Page last updated: 2024-08-05 11:14:09

imidazole antifungal drug

Any imidazole antifungal agent that has been used for the treatment of fungal infections in humans or animals.

ChEBI ID: 87069

Members (10)

MemberDefinitionRole
butoconazoleA member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to the nitrogen is substituted by a 4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl group. An antifungal agent, it is used as its nitrate salt in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans.butoconazole
butoconazole nitrateAn organic nitrate salt obtained by reaction of equimolar amounts of butaconazole and nitric acid. An antifungal agent, it is used in gynaecology for treatment of vulvovaginal infections caused by Candida species, particularly Candida albicans.butoconazole nitrate
clotrimazoleA member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.clotrimazole
croconazoleCroconazole
flutrimazoleAn imidazole antifungal agent that is imidazole in which the hydrogen attached to the nitrogen is replaced by a 2,4'-difluorotrityl group. A topical antifungal agent which displays potent broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts.flutrimazole
latoconazoleLanoconazole
neticonazoleAn enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14alpha-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.neticonazole
oxiconazoleAn oxime O-ether that is the 2,4-dichlorobenzyl ether of the oxime obtained by formal condensation of hydroxylamine with the carbonyl group of acetopnenone in which the phenyl group is substituted by chlorines at positions 2 and 4, and in which one of the hydrogens of the methyl group is replaced by a 1H-imidazol-1-yl group. An antifungal agent, it is used (generally as the nitrate salt) in creams and powders for the topical treatment of fungal skin infections.oxiconazole
sgd 301-76An organic nitrate salt resulting from the reaction of equimolar amounts of oxiconazole and nitric acid. An antifungal agent, it is used in creams and powders for the topical treatment of fungal skin infections.oxiconazole nitrate
sulconazole, mononitrate, (+-)-isomerSulconazole nitrate

Research

Studies (2,027)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990606 (29.90)18.7374
1990's357 (17.61)18.2507
2000's466 (22.99)29.6817
2010's470 (23.19)24.3611
2020's128 (6.31)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials343 (14.88%)5.53%
Reviews87 (3.77%)6.00%
Case Studies179 (7.77%)4.05%
Observational2 (0.09%)0.25%
Other1,694 (73.49%)84.16%