ascorbic-acid and Leukopenia

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Ascorbic Acid; Autoantibodies; Autoimmune Diseases; Blood Transfusion; Chloroquine; Colitis; Colitis, Ulcerative; Drug Hypersensitivity; Drug Therapy; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Humans; Internal Medicine; Leukopenia; Lupus Erythematosus, Systemic; Neutrophils; Purpura; Purpura, Thrombocytopenic; Purpura, Thrombotic Thrombocytopenic; Splenectomy; Thrombocytopenia; Thyroiditis; Toxicology; Vitamins

To evaluate the efficacy and safety of sodium copper chlorophyllin (trademarked as "Yebaike Tablet which is abbreviated as YBK in treating leukopenia.. One hundred and five patients with leukopenia caused by various factors were randomized into 3 groups. The 60 patients in the YBK group took orally YBK Tablets at the dose of 40 mg, three times per day, the 30 patients in the leucogen group were treated with Leucogen Tablets at the dose of 20 mg, three times per day, and the 15 patients in the placebo group were administered with vitamin C tablets 100 mg, three times per day. All the subjects were treated for 1 month. The change of peripheral leucocytes count after treatment and adverse drug reaction that occurred in patients were studied.. In the 60 patients treated with YBK, the treatment proved to be markedly effective in 34 cases, effective in 17 and ineffective in 9, the total effective rate being 85%, which was significantly higher than that in the placebo group (26.7%, P < 0.01) and similar to that in the leucogen group (83.3%, P > 0.05). No adverse reaction was found in the treatment course.. YBK can be used in the treatment of leukopenia caused by various factors, satisfactory in efficacy and safe in use.

Topics: Adolescent; Adult; Ascorbic Acid; Chlorophyllides; Female; Humans; Leukocyte Count; Leukopenia; Male; Middle Aged; Tablets; Thiazoles; Thiazolidines; Treatment Outcome

A major limitation in the use of AZT for AIDS treatment is the occurrence of side effects, such as leukopenia. The effects of antioxidant vitamins C and E on AZT-induced leukopenia were investigated in mice. Mice were divided into four groups: (1) controls; (2) AZT-treated; (3) treated with AZT plus vitamins C and E; and (4) pre-treated with vitamins and then treated with AZT plus vitamins. Our results demonstrate that AZT causes leukopenia in mice, which was abrogated by administration of vitamins C and E in the pre-treated group. These vitamins prevented the decrease in cellular content induced by AZT in bone marrow and diminished peroxide levels in myeloid precursors in bone marrow. AZT also caused an increase in plasma malondialdehyde and blood oxidized glutathione levels, which was prevented by the administration of antioxidant vitamins. In conclusion, oxidative stress is involved in AZT-induced leukopenia which may be prevented by antioxidant treatment.

Topics: Animals; Anti-HIV Agents; Antioxidants; Ascorbic Acid; Bone Marrow Cells; Leukopenia; Male; Mice; Mice, Inbred Strains; Vitamin E; Zidovudine

Depressed lymphocyte blastogenesis in response to mitogen stimulation, depressed iodination of protein by neutrophils, and enhanced ingestion of Staphylococcus aureus by neutrophils were detected in a bull with chronic bovine viral diarrhea (BVD). Before developing chronic BVD, the bull was vaccinated with a killed cytopathic BVD virus. Neutralizing antibodies specific for the vaccine virus were detected in serum specimens obtained from the bull immediately before death. A noncytopathic BVD virus was isolated from the spleen after death. The immunologic and virologic findings in this bull supported reported research findings on the pathogenetic mechanisms involved in chronic BVD and mucosal disease.

Topics: Animals; Ascorbic Acid; Bovine Virus Diarrhea-Mucosal Disease; Cattle; Cattle Diseases; Chronic Disease; Diarrhea Viruses, Bovine Viral; Leukopenia; Lithium; Lithium Carbonate; Male; Neutralization Tests; Neutrophils; Spleen

Possible interactions between folic acid (folate) and ascorbic acid (AA) have been suspected because megaloblastic anemia is occasionally observed in scorbutic patients, and it may or may not respond to folate treatment. Male weanling guinea pigs were fed diets containing high levels of folate and AA or diets deficient in one or both vitamins. A total of 36 animals, including 9 controls, were studied. When anorexia began to appear in the deficient groups, all animals were killed by exsanguination, and tissue samples (blood, liver, adrenal, kidney, spleen, and intestinal mucosa) were removed for AA and folate analyses. Folate and AA deficiency lowered tissue folate and AA levels, respectively. AA deficiency, either alone or in combination with folate restriction, did not affect tissue folate levels, nor did AA deficiency significantly exacerbate the anemia and leukopenia caused by folate deficiency. However, there was an unexpected decrease in AA levels in the liver and adrenal glands with folate deficiency. Although AA does not appear to be needed for normal folate metabolism, the lower AA levels associated with a folate deficiency are indicative of an interaction between the two vitamins.

Topics: Anemia, Megaloblastic; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Folic Acid; Folic Acid Deficiency; Guinea Pigs; Hematocrit; Hemoglobins; Leukopenia; Male; Organ Specificity; Tissue Distribution

Topics: Animals; Ascorbic Acid; Body Weight; Bone Resorption; Dental Caries; Dextranase; Glycoside Hydrolases; Hemoglobins; Leukopenia; Pancreatic Extracts; Penicillium; Rats; Swine

Topics: Aged; Ascorbic Acid; Dietary Proteins; Female; Hematopoiesis; Humans; Leukopenia; Male; Middle Aged; Neoplasms; Thiotepa; Vitamin B Complex

Topics: Ascorbic Acid; Cyclophosphamide; Leadership; Leukocyte Disorders; Leukopenia; Muramidase; Neoplasms; Propionates; Radiation-Protective Agents; Testosterone; Toxicology

Topics: Ascorbic Acid; Blood Platelet Disorders; Blood Platelets; Dexamethasone; Hemorrhagic Fever with Renal Syndrome; Humans; Leukopenia; Prognosis; Pyridoxine; Thiamine; Vitamin B 6

Topics: Anemia; Anemia, Aplastic; Ascorbic Acid; Bilirubin; Blood Cell Count; Blood Chemical Analysis; Blood Transfusion; Bone Marrow Examination; Child; Flavonoids; Folic Acid; Hematopoietic System; Humans; Infant; Infant, Newborn; Leukopenia; Osteoporosis; Prednisolone; Prednisone; Pyridoxine; Radiography; Riboflavin; Testosterone; Thiamine; Thrombocytopenia; Vitamin B 12