ascorbic-acid and Hypersensitivity

The continuing global increase in allergic conditions and diseases in children is now a serious public health and scientific issue. Amongst other concerns is the maternal antenatal diet as intake of essential nutrients. Even small deficits in essential vitamin C can permanently impair the developing brain for example. In this article, we first review ascorbic acid deficiency in different organs of both mother and foetus. However, major emphasis is on the importance of vitamin C in foetal immunity with studies showing an inverse relationship between maternal intake of fresh fruit and vegetables and allergic conditions in childhood, inter alia. Other review results are included.

Topics: Antioxidants; Ascorbic Acid; Child; Diet; Female; Humans; Hypersensitivity; Pregnancy; Vitamins

For more than 50 years, the Food and Nutrition Board of the National Academy of Sciences has been reviewing nutrition research and defining nutrient requirements for healthy people, referred to as the Recommended Dietary Allowances (RDA). As new nutrition research is published, the importance of vitamins as vital nutrients is underscored, and new physiologic roles and applications to human health are examined and considered with regard to updating the RDA. Each year a substantial amount of new research is published on vitamins. This review examines recent research published on the importance of vitamin C with regard to general health.

Topics: Antioxidants; Ascorbic Acid; Ascorbic Acid Deficiency; Asthma; Cardiovascular Diseases; Diabetes Mellitus; Exercise; Humans; Hypersensitivity; Neoplasms

Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents; Ascorbic Acid; Cardiovascular System; Female; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Inflammation; Male; Rats

Topics: Animals; Ascorbic Acid; Candida albicans; Cell Division; Chemotaxis, Leukocyte; Copper; Cyclic GMP; Extracellular Matrix; Extracellular Space; Histamine; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Hypersensitivity; Immunization; Inflammation; Iodides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Prostaglandins; SRS-A

Topics: Adolescent; Adult; Aged; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Capillary Fragility; Child; Child, Preschool; Environment; Female; Hormones; Humans; Hypersensitivity; Infant; Infant, Newborn; Infant, Premature; Infections; Lactation; Male; Mental Health; Middle Aged; Nutritional Requirements; Physical Exertion; Pregnancy; Wound Healing

Topics: Administration, Oral; Aged; Antigen-Antibody Reactions; Ascorbic Acid; Aspirin; Child; Common Cold; Female; Fenfluramine; Humans; Hypersensitivity; Leukemia; Leukocytes; Lung Neoplasms; Male; Mouth Mucosa; Nutritional Requirements; Scurvy

Topics: Acid-Base Equilibrium; Animals; Ascorbic Acid; Cathartics; Cats; Chronic Disease; Digestive System; Dogs; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Fertility; Gastrointestinal Diseases; Guinea Pigs; Humans; Hypersensitivity; Lethal Dose 50; Mice; Nutritional Requirements; Rabbits; Rats; Species Specificity; Vagus Nerve; Water-Electrolyte Balance

Topics: Acetone; Aminobenzoates; Amodiaquine; Ascorbic Acid; Benzimidazoles; Chemical Phenomena; Chemistry; Chloroquine; Dermatologic Agents; Hydrazines; Hypersensitivity; Melanins; Naphthalenes; Nicotinic Acids; Pharmaceutic Aids; Phenols; Photosensitivity Disorders; Pyridines; Quinolines; Radiation Effects; Salicylates; Skin; Skin Absorption; Skin Physiological Phenomena; Sunburn; Sunscreening Agents; Ultraviolet Rays

Topics: Ascorbic Acid; Carbon Isotopes; Chemistry Techniques, Analytical; Chondroitin; Collagen; Glycosaminoglycans; Granuloma; Hexosamines; Histocytochemistry; Hyaluronic Acid; Hypersensitivity; Inflammation; Proteins; Research; Sulfur Isotopes

Objective Oxidative stress appears to be a key factor in the pathogenesis of allergic diseases and a potential therapeutic target in allergy treatment. Allergic diseases are reportedly associated with reduced plasma levels of ascorbate, which is a key physiological antioxidant. Ascorbate prevents excessive inflammation without reducing the defensive capacity of the immune system. Methods An interim analysis of a multicenter, prospective, observational study was conducted to investigate the change in disease-specific and nonspecific symptoms (fatigue, sleep disorders, depression, and lack of mental concentration) during adjuvant treatment with intravenous vitamin C (Pascorbin®; Pascoe, Giessen, Germany) in 71 patients with allergy-related respiratory or cutaneous indications. Results Between the start and end of treatment, the mean sum score of three disease-specific symptoms decreased significantly by 4.71 points and that of four nonspecific symptoms decreased significantly by 4.84 points. More than 50% of patients took no other allergy-related medication besides vitamin C. Conclusions Our observations suggest that treatment with intravenous high-dose vitamin C reduces allergy-related symptoms. Our observations form a basis for planning a randomized controlled clinical trial to obtain more definitive evidence of the clinical relevance of our findings. We also obtained evidence of ascorbate deficiency in allergy-related diseases.. Clinical Trials NCT02422901.

Topics: Administration, Intravenous; Adolescent; Adult; Aged; Antioxidants; Ascorbic Acid; Child; Female; Humans; Hypersensitivity; Inflammation; Male; Middle Aged; Oxidative Stress; Prospective Studies; Young Adult

Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.5 g of intravenously administered ascorbic acid on serum histamine levels (as detected by ELISA) in 89 patients (19 with allergic and 70 with infectious diseases). When all patients were grouped together, there was a significant decline in histamine concentration from 0.83 to 0.57 ng/ml×m2 body surface area (BSA, p<0.0001). The decrease in serum histamine concentration in patients with allergic diseases (1.36 to 0.69 ng/ml×m2 BSA, p=0.0007) was greater than that in patients with infectious diseases (0.73 to 0.56 ng/ml×m2 BSA, p=0.01). Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration. Intravenous infusion of ascorbic acid clearly reduced histamine concentrations in serum, and may represent a therapeutic option in patients presenting with symptoms and diseases associated with pathologically increased histamine concentration.

Topics: Adult; Aged; Ascorbic Acid; Communicable Diseases; Female; Histamine; Humans; Hypersensitivity; Infusions, Intravenous; Male; Middle Aged; Young Adult

Antioxidant intakes in pregnancy may influence fetal immune programming and the risk of allergic disease. We investigated associations between maternal intakes of β-carotene, vitamin C, vitamin E, copper and zinc, and infant allergic outcomes. Antioxidant intakes of pregnant women (n = 420) assessed prospectively by a food frequency questionnaire, were examined in relation to allergic outcomes at 1 year of age (n = 300). The main relationships with allergic outcomes were seen with dietary vitamin C and copper. Specifically, higher maternal dietary vitamin C intake was associated with a reduced risk of any diagnosed infant allergic disease and wheeze. After adjustment for potential confounders the relationship with wheeze remained statistically significant. There was also an inverse linear relationship between vitamin C and food allergy. Higher dietary copper intake was associated with reduced risk of eczema, wheeze and any allergic disease. The relationship with wheeze and any allergic disease remained statistically significant in multivariate analysis, and there was also an inverse linear relationship between copper and food allergy. However, these relationships were only seen for nutrients present in food. There were no relationships between β-carotene, vitamin E or zinc and any allergic outcomes. In summary, this study suggests that maternal diet of fresh foods rich in vitamin C is associated with reduced risk of infant wheeze, and that copper intake is associated with reduced risk of several allergic outcomes.

Topics: Antioxidants; Ascorbic Acid; beta Carotene; Copper; Diet; Dietary Supplements; Eczema; Female; Fish Oils; Food Hypersensitivity; Humans; Hypersensitivity; Immunoglobulin E; Infant; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Pregnancy; Prenatal Exposure Delayed Effects; Prospective Studies; Ubiquitin-Protein Ligases; Vitamin E

Anti-oxidants are of growing interest in early treatment and prevention of allergic diseases in early life, but the effects on allergen-specific immune responses need to be documented further before intervention studies in infants are undertaken. The aim of this study in adults was to determine the effects of dietary anti-oxidants on allergen-specific immune responses in sensitized individuals.. In a randomized controlled trial, 54 allergic adults received an anti-oxidant supplement (n=36) comprising beta-carotene (9 mg/day), vitamin C (1500 mg/day), vitamin E (130 mg/day), zinc (45 mg/day), selenium (76 microg/day) and garlic (150 mg/day) or a placebo (n=18) for 4 weeks. Anti-oxidant capacity (AC), serum levels of vitamin C, vitamin E, beta-carotene and selenium, peripheral blood responses, exhaled nitric oxide (eNO), as a marker of airway inflammation, and plasma F(2) isoprostanes, as a measure of oxidative stress, were measured before and after supplementation.. Anti-oxidant supplementation resulted in significant increases in serum levels of vitamin C, vitamin E, beta-carotene and selenium levels, compared with the placebo group (P<0.001). There was no change in serum AC, plasma F(2)-isoprostanes, eNO or immune responses following supplementation with anti-oxidants compared with placebo.. Supplementation with anti-oxidants resulted in significantly increased levels of vitamin C, vitamin E, beta-carotene and selenium but no change in immune responses, serum AC or plasma F(2)-isoprostanes.

Topics: Adolescent; Adult; Antioxidants; Ascorbic Acid; beta Carotene; Female; Humans; Hypersensitivity; Male; Selenium; Vitamin A

Hypersensitivity to electricity is a proposed environmental illness of unknown etiology. Patients report a variety of symptoms that they relate to electric equipment. The afflicted individuals suffer from ill health. Many interventions have been tried but, to date, there is no one specific treatment that has been proven superior to other remedial actions. In general, there is a lack of controlled prospective studies.. To test the hypothesis that antioxidant therapy reduces symptoms and improves health in patients reporting hypersensitivity to electricity.. Randomized, double-blind, crossover, placebo-controlled study.. Patients referred to the Environmental Illness Research Centre, Stockholm County Council.. Sixteen patients reporting hypersensitivity to electricity.. Antioxidant supplementation (vitamins C and E, selenium).. Self-reported symptoms and reported degree of hypersensitivity to electricity, serum levels of uric acid and diphenylpycrylhydrazyl (DPPH).. The results indicated no significant differences in reported symptoms, reported hypersensitivity to electricity, or oxidative status in serum between periods of antioxidant and placebo treatments. Serum levels of DPPH and uric acid showed no correlation with the reported degree of symptoms or hypersensitivity to electricity.. The study did not show any beneficial effect of antioxidant supplementation for patients reporting hypersensitivity to electricity. The results do not support the hypothesis that oxidative stress is a major contributor to ill health in patients who report hypersensitivity to electricity.

Topics: Adult; Antioxidants; Ascorbic Acid; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Electricity; Environmental Illness; Female; Humans; Hypersensitivity; Male; Middle Aged; Prospective Studies; Selenium; Vitamin E

Topics: Adolescent; Adult; Ascorbic Acid; Clinical Trials as Topic; Double-Blind Method; Female; Histamine; Humans; Hypersensitivity; Male; Middle Aged; Random Allocation

Allergy is an excessive immune response to a specific antigen. Type I allergies, such as hay fever and food allergies, have increased significantly in recent years and have become a worldwide problem. We previously reported that an ascorbic acid derivative having palmitoyl and glucosyl groups, 2-

Topics: Animals; Anti-Allergic Agents; Ascorbic Acid; Cell Degranulation; Disease Models, Animal; Hypersensitivity; Mice; Passive Cutaneous Anaphylaxis

2-

Topics: Animals; Anti-Allergic Agents; Ascorbic Acid; Cell Degranulation; Cell Line; Humans; Hyaluronoglucosaminidase; Hypersensitivity; Male; Mice, Inbred ICR; Sugar Acids

The responses of airway rapidly adapting receptors (RARs) to ovalbumin challenge and histamine were investigated in guinea pigs which were sensitized with ovalbumin. Sensitization alone increased the basal RAR activity. Antigen challenge stimulated them. Histamine doses which caused a 50% increase in airway resistance (ED50) were reduced immediately and 24h after antigen challenge indicating respectively early and late onset airway hyperresponsiveness. At these doses, there was a greater stimulation of the RARs compared to controls. An increase in lipid peroxidation and a decrease in glutathione peroxidase were observed also. With oral intake of vitamins C and E, attenuations in the basal RAR activity, the responses of RARs to antigen challenge and the oxidative stress were observed. With an increase in ED50, the RAR response to histamine became similar as in control. It is concluded that by decreasing the RAR responses to allergen and histamine, antioxidants may reduce reflex bronchoconstriction occurring in asthmatics.

Topics: Action Potentials; Adaptation, Physiological; Airway Resistance; Animals; Ascorbic Acid; Bronchoconstriction; Erythrocyte Count; Glutathione Peroxidase; Guinea Pigs; Hemoglobins; Histamine; Histamine Agonists; Hypersensitivity; Ovalbumin; Oxidative Stress; Reactive Oxygen Species; Respiratory System; Spectrophotometry; Thiobarbituric Acid Reactive Substances; Vitamin E

Exposure to air pollutants such as formaldehyde (FA) leads to inflammation, oxidative stress and immune-modulation in the airways and is associated with airway inflammatory disorders such as asthma. The purpose of our study was to investigate the effects of exposure to FA on the allergic lung inflammation. The hypothesized link between reactive oxygen species and the effects of FA was also studied. To do so, male Wistar rats were exposed to FA inhalation (1%, 90 min daily) for 3 days, and subsequently sensitized with ovalbumin (OVA)-alum by subcutaneous route. One week later the rats received another OVA-alum injection by the same route (booster). Two weeks later the rats were challenged with aerosolized OVA. The OVA challenge of rats upon FA exposure induced an elevated release of LTB 4, TXB 2, IL-1 beta, IL-6 and VEGF in lung cells, increased phagocytosis and lung vascular permeability, whereas the cell recruitment into lung was reduced. FA inhalation induced the oxidative burst and the nitration of proteins in the lung. Vitamins C, E and apocynin reduced the levels of LTB 4 in BAL-cultured cells of the FA and FA/OVA groups, but increased the cell influx into the lung of the FA/OVA rats. In OVA-challenged rats, the exposure to FA was associated to a reduced lung endothelial cells expression of intercellular cell adhesion molecule 1 (ICAM-1). In conclusion, our findings suggest that FA down regulate the cellular migration into the lungs after an allergic challenge and increase the ability of resident lung cells likely macrophages to generate inflammatory mediators, explaining the increased lung vascular permeability. Our data are indicative that the actions of FA involve mechanisms related to endothelium-leukocyte interactions and oxidative stress, as far as the deleterious effects of this air pollutant on airways are concerned.

Topics: Air Pollutants; Animals; Ascorbic Acid; Bronchoalveolar Lavage Fluid; Capillary Permeability; Formaldehyde; Hypersensitivity; Inflammation; Lung; Lung Diseases; Male; Phagocytosis; Rats; Rats, Wistar; Respiratory Burst; Vitamin E

Ragweed extract (RWE) contains NADPH oxidases that induce oxidative stress in the airways independent of adaptive immunity (signal 1) and augment antigen (signal 2)-induced allergic airway inflammation.. To test whether inhibiting signal 1 by administering antioxidants inhibits allergic airway inflammation in mice.. The ability of ascorbic acid (AA), N-acetyl cystenine (NAC), and tocopherol to scavenge pollen NADPH oxidase-generated reactive oxygen species (ROS) was measured. These antioxidants were administered locally to inhibit signal 1 in the airways of RWE-sensitized mice. Recruitment of inflammatory cells, mucin production, calcium-activated chloride channel 3, IL-4, and IL-13 mRNA expression was quantified in the lungs.. Antioxidants inhibited ROS generation by pollen NADPH oxidases and intracellular ROS generation in cultured epithelial cells. AA in combination with NAC or Tocopherol decreased RWE-induced ROS levels in cultured bronchial epithelial cells. Coadministration of antioxidants with RWE challenge inhibited 4-hydroxynonenal adduct formation, upregulation of Clca3 and IL-4 in lungs, mucin production, recruitment of eosinophils, and total inflammatory cells into the airways. Administration of antioxidants with a second RWE challenge also inhibited airway inflammation. However, administration of AA+NAC 4 or 24 hours after RWE challenge failed to inhibit allergic inflammation.. Signal 1 plays a proinflammatory role during repeated exposure to pollen extract. We propose that inhibiting signal 1 by increasing antioxidant potential in the airways may be a novel therapeutic strategy to attenuate pollen-induced allergic airway inflammation.. Administration of antioxidants in the airways may constitute a novel therapeutic strategy to prevent pollen induced allergic airway inflammation.

Topics: Acetylcysteine; Administration, Inhalation; Animals; Antioxidants; Ascorbic Acid; Bronchitis; Chloride Channels; Hypersensitivity; Interleukin-13; Interleukin-4; Lung; Mice; Mucins; Nitrate Reductase (NAD(P)H); Plant Extracts; Pollen; Reactive Oxygen Species; Tocopherols

There has been growing interest in the role of antioxidant function in controlling inflammatory disease states, such as allergy. This study investigated the relationship between antioxidant status, markers of airways inflammation [exhaled nitric oxide (eNO)], oxidative stress (F(2) isoprostanes) and immune responses in allergic adults.. Antioxidants (vitamins C, E, beta-carotene and selenium) and total antioxidant capacity (tAC) in serum were examined in relation to eNO, plasma F(2) isoprostanes and peripheral blood mononuclear cell (PBMC) cytokine and lymphoproliferative response to house dust mite (HDM) allergen, Staphylococcus enterotoxin B (SEB), phytohaemaglutinin (PHA) and lipopolysaccharide (LPS) in 54 allergic adults.. Firstly, levels of specific vitamins did not correlate with tAC. Secondly, we did not see any evidence that specific vitamin levels (or tAC) were associated with either polarization or attenuation of in vitro immune responses. If anything, there were positive correlations between antioxidant (vitamin C and selenium) levels and HDM allergen responses [lymphoproliferation (selenium; r=0.35, P=0.013) and both Th2 IL13 (vitamin C; tau=0.254, P=0.028) and Th1 IFN-gamma (vitamin C; tau=0.302, P=0.009) responses]. There were also significant positive relationships between antioxidant levels and IL-10 responses to polyclonal stimulation by SEB (r=0.292, P=0.036) and LPS (r=0.34, P=0.015) (beta-carotene) and PHA (r=0.34, P=0.021) (tAC). Thirdly, although airways inflammation (eNO) was associated with both in vitro and in vivo (skin test reactivity) to HDM, we did not see any correlation between eNO and oxidative stress (F(2)-isoprostanes). Finally, there were no consistent relationships between oxidative stress and immune responses.. There was no evidence that higher antioxidant levels were associated with reduced allergen responsiveness in allergic adults. If anything, antioxidant status was associated with increased immune responsiveness. The significance of this needs to be addressed in future intervention studies.

Topics: Adult; Allergens; Antigens, Dermatophagoides; Antioxidants; Ascorbic Acid; Asthma; beta Carotene; Biomarkers; Breath Tests; Enterotoxins; F2-Isoprostanes; Female; Humans; Hypersensitivity; Immunologic Tests; Interleukin-10; Lipopolysaccharides; Lymphocyte Activation; Male; Nitric Oxide; Oxidative Stress; Regression Analysis; Selenium; Vitamin E

To monitor the incidence of dry socket in a sample of 696 consecutive tooth extraction patients and to test the possible therapeutic effects of vitamin C.. Following standardized extractions, 24 dry socket patients were provided 4,000 mg/day dosages of Vitamin C. Demographic and health history data were collected.. The occurrence of dry socket (3.5% overall) was greater in females and individuals with lower overall health status, and supplemental Vitamin C was associated with rapid recovery.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Ascorbic Acid; Child; Disease; Dry Socket; Female; Health Status; Humans; Hypersensitivity; Male; Middle Aged; Retrospective Studies; Sex Factors; Smoking; Tooth Extraction

I previously described that bowel tolerance (the amount that almost causes diarrhea) to oral ascorbic acid, increases in a person somewhat proportionally to the "toxicity" of his disease. Ascorbic acid ameliorates symptoms and sometimes cures certain diseases at high threshold levels near bowel tolerance. High concentrations of ascorbate cause the redox potential of the redox couple (ascorbate/dehydroascorbate, AA/DHA) to become reducing in diseased tissues. Allergic and sensitivity reactions are frequently ameliorated and sometimes completely blocked by massive doses of ascorbate. I now hypothesize that one mechanism in blocking of allergic symptoms is the reducing of the disulfide bonds between the chains in antibody molecules making their bonding antigen impossible. I further hypothesize that antibodies seek to match antigens only in areas where stray free radicals or a relatively oxidizing redox potential exists. The redox state of normal, healthy tissue does not allow for the bonding of antibodies to antigen. When antioxidant, free radical scavenging systems are overwhelmed, inflammatory, hypersensitivity, and "autoimmune" conditions may result.

Topics: Animals; Antigen-Antibody Reactions; Ascorbic Acid; Autoimmune Diseases; B-Lymphocytes; Biological Evolution; Disulfides; Drug Hypersensitivity; Food Hypersensitivity; Histamine H1 Antagonists; Humans; Hypersensitivity; Oxidation-Reduction; Pneumonia, Pneumocystis; Receptors, Antigen, T-Cell

Appetite for vitamin C varies between individuals who consume it for control of inflammatory respiratory, and central nervous symptoms, all of which may have an allergic etiology. The mechanisms affecting appetite for vitamin C are discussed. Ascorbic acid is involved in the appreciation of taste which is diminished in allergic disease, as is appetite in scorbutic conditions. The actions of some appetite-depressant drugs such as fenfluramine, are reduced by administration of vitamin C. It appears that appetite diminished when brain ascorbic levels are reduced below a critical level. When tissue ascorbic acid concentrations are reduced, cellular electric potential is diminished. Cellular electric potential is diminished in allergic disease concurrently with development of symptoms. It is suggested that patho-physiological changes in the nervous system may occur in consequence of increased utilisation of ascorbic acid resulting from allergic and iatrogenic challenge. Appetite for vitamin C would be then be affected on an idiosyncratic basis. It is possible that this appetite is controlled by a neurological feed-back mechanism, activation of which is determined by reduction in cellular electric potential of tissues depleted by ascorbic acid.

Topics: Absorption; Appetite; Ascorbic Acid; Body Weight; Brain; Cheek; Energy Metabolism; Female; Humans; Hypersensitivity; Male; Mouth Mucosa; Taste; Time Factors

Skin test anergy (A) to recall antigens identifies surgical patients at high risk for sepsis. We studied neutrophil function in such patients to assess any alteration in their host defense mechanisms. Neutrophil adherence was measured with a modified adherence assay capable of measuring the adherence of neutrophils in whole blood or purified neutrophil suspensions, and neutrophil chemotaxis was assessed by the Boyeden technique. Twenty-one laboratory controls had a neutrophil adherence of 71.5 +/- 3.8% (mean +/-SD) and chemotaxis of 128.1 +/- 2.4,micro (mean +/-SD). Fifty-four hospitalized patients with normal skin tests had neutrophil adherence of 72.5 +/- 13.1% (p ~ 0.5 relative to control) and chemotaxis of 123.3 +/- 3.1 micro (p ~ 0.5). Twenty three relatively anergic patients had values of 84.3 +/- 7.9% (p < 0.001) and 103.7 +/- 2.0 micro (p < 0.001). Forty five A patients had adherence of 85.0 +/- 7.0% (p < 0.001) and chemotaxis of 90.4 +/- 2.9 micro (p < 0.001). The correlation coefficient between increased neutrophil adherence and decreased chemotaxis r = 0.81 has p < 0.0005. A factor which increased the adherence of normal control neutrophils was found in the plasma but not the serum of anergic patients. Inhibitors of control neutrophil chemotaxis have been shown in both serum and plasma of patients with decreased autologous neutrophil chemotaxis. We propose that this altered neutrophil function (possibly with other defects) in anergic patients may compromise their host defenses and render them susceptible to infection.

Topics: Adolescent; Adult; Aged; Ascorbic Acid; Aspirin; Chemotaxis, Leukocyte; Ethanol; Female; Humans; Hydrocortisone; Hypersensitivity; Immune Adherence Reaction; Levamisole; Male; Middle Aged; Neutrophils; Risk; Skin Tests; Surgical Procedures, Operative

Topics: Administration, Topical; Adolescent; Adult; Aged; Antazoline; Anti-Inflammatory Agents; Ascorbic Acid; Child; Child, Preschool; Conjunctivitis; Drug Combinations; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Hydrocortisone; Hypersensitivity; Infant; Infant, Newborn; Male; Middle Aged; Naphazoline

Topics: Adolescent; Adult; Ascorbic Acid; Cardiovascular Diseases; Collagen Diseases; Electron Spin Resonance Spectroscopy; Flavonoids; Freeze Drying; Humans; Hypersensitivity; Middle Aged; Pneumonia

Topics: Allergens; Antigen-Antibody Reactions; Ascorbic Acid; Humans; Hypersensitivity; Hypersensitivity, Immediate; Leukocytes; Skin Tests

Topics: Antigens; Ascorbic Acid; Common Cold; Dust; Humans; Hypersensitivity; Leukocytes; Mites; Nasal Cavity; Respiratory Hypersensitivity; Seasons

Topics: Adolescent; Ascorbic Acid; Child; Child, Preschool; Female; Humans; Hypersensitivity; Male

Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Breast Feeding; Canada; Citrus; Fruit; Humans; Hypersensitivity; Infant; Milk; Nutrition Surveys; Toxicology; Vitamin D; Vitamin D Deficiency; Vitamins

Topics: Air Pollution; Ascorbic Acid; Blood Chemical Analysis; Cholinesterases; Dust; Hypersensitivity; Oxides; Rabbits; Research; Toxicology; Vanadium; Vanadium Compounds

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Allergic Agents; Ascorbic Acid; Bradykinin; Cyproheptadine; Flavonoids; Histamine H1 Antagonists; Hypersensitivity; Pharmacology; Selective Serotonin Reuptake Inhibitors; Serotonin

Topics: Ascorbic Acid; Child; Humans; Hypersensitivity; Immune System Diseases; Infant; Infant Nutrition Disorders; Medical Records; Vitamin D; Vitamins

Scorbutic guinea pigs injected with CNS and mycobacterium to induce experimental allergic encephalomyelitis (EAE) showed no clear-cut neurological signs and failed to show histological evidence of central nervous system damage. The degree of protection afforded by vitamin C deprivation was related directly to the duration of the scorbutogenic diet and inversely to the strength of the CNS challenge. Vitamin C deprivation also abolished tuberculin sensitivity as measured by the PPD skin reaction. Upon restoration of vitamin C, the animals recovered their sensitivity to PPD but did not develop EAE. It was further demonstrated that these effects of vitamin C deprivation were not related to inanition or to the endogenous levels of 17-hydroxycorticosteroids.

Topics: Animals; Ascorbic Acid; Central Nervous System; Encephalomyelitis; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Hypersensitivity; Vitamin D Deficiency

Topics: Ascorbic Acid; Calcium; Cholestanes; Fathers; Humans; Hypercalcemia; Hypersensitivity; Incidence; Infant; Sarcoidosis; Vitamin D; Vitamins

Topics: Anti-Allergic Agents; Ascorbic Acid; Histamine H1 Antagonists; Hypersensitivity; Immune System Diseases; Prednisone

Topics: Adrenal Glands; Anaphylaxis; Animals; Ascorbic Acid; Cortisone; Guinea Pigs; Hypersensitivity; Immune System Diseases; Lactic Acid; Potassium; Sodium Salicylate

Topics: Ascorbic Acid; Cortisone; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Humans; Hypersensitivity; Vitamins

Topics: Ascorbic Acid; Diphenhydramine; Humans; Hypersensitivity; Immune System Diseases; Respiratory System; Respiratory Tract Diseases; Vitamins

Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Hypersensitivity; Rheumatic Diseases

Topics: Alloxan; Ascorbic Acid; Carbohydrate Metabolism; Carbohydrates; Cortisone; Desensitization, Immunologic; Humans; Hypersensitivity; Tuberculin

Topics: Albumins; Animals; Ascorbic Acid; Edema; Egg White; Hypersensitivity; Rats; Vitamins

Topics: Ascorbic Acid; Humans; Hypersensitivity; Immune System Diseases; Respiratory Hypersensitivity; Vitamins

Topics: Anti-Allergic Agents; Ascorbic Acid; Flavonoids; Hypersensitivity; Immune System Diseases; Rutin; Vitamins

Topics: Anti-Allergic Agents; Antipyrine; Ascorbic Acid; Humans; Hypersensitivity; Immune System Diseases; Salicylates; Vitamins

Topics: Administration, Oral; Ascorbic Acid; Hypersensitivity; Immune System Diseases; Procaine; Pruritus; Vitamins

Topics: Ascorbic Acid; Humans; Hypersensitivity; Leukocytes; Skin Diseases

Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Ascorbic Acid; Histamine Antagonists; Humans; Hypersensitivity; Hypnotics and Sedatives; Vitamins

Topics: Ascorbic Acid; Eye; Eye Hemorrhage; Humans; Hypersensitivity; Niacin; Nicotinic Acids; Shwartzman Phenomenon; Vitamins

Topics: Adrenal Cortex Hormones; Ascorbic Acid; Desoxycorticosterone; Hypersensitivity; Shwartzman Phenomenon; Vitamins

Topics: Anaphylaxis; Ascorbic Acid; Flavonoids; Histamine; Hypersensitivity; Immune System Diseases; Skin; Vitamins

Topics: Adrenal Glands; Anaphylaxis; Ascorbic Acid; Humans; Hypersensitivity

Topics: Anaphylaxis; Ascorbic Acid; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Imidazoles

Topics: Adrenal Cortex Hormones; Ascorbic Acid; Humans; Hypersensitivity; Immune System Diseases; Sodium; Vitamins

Topics: Acetylcholine; Ascorbic Acid; Calcium; Calcium, Dietary; Cholinergic Antagonists; Desensitization, Immunologic; Dithionite; Humans; Hypersensitivity; Magnesium