A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
| Member | Definition | Class |
|---|
| aminosalicylic acid | An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4. | 4-aminosalicylic acid |
| azomycin | An imidazole that is 1H-imidazole substituted at position 2 by a nitro group. | 2-nitroimidazole |
| bedaquiline | A quinoline-based antimycobacterial drug used (as its fumarate salt) for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of the mycobacteria. | bedaquiline |
| caribenol a | A terpene lactone that is 3,4,5,5a,6,7,7a,10,10a,10b-decahydro-2H-1-oxabenzo[cd]cyclopenta[h]azulen-2-one substituted by a hydroxy group at position 10b and methyl groups at positions 3, 6, 9 and 10a. It is isolated from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae and exhibits antitubercular and antimalarial activity. | caribenol A |
| cycloserine | A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). | D-cycloserine zwitterion; D-cycloserine |
| ethambutol | An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone. | ethambutol |
| ethambutol hydrochloride | The dihydrchloride salt of ethambutol. A bacteriostatic antimycobacterial drug, it is effective against Mycobacterium tuberculosis and some other mycobacteria. It is used in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol dihydrochloride is used alone. | ethambutol dihydrochloride |
| ethionamide | A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide. | ethionamide |
| hentriacontane | | hentriacontane |
| isoniazid | A carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. | isoniazide |
| lomefloxacin | A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. | lomefloxacin |
| lomefloxacin hydrochloride | The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for the treatment of otitis externa and otitis media. | lomefloxacin hydrochloride |
| pyrazinamide | A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. | pyrazinecarboxamide |
| pyrazinoic acid | The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide. | pyrazine-2-carboxylic acid |
| rifampin | A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei). | rifampicin zwitterion; rifampicin |
| rifamycin sv | A member of the class of rifamycins that exhibits antibiotic and antitubercular properties. | rifamycin SV |
| rifapentine | | rifapentine |
| s-ethylcysteine | A S-alkyl-L-cysteine that is L-cysteine in which the hydrogen of the thiol group is substituted by an ethyl group. | S-ethyl-L-cysteine zwitterion; S-ethyl-L-cysteine |
| viomycin | A cyclic peptide antibiotic produced by the actinomycete Streptomyces puniceus, used in the treatment of tuberculosis. | viomycin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 29.9033 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 3.1623 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.8709 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 33.2058 | 1 | 3 |
| AR protein | Homo sapiens (human) | Potency | 26.7374 | 4 | 4 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 10.1090 | 2 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 0.0213 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 23.0999 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 33.8078 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 66.8968 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 29.8975 | 1 | 7 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 12.5893 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 18.2406 | 1 | 2 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 46.6865 | 2 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 3.7908 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.5637 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.6108 | 2 | 12 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 33.9261 | 1 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 18.8336 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 63.0957 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0092 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 5.6234 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.9728 | 7 | 12 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 1.7990 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 44.2846 | 5 | 9 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.3364 | 1 | 10 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 9.5727 | 2 | 5 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 18.8876 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 3.7908 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.6108 | 1 | 6 |
| geminin | Homo sapiens (human) | Potency | 3.6537 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 27.0459 | 2 | 5 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 23.1494 | 3 | 5 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 38.3220 | 2 | 11 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 3.7908 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.5849 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 3.7908 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 3.7908 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 5.0119 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 24.7028 | 1 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 28.1838 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 38.9999 | 3 | 6 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0977 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 1.1883 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 14.1254 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 0.2282 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 10.6910 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 75.6863 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.6272 | 4 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 32.9838 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 11.7031 | 1 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 23.9031 | 1 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.5323 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.1508 | 3 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 2.2387 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 0.3575 | 1 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 25.1925 | 2 | 6 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 19.5147 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 34.8334 | 3 | 6 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 17.5734 | 1 | 2 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 0.2239 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 8.2753 | 2 | 8 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 37.6460 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.5261 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 | Escherichia coli | IC50 | 1,000.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 26.6500 | 2 | 2 |
| Arylacetamide deacetylase | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| ATP synthase subunit c | Mycolicibacterium smegmatis | IC50 | 0.0119 | 3 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 100.8200 | 1 | 5 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 325.5006 | 7 | 18 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 509.4500 | 1 | 4 |
| Bile salt export pump | Homo sapiens (human) | Ki | 31.0000 | 1 | 1 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 7.8500 | 1 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 93.6600 | 1 | 5 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 240.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 750.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1,230.0000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 8.3190 | 1 | 1 |
| Chain A, N-methyl-D-aspartate Receptor Subunit 1 | Rattus norvegicus (Norway rat) | Ki | 241.0000 | 1 | 3 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 56.0000 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 5.8000 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 374.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 35.0000 | 4 | 4 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 36.0000 | 1 | 1 |
| D-alanine--D-alanine ligase | Enterococcus faecalis V583 | IC50 | 262.0000 | 1 | 1 |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | Ki | 0.0010 | 1 | 1 |
| DNA gyrase subunit A | Escherichia coli K-12 | IC50 | 1,000.0000 | 1 | 1 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 2 |
| DNA gyrase subunit B | Escherichia coli K-12 | IC50 | 1,000.0000 | 1 | 1 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 2 |
| DNA-directed RNA polymerase subunit beta | Escherichia coli K-12 | IC50 | 50.0100 | 1 | 5 |
| DNA-directed RNA polymerase subunit beta | Escherichia coli O127:H6 str. E2348/69 | IC50 | 511.3333 | 3 | 3 |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | IC50 | 0.0100 | 1 | 1 |
| DNA-directed RNA polymerase subunit beta | Shigella sonnei Ss046 | IC50 | 50.0100 | 1 | 5 |
| Endonuclease 8-like 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Endonuclease III-like protein 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | IC50 | 4.1600 | 2 | 2 |
| Formamidopyrimidine-DNA glycosylase | Escherichia coli K-12 | IC50 | 50.0000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | IC50 | 4.8350 | 2 | 2 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | IC50 | 2.3000 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Isocitrate lyase | Mycobacterium tuberculosis H37Rv | IC50 | 455.8000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| microphthalmia-associated transcription factor isoform 9 | Homo sapiens (human) | IC50 | 2.8341 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 95.3600 | 1 | 5 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 4.8500 | 2 | 2 |
| N-glycosylase/DNA lyase | Homo sapiens (human) | IC50 | 50.0000 | 4 | 4 |
| NAD-dependent protein deacetylase sirtuin-6 | Homo sapiens (human) | IC50 | 671.8500 | 1 | 2 |
| NH(3)-dependent NAD(+) synthetase | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.0000 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| Pantothenate synthetase | Mycobacterium tuberculosis H37Rv | IC50 | 25.0000 | 3 | 6 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 502.0000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9490 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 270.8411 | 9 | 9 |
| Proton-coupled amino acid transporter 1 | Homo sapiens (human) | Ki | 4,400.0000 | 1 | 1 |
| Putative FAD-containing monooxygenase MymA | Mycobacterium tuberculosis H37Rv | IC50 | 4.9000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 4.3600 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 12.4000 | 2 | 2 |
| Solute carrier organic anion transporter family member 1A2 | Homo sapiens (human) | Ki | 31.0000 | 1 | 2 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 3.3867 | 2 | 3 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 1.2460 | 5 | 5 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 6.7000 | 2 | 3 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.1333 | 2 | 3 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 33.0000 | 2 | 2 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | Staphylococcus epidermidis RP62A | IC50 | 300.0000 | 1 | 1 |