A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare.
ChEBI ID: 74530
| Member | Definition | Class |
|---|---|---|
| galantamine | A benzazepine alkaloid isolated from certain species of daffodils. | galanthamine |
| neostigmine | A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor. | neostigmine |
| pantothenic acid | A pantothenic acid having R-configuration. | (R)-pantothenic acid |
| physostigmine | physostigmine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 8,638 (60.57) | 18.7374 |
| 1990's | 1,667 (11.69) | 18.2507 |
| 2000's | 1,728 (12.12) | 29.6817 |
| 2010's | 1,686 (11.82) | 24.3611 |
| 2020's | 542 (3.80) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,027 (6.36%) | 5.53% |
| Reviews | 781 (4.84%) | 6.00% |
| Case Studies | 743 (4.60%) | 4.05% |
| Observational | 43 (0.27%) | 0.25% |
| Other | 13,557 (83.94%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.5381 | 4 | 8 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.9872 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 6.8590 | 1 | 1 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 61.5362 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 19.1172 | 1 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 23.9341 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.2818 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 15.8114 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 0.9772 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0049 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.6799 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 28.7026 | 4 | 4 |
| geminin | Homo sapiens (human) | Potency | 1.4581 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 18.5412 | 2 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.5900 | 1 | 2 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 12.9953 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 13.4991 | 1 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 6.7834 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 44.5346 | 3 | 3 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 21.6028 | 2 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.3762 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 15.9556 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0752 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 25.1189 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 9.4411 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 29.9349 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 5.8703 | 107 | 128 |
| Acetylcholinesterase | Gallus gallus (chicken) | IC50 | 0.0200 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 17.1474 | 109 | 126 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 0.9321 | 5 | 5 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 0.3578 | 9 | 12 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | IC50 | 0.4374 | 10 | 11 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 1.0870 | 6 | 6 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 11.9456 | 5 | 6 |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | Ki | 16.0950 | 1 | 2 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 1.9898 | 5 | 6 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 0.0189 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8570 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8570 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8570 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 505.1429 | 4 | 7 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 8.9098 | 10 | 12 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 0.0180 | 3 | 3 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 8.0000 | 1 | 1 |
| Chain A, ACETYLCHOLINESTERASE | Tetronarce californica (Pacific electric ray) | IC50 | 0.5060 | 1 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 13.8596 | 60 | 65 |
| Cholinesterase | Homo sapiens (human) | IC50 | 566,903,896,477.0687 | 63 | 77 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.2800 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | Ki | 3.8705 | 2 | 2 |
| Cholinesterase | Homo sapiens (human) | Ki | 17.4458 | 5 | 6 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 12.7300 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | IC50 | 4.7897 | 1 | 4 |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | IC50 | 3.2000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 160.0000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Small conductance calcium-activated potassium channel protein 3 | Rattus norvegicus (Norway rat) | IC50 | 12.7000 | 1 | 1 |
| Vascular endothelial growth factor receptor 1 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 0.5900 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | EC50 | 1.1000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | K | 0.0343 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Kc | 0.2500 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | MIC | 0.0000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | K | 0.1208 | 3 | 3 |
| Type II pantothenate kinase | Staphylococcus aureus subsp. aureus MSSA476 | Km | 19.0000 | 1 | 1 |
| Type III pantothenate kinase | Pseudomonas aeruginosa PAO1 | Km | 20.0000 | 1 | 1 |