| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID177898 | Inhibition of dopamine accumulation in striatum part of rat brain after subcutaneous administration | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID177644 | Effect on dopamine accumulation in limbic system of rat. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177484 | Effect on Dopa accumulation upon subcutaneous administration in the hemispheres of rat brain; I - inactive at highest dose (50 umol/kg) | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID65133 | Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells | 2003 | Journal of medicinal chemistry, Oct-09, Volume: 46, Issue:21
| Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach. |
| AID64635 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D2L of CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID65081 | Binding affinity against dopamine receptor D2 in rat brain tissue using [3H]spiperone | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177127 | ED50 value was measured as dose required to produce a half-maximal reduction of Dopa accumulation in the striatum of reserpinized rat brain. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID177896 | Inhibition of dopamine accumulation in limbic part of rat brain after subcutaneous administration | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID177489 | Effect on half-maximal decrease of DOPA formation in rat limbic regions | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| C1- and C3-methyl-substituted derivatives of 7-hydroxy-2-(di-n-propylamino)tetralin: activities at central dopamine receptors. |
| AID177637 | Effect on 5-HTP accumulation in striatum of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID64006 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D4.2 of CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID64922 | In vitro affinity at mutant D2 receptor (S194A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID4216 | Binding affinity against 5-hydroxytryptamine 1A receptor in homogenated rat brain tissue, using by [3H]8-OH-DPAT as radioligand | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177870 | Inhibition of 5-Hydroxy tryptamine accumulation in hemispheres of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID1298705 | Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cells | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID64925 | In vitro affinity at wild type Dopamine receptor D2 on C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID177480 | Effect on Dopa accumulation upon subcutaneous administration in the carpus striatum of rat brain | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID312282 | Displacement of [3H]spiperone from human cloned dopamine D2L receptor expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration |
| AID173570 | Dose required for postsynaptic agonism using motor activity test in reserpinized rats | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series. |
| AID61137 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain limbic area by sc administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID170086 | Postsynaptic agonistic activity using motor activity test in reserpinized rats per 30 min | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series. |
| AID177121 | ED50 value was measured as dose required to produce a half-maximal reduction of Dopa accumulation in limbic area of reserpinized rat brain. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID63088 | In vitro binding affinity at human Dopamine receptor D2 expressed in CHO K1 cells was measured by its ability to displace [3H]- N-0437 | 2002 | Journal of medicinal chemistry, Jul-04, Volume: 45, Issue:14
| Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety. |
| AID65080 | Binding affinity against dopamine receptor D2 in homogenated rat brain tissue, using by ([3H]-N00437) as radioligand; Not tested | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID62709 | Presynaptic agonistic activity against dopamine receptor in striatum | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series. |
| AID64502 | Binding affinity was evaluated by calculating competition for [3H]N-0437 binding on Dopamine receptor D2L of CHO K-1 cells | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID177646 | Effect on dopamine accumulation in striatum of rat. | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID177485 | Effect on Dopa accumulation upon subcutaneous administration in the limbic system of rat brain | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID192729 | post-synaptic agonistic effects by increase in locomotor activity at the dose of 2.2 umol/kg, sc in reserpinized rat | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID446397 | Displacement of [3H]spiperone from human dopamine D3 receptor expressed in HEK293 cells | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID446399 | Selectivity index, ratio of Ki for human dopamine D2L receptor to Ki for human dopamine D3 receptor | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID65147 | In vitro binding affinity at human Dopamine receptor D3 expressed in CHO K1 cells was measured by its ability to displace [3H]spiperone | 2002 | Journal of medicinal chemistry, Jul-04, Volume: 45, Issue:14
| Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety. |
| AID312283 | Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in HEK293 cells | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration |
| AID3608 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain striatal area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID446398 | Displacement of [3H]spiperone from human dopamine D2L receptor expressed in HEK293 cells | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models. |
| AID65145 | In vitro ability to displace [3H]spiperone from human cloned Dopamine receptor D3 stably expressed in CHO cells. | 2001 | Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
| Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. |
| AID181024 | Percent reduction of hemispheres in cortex was measured in the brain of reserpinized rats; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID177299 | Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the limbic system of rat brain; I - inactive at highest dose (50 umol/kg) | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID177497 | Effect on 5-HTP accumulation in hemispheres of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID195773 | Tested for locomotor activity by measuring accumulated counts/30 min in reserpine-pretreated rats | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| C1- and C3-methyl-substituted derivatives of 7-hydroxy-2-(di-n-propylamino)tetralin: activities at central dopamine receptors. |
| AID239943 | Inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cells | 2005 | Journal of medicinal chemistry, Apr-07, Volume: 48, Issue:7
| CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. |
| AID1298711 | Selectivity index, ratio of Ki for human beta2 receptor to Ki for human D2S receptor | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID177284 | ED50 value was measured as dose required to produce a half-maximal reduction of Serotonin (5-HTP) accumulation in striatum of reserpinized rat brain; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID177643 | Effect on dopamine accumulation in hemispheres of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID64316 | In vitro ability to displace [3H]pramipexole from high affinity binding sites of bovine cloned D2 receptors stably expressed in CHO cells. | 2001 | Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
| Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. |
| AID64923 | In vitro affinity at mutant D2 receptor (S197A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID62342 | In vitro ability to displace [3H]spiperone from cloned bovine Dopamine receptor D2 stably expressed in CHO cells; Not determined | 2001 | Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
| Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. |
| AID65118 | Binding affinity was evaluated by calculating competition for [3H]spiperone binding on Dopamine receptor D3 expressed on CHO K-1 cells. | 1996 | Journal of medicinal chemistry, Oct-11, Volume: 39, Issue:21
| Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity. |
| AID177297 | Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the hemisphere of rat brain; I - inactive at highest dose (50 umol/kg) | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID177635 | Effect on 5-HTP accumulation in limbic system of rat; Inactive | 1988 | Journal of medicinal chemistry, Jun, Volume: 31, Issue:6
| Occurrence and pharmacological significance of metabolic ortho-hydroxylation of 5- and 8-hydroxy-2-(di-n-propylamino)tetralin. |
| AID312284 | Selectivity for human D3 receptor over human D2L receptor | 2008 | Journal of medicinal chemistry, Jan-10, Volume: 51, Issue:1
| Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration |
| AID177874 | Inhibition of 5-Hydroxy tryptamine accumulation in striatum part of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID1298708 | Displacement of [3H]spiperone from human D2S receptor expressed in CHO cells | 2016 | Bioorganic & medicinal chemistry, 06-15, Volume: 24, Issue:12
| Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. |
| AID172485 | DA agonist induced behavior was charecterised by increased locomotion, sniffing and licking.+ indicates low intensity of behavioral effect | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177492 | Effect on half-maximal decrease of DOPA formation in rat striatal regions | 1987 | Journal of medicinal chemistry, Oct, Volume: 30, Issue:10
| C1- and C3-methyl-substituted derivatives of 7-hydroxy-2-(di-n-propylamino)tetralin: activities at central dopamine receptors. |
| AID63194 | In vitro ability to displace [3H]SCH-23,390 from cloned bovine Dopamine receptor D1 stably expressed in CHO cells; Not determined | 2001 | Bioorganic & medicinal chemistry letters, Nov-05, Volume: 11, Issue:21
| Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding. |
| AID3596 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain hemispheral area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177295 | Effect of compound on 5-Hydroxy transaminase accumulation upon subcutaneous administration in the corpus striatum of rat brain; I - inactive at highest dose (50 umol/kg) | 1989 | Journal of medicinal chemistry, Oct, Volume: 32, Issue:10
| Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties. |
| AID61142 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain striatal area by sc administration | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177278 | ED50 value was measured as dose required to produce a half-maximal reduction of Serotonin (5-HTP) accumulation in limbic area of reserpinized rat brain; I is Inactive, no significant effect at doses approximately 40 times the ED50 for Dopa accumulation | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Monophenolic octahydrobenzo[f]quinolines: central dopamine- and serotonin-receptor stimulating activity. |
| AID64921 | In vitro affinity at mutant D2 receptor (S193A) in C6 (glioma) cell membranes. | 2000 | Journal of medicinal chemistry, Aug-10, Volume: 43, Issue:16
| CoMFA-based prediction of agonist affinities at recombinant wild type versus serine to alanine point mutated D2 dopamine receptors. |
| AID62706 | Presynaptic agonistic activity against dopamine receptor in limbic system | 1986 | Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
| A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series. |
| AID61005 | Effective dose for half-maximal decrease in the accumulation of DOPA in reserpinized rat brain hemispheral area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID177872 | Inhibition of 5-Hydroxy tryptamine accumulation in limbic part of rat brain after subcutaneous administration; I= Inactive | 1981 | Journal of medicinal chemistry, Aug, Volume: 24, Issue:8
| 8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist. |
| AID3602 | Effective dose for half-maximal decrease in the accumulation of 5-hydroxytryptophan (5-HTP) in reserpinized rat brain limbic area by sc administration; Inactive | 1993 | Journal of medicinal chemistry, Oct-29, Volume: 36, Issue:22
| Orally active central dopamine and serotonin receptor ligands: 5-, 6-, 7-, and 8-[[trifluoromethyl)sulfonyl]oxy]-2-(di-n-propylamino)tetralins and the formation of active metabolites in vivo. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |