro-beta-erythroidine	An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene.	dihydro-beta-erythroidine
dizocilpine	An organic heterotetracyclic compound that is 1-methyl-8-azabicyclo[3.2.1]octane ortho-fused to two benzene rings at positions 2-3 and 6-7 (the 5S,10R-stereoisomer). It is a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor and affects cognitive function, learning, and memory.	dizocilpine
dizocilpine maleate	A maleate salt obtained by reaction of dizocilpine with one equivalent of maleic acid.	dizocilpine maleate
erysodine	An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities.	erysodine
kynurenic acid	A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4.	kynurenic acid
pancuronium	A steroid ester in which a 5alpha-androstane skeleton is C-3alpha- and C-17beta-disubstituted with acetoxy groups and 2beta- and 16beta-disubstituted with 1-methylpiperidinium-1-yl groups. It is a non-depolarizing curare-mimetic muscle relaxant.	pancuronium
pancuronium bromide	A bromide salt consisting of two bromide ions and one pancuronium dication.	pancuronium bromide
tramadol	A 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol in which both stereocentres have R-configuration; the (R,R)-enantiomer of the racemic opioid analgesic tramadol, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.	(R,R)-tramadol
tramadol hydrochloride	A hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer.	(R,R)-tramadol hydrochloride
trimethaphan	A complex heterocyclic sulfonium compound with an imidazolium core, used to treat hypertension.	trimethaphan
tubocurarine	A benzylisoquinoline alkaloid muscle relaxant which constitutes the active component of curare.	tubocurarine
u 18666a	A hydrochloride obtained by reaction of 3beta-(2-diethylaminoethoxy)androst-5-en-17-one with one equivalent of hydrochloric acid. It is a cholesterol synthesis and transport inhibitor.	3beta-(2-diethylaminoethoxy)androst-5-en-17-one hydrochloride
vecuronium	A 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidino- and 16beta-N-methylpiperidinium substituents.	vecuronium
vecuronium bromide	The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium substituents.	vecuronium bromide

Research

Studies (23,535)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	6,731 (28.60)	18.7374
1990's	6,526 (27.73)	18.2507
2000's	5,117 (21.74)	29.6817
2010's	3,959 (16.82)	24.3611
2020's	1,202 (5.11)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	3,121 (11.52%)	5.53%
Reviews	929 (3.43%)	6.00%
Case Studies	1,464 (5.40%)	4.05%
Observational	86 (0.32%)	0.25%
Other	21,495 (79.33%)	84.16%

Protein Targets (146)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	17.9008	1	2
acetylcholinesterase	Homo sapiens (human)	Potency	19.6553	3	3
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	39.8107	1	2
alpha-galactosidase	Homo sapiens (human)	Potency	8.9125	1	1
AR protein	Homo sapiens (human)	Potency	2.3066	3	3
arylsulfatase A	Homo sapiens (human)	Potency	0.0675	1	1
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	5.0202	2	3
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	89.1251	1	1
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	25.4181	1	3
Chain A, HADH2 protein	Homo sapiens (human)	Potency	20.3596	2	4
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	89.1251	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	22.4038	1	2
Chain B, HADH2 protein	Homo sapiens (human)	Potency	20.3596	2	4
chromobox protein homolog 1	Homo sapiens (human)	Potency	0.0274	1	2
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	19.9526	1	1
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	1.7377	1	1
cytochrome P450 2D6	Homo sapiens (human)	Potency	27.4096	1	2
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	20.4839	2	4
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	17.3901	2	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	2.2664	1	1
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	0.0398	1	1
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	0.0089	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	11.5466	5	7
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	7.9876	1	6
G	Vesicular stomatitis virus	Potency	1.7377	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	20.4839	1	2
geminin	Homo sapiens (human)	Potency	23.7630	2	3
glp-1 receptor, partial	Homo sapiens (human)	Potency	6.3096	1	1
GLS protein	Homo sapiens (human)	Potency	15.0083	2	3
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	4.2732	3	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	Homo sapiens (human)	Potency	50.1187	1	1
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	1.7377	1	1
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	1.7377	1	2
Interferon beta	Homo sapiens (human)	Potency	1.7377	1	1
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	12.5893	1	1
lysosomal alpha-glucosidase preproprotein	Homo sapiens (human)	Potency	0.2512	1	1
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	15.8124	1	2
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	0.1086	1	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	10.0000	2	2
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	26.6011	1	1
Parkin	Homo sapiens (human)	Potency	1.8356	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	4.5605	1	1
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	33.4889	1	1
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	8.9125	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	7.0795	1	1
pregnane X nuclear receptor	Homo sapiens (human)	Potency	1.9953	1	1
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	37.6858	1	1
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	0.2075	1	1
TDP1 protein	Homo sapiens (human)	Potency	11.8368	2	8
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	89.1251	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	8.5772	2	5
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	21.0995	2	5
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	39.8107	2	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	4
Bile salt export pump	Homo sapiens (human)	IC50	133.4000	2	5
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	4
Cholinesterase	Homo sapiens (human)	IC50	16.0000	1	1
Delta-type opioid receptor	Homo sapiens (human)	Ki	10.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	IC50	39.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	Ki	137.0000	1	1
GABA theta subunit	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Ki	70.4335	2	2
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Homo sapiens (human)	IC50	2,900.0000	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Glutamate receptor 1	Rattus norvegicus (Norway rat)	IC50	101.0000	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	IC50	101.0000	1	1
Glutamate receptor 3	Rattus norvegicus (Norway rat)	IC50	101.0000	1	1
Glutamate receptor 4	Rattus norvegicus (Norway rat)	IC50	101.0000	1	1
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	2
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	2
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	2
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	2
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	IC50	1,000.0000	1	2
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	IC50	7.5045	2	2
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	IC50	44.5718	10	11
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Ki	0.5198	7	11
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	IC50	7.5145	2	2
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	IC50	7.5045	2	2
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 2B	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	IC50	15.0000	1	1
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 2C	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	IC50	15.0000	1	1
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 2D	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	IC50	15.0000	1	1
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 3A	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	IC50	15.0000	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	IC50	45.0089	9	10
Glutamate receptor ionotropic, NMDA 3B	Homo sapiens (human)	Ki	0.0040	1	2
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Ki	0.0318	6	10
Kappa-type opioid receptor	Homo sapiens (human)	Ki	10.0000	1	1
Lysosomal Pro-X carboxypeptidase	Homo sapiens (human)	IC50	0.0053	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	Ki	1,300.0000	1	1
Mitogen-activated protein kinase 12	Homo sapiens (human)	Ki	1,300.0000	1	1
Mitogen-activated protein kinase 13	Homo sapiens (human)	Ki	1,300.0000	1	1
Mitogen-activated protein kinase 14	Homo sapiens (human)	Ki	1,300.0000	1	1
Mu-type opioid receptor	Homo sapiens (human)	Ki	2.4000	1	1
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	IC50	5.6500	1	2
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	IC50	40.3500	1	2
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	102.1500	1	4
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Muscarinic acetylcholine receptor M2	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Muscarinic acetylcholine receptor M3	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Muscarinic acetylcholine receptor M4	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	IC50	0.0020	1	1
Muscarinic acetylcholine receptor M5	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	IC50	74.3333	3	3
Neuronal acetylcholine receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Ki	100.0000	1	1
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	IC50	0.1470	3	3
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	IC50	0.0124	2	3
Neuronal acetylcholine receptor subunit alpha-4	Homo sapiens (human)	Ki	0.0740	2	2
Neuronal acetylcholine receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Ki	33.6533	3	3
Neuronal acetylcholine receptor subunit alpha-5	Homo sapiens (human)	IC50	0.0110	1	1
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	IC50	7.0000	1	1
Neuronal acetylcholine receptor subunit alpha-7	Homo sapiens (human)	Ki	9.0000	1	2
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	IC50	0.1470	3	3
Neuronal acetylcholine receptor subunit beta-2	Mus musculus (house mouse)	IC50	1.2000	1	1
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	IC50	0.0300	1	1
Neuronal acetylcholine receptor subunit beta-2	Homo sapiens (human)	Ki	0.0740	2	2
Neuronal acetylcholine receptor subunit beta-2	Rattus norvegicus (Norway rat)	Ki	0.4800	2	2
Neuronal acetylcholine receptor subunit beta-4	Mus musculus (house mouse)	IC50	1.2000	1	1
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	IC50	74.3333	3	3
Neuronal acetylcholine receptor subunit beta-4	Rattus norvegicus (Norway rat)	Ki	100.0000	2	2
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	IC50	1.7000	1	1
Sigma non-opioid intracellular receptor 1	Homo sapiens (human)	Ki	59.1670	1	2
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	Ki	59.1670	1	1
Small conductance calcium-activated potassium channel protein 1	Rattus norvegicus (Norway rat)	IC50	6.8000	1	1
Small conductance calcium-activated potassium channel protein 2	Rattus norvegicus (Norway rat)	IC50	6.8000	1	1
Small conductance calcium-activated potassium channel protein 3	Rattus norvegicus (Norway rat)	IC50	6.8000	1	1
Small conductance calcium-activated potassium channel protein 3	Rattus norvegicus (Norway rat)	Ki	5.9000	1	1
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	88.7600	1	1
Solute carrier family 22 member 1	Homo sapiens (human)	Ki	176.0000	2	2
Solute carrier family 22 member 2	Homo sapiens (human)	IC50	41.1500	1	2
Vesicular glutamate transporter 3	Rattus norvegicus (Norway rat)	Ki	1,300.0000	1	1

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Amine oxidase [flavin-containing] A	Rattus norvegicus (Norway rat)	Kd	6.4000	1	1
Aryl hydrocarbon receptor	Homo sapiens (human)	EC50	0.3000	1	1
G protein-coupled receptor GPR35	Rattus norvegicus (Norway rat)	EC50	66.0000	1	1
G-protein coupled receptor 35	Homo sapiens (human)	EC50	199.8000	9	9
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Kd	0.0372	1	1
Histamine H3 receptor	Rattus norvegicus (Norway rat)	EC50	500.0000	1	1
Mu-type opioid receptor	Homo sapiens (human)	EC50	1.0000	1	1
NPYLR7B	Aedes aegypti (yellow fever mosquito)	EC50	20.0000	1	1
Small conductance calcium-activated potassium channel protein 3	Rattus norvegicus (Norway rat)	Kd	6.4000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Glutamate receptor 1	Rattus norvegicus (Norway rat)	Kb	137.0000	2	2
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Kb	137.0000	2	2
Glutamate receptor 3	Rattus norvegicus (Norway rat)	Kb	137.0000	2	2
Glutamate receptor 4	Rattus norvegicus (Norway rat)	Kb	137.0000	2	2
Glutamate receptor ionotropic, kainate 1	Rattus norvegicus (Norway rat)	Kb	89.0000	1	1
Glutamate receptor ionotropic, kainate 2	Rattus norvegicus (Norway rat)	Kb	89.0000	1	1
Glutamate receptor ionotropic, kainate 3	Rattus norvegicus (Norway rat)	Kb	89.0000	1	1
Glutamate receptor ionotropic, kainate 4	Rattus norvegicus (Norway rat)	Kb	89.0000	1	1
Glutamate receptor ionotropic, kainate 5	Rattus norvegicus (Norway rat)	Kb	89.0000	1	1
Glutamate receptor ionotropic, NMDA 1	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 2A	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 2C	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 2D	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 3A	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6
Glutamate receptor ionotropic, NMDA 3B	Rattus norvegicus (Norway rat)	Kb	77.0967	4	6