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aporphine alkaloid
Any benzylisoquinoline alkaloid that has a structure based on 4H-dibenzo[de,g]quinoline or its 3-methyl derivative.
ChEBI ID: 134209
Members (23)
| Member | Definition | Role |
|---|---|---|
| (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | (8R)-7-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | |
| (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,13,14-triol | |
| 1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | 1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol | |
| 10,11-dihydroxy-n-allylnoraporphine | (8R)-7-prop-2-enyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-13,14-diol | |
| 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | 6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | |
| actinodaphine | An organic heteropentacyclic compound 6,7,7a,8-tetrahydro-5H-benzo[g][1,3]dioxolo[4',5':4,5]benzo[1,2,3-de]quinoline bering additional hydroxy and methoxy substituents at positions 10 and 11 respectively. | actinodaphnine |
| anonaine | An aporphine alkaloid that exhibits anti-cancer, trypanocidal and antiplasmodial activites. | (-)-annonaine |
| apomorphine | apomorphine | |
| aporphine | An isoquinoline alkaloid that is the N-methyl derivative of 5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. | aporphine |
| asimilobine | R-(-)-asimilobine | |
| boldine | Boldine | |
| bulbocapnine | An aporphine alkaloid that has been isolated from Corydalis and exhibits inhibitory activity against enzymes such as tyrosine 3-monooxygenase and diamine oxidase. | bulbocapnine |
| corytuberine | An aporphine alkaloid that is aporphine which is substituted by hydroxy groups at positions 1 and 11, and by methoxy groups at positions 2 and 10 (the S enantiomer). | (S)-corytuberine |
| dicentrine | Dicentrine | |
| glaucine | An aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. | (S)-glaucine |
| isocorydine | Isocorydine | |
| isoteolin | Isoboldine | |
| laurolitsine | An aporphine alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV-1 integrase. | laurolistine |
| magnoflorine | An aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. | (S)-magnoflorine |
| n-methylactinodaphnine | (+)-Cassythicine | |
| n-n-propylnorapomorphine | (8R)-7-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-13,14-diol | |
| R-(-)-actinodaphnine | R-(-)-actinodaphnine | |
| xylopine | Xylopine |
Research
Studies (9,231)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4,886 (52.93) | 18.7374 |
| 1990's | 1,907 (20.66) | 18.2507 |
| 2000's | 1,325 (14.35) | 29.6817 |
| 2010's | 914 (9.90) | 24.3611 |
| 2020's | 199 (2.16) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 295 (2.97%) | 5.53% |
| Reviews | 438 (4.41%) | 6.00% |
| Case Studies | 119 (1.20%) | 4.05% |
| Observational | 11 (0.11%) | 0.25% |
| Other | 9,062 (91.30%) | 84.16% |