A compound which causes a reduction in the levels of glutathione in cells.
ChEBI ID: 68509
| Member | Definition | Class |
|---|---|---|
| diethyl maleate | A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis. | diethyl maleate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 264 (37.08) | 18.7374 |
| 1990's | 242 (33.99) | 18.2507 |
| 2000's | 138 (19.38) | 29.6817 |
| 2010's | 61 (8.57) | 24.3611 |
| 2020's | 7 (0.98) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.13%) | 5.53% |
| Reviews | 3 (0.40%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 737 (99.46%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Ataxin-2 | Homo sapiens (human) | Potency | 76.9588 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 76.9588 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.3872 | 1 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 0.2169 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 18.9920 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 0.6918 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 66.0492 | 2 | 2 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 0.0426 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0019 | 1 | 1 |