Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
ChEBI ID: 37956
| Member | Definition | Class |
|---|---|---|
| buclizine | An N-alkylpiperazine carrying (4-chlorophenyl)(phenyl)methyl and 4-tert-butylbenzyl groups. | buclizine |
| chlorpheniramine | A tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. | chlorphenamine |
| cinnarizine | cinnarizine | |
| clemizole | A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively. | clemizole |
| clozapine | A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. | clozapine |
| cubebin | A lignan that consists of tetrahydrofuran-2-ol substituted by two 1,3-benzodioxol-5-ylmethyl groups at positions 3 and 4 respectively (the 2S,3R,4R stereoisomer). It is isolated from the leaves of Piper nigrum and exhibits analgesic, anti-inflammatory, antimicrobial and trypanocidal activities. | (-)-cubebin |
| demethylmirtazapine | A benzazepine metabolite resulting from demethylation of the antidpressant, mirtazapine. | N-demethylmirtazapine |
| doxylamine | doxylamine | |
| epinastine | A benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine. | epinastine |
| methdilazine | A phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. | methdilazine |
| methixene | metixene | |
| mirtazapine | mirtazapine | |
| olanzapine | A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4. | olanzapine |
| pizotyline | A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods. | pizotifen |
| profenamine | A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease. | profenamine |
| profenamine hydrochloride | The monohydrochloride salt of profenamine. An antimuscarinic, it is used for the symptomatic treatment of Parkinson's disease. | profenamine hydrochloride |
| propiomazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 2-(dimethylamino)propyl group at nitrogen atom and a propanoyl group at position 2. | propiomazine |
| quercetin 3-o-glucopyranoside | A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells | quercetin 3-O-beta-D-glucopyranoside |
| quetiapine | quetiapine | |
| thiethylperazine | A member of the class of phenothiazines that is perazine substituted by a ethylsulfanyl group at position 2. | thiethylperazine |
| ziprasidone | A piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms. | ziprasidone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,492 (12.66) | 18.7374 |
| 1990's | 3,409 (17.31) | 18.2507 |
| 2000's | 6,396 (32.49) | 29.6817 |
| 2010's | 5,511 (27.99) | 24.3611 |
| 2020's | 1,881 (9.55) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3,264 (14.16%) | 5.53% |
| Reviews | 2,492 (10.81%) | 6.00% |
| Case Studies | 4,199 (18.21%) | 4.05% |
| Observational | 122 (0.53%) | 0.25% |
| Other | 12,976 (56.29%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 10.0000 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 26.1157 | 2 | 5 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 19.5853 | 9 | 28 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 26.6452 | 2 | 4 |
| arylsulfatase A | Homo sapiens (human) | Potency | 16.0154 | 1 | 5 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.1612 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 22.0899 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 8.8327 | 2 | 5 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 21.2658 | 2 | 3 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 8.4921 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 16.7206 | 1 | 3 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0035 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 69.6614 | 1 | 3 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 11.6018 | 1 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 24.0353 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 194.5687 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 10.0000 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 33.1913 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 1.6010 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 14.5329 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 33.1913 | 2 | 3 |
| chaperonin-containing TCP-1 beta subunit homolog | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 42.1471 | 1 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.3920 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 21.6599 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 19.3738 | 1 | 3 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 9.2711 | 1 | 5 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 5.2693 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.4231 | 2 | 14 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 17.6071 | 2 | 10 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 22.6874 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 6.1422 | 3 | 5 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 40.6056 | 1 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0920 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 1.7783 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 20.7370 | 7 | 22 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.4915 | 1 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 19.9119 | 9 | 15 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 11.8080 | 1 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 26.2267 | 4 | 12 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 22.5001 | 2 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 6.1454 | 1 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 24.9053 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 19.3738 | 1 | 3 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.4231 | 1 | 7 |
| geminin | Homo sapiens (human) | Potency | 14.6313 | 3 | 8 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 11.1731 | 2 | 11 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 16.7470 | 2 | 6 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 13.5481 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 15.1424 | 3 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 30.0474 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 14.1898 | 2 | 19 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9315 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 19.3738 | 1 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 15.9866 | 1 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.1272 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 19.3738 | 1 | 6 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 8.5738 | 1 | 6 |
| Interferon beta | Homo sapiens (human) | Potency | 12.9790 | 2 | 6 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.1319 | 1 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 40.5334 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 7.9030 | 3 | 4 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 18.2406 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 19.2918 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 18.7353 | 2 | 7 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 2.6463 | 2 | 5 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.2783 | 3 | 3 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.0000 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 19.2344 | 2 | 4 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 20.1403 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 17.0217 | 2 | 4 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 10.9954 | 3 | 7 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 0.0079 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 11.3723 | 1 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 47.7548 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 16.9301 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 18.6891 | 3 | 7 |
| PINK1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| polyprotein | Zika virus | Potency | 24.9053 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.4668 | 1 | 5 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 8.9781 | 1 | 8 |
| PPM1D protein | Homo sapiens (human) | Potency | 6.5842 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 18.0070 | 2 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 23.6174 | 3 | 7 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 0.0079 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 12.8448 | 2 | 5 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 32.1647 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.4812 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 6.9131 | 2 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.5724 | 2 | 9 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.7155 | 2 | 29 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 21.4215 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 22.9715 | 4 | 7 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 20.6742 | 2 | 18 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 25.5898 | 3 | 6 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 32.3756 | 1 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 10.9702 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.8422 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 66.8968 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 30.0474 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0140 | 1 | 3 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 2.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.2646 | 3 | 6 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.7033 | 19 | 37 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.2944 | 9 | 11 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.7257 | 3 | 5 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.4346 | 2 | 4 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0838 | 5 | 11 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0851 | 11 | 12 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0255 | 49 | 80 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0105 | 24 | 30 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.1894 | 2 | 7 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0355 | 7 | 8 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.1030 | 6 | 11 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0136 | 7 | 8 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5215 | 3 | 7 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0328 | 8 | 9 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.1920 | 26 | 48 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0127 | 11 | 12 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | IC50 | 110.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.7503 | 4 | 6 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.0320 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.3539 | 2 | 4 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.3539 | 2 | 4 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.3539 | 2 | 4 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.3539 | 2 | 4 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.7118 | 2 | 5 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.4398 | 2 | 4 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.2239 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0163 | 4 | 5 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0500 | 28 | 44 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.2842 | 30 | 43 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 437.2971 | 6 | 7 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 3,492.5171 | 6 | 7 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 173.2000 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.2190 | 1 | 2 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 4.5000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.9007 | 2 | 3 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 16.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.1330 | 1 | 2 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 7.1050 | 2 | 2 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | IC50 | 1.5866 | 2 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0753 | 8 | 9 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0238 | 10 | 20 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5099 | 11 | 21 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0753 | 8 | 9 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0225 | 9 | 17 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5128 | 11 | 21 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.2803 | 2 | 5 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0753 | 8 | 9 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0507 | 10 | 21 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5924 | 9 | 18 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.7303 | 2 | 5 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.4353 | 2 | 3 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.2692 | 5 | 16 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1043 | 6 | 9 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.6020 | 2 | 5 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.4353 | 2 | 3 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.3183 | 3 | 12 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1171 | 4 | 7 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.3622 | 2 | 5 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.4353 | 2 | 3 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.1923 | 4 | 15 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1171 | 4 | 7 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 37.5237 | 2 | 3 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 8.6606 | 1 | 1 |
| Angiotensin-converting enzyme | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 3 |
| Arginase | Leishmania amazonensis | IC50 | 2.0000 | 1 | 1 |
| Aspartate aminotransferase, cytoplasmic | Homo sapiens (human) | IC50 | 5.3900 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 10.7000 | 1 | 1 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 18.0000 | 2 | 2 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1500 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 28.4300 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 171.4162 | 4 | 13 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 196.5000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 0.1110 | 2 | 2 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 3.3106 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 0.0757 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 0.0038 | 1 | 1 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 0.0200 | 1 | 1 |
| Chloroquine resistance transporter | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 54.0000 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 1.1600 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.7033 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | Ki | 4,033.3467 | 3 | 3 |
| Cruzipain | Trypanosoma cruzi | IC50 | 212.0000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0280 | 1 | 6 |
| D | Bos taurus (cattle) | IC50 | 4.0900 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 0.9957 | 8 | 13 |
| D | Bos taurus (cattle) | Ki | 0.4200 | 8 | 13 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.3523 | 13 | 24 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.2028 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.3468 | 13 | 25 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.4890 | 2 | 2 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1742 | 2 | 2 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 1.8040 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.3129 | 8 | 13 |
| D(2) dopamine receptor | Mus musculus (house mouse) | IC50 | 0.2900 | 1 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6164 | 19 | 29 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.6900 | 1 | 1 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.2540 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.1462 | 86 | 119 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1774 | 27 | 56 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 0.4402 | 2 | 5 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.4660 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.4324 | 37 | 57 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.2813 | 5 | 6 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0868 | 12 | 13 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.2593 | 52 | 66 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0880 | 5 | 5 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 102.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| Estrogen receptor 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| estrogen receptor beta isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 2 |
| Glucose-6-phosphate 1-dehydrogenase | Homo sapiens (human) | Ki | 497.2000 | 1 | 1 |
| Heat sensitive channel TRPV3 | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.0395 | 2 | 5 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0504 | 1 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0259 | 13 | 29 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 3.6100 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 3.5500 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 0.8155 | 2 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 0.1925 | 3 | 3 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 1.6600 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 3 | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| Lethal(3)malignant brain tumor-like protein 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 0.9500 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| MBT domain-containing protein 1 | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 41.4333 | 1 | 3 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 41.4333 | 1 | 3 |
| Mu-type opioid receptor | Homo sapiens (human) | IC50 | 2.2720 | 1 | 1 |
| Mu-type opioid receptor | Homo sapiens (human) | Ki | 0.9220 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 29.8000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 5 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 1.0314 | 3 | 5 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.3537 | 5 | 9 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.1501 | 8 | 20 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0136 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.9104 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.4410 | 5 | 7 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 1.2397 | 2 | 6 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0356 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.4107 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.4410 | 5 | 7 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.9060 | 2 | 7 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 1.3597 | 1 | 4 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.4410 | 5 | 7 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.6354 | 3 | 11 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 0.9532 | 1 | 4 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.4410 | 5 | 7 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 1.1024 | 2 | 8 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 423.6500 | 2 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 55.2855 | 1 | 2 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.6606 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | IC50 | 2.3000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.7680 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 12.9318 | 15 | 40 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 17.4001 | 5 | 7 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Short transient receptor potential channel 3 | Homo sapiens (human) | IC50 | 9.1000 | 1 | 1 |
| Short transient receptor potential channel 4 | Mus musculus (house mouse) | IC50 | 6.4000 | 1 | 1 |
| Short transient receptor potential channel 5 | Mus musculus (house mouse) | IC50 | 1.1000 | 1 | 1 |
| Short transient receptor potential channel 6 | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| Short transient receptor potential channel 7 | Mus musculus (house mouse) | IC50 | 26.5000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 1.1668 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0090 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 3.1603 | 2 | 3 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 16.9000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 2.1159 | 2 | 7 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.2392 | 4 | 5 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 6.8205 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.4487 | 2 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 68.1007 | 2 | 3 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.4233 | 2 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 50.6672 | 2 | 4 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | IC50 | 0.7000 | 2 | 3 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 4.8063 | 3 | 8 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 20.4600 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | IC50 | 26.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | IC50 | 0.5067 | 2 | 3 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.9161 | 2 | 7 |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | Ki | 0.0180 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 25.9700 | 2 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 3.1354 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.1259 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.2500 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 78.8000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 7.8600 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | Kd | 61.0000 | 1 | 1 |
| glycogen synthase kinase-3 beta isoform 1 | Homo sapiens (human) | EC50 | 15.8000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | EC50 | 0.0004 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Kd | 0.0016 | 1 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Kd | 0.0294 | 4 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 40.0000 | 1 | 3 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | EC50 | 7.8600 | 1 | 1 |
| Proteasome subunit alpha type-6 | Homo sapiens (human) | EC50 | 11.9000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | EC50 | 0.0013 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.8600 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 7.8600 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 7.8600 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 7.8600 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.8600 | 1 | 1 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 15.8500 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 7.8600 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 7.8600 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 7.8600 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Activity | 0.0028 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | INH | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | INH | 0.0064 | 1 | 1 |
| Arginase | Leishmania amazonensis | Kis | 6.9000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 26.2000 | 1 | 3 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Km | 43.7667 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Km | 45.2400 | 4 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Activity | 0.1328 | 1 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | pKi | 0.0069 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | pKi | 0.0066 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | pKi | 0.0073 | 1 | 1 |
| FAD-linked sulfhydryl oxidase ALR | Homo sapiens (human) | AC50 | 0.3690 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Activity | 0.0221 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | INH | 0.0012 | 1 | 1 |
| Pleiotropic ABC efflux transporter of multiple drugs | Saccharomyces cerevisiae S288C | INH | 5.6000 | 1 | 1 |
| Snq2p | Saccharomyces cerevisiae EC1118 | INH | 3.2000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 144.5000 | 2 | 2 |