ascorbic-acid and Sarcoma-37

The mitotic activity of the transplantable mouse tumors, Sarcoma 37, Krebs-2, and Ehrlich carcinomas, in the ascites form, were inhibited after treatment with a mixture of vitamins C and B12 with no apparent toxic side effects. These vitamins when administered alone, at the same dosage, did not seem to have any apparent effect on mitosis or the morphology of the cells studied. Microscopic examination of the stained ascites fluid taken from the mice treated with the vitamin mixture showed few tumor cells, and these in various stages of disintegration. Also, an increase in lymphocytes, monocytes and neutrophils were noticed; however, later in the experiment, no tumor cells could be found and monocytes and macrophages were abundant.

Topics: Animals; Ascorbic Acid; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Depression, Chemical; Female; Mice; Mitosis; Sarcoma 37; Time Factors; Vitamin B 12

D-Isoascorbic acid, an isomer of vitamin C, and betaine hydrate (quaternary amine) were found to inhibit mitoses of sarcoma 37, Ehrlich carcinoma, and L1210 leukemia cells in vitro. However, the combined effect of these compounds produced a greater inhibitory activity than when either was administered individually.

Topics: Animals; Ascorbic Acid; Betaine; Carcinoma, Ehrlich Tumor; Cell Line; Drug Therapy, Combination; Leukemia L1210; Mice; Mitosis; Neoplasms, Experimental; Sarcoma 37