Page last updated: 2024-08-05 15:22:01
gout suppressant
A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout.
ChEBI ID: 35845
Members (6)
| Member | Definition | Class |
|---|---|---|
| allopurinol | A bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. | allopurinol |
| colchicine | A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. | (S)-colchicine |
| indomethacin | A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. | indometacin |
| naproxen | A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. | naproxen |
| oxyphenbutazone | A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome. | oxyphenbutazone |
| sarsasapogenin, (3beta,5alpha,25r)-isomer | A widely used steroidal sapogenin isolated from several plant species and used for synthesizing steroid drugs. | tigogenin |
Research
Studies (61,267)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 25,675 (41.91) | 18.7374 |
| 1990's | 13,628 (22.24) | 18.2507 |
| 2000's | 10,007 (16.33) | 29.6817 |
| 2010's | 8,985 (14.67) | 24.3611 |
| 2020's | 2,972 (4.85) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,190 (6.36%) | 5.53% |
| Reviews | 3,601 (5.47%) | 6.00% |
| Case Studies | 4,180 (6.34%) | 4.05% |
| Observational | 92 (0.14%) | 0.25% |
| Other | 53,826 (81.69%) | 84.16% |
Protein Targets (270)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 2.0251 | 2 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.2939 | 1 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 10.6523 | 10 | 42 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 17.8211 | 2 | 4 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 14.9231 | 3 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.1228 | 1 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.0379 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.1359 | 2 | 6 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 1.8493 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 3.7578 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 3.7578 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 12.1338 | 3 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 16.6038 | 1 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 24.8401 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 35.4813 | 1 | 1 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 23.9535 | 1 | 6 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 25.1574 | 1 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 19.9072 | 2 | 2 |
| CREB-binding protein | Homo sapiens (human) | Potency | 5.0119 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 20.9752 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 9.8365 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 34.6713 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 8.3216 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 17.0674 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 14.9711 | 2 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 32.3513 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 40.4392 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 7.5193 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 2.5119 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 9.7519 | 11 | 40 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 32.7868 | 3 | 8 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.9688 | 7 | 36 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.9888 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.4754 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 10.5422 | 4 | 11 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 6.7016 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 1.9924 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 9.8365 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 17.0674 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 1.3175 | 4 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 1.7172 | 2 | 8 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 20.2208 | 1 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 7.7478 | 4 | 11 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 21.2430 | 1 | 6 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 10.2663 | 1 | 2 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 16.2400 | 2 | 3 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 20.9752 | 1 | 9 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 25.1566 | 2 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 9.8365 | 1 | 2 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 14.1254 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 42.7351 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 7.5397 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 9.6152 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 9.8365 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 3.9626 | 2 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 35.4756 | 1 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 3.5471 | 2 | 5 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 10.5910 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 40.6011 | 2 | 3 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 17.2168 | 2 | 3 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 0.8913 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 2.0484 | 1 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 8.5003 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 17.5889 | 3 | 14 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 12.9935 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 35.6278 | 1 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 3.2976 | 1 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.5598 | 2 | 3 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 6.6832 | 3 | 9 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 0.0955 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 6.5440 | 5 | 14 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 10.9345 | 5 | 16 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| polyprotein | Zika virus | Potency | 1.9924 | 1 | 2 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.0466 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 2.3064 | 3 | 7 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 6.3396 | 1 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 22.7123 | 2 | 5 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.2807 | 2 | 14 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 119.2187 | 1 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 1.4702 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 7.6510 | 4 | 19 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 4.6451 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 15.5537 | 2 | 8 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 15.5537 | 2 | 8 |
| Smad3 | Homo sapiens (human) | Potency | 3.3727 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 19.7312 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 18.2406 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 6.5308 | 2 | 15 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 10.0000 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 9.8064 | 3 | 5 |
| Thrombopoietin | Homo sapiens (human) | Potency | 0.5012 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 6.7740 | 2 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 15.6885 | 1 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 7.0166 | 2 | 9 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 36.5123 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 2.3802 | 2 | 8 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 8.9546 | 5 | 14 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 22.2852 | 5 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 21.2430 | 1 | 6 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 589.5000 | 1 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 589.5000 | 1 | 2 |
| Albumin | Homo sapiens (human) | Ki | 15,135,600,000.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 5.0000 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C1 | Homo sapiens (human) | IC50 | 106.5000 | 3 | 4 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 43.2943 | 6 | 7 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 2.5900 | 9 | 10 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | Ki | 1.1850 | 2 | 2 |
| Aldo-keto reductase family 1 member C4 | Homo sapiens (human) | IC50 | 84.6667 | 2 | 3 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 116.2500 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 42.0000 | 4 | 5 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 50.0000 | 4 | 4 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 43.5450 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 200.0927 | 4 | 11 |
| C-X-C chemokine receptor type 3 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 158.5000 | 2 | 4 |
| caspase recruitment domain family, member 15 | Homo sapiens (human) | IC50 | 6.6330 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 28.6667 | 1 | 6 |
| Caspase-3 | Homo sapiens (human) | IC50 | 28.6667 | 1 | 6 |
| Caspase-4 | Homo sapiens (human) | IC50 | 28.6667 | 1 | 6 |
| Caspase-5 | Homo sapiens (human) | IC50 | 28.6667 | 1 | 6 |
| Caspase-9 | Homo sapiens (human) | IC50 | 28.6667 | 1 | 6 |
| Chain A, membrane-associated prostaglandin E synthase-2 | Macaca fascicularis (crab-eating macaque) | IC50 | 1,000.0000 | 1 | 1 |
| Cytochrome c oxidase subunit 2 | Homo sapiens (human) | IC50 | 0.3400 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytosolic phospholipase A2 gamma | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Dehydrogenase/reductase SDR family member 9 | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| Dihydrofolate reductase | Homo sapiens (human) | Ki | 7,000.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 80.0000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 63.1250 | 3 | 4 |
| Histamine H3 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 8.6900 | 1 | 1 |
| Hormone-sensitive lipase | Rattus norvegicus (Norway rat) | IC50 | 1.2000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Mus musculus (house mouse) | IC50 | 0.0820 | 1 | 2 |
| Interleukin-8 | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 22.1667 | 3 | 3 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | IC50 | 12.3000 | 2 | 2 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 101.2000 | 1 | 4 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0040 | 1 | 1 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0002 | 1 | 2 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 24.3500 | 5 | 5 |
| Nuclear receptor ROR-gamma | Mus musculus (house mouse) | IC50 | 11.1000 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 67.5680 | 1 | 1 |
| P2Y purinoceptor 12 | Rattus norvegicus (Norway rat) | IC50 | 0.9600 | 1 | 1 |
| Phospholipase A2, major isoenzyme | Sus scrofa (pig) | IC50 | 1,000.0000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,000.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 645.6667 | 5 | 6 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 301.9950 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 11.8000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | IC50 | 10.0000 | 1 | 1 |
| Prostaglandin D2 receptor | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin D2 receptor 2 | Homo sapiens (human) | Ki | 4.0250 | 2 | 2 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 40.6000 | 1 | 1 |
| Prostaglandin E2 receptor EP1 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP2 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP3 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin E2 receptor EP4 subtype | Mus musculus (house mouse) | Ki | 10.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 1.6283 | 59 | 68 |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | IC50 | 0.0110 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 2.4668 | 80 | 101 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Ki | 7.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 75.1870 | 11 | 16 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.4854 | 8 | 8 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 17.0509 | 99 | 119 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | IC50 | 1.2653 | 13 | 22 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 102.7605 | 26 | 30 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | Ki | 9.8600 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 0.7764 | 6 | 9 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 0.4891 | 8 | 8 |
| Prostaglandin-H2 D-isomerase | Mus musculus (house mouse) | IC50 | 1.1000 | 2 | 2 |
| receptor-interacting serine/threonine-protein kinase 2 isoform 1 | Homo sapiens (human) | IC50 | 6.6330 | 1 | 1 |
| Rho-associated protein kinase 2 | Rattus norvegicus (Norway rat) | IC50 | 7.7000 | 1 | 2 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Serum paraoxonase/arylesterase 1 | Homo sapiens (human) | Ki | 97.0000 | 1 | 1 |
| Shiga toxin subunit A | Shigella dysenteriae | IC50 | 23.9000 | 1 | 1 |
| Sigma intracellular receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.4900 | 1 | 1 |
| Similar to alpha-tubulin isoform 1 | Bos taurus (cattle) | IC50 | 3.5316 | 20 | 38 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 0.2000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 14.0000 | 1 | 1 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 0.1200 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 4.4000 | 1 | 2 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 12.0500 | 2 | 4 |
| Solute carrier family 22 member 8 | Homo sapiens (human) | Ki | 5.9500 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A3 | Rattus norvegicus (Norway rat) | Ki | 1,000.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 12.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 38.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 140.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.5680 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 5.7000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 50.0500 | 2 | 2 |
| Tubulin alpha-1A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 4.6759 | 28 | 28 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Ki | 5.7500 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | IC50 | 21.7071 | 42 | 42 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 4.8445 | 26 | 26 |
| Tubulin beta chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta chain | Sus scrofa (pig) | Ki | 5.7500 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-1 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-2A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-2B chain | Bos taurus (cattle) | IC50 | 469.7233 | 24 | 24 |
| Tubulin beta-2B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-2B chain | Bos taurus (cattle) | Ki | 0.7800 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-3 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-4A chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-4B chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-6 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | IC50 | 22.8838 | 39 | 39 |
| Tubulin beta-8 chain | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | IC50 | 28.8000 | 2 | 2 |
| Vesicular acetylcholine transporter | Tetronarce californica (Pacific electric ray) | IC50 | 2.6200 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 13.7520 | 42 | 42 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 10.9968 | 40 | 40 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Ki | 1.8000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | Ki | 2.8917 | 6 | 6 |
| Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase | Rattus norvegicus (Norway rat) | IC50 | 9.3177 | 3 | 3 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine receptor A2a | Homo sapiens (human) | Kd | 77.0000 | 1 | 1 |
| Albumin | Homo sapiens (human) | Kd | 60.3500 | 2 | 2 |
| Androgen receptor | Homo sapiens (human) | EC50 | 0.0001 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 50.0000 | 1 | 1 |
| Prostaglandin D2 receptor 2 | Homo sapiens (human) | EC50 | 0.3890 | 1 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | Kd | 1.0200 | 1 | 1 |
| Purine nucleoside phosphorylase | Mycobacterium tuberculosis H37Rv | Kd | 1,000.0000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | Kd | 7.5000 | 2 | 2 |
| Tubulin alpha-1B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-1C chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-3C chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-3E chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin alpha-4A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta chain | Sus scrofa (pig) | Kd | 7.5000 | 2 | 2 |
| Tubulin beta-1 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-1 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-2A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-2A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-2B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-2B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-3 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-3 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-4A chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-4A chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-4B chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-4B chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-6 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-6 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin beta-8 chain | Homo sapiens (human) | EC50 | 0.2000 | 1 | 1 |
| Tubulin beta-8 chain | Homo sapiens (human) | Kd | 5.6790 | 2 | 2 |
| Tubulin polymerization-promoting protein | Bos taurus (cattle) | EC50 | 0.7500 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Kd | 0.0005 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 23.1650 | 2 | 2 |
| Caspase-1 | Homo sapiens (human) | ID50 | 30.0000 | 1 | 1 |
| Hypoxanthine-guanine phosphoribosyltransferase | Homo sapiens (human) | Km | 91.4500 | 2 | 2 |
| Microphthalmia-associated transcription factor | Homo sapiens (human) | AC50 | 35.0000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 0.2600 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | Activity | 1.0600 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | Change | 100.0000 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | ID50 | 25.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | Inhibition | 20.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | Kinact | 3.9000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | Change | 0.2000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | ID50 | 0.4300 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | Activity | 0.2500 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | Change | 0.2000 | 2 | 2 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | ID50 | 0.4300 | 1 | 1 |
| Solute carrier family 22 member 7 | Rattus norvegicus (Norway rat) | Km | 0.3660 | 1 | 1 |
| Tubulin alpha-1A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-1B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-1C chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-3C chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-3E chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin alpha-4A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-1 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-2A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-2B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-3 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-4A chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-4B chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-6 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| Tubulin beta-8 chain | Homo sapiens (human) | Activity | 9.4733 | 9 | 9 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 7.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | Km | 58.3750 | 4 | 4 |