Conditions > Endemic Goiter
Page last updated: 2024-09-28

Endemic Goiter

A form of IODINE deficiency disorders characterized by an enlargement of the THYROID GLAND in a significantly large fraction of a POPULATION GROUP. Endemic goiter is common in mountainous and iodine-deficient areas of the world where the DIET contains insufficient amount of iodine.

Synonyms(2)

Synonym
Endemic Goiter
Goiter, Endemic

Research Excerpts

Overview

ExcerptReference
"Endemic goiter is one of the health effects of iodine deficiency."( Nakamura, H, 1991)
"Endemic goiter is a health problem in many areas of the world; in some areas the disease is so severe that cretinism and other defects are found."( Fierro-Benitez, R; Kevany, J; Pretell, EA; Stanbury, JB, 1969)
"Even as endemic goiter is decreasing in Austria, an increase of salt iodization to 1 : 50000 according to the swiss procedure might eliminate definitely endemic goiter in Austria."( Ehlich, P; Fill, H; Glatzl, J; Obendorf, L; Platzer, S; Riccabona, G, 1981)
"The main cause of endemic goiter is iodine deficiency."( Gärtner, R, 1995)
"Although endemic goiter is an easily controlled chronic disease, it continues to be a serious global public health problem."( Avendaño, M; Biolley, E; Burgueño, M; Carvajal, F; Leiva, L; Muzzo, S; Vargas, S, 1997)
"Endemic goiter is no longer a problem in Chile."( Avendaño, M; Biolley, E; Burgueño, M; Carvajal, F; Leiva, L; Muzzo, S; Vargas, S, 1997)
"Endemic goiter is an adaptive disease produced by the persistent stimulation of the thyroid gland as consequence of the thyrotropin increased secretion due to the iodine deficiency."( Fenzi, G; Macchia, PE, 1998)
"Endemic goiter is epidemiologically associated with cretinism, deaf-mutism, and mental retardation."( Ake, O; Chaventre, A; Koffi, M; Kouame, P; Nama-Diarra, AJ, 1999)
"Endemic goiter is not longer a problem in Chile."( Biolley, E; Carvajal, F; Leiva, L; Muzzo, S; Ramírez, I, 2003)
"The main cause of endemic goiter is iodine deficiency, which is also the principal cause of mental retardation and avoidable cerebral palsy throughout the world."( Alfayate Guerra, R; Flores Serrano, J; Guirao Carratalá, MD; Pico Alfonso, A; Ruiz Pérez, L; Sánchez Serrano, FJ; Sánchez-Paya, J; Sanguino López, L; Zapico Alvarez-Cascos, MD; Zubiaur Cantalapiedra, A, 2007)

Context

ExcerptReference
"Although endemic goiter has been shown to have a high prevalence in Turkey, little is known about the concentration of urinary iodine, plasma selenium (Se), copper (Cu), and zinc (Zn) in these patients."( Aydin, A; Beyhan, Z; Isimer, A; Oktenli, C; Ozata, M; Ozdemir, IC; Salk, M; Sayin, S, 1999)
"The adolescents with endemic goiter have a reallocation of protein matter between erythrocytes, plasma and urine."( Khomyakova, I; Kireev, R; Popovsky, A, 2005)

Treatment

ExcerptReference
"In comparison, treatment of endemic goiter with iodine also lead to a reduction of hypertrophy, but as demonstrated in rats, also to a reduction of hyperplasia."( Gärtner, R, 1994)

Research

Studies (1,308)

TimeframeStudies, This Condition (%)All Conditions %
pre-1990704 (53.82)23.3326
1990's287 (21.94)12.5806
2000's222 (16.97)18.1394
2010's89 (6.80)28.8240
2020's6 (0.46)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bromide0low10
carbamates0low10
chlorine0low30
creatine0low10
lactic acid0low10
hydrogen carbonate0low10
iodine0medium1,03844
nickel0low10
niacinamide0low10
niacin0low10
nitrates0low40
pyridine0low10
pyruvic acid0low10
sulfites0low10
thiamine0low10
hydroxyindoleacetic acid0low10
amiodarone0low10
aristolochic acid i0low10
lidocaine0low10
1-methyl-3-isobutylxanthine0low10
aminosalicylic acid0low20
potassium iodide0medium336
sodium fluoride0low10
sodium iodide0low140
krypton0low10
thymidine0low30
hydroxyproline0low10
thyroxine0medium22129
triiodothyronine0medium1287
cyanides0low20
galactose0low10
edetic acid0low10
tyrosine0low20
methionine0low10
norethindrone0low10
phencyclidine0low10
oxazoles0low10
diiodotyrosine0medium101
thiocyanate0low170
chlormadinone acetate0low10
homocystine0low10
limestone0low20
malondialdehyde0low10
d-alpha tocopherol0low20
mannose0low10
carbonates0low20
manganese0low30
mercury0low10
molybdenum0low10
technetium0low40
cadmium0low20
chromium0low10
vanadium0low10
bromine0low20
fluorine0low30
chlorine0low20
fluorides0low110
iodine0medium924
carbimazole0low20
cetylpyridinium chloride anhydrous0low30
transferrin0low10
isothiocyanic acid0low10
trazodone hydrochloride0low10
glucose, (beta-d)-isomer0low10
metaperiodate0low10
fluorodeoxyglucose f180low10
cobalt0low30
perchlorate0low20
borneo0low20
thyroxine, triiodothyronine drug combination0low10
monoiodotyrosine0low30
ochratoxin a0low10
tretinoin0low10
retinol0low130
riboflavin0low20
potassium perchlorate0low20
glycosides0low30
retinol acetate0low10
propylthiouracil0low10
phenylthiourea0low70
thiouracil0low40
methimazole0low30
thiourea0low40
lithium0low20
17-ketosteroids0low20
vitexin0low10
apigenin0low20
luteolin0low10
lead0low20
antimony0low10
aluminum0low10
bismuth0low10
sulfur0low30
thyronines0low20
phosphorus0low30
boron0low10
selenium0low210
mannosylretinylphosphate0low10
mocetinostat0medium11
pituitrin0low10
nad0low10
endothelin-10low10
phosphatidylcholines0low10
non-ovlon0low10
technetium tc 99m sestamibi0medium41
potassium iodate0low90
sodium iodate0low10
sodium pertechnetate tc 99m0medium61
sodium ethylxanthate0low30
triiodothyronine, reverse0low30
ascorbic acid0low20
epidermal growth factor0low10
transforming growth factor beta0low10
phytoestrogens0low10
caseins0low10
exudates0low170
cyclic gmp0low10

Protein Targets (902)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE130013
aldehyde dehydrogenase 1 family, member A1200020
glucocorticoid receptor [Homo sapiens]230023
farnesoid X nuclear receptor180018
estrogen nuclear receptor alpha370037
Voltage-dependent calcium channel gamma-2 subunit130013
Cellular tumor antigen p53200020
Glutamate receptor 2130013
Choline O-acetyltransferase 0102
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chain A, Phosphodiesterase 9A0101
Chain A, JmjC domain-containing histone demethylation protein 3A7007
Chain A, Class I phosphodiesterase PDEB10101
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera0101
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera0101
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
glp-1 receptor, partial5005
thyroid stimulating hormone receptor110011
estrogen-related nuclear receptor alpha290029
Phosphodiesterase 0202
mitogen-activated protein kinase 1100010
geminin220022
cytochrome P450 3A4 isoform 1120012
histone acetyltransferase KAT2A isoform 17007
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Gamma-aminobutyric acid receptor subunit pi121114
Monocarboxylate transporter 40102
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A0101
Renin0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D 0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
Gamma-aminobutyric acid receptor subunit beta-1121114
Gamma-aminobutyric acid receptor subunit delta121114
Gamma-aminobutyric acid receptor subunit gamma-2121114
Gamma-aminobutyric acid receptor subunit alpha-5121114
Gamma-aminobutyric acid receptor subunit alpha-3121114
Gamma-aminobutyric acid receptor subunit gamma-1122115
Gamma-aminobutyric acid receptor subunit alpha-2121114
Adenosine receptor A10204
Gamma-aminobutyric acid receptor subunit alpha-4121114
Gamma-aminobutyric acid receptor subunit gamma-3121114
Adenosine receptor A30101
Adenosine receptor A2a0001
Adenosine receptor A2b0001
Adenosine receptor A2b0202
Gamma-aminobutyric acid receptor subunit alpha-6121114
Adenosine receptor A10215
Adenosine receptor A2a0204
Sodium-dependent serotonin transporter0202
Adenosine receptor A2a0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Gamma-aminobutyric acid receptor subunit alpha-1121114
Gamma-aminobutyric acid receptor subunit beta-3121114
Gamma-aminobutyric acid receptor subunit beta-2121114
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0202
Voltage-dependent L-type calcium channel subunit alpha-1C0303
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0202
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Phosphodiesterase 0101
GABA theta subunit121114
Phosphodiesterase 0101
Gamma-aminobutyric acid receptor subunit epsilon121114
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Chain A, 2-oxoglutarate Oxygenase7007
Microtubule-associated protein tau130013
thioredoxin glutathione reductase4004
Smad35005
euchromatic histone-lysine N-methyltransferase 2190019
microphthalmia-associated transcription factor isoform 90101
Carbonic anhydrase 1021023
Carbonic anhydrase 2021023
Tyrosine-protein phosphatase non-receptor type 10011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE110011
acetylcholinesterase110011
phosphopantetheinyl transferase120012
hypoxia-inducible factor 1 alpha subunit100010
RAR-related orphan receptor gamma230023
SMAD family member 28008
ATAD5 protein, partial6006
Fumarate hydratase3003
USP1 protein, partial150015
NFKB1 protein, partial4004
PPM1D protein4004
SMAD family member 38008
TDP1 protein200020
Thrombopoietin4004
AR protein260026
caspase 7, apoptosis-related cysteine protease5005
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)6006
estrogen receptor 2 (ER beta)160016
nuclear receptor subfamily 1, group I, member 3190019
progesterone receptor180018
EWS/FLI fusion protein7007
retinoic acid nuclear receptor alpha variant 1260026
retinoid X nuclear receptor alpha200020
pregnane X nuclear receptor230023
G120012
cytochrome P450 2D6120012
polyprotein3003
peroxisome proliferator-activated receptor delta150015
peroxisome proliferator activated receptor gamma200020
caspase-35005
thyroid stimulating hormone receptor120012
v-jun sarcoma virus 17 oncogene homolog (avian)170017
Histone H2A.x8008
cytochrome P450 2D6 isoform 14004
cellular tumor antigen p53 isoform a7007
cytochrome P450 2C9 precursor4004
D(1A) dopamine receptor2002
chromobox protein homolog 1140014
thyroid hormone receptor beta isoform a100010
potassium voltage-gated channel subfamily H member 2 isoform d5005
thyroid hormone receptor beta isoform 2190019
heat shock protein beta-1130013
huntingtin isoform 21001
flap endonuclease 17007
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 1250025
peptidyl-prolyl cis-trans isomerase NIMA-interacting 18008
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
nuclear receptor ROR-gamma isoform 19009
peripheral myelin protein 229009
survival motor neuron protein isoform d100010
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)9009
lamin isoform A-delta10150015
Polyunsaturated fatty acid lipoxygenase ALOX15B4004
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 409010
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier organic anion transporter family member 1A40204
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40404
Lysine-specific demethylase PHF20101
Bile salt export pump012012
Interferon beta130013
HLA class I histocompatibility antigen, B alpha chain 120012
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20202
Integrin beta-36006
Tyrosine-protein kinase Fyn0303
ATP-dependent translocase ABCB10202
Aldo-keto reductase family 1 member B10606
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10629
Integrin alpha-IIb6006
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Adenosine receptor A30404
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0336
Thyroid hormone receptor beta0336
Muscarinic acetylcholine receptor M10404
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0405
Androgen receptor0606
Alpha-1B adrenergic receptor0606
Lethal factor0101
Alpha-2B adrenergic receptor0415
Thyroid hormone receptor beta0202
Muscarinic acetylcholine receptor M30404
ATP-dependent translocase ABCB10202
Substance-K receptor0404
D(1A) dopamine receptor0405
D(4) dopamine receptor0405
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0415
Histamine H2 receptor0404
Endothelin-1 receptor0303
5-hydroxytryptamine receptor 2A0505
5-hydroxytryptamine receptor 2C0404
Lysine-specific demethylase 5A0101
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0606
Melanocortin receptor 40404
C-8 sterol isomerase0101
Melanocortin receptor 50404
Mu-type opioid receptor0607
D(3) dopamine receptor0405
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0303
Squalene synthase0101
Delta-type opioid receptor0405
Kappa-type opioid receptor0405
5-hydroxytryptamine receptor 2B0606
C-C chemokine receptor type 20202
Melanocortin receptor 30404
Alpha-1A adrenergic receptor0606
Histamine H2 receptor6006
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein5128
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20505
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Sodium channel protein type 5 subunit alpha0303
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0303
Lysine-specific demethylase 7A0101
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 1120012
Canalicular multispecific organic anion transporter 1010010
Sodium channel protein type 2 subunit alpha0202
Ataxin-26006
Sigma non-opioid intracellular receptor 10505
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0112
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0202
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0202
Sodium channel protein type 10 subunit alpha0202
cytochrome P450 2C9, partial120012
ATP-dependent phosphofructokinase7007
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, Cruzipain5005
Chain A, Transthyretin0022
Chain A, Transthyretin0022
Chain A, Transthyretin0022
Chain A, Transthyretin0022
Chain B, Transthyretin0022
Chain A, Transthyretin0022
Chain B, Transthyretin0022
Chain A, Casein kinase II subunit alpha0202
Chain A, Casein kinase II subunit alpha0202
Chain A, Casein Kinase Ii Subunit Alpha0202
Luciferase9009
interleukin 85005
endonuclease IV3003
BRCA12002
RGS122002
15-lipoxygenase, partial6006
GLS protein9009
GLI family zinc finger 3180018
apical membrane antigen 1, AMA14004
regulator of G-protein signaling 46006
cytochrome P450 family 3 subfamily A polypeptide 4170017
Neuraminidase 0505
67.9K protein5005
glucocerebrosidase4004
Parkin2002
vitamin D (1,25- dihydroxyvitamin D3) receptor180018
arylsulfatase A2002
pyruvate kinase2002
IDH17007
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
aryl hydrocarbon receptor120012
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a9009
Replicase polyprotein 1ab0224
NPC intracellular cholesterol transporter 1 precursor1001
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta2002
cytochrome P450 2C19 precursor3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 17007
nuclear factor erythroid 2-related factor 2 isoform 27007
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
histone deacetylase 9 isoform 33003
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
glycogen synthase kinase-3 beta isoform 10022
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
DNA polymerase eta isoform 16006
DNA polymerase iota isoform a (long)7007
DNA polymerase kappa isoform 1100010
M-phase phosphoprotein 86006
pyruvate kinase PKM isoform b1001
neuropeptide S receptor isoform A5005
Gamma-aminobutyric acid receptor subunit pi0202
Gamma-aminobutyric acid receptor subunit delta0202
Polyphenol oxidase 207010
Aldo-keto reductase family 1 member B100303
G2/mitotic-specific cyclin-B20202
Poly [ADP-ribose] polymerase tankyrase-10202
Lysozyme C-10101
Cationic trypsin0202
Transthyretin0226
Estrogen receptor0303
Glucocorticoid receptor0406
Cytochrome P450 1A10404
Amyloid-beta precursor protein0606
Myeloperoxidase0202
Cytochrome P450 1A20224
Cyclin-dependent kinase 10202
Beta-glucuronidase0101
Seed linoleate 13S-lipoxygenase-10307
Neutrophil elastase0404
Ornithine decarboxylase1002
Poly [ADP-ribose] polymerase 10303
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0325
Replicase polyprotein 1ab0325
Androgen receptor0204
Sialidase0202
Serine/threonine-protein kinase pim-10203
Aromatase0101
Angiotensin-converting enzyme0404
Cystic fibrosis transmembrane conductance regulator0112
17-beta-hydroxysteroid dehydrogenase type 10101
Pyruvate kinase PKM0101
G2/mitotic-specific cyclin-B10202
Gamma-aminobutyric acid receptor subunit alpha-10202
Urease subunit alpha0303
Aldo-keto reductase family 1 member B10303
G2/mitotic-specific cyclin-B0202
Mucin-10101
Glycogen synthase kinase-3 beta0202
Gamma-aminobutyric acid receptor subunit beta-10202
Gamma-aminobutyric acid receptor subunit gamma-20202
Casein kinase II subunit alpha'0202
Amine oxidase [flavin-containing] A0202
Acetylcholinesterase0202
Carbonic anhydrase 4014016
Amine oxidase [flavin-containing] B0202
Dipeptidyl peptidase 40202
Proteasome subunit beta type-50203
Gamma-aminobutyric acid receptor subunit beta-30202
Substance-P receptor0303
Gamma-aminobutyric acid receptor subunit alpha-50202
Multidrug resistance-associated protein 1 0101
Gamma-aminobutyric acid receptor subunit alpha-30202
Prostaglandin G/H synthase 20202
Receptor-type tyrosine-protein kinase FLT30202
Testosterone 17-beta-dehydrogenase 30101
17-beta-hydroxysteroid dehydrogenase type 20101
Acetylcholinesterase0101
Peroxisome proliferator-activated receptor gamma0022
Homeobox protein Nkx-2.5 0202
Tyrosine-protein kinase SYK0224
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit beta-20202
Xanthine dehydrogenase/oxidase0505
Gamma-aminobutyric acid receptor subunit alpha-40202
Glycogen synthase kinase-3 alpha0202
Glycogen synthase kinase-3 beta0202
Estrogen receptor0011
Nuclear receptor ROR-gamma5117
Death-associated protein kinase 10202
Mitogen-activated protein kinase 100202
Beta-secretase 10102
Casein kinase II subunit beta0202
Casein kinase II subunit alpha0303
Urease subunit beta0303
Gamma-aminobutyric acid receptor subunit epsilon0202
Disintegrin and metalloproteinase domain-containing protein 172002
Lactoperoxidase0101
Xanthine dehydrogenase/oxidase0304
MO15-related protein kinase Pfmrk 0101
Inositol monophosphatase 14004
Cyclin-dependent kinase 60202
Cyclin-dependent-like kinase 5 0202
Cyclin homolog0202
Transcription factor GATA-4 0202
Cyclin-dependent kinase 5 activator 10202
Gamma-aminobutyric acid receptor subunit alpha-60202
Mitogen-activated protein kinase 140202
Cytochrome P450 1B10404
Carbonic anhydrase 30202
Substance-K receptor0303
Reverse transcriptase/RNaseH 0101
Integrase 0202
Gamma-aminobutyric acid receptor subunit gamma-10202
Casein kinase II subunit alpha 30202
Inositol polyphosphate multikinase0202
G2/mitotic-specific cyclin-B30202
Estrogen receptor beta0101
Enoyl-acyl-carrier protein reductase 0303
Aurora kinase B0202
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 54004
Gamma-aminobutyric acid receptor subunit gamma-30202
Myocilin0011
Cyclin-dependent kinase 10202
Prenyltransferase homolog0001
Poly [ADP-ribose] polymerase tankyrase-20202
MAP kinase-interacting serine/threonine-protein kinase 20202
Carboxylic ester hydrolase 0101
NADPH oxidase 40202
Dipeptidyl peptidase 30202
Estrogen receptor beta0011
Inositol hexakisphosphate kinase 20202
Short transient receptor potential channel 50202
Gamma-aminobutyric acid receptor subunit theta0202
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Sialidase-20202
2,3-bisphosphoglycerate-independent phosphoglycerate mutase1001
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Cyclin-dependent kinase 20202
Chain A, Hyaluronidase, phage associated0101
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Pancreatic alpha-amylase0202
Albumin0101
Urease0304
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0505
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
pregnane X receptor5005
activating transcription factor 6120012
Carbonic anhydrase013015
Carbonic anhydrase 1509011
Lactoperoxidase0202
Chain A, Ferritin light chain6006
thyrotropin-releasing hormone receptor4004
vitamin D3 receptor isoform VDRA9009
Caspase-20011
bromodomain adjacent to zinc finger domain 2B5005
nuclear receptor subfamily 1, group I, member 21001
transcriptional regulator ERG isoform 33003
importin subunit beta-1 isoform 16006
snurportin-16006
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Cytochrome P450 2C190213
Proteasome subunit beta type-110001
thioredoxin reductase110011
NADPH oxidase 10101
Snq2p0001
Adenylate cyclase type 1 0202
Caspase-75005
Spike glycoprotein0123
caspase-35005
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0203
Transmembrane protease serine 20123
Glutamate receptor ionotropic, NMDA 2D0202
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0202
Bile salt export pump0202
Potassium channel subfamily K member 20202
Epidermal growth factor receptor0202
Albumin0011
Albumin0011
Major prion protein0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Major prion protein0011
Procathepsin L0123
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M40112
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50112
Cys-loop ligand-gated ion channel0101
Calmodulin-10213
Cytochrome P450 2D60224
Muscarinic acetylcholine receptor M20112
Cytochrome P450 2C9 0224
Polyunsaturated fatty acid lipoxygenase ALOX150202
5-hydroxytryptamine receptor 2A0202
Sphingomyelin phosphodiesterase0101
Alpha-2C adrenergic receptor0202
D0202
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0202
D(2) dopamine receptor0101
Proteasome subunit beta type-10001
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0303
Sodium-dependent dopamine transporter0213
Alpha-1D adrenergic receptor0202
D(1B) dopamine receptor0202
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
5-hydroxytryptamine receptor 1B0202
Trypanothione reductase0202
D(4) dopamine receptor0202
5-hydroxytryptamine receptor 2B0101
Histamine H1 receptor0101
5-hydroxytryptamine receptor 7 0101
Pleiotropic ABC efflux transporter of multiple drugs0102
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0202
Glutamate receptor ionotropic, NMDA 1 0305
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Gastrin/cholecystokinin type B receptor0101
Proteasome subunit alpha type-60012
D(2) dopamine receptor0203
Calmodulin 0112
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0305
Glutamate receptor ionotropic, NMDA 2B0305
Glutamate receptor ionotropic, NMDA 2C0306
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10303
Aldehyde oxidase0202
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 2D0305
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0305
D0101
Proteasome subunit beta type-70001
Angiotensin-converting enzyme 2 0123
Glutamate receptor ionotropic, NMDA 3A0305
Histamine H3 receptor0101
Sodium- and chloride-dependent creatine transporter 10101
Proton-coupled amino acid transporter 10202
Multidrug resistance-associated protein 50001
GTP-binding nuclear protein Ran isoform 13003
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, ATP-DEPENDENT DNA HELICASE Q15005
WRN3003
eyes absent homolog 2 isoform a1001
C-terminal-binding protein 11001
Eyes absent homolog 20202
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
Beta-galactosidase0101
Lipopolysaccharide heptosyltransferase 10101
PA-I galactophilic lectin0011
Jacalin0011
Glycogen phosphorylase, muscle form0101
Asialoglycoprotein receptor 10112
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 60204
Carbonic anhydrase 5A, mitochondrial0305
Carbonic anhydrase 70204
Carbonic anhydrase 90305
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase0103
Carbonic anhydrase 130102
Carbonic anhydrase 5B, mitochondrial0103
hypothetical protein, conserved1001
alpha-galactosidase3003
Uracil nucleotide/cysteinyl leukotriene receptor0101
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
dopamine D1 receptor1001
integrase, partial0202
lens epithelium-derived growth factor p750202
Bloom syndrome protein isoform 15005
hexokinase-4 isoform 11001
atrial natriuretic peptide receptor 1 precursor1001
glucokinase regulatory protein1001
Carbonic anhydrase 120103
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Carbonic anhydrase 30002
Solute carrier family 15 member 10101
Carbonic anhydrase0002
Large neutral amino acids transporter small subunit 10303
SLC16A10 protein0002
Carbonic anhydrase 0002
Carbonic anhydrase-like protein, putative0002
Carbonic anhydrase0002
Carbonic anhydrase 0002
Monocarboxylate transporter 100002
Carbonic anhydrase 140002
phosphoglycerate kinase2002
Chain A, Beta-lactamase3003
Potassium channel subfamily K member 30101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Multidrug and toxin extrusion protein 10202
Genome polyprotein 0101
histidine kinase 0101
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70001
P531001
lysosomal alpha-glucosidase preproprotein3003
galactokinase1001
polyunsaturated fatty acid lipoxygenase ALOX121001
DNA polymerase beta2002
muscleblind-like protein 1 isoform 13003
POsterior Segregation0011
Interstitial collagenase0101
Prostaglandin G/H synthase 10101
Chemotaxis protein CheA0101
Tyrosine-protein kinase Yes0101
72 kDa type IV collagenase0101
Stromelysin-10101
Polyunsaturated fatty acid 5-lipoxygenase0202
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0101
Alpha-amylase 1A 0101
Fatty acid synthase0101
Matrix metalloproteinase-90101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Aldo-keto reductase family 1 member B10101
Cruzipain0101
Cytosol aminopeptidase0101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Alpha-synuclein0303
Macrophage metalloelastase0101
Kappa-type opioid receptor0101
Collagenase 30101
1-deoxy-D-xylulose 5-phosphate reductoisomerase0101
Fatty acid synthase0202
Lactoylglutathione lyase0101
Protein polybromo-10011
Histone-lysine N-methyltransferase SETD70101
3-oxoacyl-acyl-carrier protein reductase 0202
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0202
MAP kinase-interacting serine/threonine-protein kinase 10101
G-protein coupled receptor 350112
DNA topoisomerase 10101
Zinc finger protein mex-50011
M1-family alanyl aminopeptidase0101
large T antigen0112
Alpha-mannosidase 2C10101
Fucose-binding lectin PA-IIL0101
CD209 antigen0101
Dopamine beta-hydroxylase 0202
Lanosterol 14-alpha demethylase0101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Cytochrome P450 3A40224
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Histone deacetylase 40101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Iodotyrosine deiodinase0011
fMet-Leu-Phe receptor0101
Tyrosine 3-monooxygenase0101
Tyrosine 3-monooxygenase0101
Iodotyrosine deiodinase 10011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Neuronal acetylcholine receptor subunit alpha-41001
Cholesteryl ester transfer protein0101
Neuronal acetylcholine receptor subunit beta-21001
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Tissue factor0101
Cytochrome P450 3A50101
NAD-dependent protein deacetylase HST20101
Fatty-acid amide hydrolase 10101
Protein mono-ADP-ribosyltransferase PARP150101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
Sodium/iodide cotransporter0101
Sex hormone-binding globulin0011
Estrogen receptor0011
Progesterone receptor0224
Estrogen receptor beta0011
nuclear factor NF-kappa-B p105 subunit isoform 13003
Solute carrier family 22 member 60001
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A30003
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase0101
Solute carrier family 22 member 60001
Solute carrier family 22 member 200202
Solute carrier family 22 member 80001
Solute carrier family 22 member 60202
Solute carrier family 22 member 190001
Solute carrier family 22 member 110001
Solute carrier family 22 member 80001
Solute carrier family 2, facilitated glucose transporter member 90112
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Cholinesterase0101
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
Chain A, PROTEIN (CATECHOL OXIDASE)0101
Tyrosinase0101
Succinyl-diaminopimelate desuccinylase0101
Taste receptor type 2 member 380036
NADH-cytochrome b5 reductase 3 0101
Thyroid peroxidase0101
Nicotinate phosphoribosyltransferase0101
Monocarboxylate transporter 20001
Monocarboxylate transporter 10001
C-terminal-binding protein 20101
Monocarboxylate transporter 20101
Prolyl 4-hydroxylase0101
Solute carrier organic anion transporter family member 2A10101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
nonstructural protein 12002
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
caspase-1 isoform alpha precursor2002
Quinolone resistance protein NorA0102
DNA topoisomerase 10101
Chromaffin granule amine transporter0101
Caspase-72002
Synaptic vesicular amine transporter0101
Synaptic vesicular amine transporter0213
Synaptic vesicular amine transporter0101
Solute carrier family 22 member 10202
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10204
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
NPYLR7B0011
tumor necrosis factor1001
Riboflavin-binding protein0112
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Carbonic anhydrase 0202
Mu-type opioid receptor0202
Carbonic anhydrase 0202
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 20101
isocitrate dehydrogenase 1, partial1001
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease subunit alpha0101
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
Chain X, Thyroid hormone receptor beta-10022
Chain X, Thyroid hormone receptor beta-10022
serine/threonine-protein kinase PLK11001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50002
Proliferating cell nuclear antigen0202
Retinoic acid receptor RXR-alpha0246
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0044
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 4C10102
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
acid sphingomyelinase1001
HLA class I histocompatibility antigen, A alpha chain 0011
Chain A, Nuclear Receptor ROR-beta0101
Ornithine decarboxylase0001
Retinoic acid receptor alpha0227
Retinoic acid receptor beta0227
Retinoic acid receptor alpha0123
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Retinoic acid receptor gamma0123
Retinoic acid receptor beta0123
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0123
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-beta0123
Retinoic acid receptor RXR-gamma0123
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Cellular retinoic acid-binding protein 10102
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10011
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Prothrombin0011
Sigma non-opioid intracellular receptor 10011
Solute carrier organic anion transporter family member 4C10001
Solute carrier organic anion transporter family member 4A10001
Solute carrier organic anion transporter family member 1C10101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Tubulin--tyrosine ligase0101
Taste receptor type 2 member 140001
Chain A, Uracil-DNA Glycosylase0101
TAR DNA-binding protein 431001
Protein cereblon0202
2-5A-dependent ribonuclease0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]